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    T CELL RECEPTORS AND METHODS OF USE THEREOF
    156.
    发明申请
    T CELL RECEPTORS AND METHODS OF USE THEREOF 有权

    公开(公告)号：US20220281942A1

    公开(公告)日：2022-09-08

    申请号：US17631825

    申请日：2020-07-29

    Applicant: University Health Network

    Inventor： Naoto HIRANO ,  Kenji SUGATA ,  Kayoko SASO

    IPC: C07K14/725 ,  A61P35/04 ,  C07K16/30 ,  C07K14/55 ,  C07K14/54

    Abstract: The present disclosure is directed recombinant T cell receptors capable of binding a CCND1 epitope and nucleic acid molecules encoding the same. In some aspects, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other aspects of the disclosure are directed to vectors comprising the nucleic acid molecule and cells comprising the recombinant TCR, the nucleic acid molecule, or the vector. Still other aspects of the disclosure are directed to methods of using the same. In some aspects, the methods comprise treating a cancer in a subject in need thereof.

    INTELLIGENT VECTOR ELECTRODE FOR A PACEMAKER OR AN IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR
    157.
    发明申请
    INTELLIGENT VECTOR ELECTRODE FOR A PACEMAKER OR AN IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR 有权

    公开(公告)号：US20220226637A1

    公开(公告)日：2022-07-21

    申请号：US17607600

    申请日：2020-05-06

    Applicant: University Health Network

    Inventor： Kumaraswamy Nanthakumar

    IPC: A61N1/05 ,  A61N1/365 ,  A61N1/37

    Abstract: A multi-electrode implantable device for sensing cardiac signals and various methods for using the sensed cardiac signals are described herein. The multi-electrode device comprises a tetrahedral electrode cluster at a tip at a distal end of the lead/device; four electrodes embedded in the tetrahedral configuration; and four individual wires extending from the electrodes within the lead for receiving voltages sensed by the four electrodes. The methods can be used for deriving various physiological features that can be used in various ways including: diagnosing a physiological condition, efficient sensing of physiological signals, applying more efficient pacing by a pacemaker and indirect cardiac mapping. One or more of the physiological features may be used for applying appropriate treatment methods by a pacemaker/ICD or for applying cardiac ablation or cryofreezing.

    Method and system with spectral filtering and thermal mapping for imaging and collection of data for diagnostic purposes from bacteria
    158.
    发明授权
    Method and system with spectral filtering and thermal mapping for imaging and collection of data for diagnostic purposes from bacteria 有权

    公开(公告)号：US11375898B2

    公开(公告)日：2022-07-05

    申请号：US14719493

    申请日：2015-05-22

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

    IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

    Abstract: A system for acquiring data regarding a wound in tissue comprises at least one light source configured to directly illuminate a target surface with a homogeneous field of excitation light. An optical sensor is configured to detect signals responsive to illumination of an illuminated portion of a wound and the area around the wound. A thermal sensor is configured to detect thermal information regarding the illuminated portion of the wound and the area around the wound. A processor receives the detected signals and the detected thermal information and outputs data regarding the illuminated portion of the wound and the area around the wound. The output data may include wound size of the illuminated portion of the wound, bacterial load of the illuminated portion of the wound, or at least one temperature associated with the illuminated portion of the wound and the area around the wound. The data output by the processor may be displayed on a display of the system.

    T CELL RECEPTORS AND METHODS OF USE THEREOF
    160.
    发明申请
    T CELL RECEPTORS AND METHODS OF USE THEREOF 有权

    公开(公告)号：US20220168347A1

    公开(公告)日：2022-06-02

    申请号：US17436943

    申请日：2020-03-03

    Applicant: University Health Network

    Inventor： Naoto HIRANO ,  Kenji MURATA ,  Kayoko SASO

    IPC: A61K35/17 ,  A61K39/00 ,  C07K14/725 ,  C07K14/74 ,  C07K16/28 ,  C12N15/62

    Abstract: The present disclosure is directed recombinant T cell receptors capable of binding a gp100 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other aspects of the disclosure are directed to vectors comprising the nucleic acid molecule and cells comprising the recombinant TCR, the nucleic acid molecule, or the vector. Still other aspects of the disclosure are directed to methods of using the same. In some embodiments, the methods comprise treating a cancer in a subject in need thereof.

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