公开(公告)号：US20210078933A1

公开(公告)日：2021-03-18

申请号：US16620001

申请日：2018-07-16

Applicant: LONZA LTD

Inventor： Michael BERSIER ,  Anna KULESZA ,  Paul HANSELMANN ,  Christof AELLIG ,  Sarah FILLIGER

IPC: C07C201/08 ,  C07C205/58

Abstract: The invention discloses a method for preparation of 5-fluoro-2-methyl-3-nitrobenzoic acid and its methyl ester by conversion of 5-fluoro-2-methylbenzoic acid with fuming nitric acid and oleum and subsequent conversion with methanol.

公开(公告)号：US10815189B2

公开(公告)日：2020-10-27

申请号：US16491287

申请日：2018-03-05

Applicant: Covestro Deutschland AG

Inventor： Denise Chan ,  Thomas Knauf ,  Juergen Muennig

IPC: C07C201/08 ,  C07C201/16

Abstract: The invention relates to a method for continuous production of nitrobenzene by means of nitration of benzene with nitric acid and sulfuric acid, in which load change (i.e. a reduction or increase in the quantity of nitric acid supplied to the process per time interval) is particularly advantageously developed. The invention particularly relates to a method in which, in the case of a load reduction, the ratio of the masses of benzene and nitric acid supplied per time interval is significantly increased compared to said ratio before the load change and/or the ratio of the masses of nitric acid and sulfuric acid supplied per time interval is significantly reduced compared to said ratio before the load change. In the event of a load increase, the reverse is carried out.

公开(公告)号：US20190315768A1

公开(公告)日：2019-10-17

申请号：US16451509

申请日：2019-06-25

Applicant: Angus Chemical Company

Inventor： Daniel M. Trauth ,  George D. Green ,  Raymond J. Swedo ,  Richard L. James ,  Ian A. Tomlinson

IPC: C07D498/10 ,  C07D498/04 ,  A01N43/90 ,  C07C201/08 ,  C07C201/12 ,  C07C205/02 ,  C07C215/28 ,  C07C205/04 ,  C07C205/05 ,  C07C205/15 ,  C07C205/16 ,  C07C215/20 ,  C08G18/32 ,  A01N43/76 ,  C07D263/52 ,  C07D263/04 ,  C07C239/10 ,  C07C215/42 ,  C07C215/08 ,  C07C205/18 ,  C07C205/06

Abstract: Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

公开(公告)号：US10399931B2

公开(公告)日：2019-09-03

申请号：US16084979

申请日：2017-03-23

Applicant: SHANDONG XINHUA PHARMACEUTICAL CO., LTD. ,  SHENYANG PHARMACEUTICAL UNIVERSITY

Inventor： Guoliang Chen ,  Zhonghui Zheng ,  Libo Zou ,  Daiming Zhang ,  Chunling Yuan ,  Fulong Ren ,  Xuefei Bao ,  Jinheng Gao ,  Linbo Zhou ,  Wuhong Fang

IPC: C07C275/38 ,  C07C2/86 ,  C07C201/08 ,  C07C209/36 ,  C07C231/02 ,  C07C269/04 ,  C07C271/28 ,  C07C273/18 ,  C07C303/38 ,  C07C311/48 ,  C07D211/62 ,  C07D295/195 ,  A61K31/167 ,  C07C259/10 ,  C07C233/65 ,  C07C233/80

Abstract: An octahydroanthracene compound having the structure shown in formula (I) and (II), preparation method and application thereof are disclosed. The octahydroanthracene compound has a good therapeutic effect on tumors and neurodegenerative diseases. The preparation of the octahydroanthracene compound is mainly carried out by using benzene as a starting material, and being subjected to Friedel-Crafts reaction, nitration, reduction, (sulfo-) amide formation, reduction, urea formation or amide formation, thus obtaining a target compound.

公开(公告)号：US20190071393A1

公开(公告)日：2019-03-07

申请号：US16084979

申请日：2017-03-23

Applicant: SHENYANG PHARMACEUTICAL UNIVERSITY

Inventor： Guoliang CHEN ,  Zhonghui ZHENG ,  Libo ZOU ,  Daiming ZHANG ,  Chunling YUAN ,  Fulong REN ,  Xuefei BAO ,  Jinheng GAO ,  Linbo ZHOU ,  Wuhong FANG

IPC: C07C275/38 ,  C07C2/86 ,  C07C201/08 ,  C07C209/36 ,  C07C231/02 ,  C07C273/18 ,  C07D295/195 ,  C07C271/28 ,  C07C269/04 ,  C07C311/48 ,  C07C303/38 ,  C07D211/62

CPC classification number: C07C275/38 ,  A61K31/167 ,  C07C2/861 ,  C07C201/08 ,  C07C209/36 ,  C07C231/02 ,  C07C231/12 ,  C07C233/65 ,  C07C233/80 ,  C07C259/10 ,  C07C269/04 ,  C07C269/06 ,  C07C271/28 ,  C07C271/60 ,  C07C273/1809 ,  C07C275/42 ,  C07C303/38 ,  C07C311/48 ,  C07C2603/22 ,  C07C2603/24 ,  C07D211/62 ,  C07D295/195 ,  C07C13/58 ,  C07C205/11 ,  C07C211/45 ,  C07C233/66

Abstract: An octahydroanthracene compound having the structure shown in formula (I) and (II), preparation method and application thereof are disclosed. The octahydroanthracene compound has a good therapeutic effect on tumors and neurodegenerative diseases. The preparation of the octahydroanthracene compound is mainly carried out by using benzene as a starting material, and being subjected to Friedel-Crafts reaction, nitration, reduction, (sulfo-) amide formation, reduction, urea formation or amide formation, thus obtaining a target compound.

公开(公告)号：US10155720B2

公开(公告)日：2018-12-18

申请号：US15310215

申请日：2015-05-11

Applicant: Covestro Deutschland AG

Inventor： Bernd Pennemann ,  Antoni Mairata ,  Antonia Zock

IPC: C07C209/36 ,  C07C201/08 ,  C07C201/16 ,  B01D17/04 ,  B01D17/06

Abstract: The invention concerns a method for producing toluenediamine by hydrogenation of dinitrotoluene in the presence of a catalyst, a dinitrotoluene being used as starting material and being processed by applying an electrical voltage.

公开(公告)号：US20180346405A1

公开(公告)日：2018-12-06

申请号：US16009396

申请日：2018-06-15

Applicant: Covestro Deutschland AG

Inventor： Thomas Knauf ,  Peter Drinda

IPC: C07C201/08 ,  B01J19/24 ,  B01J19/18 ,  B01J19/00 ,  C07C201/16 ,  C07C205/06

CPC classification number: C07C201/08 ,  B01J19/0006 ,  B01J19/002 ,  B01J19/1881 ,  B01J19/24 ,  B01J19/2465 ,  B01J2219/00006 ,  B01J2219/0004 ,  B01J2219/00268 ,  C07C201/16 ,  C07C205/06

Abstract: The present invention relates to a process for the continuous production of nitrobenzene by the nitration of benzene with nitric acid and sulphuric acid under adiabatic conditions, not the entire production plant being shut down during a production stop, but the production plant being entirely or at least partly operated in recirculation mode. The invention further relates to a plant for producing nitrobenzene and to a method for operating a plant for producing nitrobenzene.

公开(公告)号：US09771291B2

公开(公告)日：2017-09-26

申请号：US14784699

申请日：2014-04-14

Applicant: COVESTRO DEUTSCHLAND AG

Inventor： Thomas Knauf ,  Antoni Mairata ,  Erik Sluyts ,  Jan Van Tricht

IPC: C02F9/00 ,  C02F1/02 ,  C02F1/20 ,  C07C201/08 ,  C07C201/16 ,  C07C209/36 ,  C02F1/04 ,  C02F101/32 ,  C02F101/38 ,  C02F103/18

CPC classification number: C02F9/00 ,  C02F1/025 ,  C02F1/04 ,  C02F1/20 ,  C02F2101/322 ,  C02F2101/38 ,  C02F2103/18 ,  C02F2209/06 ,  C02F2301/046 ,  C07C201/08 ,  C07C201/16 ,  C07C209/36 ,  C07C205/06

Abstract: The invention relates to a process for working up alkaline waste water which is formed during washing of crude nitrobenzene obtained by nitration of benzene, wherein (i) the alkaline waste water is heated under an increased pressure with respect to atmospheric pressure with exclusion of oxygen and is then cooled and expanded; (ii) the waste water obtained in (i) is purified further by stripping with a stripping gas and the stripping gas stream loaded with impurities is then cooled to a temperature of from 10° C. to 60° C.; and (iii) the liquid process product obtained in (ii) by cooling the stripping gas stream loaded with impurities is separated into an aqueous and an organic phase and the organic phase is used further in an aniline production process.

公开(公告)号：US20170144963A1

公开(公告)日：2017-05-25

申请号：US15310215

申请日：2015-05-11

Applicant: COVESTRO DEUTSCHLAND AG

Inventor： Bernd Pennemann ,  Antoni Mairata ,  Antonia Zock

IPC: C07C209/36 ,  B01D17/06 ,  B01D17/04 ,  C07C201/08 ,  C07C201/16

CPC classification number: C07C209/36 ,  B01D17/045 ,  B01D17/06 ,  B01D2257/80 ,  C07C201/08 ,  C07C201/16 ,  Y02P20/582 ,  C07C205/06 ,  C07C211/50

Abstract: The invention concerns a method for producing toluenediamine by hydrogenation of dinitrotoluene in the presence of a catalyst, a dinitrotoluene being used as starting material and being processed by applying an electrical voltage.

公开(公告)号：US20170029361A1

公开(公告)日：2017-02-02

申请号：US15293507

申请日：2016-10-14

Applicant: Nippon Soda Co., Ltd.

Inventor： Hiroki Inoue ,  Yuzuru Sakata ,  Shinichi Kobayashi ,  Yoshikazu Ito ,  Takashi Kitayama

IPC: C07C205/12 ,  C07C17/06 ,  C07C201/08

CPC classification number: C07C209/74 ,  C07C17/00 ,  C07C17/06 ,  C07C17/12 ,  C07C201/08 ,  C07C201/14 ,  C07C205/12 ,  C07C209/32 ,  C07C211/52 ,  C07C25/13

Abstract: The present invention provides a halogenated aniline represented by formula (I) (wherein each of X1 and X2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.

Abstract translation: 本发明提供由式（I）表示的卤代苯胺（其中，X 1和X 2各自独立地表示氯原子，溴原子或碘原子），卤代苯胺的制造方法等。