公开(公告)号：US20240238223A1

公开(公告)日：2024-07-18

申请号：US18475312

申请日：2023-09-27

Applicant: Shenyang Pharmaceutical University

Inventor： Yongkui JING ,  Juanjuan YANG ,  Dake SONG ,  Yuetong WANG ,  Guoliang CHEN

IPC: A61K31/165 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K31/165 ,  A61K45/06 ,  A61P35/00

Abstract: The present disclosure relates to the field of tumor drug therapy, in particular to use of a methylaminocolchicine and salts thereof. The use includes use of a methylamino-substituted colchicine at C10 position and salts thereof in preparation of antitumor drugs, use thereof in antitumor drugs for antagonizing microtubule inhibitor resistance, or use thereof in combination an antitumor drug. In the present disclosure, the methylaminocolchicine and the salts thereof have significant antitumor effects, are more active than paclitaxel, vincristine, and colchicine, do not exhibit cross resistance to the paclitaxel and the vincristine, and inhibit paclitaxel-resistant cell growth in vivo. With in vivo acceptable therapeutic indexes, the methylaminocolchicine and the salts thereof have a synergistic antitumor effect when used in combination with an anti-apoptotic protein Bcl-2/Bcl-xL inhibitor.

公开(公告)号：US20190071393A1

公开(公告)日：2019-03-07

申请号：US16084979

申请日：2017-03-23

Applicant: SHENYANG PHARMACEUTICAL UNIVERSITY

Inventor： Guoliang CHEN ,  Zhonghui ZHENG ,  Libo ZOU ,  Daiming ZHANG ,  Chunling YUAN ,  Fulong REN ,  Xuefei BAO ,  Jinheng GAO ,  Linbo ZHOU ,  Wuhong FANG

IPC: C07C275/38 ,  C07C2/86 ,  C07C201/08 ,  C07C209/36 ,  C07C231/02 ,  C07C273/18 ,  C07D295/195 ,  C07C271/28 ,  C07C269/04 ,  C07C311/48 ,  C07C303/38 ,  C07D211/62

CPC classification number: C07C275/38 ,  A61K31/167 ,  C07C2/861 ,  C07C201/08 ,  C07C209/36 ,  C07C231/02 ,  C07C231/12 ,  C07C233/65 ,  C07C233/80 ,  C07C259/10 ,  C07C269/04 ,  C07C269/06 ,  C07C271/28 ,  C07C271/60 ,  C07C273/1809 ,  C07C275/42 ,  C07C303/38 ,  C07C311/48 ,  C07C2603/22 ,  C07C2603/24 ,  C07D211/62 ,  C07D295/195 ,  C07C13/58 ,  C07C205/11 ,  C07C211/45 ,  C07C233/66

Abstract: An octahydroanthracene compound having the structure shown in formula (I) and (II), preparation method and application thereof are disclosed. The octahydroanthracene compound has a good therapeutic effect on tumors and neurodegenerative diseases. The preparation of the octahydroanthracene compound is mainly carried out by using benzene as a starting material, and being subjected to Friedel-Crafts reaction, nitration, reduction, (sulfo-) amide formation, reduction, urea formation or amide formation, thus obtaining a target compound.