Abstract:
The invention provides inhibitors of α-crystallin aggregation and methods of using α-crystallin aggregation inhibitors to, e.g., treat or prevent cataracts in a subject having or at risk of developing cataracts. The invention further provides high throughput methods of screening compounds for modulation of protein thermal stability, the method comprising contacting a protein with each of a plurality of test compounds; and (b) measuring the melting transition (Tm) of the protein in the presence of each of the plurality of test compounds, wherein a compound that decreases or increases the apparent Tm by at least 2 standard deviations is identified as a pharmacological protein chaperone.
Abstract:
An e-Petri dish comprising a transparent layer having a specimen surface and a light detector configured to sample a sequence of sub-pixel shifted projection images of a specimen located on the specimen surface. The sub-pixel shifted projection images associated with light from a plurality of illumination angles provided by an illumination source.
Abstract:
A wavelength scanning apparatus that detects at least four different fluorescent emission wavelengths simultaneously or nearly simultaneously is described. The wavelength scanning apparatus includes a heating block having at least four sample wells, each sample well configured for receiving a sample, at least four excitation activation apertures, and at least four fluorescence emission discharge apertures. The wavelength scanning apparatus also includes an analysis scanner having at least four light sources, where the at least four light sources excite at least four fluorophores, at least four excitation light filters that filter out light except that of the desired excitation wavelength/s, at least four fluorescence emission light filters that filter out light except that of the desired fluorescent emission wavelengths, and at least four photodetectors to detect light of the desired fluorescent emission wavelengths.
Abstract:
Methods and systems for design based sampling and binning for yield critical defects are provided. One method includes aligning each image patch in each inspection image frame generated for a wafer by an optical subsystem of an inspection system to design information for the wafer. The method also includes deriving multiple layer design attributes at locations of defects detected in the image patches. In addition, the method includes building a decision tree with the multiple layer design attributes. The decision tree is used to separate the defects into bins with different yield impacts on a device being formed on the wafer. The method also includes binning the defects with the decision tree.
Abstract:
The present application involves a railroad track asset surveying system comprising an image capture sensor, a location determining system, and an image processor. The image capture sensor is mounted to a railroad vehicle. The location determining system holds images captured by the image capture sensor. The image processor includes an asset classifier and an asset status analyser. The asset classifier detects an asset in one or more captured images and classifies the detected asset by assigning an asset type to the detected asset from a predetermined list of asset types according to one or more features in the captured image. The asset status analyser identifies an asset status characteristic and compares the identified status characteristic to a predetermined asset characteristic so as to evaluate a deviation therefrom.
Abstract:
To detect an infinitesimal defect, highly precisely measure the dimensions of the detect, a detect inspection device is configured to comprise: a irradiation unit which irradiate light in a linear region on a surface of a sample; a detection unit which detect light from the linear region; and a signal processing unit which processes a signal obtained by detecting light and detecting a defect. The detection unit includes: an optical assembly which diffuses the light from the sample in one direction and forms an image in a direction orthogonal to the one direction; and a detection assembly having an array sensor in which detection pixels are positioned two-dimensionally, which detects the light diffused in the one direction and imaged in the direction orthogonal to the one direction, adds output signals of each of the detection pixels aligned in the direction in which the light is diffused, and outputs same.
Abstract:
A wavelength scanning apparatus that detects at least four different florescent emission wavelengths simultaneously or nearly simultaneously is described. The wavelength scanning apparatus includes a heating block having at least four sample wells, each sample well configured for receiving a sample, at least four excitation activation apertures, and at least four fluorescence emission discharge apertures. The wavelength scanning apparatus also includes an analysis scanner having at least four light sources, where the at least four light sources excite at least four fluorophores, at least four excitation light filters that filter out light except that of the desired excitation wavelength/s, at least four fluorescence emission light filters that filter out light except that of the desired florescent emission wavelengths, and at least four photodetectors to detect light of the desired florescent emission wavelengths.
Abstract:
A method and apparatus for optimizing inspection high-speed optical inspection of parts using intelligent image analysis to determine optimal focus using high numerical aperture (NA) optics, achieve a superior signal-to-noise ratio, resolution, and inspection speed performance with very limited depth of field lenses.
Abstract:
In order to determine the locations of individual fluorescent molecules in a sample, which keep a minimum distance with regard to each other, the individual molecules are excited for emission of fluorescence light by means of excitation light. The fluorescence light is registered for different positions of a zero point of an intensity distribution of the excitation light. The distance between these positions is at least half the minimum distance of the fluorescent molecules. The locations of the fluorescent molecules are derived from the course of the intensity of the fluorescence light over the positions of the zero point of the excitation light.
Abstract:
Techniques are disclosed for tracking the position of moving parts and assemblies using 3D laser projection, and projecting templates and other information onto the parts and assemblies based on position. The projected template may then be used, for example, to assist in fabrication of an assembly by indicating where to put a next component or layer, or to assist in post-fabrication inspection of an assembly by indicating where the various components or layers should have been placed. Reference targets can be used as fiducial points for aligning a laser projector with the work piece in question. When the work piece rotates or is otherwise moved to a next manufacturing or inspection position, the relative position of the laser projector and the work piece is updated by bucking-in to the reference targets. The laser projector can then project patterns or other information onto the work piece at the appropriate locations.