公开(公告)号：US20230010772A1

公开(公告)日：2023-01-12

申请号：US17782632

申请日：2020-12-04

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Mark R. Bray ,  Jacqueline M. Mason ,  Graham Fletcher

IPC: A61K31/5377 ,  A61K31/635 ,  A61K31/706 ,  A61P35/00 ,  A61K9/00

Abstract: The invention is related to a method of treating a subject with acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, non-Hodgkin’s lymphoma, Burkitt lymphoma, or diffuse large B-cell lymphoma, or myelodysplastic syndrome by administration of Compound (I): (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230390294A1

公开(公告)日：2023-12-07

申请号：US18235679

申请日：2023-08-18

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Mark Robert Bray ,  Jacqueline M. Mason ,  Tak Wah Mak ,  Graham Fletcher

IPC: A61K31/519 ,  A61P35/00 ,  A61K39/395

CPC classification number: A61K31/519 ,  A61P35/00 ,  A61K39/3955

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：US20210060026A1

公开(公告)日：2021-03-04

申请号：US16644633

申请日：2018-09-07

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Jacqueline M. Mason ,  Mark R. Bray ,  Tak Wah Mak ,  Graham Fletcher

IPC: A61K31/5377 ,  A61K39/395 ,  A61P35/00

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula (Formula (I)) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：US11766437B2

公开(公告)日：2023-09-26

申请号：US16635320

申请日：2018-08-01

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Mark Robert Bray ,  Jacqueline M. Mason ,  Tak W. Mak ,  Graham Fletcher

IPC: A61K31/519 ,  A61P35/00 ,  A61K39/395

CPC classification number: A61K31/519 ,  A61K39/3955 ,  A61P35/00

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：US20200230144A1

公开(公告)日：2020-07-23

申请号：US16635320

申请日：2018-08-01

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Mark Robert Bray ,  Jacqueline M. Mason ,  Tak W. Mak ,  Graham Fletcher

IPC: A61K31/519 ,  A61K39/395 ,  A61P35/00

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：US12109215B2

公开(公告)日：2024-10-08

申请号：US16644633

申请日：2018-09-07

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Jacqueline M. Mason ,  Mark R. Bray ,  Tak Wah Mak ,  Graham Fletcher

IPC: A61K31/5377 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K31/5377 ,  A61K39/3955 ,  A61P35/00

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula (Formula (I)) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：US20230165871A1

公开(公告)日：2023-06-01

申请号：US17917027

申请日：2021-04-05

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Graham Fletcher ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: A61K31/5377 ,  C07K16/28 ,  A61K45/06

CPC classification number: A61K31/5377 ,  A61K45/06 ,  C07K16/2827

Abstract: Provided herein are methods of treating triple negative breast cancer using an effective amount of Compound (I) represented by the formula: or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor, wherein the checkpoint inhibitor is a PD-1 inhibitor or a PD-L1 inhibitor. Uses of an effective amount of Compound [I] and an effective amount of an immune checkpoint inhibitor, wherein the checkpoint inhibitor is a PD-linhibitor or a PD-L1 inhibitor for treating triple negative breast cancer are also provided herein.