公开(公告)号：US20190071393A1

公开(公告)日：2019-03-07

申请号：US16084979

申请日：2017-03-23

Applicant: SHENYANG PHARMACEUTICAL UNIVERSITY

Inventor： Guoliang CHEN ,  Zhonghui ZHENG ,  Libo ZOU ,  Daiming ZHANG ,  Chunling YUAN ,  Fulong REN ,  Xuefei BAO ,  Jinheng GAO ,  Linbo ZHOU ,  Wuhong FANG

IPC: C07C275/38 ,  C07C2/86 ,  C07C201/08 ,  C07C209/36 ,  C07C231/02 ,  C07C273/18 ,  C07D295/195 ,  C07C271/28 ,  C07C269/04 ,  C07C311/48 ,  C07C303/38 ,  C07D211/62

CPC classification number: C07C275/38 ,  A61K31/167 ,  C07C2/861 ,  C07C201/08 ,  C07C209/36 ,  C07C231/02 ,  C07C231/12 ,  C07C233/65 ,  C07C233/80 ,  C07C259/10 ,  C07C269/04 ,  C07C269/06 ,  C07C271/28 ,  C07C271/60 ,  C07C273/1809 ,  C07C275/42 ,  C07C303/38 ,  C07C311/48 ,  C07C2603/22 ,  C07C2603/24 ,  C07D211/62 ,  C07D295/195 ,  C07C13/58 ,  C07C205/11 ,  C07C211/45 ,  C07C233/66

Abstract: An octahydroanthracene compound having the structure shown in formula (I) and (II), preparation method and application thereof are disclosed. The octahydroanthracene compound has a good therapeutic effect on tumors and neurodegenerative diseases. The preparation of the octahydroanthracene compound is mainly carried out by using benzene as a starting material, and being subjected to Friedel-Crafts reaction, nitration, reduction, (sulfo-) amide formation, reduction, urea formation or amide formation, thus obtaining a target compound.