公开(公告)号：US06903049B2

公开(公告)日：2005-06-07

申请号：US09683865

申请日：2002-02-25

Applicant: Grigorii Lev Soloveichik

Inventor： Grigorii Lev Soloveichik

IPC: B01J31/12 ,  B01J31/18 ,  B01J31/22 ,  B01J31/26 ,  C07C68/00 ,  B01J23/42

CPC classification number: B01J31/2213 ,  B01J31/1805 ,  B01J31/26 ,  B01J2531/16 ,  B01J2531/46 ,  B01J2531/824 ,  B01J2531/90 ,  C07C68/005 ,  C07C69/96

Abstract: The present disclosure is directed to a catalyst composition used in the production of aromatic carbonates, and in particular to a catalyst composition which comprises an activating solvent. In one embodiment the disclosure relates to a catalyst composition which comprises to a combination of two activating solvents, a first activating solvent chosen for its coordinative properties, and a second activating solvent chosen for its dielectric constant properties. In alternative embodiments, the present disclosure also pertains to a method for producing aromatic carbonates using the catalyst compositions disclosed herein.

Abstract translation: 本公开涉及用于制备芳族碳酸酯的催化剂组合物，特别涉及包含活化溶剂的催化剂组合物。 在一个实施方案中，本公开涉及一种催化剂组合物，其包含两种活化溶剂，根据其配位性质选择的第一活化溶剂和根据其介电常数性质选择的第二活化溶剂的组合。 在替代实施方案中，本公开还涉及使用本文公开的催化剂组合物生产芳族碳酸酯的方法。

公开(公告)号：US20050113244A1

公开(公告)日：2005-05-26

申请号：US10722195

申请日：2003-11-25

Applicant: David Gervasi ,  Santokh Badesha ,  John Spiewak

Inventor： David Gervasi ,  Santokh Badesha ,  John Spiewak

IPC: C07C49/92 ,  C07F1/08 ,  B01J31/00

CPC classification number: C07C49/92 ,  B01J31/0202 ,  B01J31/0205 ,  B01J31/0209 ,  B01J31/0231 ,  B01J31/0232 ,  B01J31/04 ,  B01J31/1805 ,  B01J31/1815 ,  B01J31/2234 ,  B01J2531/16 ,  B01J2531/52 ,  B01J2531/827 ,  B01J2531/94 ,  B01J2540/225 ,  B01J2540/64

Abstract: A process for solubilizing an organometallic compound in a fluorinated solvent to form an organometallic solution by adding and reacting a co-solubilizer having a partly fluorinated polymer, an organometallic compound, and a fluorinated solvent, and the co-solubilizer has the ability to cause the organometallic compound to become miscible in a fluorinated solvent, and further, the co-solubilizer is not a catalyst and is present in the final organometallic solution.

Abstract translation: 通过加入并使具有部分氟化的聚合物，有机金属化合物和氟化溶剂的共增溶剂和共溶解剂进行反应而使有机金属化合物溶解在氟化溶剂中以形成有机金属溶液的方法，并且该助溶剂具有使 有机金属化合物在氟化溶剂中混溶，此外，共增溶剂不是催化剂并存在于最终的有机金属溶液中。

公开(公告)号：US20050107621A1

公开(公告)日：2005-05-19

申请号：US10944055

申请日：2004-09-20

Applicant: Jun Takehara ,  Jingping Qu ,  Kazuaki Kanno ,  Hiroshi Kawabata ,  Yasumasa Dekishima ,  Makoto Ueda ,  Kyoko Endo ,  Takeshi Murakami ,  Tomoko Sasaki ,  Hisatoshi Uehara ,  Youichi Matsumoto ,  Shihomi Suzuki

Inventor： Jun Takehara ,  Jingping Qu ,  Kazuaki Kanno ,  Hiroshi Kawabata ,  Yasumasa Dekishima ,  Makoto Ueda ,  Kyoko Endo ,  Takeshi Murakami ,  Tomoko Sasaki ,  Hisatoshi Uehara ,  Youichi Matsumoto ,  Shihomi Suzuki

IPC: A61K31/381 ,  C07D333/16 ,  C07D333/22

CPC classification number: C07D333/16 ,  B01J31/1805 ,  B01J31/2295 ,  B01J2231/643 ,  B01J2531/80 ,  B01J2531/821

Abstract: The object of the present invention is to provide 3-hydroxy-3-(2-thienyl)propionamides useful as synthesis intermediates of pharmaceutical preparations and the like and a method for obtaining optically active 3-amino-1-(2-thienyl)-1-propanols using the same with high reaction yield, high optical yield and industrially low cost. According to the present invention, 3-amino-1-(2-thienyl)-1-propanols are obtained by carrying out asymmetric reduction of a β-ketocarbonyl compound having thiophene ring in the presence of a catalyst constituted from a compound of a group VIII or IX metal in the periodic table (e.g., a ruthenium compound) and an asymmetric ligand represented by a specified optically active diamine derivative (e.g., a diphenylethylenediamine derivative), or using a cell, a treated product of said cell or the like of a microorganism, and as occasion demands, carrying out amidation of the ester group and then carrying out reduction of the amido group. (each of the substituents is as described in claim 1).

Abstract translation: 本发明的目的是提供可用作药物制剂等的合成中间体的3-羟基-3-（2-噻吩基）丙酰胺和获得光学活性3-氨基-1-（2-噻吩基） 使用相同的1-丙醇，反应产率高，光学收率高，工业成本低。 根据本发明，3-氨基-1-（2-噻吩基）-1-丙醇通过在由组合的化合物构成的催化剂存在下进行具有噻吩环的β-酮羰基化合物的不对称还原而得到 VIII或IX族金属（例如钌化合物）和由特定光学活性二胺衍生物（例如二苯基乙二胺衍生物）表示的不对称配体，或使用电池，所述电池等的处理产物 微生物，根据需要，进行酯基的酰胺化，然后进行酰胺基的还原。 （每个取代基如权利要求1所述）。

公开(公告)号：US06878665B2

公开(公告)日：2005-04-12

申请号：US10490409

申请日：2002-09-16

Applicant: Sébastien Duprat de Paule ,  Nicolas Champion ,  Virginie Vidal ,  Jean-Pierre Genet ,  Philippe Dellis

Inventor： Sébastien Duprat de Paule ,  Nicolas Champion ,  Virginie Vidal ,  Jean-Pierre Genet ,  Philippe Dellis

IPC: B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C29/145 ,  C07C31/20 ,  C07C67/303 ,  C07C67/31 ,  C07C69/675 ,  C07F9/655 ,  C07F15/00 ,  B01J31/00 ,  C07C29/14 ,  C07F9/02

CPC classification number: B01J31/181 ,  B01J31/1805 ,  B01J31/2295 ,  B01J31/2457 ,  B01J2231/348 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0266 ,  B01J2531/16 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/847 ,  C07B53/00 ,  C07B2200/07 ,  C07C67/303 ,  C07C67/31 ,  C07F9/65517 ,  C07F9/65522 ,  C07F15/0046 ,  C07F15/0073 ,  C07C69/34 ,  C07C69/732 ,  C07C69/675

Abstract: The invention relates to novel diphosphines, in optically pure or racemic form, of formula (I): in which: R1 and R2 are a (C5-C7)cycloalkyl group, an optionally substituted phenyl group or a 5-membered heteroaryl group; and A is (CH2—CH2) or CF2. The invention further relates to the use of a compound of formula (I) as a ligand for the preparation of a metal complex useful as a chiral catalyst in asymmetric catalysis, and to the chiral metal catalysts comprising at least one ligand of formula (I).

Abstract translation: 本发明涉及式（I）的光学纯的或外消旋形式的新型二膦：其中：R1和R2是（C5-C7）环烷基，任意取代的苯基或5元杂芳基; 并且A是（CH 2 -CH 2）或CF 2。本发明还涉及式（I）化合物作为配体用于制备在不对称催化中用作手性催化剂的金属络合物和手性金属催化剂的用途 包含至少一种式（I）的配体。

公开(公告)号：US06867302B2

公开(公告)日：2005-03-15

申请号：US10194859

申请日：2002-07-12

Applicant: Milton R. Smith, III ,  Robert E. Maleczka

Inventor： Milton R. Smith, III ,  Robert E. Maleczka

IPC: B01J31/12 ,  B01J31/14 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  B01J31/28 ,  C07C1/32 ,  C07C17/269 ,  C07F5/02 ,  C07F15/00 ,  C07F17/02 ,  C08G61/10 ,  C07D213/14 ,  C07D213/08

CPC classification number: C08G61/10 ,  B01J31/1805 ,  B01J31/22 ,  B01J31/2295 ,  B01J31/24 ,  B01J31/2404 ,  B01J31/2409 ,  B01J2231/4211 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/842 ,  C07C1/321 ,  C07C17/269 ,  C07C2531/22 ,  C07F5/025 ,  C07F15/0033 ,  C07F15/004 ,  C07F15/0073 ,  C07F15/008 ,  C07F17/02 ,  C08G2261/312 ,  C07C15/00 ,  C07C22/08 ,  C07C25/18

Abstract: A process for producing organic substituted aromatic or heteroaromatic compounds including biaryl and biheteroaryl compounds in a two-step reaction. In the first step, the aromatic or heteroaromatic compound is borylated in a reaction comprising a borane or diborane reagent (any boron reagent where the boron reagent contains a B—H, B—B or B—Si bond) and an iridium or rhodium catalytic complex. In the second step, a metal catalyst catalyzes the formation of the organic substituted aromatic or heteroaromatic compound from the borylated compound and an electrophile such as an aryl or organic halide, triflate (OSO2CF3), or nonaflate (OSO2C4F9). The steps in the process can be performed in a single reaction vessel or in separate reaction vessels. The present invention also provides a process for synthesis of complex polyphenylenes starting from halogenated aromatic compounds.

Abstract translation: 一种在两步反应中制备包括联芳基和双杂芳基化合物的有机取代的芳族或杂芳族化合物的方法。 在第一步中，在包含硼烷或乙硼烷试剂（硼试剂含有B-H，B-B或B-Si键的任何硼试剂）和铱或铑催化络合物的反应中，芳族或杂芳族化合物被硼酸化。 在第二步中，金属催化剂催化从硼化化合物和亲电体如芳基或有机卤化物，三氟甲磺酸酯（OSO 2 CF 3）或非卤化物（OSO 2 C 4 F 9）形成有机取代的芳香族或杂芳族化合物。 该方法中的步骤可以在单个反应容器中或在单独的反应容器中进行。 本发明还提供从卤代芳族化合物开始合成络合聚苯的方法。

公开(公告)号：US06858688B2

公开(公告)日：2005-02-22

申请号：US10380475

申请日：2001-09-19

Applicant: Shahram Mihan ,  Wolfgang Beck ,  Walter Ponikwar

Inventor： Shahram Mihan ,  Wolfgang Beck ,  Walter Ponikwar

IPC: B01J23/755 ,  B01J31/14 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  C07C229/76 ,  C07F9/50 ,  C07F15/04 ,  C08F2/22 ,  C08F4/42 ,  C08F4/70 ,  C08F10/00

CPC classification number: B01J31/143 ,  B01J23/755 ,  B01J31/1805 ,  B01J31/2226 ,  B01J31/226 ,  B01J31/2404 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07C229/76

Abstract: An amino acid complex of the formula I, where M is selected from among Fe, Co, Ni, Pd, Pt and Ir, preferably Ni, can be used for the polymerization of olefins.

Abstract translation: 式I的氨基酸配合物，其中M选自Fe，Co，Ni，Pd，Pt和Ir，优选为Ni，可用于烯烃聚合。

公开(公告)号：US06855797B2

公开(公告)日：2005-02-15

申请号：US10132347

申请日：2002-04-25

Applicant: Donald Edward Putzig ,  Edward Francis McBride ,  Clive Alexander Hamilton ,  Andrea Clare Smith

Inventor： Donald Edward Putzig ,  Edward Francis McBride ,  Clive Alexander Hamilton ,  Andrea Clare Smith

IPC: B01J31/04 ,  B01J31/12 ,  B01J31/18 ,  B01J31/22 ,  B01J31/26 ,  B01J31/28 ,  C08G63/82 ,  C08G63/83 ,  C08G63/85 ,  C08G63/78 ,  C08G3/02

CPC classification number: C08G63/82 ,  B01J31/04 ,  B01J31/1805 ,  B01J31/223 ,  B01J31/26 ,  B01J2231/14 ,  B01J2231/40 ,  B01J2531/46 ,  B01J2531/96 ,  C08G63/826 ,  C08G63/83 ,  C08G63/85

Abstract: A process that can be used as catalyst in esterification, transesterification or polycondensation is disclosed, which comprises a stable solution comprising (a) titanium in the form of a titanium α-hydroxycarboxylic acid or its salt, (b) a C1-C6 carboxylic acid, and (c) zinc in the form of a water-soluble zinc salt, and (d) water. Also disclosed is an esterification, transesterification or polycondensation process, which comprises contacting, in the presence of the solution process, an organic acid or its ester or its salt with an alcohol, optionally in the presence of a phosphorus compound, an organic or inorganic toning agent such as cobalt acetate, or combinations thereof. The process can also comprise combining aqueous solutions of a titanium α-hydroxycarboxylic acid or its salt and a zinc salt in an alcohol to produce an alcohol solution contacting the alcohol solution with a mixture comprising organic acid or its ester or its salt and a second alcohol, or comprise combining an aqueous solutions of a titanium α-hydroxycarboxylic acid or its salt and aqueous solution of a zinc salt with the mixture.

Abstract translation: 公开了可用作酯化，酯交换或缩聚催化剂的方法，其包括稳定的溶液，其包含（a）钛α-羟基羧酸或其盐形式的钛，（b）C1-C6羧酸 ，（c）水溶性锌盐形式的锌，（d）水。 还公开了酯化，酯交换或缩聚方法，其包括在溶液方法存在下，有机酸或其酯或其盐与醇，任选在磷化合物，有机或无机调色剂 例如乙酸钴或其组合。 该方法还可以包括将钛α-羟基羧酸或其盐的水溶液与锌盐的醇溶液混合，以产生与醇溶液接触的醇溶液与包含有机酸或其酯或其盐的混合物和第二醇 或者包括将钛α-羟基羧酸或其盐的水溶液与锌盐的水溶液与混合物组合。

公开(公告)号：US20050010068A1

公开(公告)日：2005-01-13

申请号：US10496662

申请日：2002-11-29

Applicant: Andrew Holmes ,  Chandrashekar Ramarao ,  Richard Gordon ,  Steven Ley ,  Tessa Early

Inventor： Andrew Holmes ,  Chandrashekar Ramarao ,  Richard Gordon ,  Steven Ley ,  Tessa Early

IPC: B01J13/16 ,  B01J23/40 ,  B01J31/04 ,  B01J31/06 ,  B01J31/16 ,  B01J31/18 ,  B01J31/24 ,  B01J31/28 ,  B01J35/00 ,  C07B37/04 ,  C07B61/00 ,  C07C1/26 ,  C07C1/32 ,  C07C17/26 ,  C07C17/266 ,  C07C17/269 ,  C07C25/13 ,  C07C29/48 ,  C07C29/58 ,  C07C41/30 ,  C07C43/20 ,  C07C45/64 ,  C07C45/68 ,  C07C67/343 ,  C07C69/618 ,  C07C69/708 ,  C07C201/12 ,  C07C205/06 ,  C07C205/56 ,  C07C39/17

CPC classification number: B01J31/04 ,  B01J13/16 ,  B01J23/40 ,  B01J31/06 ,  B01J31/165 ,  B01J31/1805 ,  B01J31/24 ,  B01J31/28 ,  B01J35/0013 ,  B01J2231/4211 ,  B01J2231/4255 ,  B01J2231/4261 ,  B01J2231/4266 ,  B01J2531/82 ,  B01J2531/922 ,  C07B37/04 ,  C07C1/26 ,  C07C1/321 ,  C07C1/325 ,  C07C17/263 ,  C07C17/266 ,  C07C17/269 ,  C07C29/48 ,  C07C41/30 ,  C07C45/64 ,  C07C45/68 ,  C07C67/343 ,  C07C201/12 ,  C07C2523/44 ,  C07C2531/04 ,  C07C2531/12 ,  Y02P20/544 ,  C07C15/14 ,  C07C25/18 ,  C07C69/734 ,  C07C69/618 ,  C07C69/65 ,  C07C205/06 ,  C07C205/56 ,  C07C43/205

Abstract: There is provided processes for metal mediated reactions, particularly cross coupling and carbometallation reactions, wherein the metal is present as a catalyst system comprising a catalyst microencapsulated within a permeable polymer microcapsule shell and the reaction is carried out under super-critical or near super-critical conditions. Preferred metal-mediated cross coupling reactions include Heck, Suzuki, Sonogashira and Stille reactions. Preferred carbometallation reactions include hydroformylations.

Abstract translation: 提供了用于金属介导的反应，特别是交叉偶联和金属金属化反应的方法，其中金属作为催化剂体系存在，该催化剂体系包含微囊化在可渗透的聚合物微胶囊壳内的催化剂，反应在超临界或接近超临界 条件。 优选的金属介导的交叉偶联反应包括Heck，Suzuki，Sonogashira和Stille反应。 优选的金属化反应包括加氢甲酰化。

公开(公告)号：US20050009687A1

公开(公告)日：2005-01-13

申请号：US10837257

申请日：2004-04-30

Applicant: John Verkade ,  Jnaneshwara Kindel

Inventor： John Verkade ,  Jnaneshwara Kindel

IPC: B01J31/02 ,  B01J31/18 ,  B01J31/22 ,  C07F7/00 ,  C08G63/82 ,  B01J23/00 ,  B01J25/00 ,  B01J29/00

CPC classification number: C08G63/823 ,  B01J31/0212 ,  B01J31/0214 ,  B01J31/1805 ,  B01J31/2226 ,  B01J31/2239 ,  B01J31/2243 ,  B01J31/2295 ,  B01J2531/0216 ,  B01J2531/0238 ,  B01J2531/0247 ,  B01J2531/46 ,  C07F7/003

Abstract: Titanium alkoxide catalysts for polymerization of cyclic esters such as LA and CL and methods of polymerization are disclosed. Titanium is known to be non-toxic and the various compounds described herein can catalyze cyclic esters to produce polyesters with controlled molecular weights and relatively narrow molecular weight distributions. In one embodiment, caged titanium alkoxides catalysts are used. The caged titanium alkoxides can be atranes or non-atranes.

Abstract translation: 公开了用于聚合环状酯如LA和CL的聚氧化钛催化剂和聚合方法。 已知钛是无毒的，并且本文所述的各种化合物可以催化环酯以产生具有受控分子量和相对窄的分子量分布的聚酯。 在一个实施方案中，使用笼形钛醇盐催化剂。 笼式钛醇盐可以是起重机或非起重机。

公开(公告)号：US06821920B2

公开(公告)日：2004-11-23

申请号：US10351338

申请日：2003-01-27

Applicant: Nancy W. Eilerts ,  Gil R. Hawley

Inventor： Nancy W. Eilerts ,  Gil R. Hawley

IPC: C08F470

CPC classification number: B01J31/2234 ,  B01J31/143 ,  B01J31/1805 ,  B01J2531/847 ,  C08F10/00 ,  C08F110/02 ,  C08F110/06 ,  C08F210/16 ,  C08F2500/12 ,  C08F2500/07 ,  C08F2500/08 ,  C08F4/7006

Abstract: Novel catalyst systems which comprise diimine nickel complexes comprising additional ligands selected from the group consisting of acetylacetonate, hexaflourylacetylacetonate, halogens and mixtures thereof can be used with methylaluminoxane in slurry polymerization processes to polymerize mono-1-olefins and, optionally one or more higher mono-1-olefin comonomer(s), to produce high molecular weight polymers.

Abstract translation: 包含二亚胺镍络合物的新型催化剂体系包括选自乙酰丙酮化物，六氟乙酰丙酮化合物，卤素及其混合物的另外的配体，可用于淤浆聚合方法中的甲基铝氧烷以聚合单-1-烯烃和任选的一种或多种高级单 - 1-烯烃共聚单体，以产生高分子量聚合物。