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    Stable Cell Line Secreting Chikungunya Virus (CHIKV) Virus Like Particles (VLP) for Vaccines
    132.
    发明申请
    Stable Cell Line Secreting Chikungunya Virus (CHIKV) Virus Like Particles (VLP) for Vaccines 有权

    公开(公告)号：US20210163544A1

    公开(公告)日：2021-06-03

    申请号：US17268573

    申请日：2019-09-26

    Applicant: Texas Tech University System

    Inventor： Himanshu Garg ,  Anjali Joshi

    IPC: C07K14/005 ,  C12N7/00 ,  C12N15/86

    Abstract: The present invention includes nucleic acids, proteins, Chikungunya virus (CHIKV) Virus Like Particles (VLP), and methods of making a Chikungunya virus (CHIKV) Virus Like Particles (VLP) comprising: inserting one or more nucleic acids into a lentiviral backbone, wherein the nucleic acid encodes one or more Chikungunya virus (CHIKV) proteins; transfecting the one or more nucleic acids into the lentiviral backbone into a cell line; culturing the transfected cell line under conditions in which the Chikungunya virus (CHIKV) Virus Like Particles (VLP) are released from the cell line; and isolating the Chikungunya virus (CHIKV) Virus Like Particles (VLP) from a culture supernatant.

    Method for optimization of huff-n-puff gas injections in hydrocarbon reservoirs
    133.
    发明授权
    Method for optimization of huff-n-puff gas injections in hydrocarbon reservoirs 有权

    公开(公告)号：US11008840B2

    公开(公告)日：2021-05-18

    申请号：US16694817

    申请日：2019-11-25

    Applicant: Texas Tech University System

    Inventor： James J. Sheng

    IPC: E21B43/16 ,  E21B47/06 ,  G01V99/00

    Abstract: Methods for optimization of liquid oil production by huff-n-puff in shale reservoirs to achieve an improved (and optimal) oil recovery factor. The process determines and utilizes the optimum huff and puff times, number of cycles and soaking time under practical operation and reservoir conditions. The huff time in the process is a period so long that the pressure near the wellbore reaches the set maximum injection pressure during the huff period. The puff time in the process is the time required for the pressure near the wellbore to reach the set minimum production pressure during the puff period. Soaking is typically not necessary during the huff-n-puff gas injection in shale oil reservoirs. The number of huff-n-puff cycles is determinable by the time in which the economic rate cut-off is reached.

    SOLID-STATE NEUTRON DETECTOR
    134.
    发明申请
    SOLID-STATE NEUTRON DETECTOR 有权

    公开(公告)号：US20210111299A1

    公开(公告)日：2021-04-15

    申请号：US16897742

    申请日：2020-06-10

    Applicant: Texas Tech University System

    Inventor： Hongxing Jiang ,  Jingyu Lin ,  Jing Li ,  Avisek Maity ,  Sam Grenadier

    IPC: H01L31/115 ,  G01T3/08 ,  H01L31/0224 ,  H01L31/036 ,  H01L31/02 ,  H01L31/18 ,  H01L31/0304

    Abstract: A method for fabricating a neutron detector includes providing an epilayer wafer of Boron-10 enriched hexagonal boron nitride (h-10BN or h-BN or 10BN or BN) having a thickness (t), dicing or cutting the epilayer wafer into one or more BN strips having a width (W) and a length (L), and depositing a first metal contact on a first surface of at least one of the BN strip and a second metal contact on a second surface of the at least one BN strip. The neutron detector includes an electrically insulating submount, a BN epilayer of Boron-10 enriched hexagonal boron nitride (h-10BN or h-BN or 10BN or BN) placed on the insulating submount, a first metal contact deposited on a first surface of the BN epilayer, and a second metal contact deposited on a second surface of the BN epilayer.

    Multiplexed shRNAs and uses thereof
    135.
    发明授权
    Multiplexed shRNAs and uses thereof 有权

    公开(公告)号：US10968451B2

    公开(公告)日：2021-04-06

    申请号：US15519359

    申请日：2015-10-14

    Applicant: Texas Tech University System

    Inventor： Haoquan Wu ,  Jang-gi Choi

    IPC: C12N15/113 ,  A61K48/00

    Abstract: Nucleic acid molecules such as shRNA clusters and artificial miRNA clusters are disclosed, Also disclosed are methods of use, compositions, cells, viral particles, and kits relating to the nucleic acid molecules disclosed herein. The disclosure provides, at least in part nucleic acid molecules such as shRNA clusters encoding shRNA-like molecules and artificial miRNA clusters encoding modified pri-miRNA-like molecules. The shRNA clusters and artificial miRNA clusters disclosed herein can be used, for example, to produce artificial RNA molecules, e.g., RNAi molecules. Cells, viral particles, compositions (e.g., pharmaceutical compositions), kits, and methods relating to the nucleic acid molecules, e.g., shRNA clusters and artificial miRNA clusters, are also disclosed. The nucleic acid molecules (e.g., shRNA clusters and artificial miRNA clusters), artificial RNA molecules (e.g., RNAi molecules), cells, viral particles, compositions (e.g., pharmaceutical compositions), and kits and methods disclosed herein can be used to treat or prevent a disease, e.g., HIV infection and/or AIDS.

    High Efficient Delivery of Plasmid DNA Into Human and Vertebrate Primary Cells In Vitro and In Vivo by Nanocomplexes
    136.
    发明申请
    High Efficient Delivery of Plasmid DNA Into Human and Vertebrate Primary Cells In Vitro and In Vivo by Nanocomplexes 有权

    公开(公告)号：US20210095309A1

    公开(公告)日：2021-04-01

    申请号：US16956627

    申请日：2018-12-03

    Applicant: Texas Tech University System

    Inventor： Huanyu Dou

    IPC: C12N15/85

    Abstract: The present invention includes synthesis of polyethyleneimine800-EpoxyC8-22 (PEI800-C8-22) lipids, e.g., Polyethyleneimine800-EpoxyC16 (PEI800-C16), PEI12C16, PEI8C16, and PEI4C16 lipids, compositions and methods for transfecting primary leukocytes, myeloid cells, lymphoid cells, monocytes, macrophages and dendritic cells (DC) comprising a transfection complex comprising: one or more nanoparticles; and Polyethyleneimine800-EpoxyC16 (PEI800-C16), PEI12C16, PEI8C16, and PEI4C16 lipids complexed with one or more nucleic acids, such as, e.g., DNA, RNA, nucleic acid vectors, shRNA, miRNA, and RNAi on or about the nanoparticles.

    Diagnostic tool for eye disease detection using smartphone
    137.
    发明授权
    Diagnostic tool for eye disease detection using smartphone 有权

    公开(公告)号：US10952604B2

    公开(公告)日：2021-03-23

    申请号：US16294902

    申请日：2019-03-06

    Applicant: Texas Tech University System

    Inventor： Behnam Askarian ,  Jo Woon Chong ,  Fatemehsadat Tabei

    IPC: A61B3/00 ,  G06T7/00 ,  G06K9/62 ,  G06T7/13 ,  A61B3/107 ,  A61B3/14

    Abstract: Diagnostic tool for eye disease detection using a smartphone. At least some of the example embodiments are methods including capturing, by way of a camera lens on a device, an image of an eye to create a raw specimen; processing the raw specimen to create a processes specimen; performing edge detection on the processed specimen to detect a boundary of a cornea; extracting a region of interest of the cornea; identifying a boundary of the region of interest using a boundary tracing technique to identify a second boundary; analyzing the second boundary of the region of interest, by measuring a slope of the second boundary; and classifying the region of interest as including an eye disease, based on the analyzing the second boundary.

    MICROFLUIDIC DEVICES AND METHODS FOR BIOASSAYS
    138.
    发明申请
    MICROFLUIDIC DEVICES AND METHODS FOR BIOASSAYS 有权

    公开(公告)号：US20210031202A1

    公开(公告)日：2021-02-04

    申请号：US17063806

    申请日：2020-10-06

    Applicant: Texas Tech University System

    Inventor： Siva A. Vanapalli ,  Swastika S. Bithi

    IPC: B01L3/00

    Abstract: A microfluidic device includes a substrate and a cover. The substrate has an inlet port, a first microchannel, one or more parking loops, a second microchannel and an outlet port for each microchannel network. The first microchannel is connected to the inlet port, the second microchannel is connected to the outlet port, the parking loops are connected between the first and second microchannels. Each parking loop includes a parking loop inlet, a parking loop output, a fluidic trap connected between the parking loop inlet and the parking loop outlet, and a bypass microchannel connected to the parking loop inlet and the parking loop outlet. The cover is attached to a top of the substrate and has an inlet opening and an outlet opening through the cover for each microchannel network. The inlet and outlet openings of the cover are disposed above the inlet and outlet ports in the substrate.

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