Apparatus for investigating fast chemical reactions by optical detection
    151.
    发明授权
    Apparatus for investigating fast chemical reactions by optical detection 失效
    用于通过光学检测来调查快速化学反应的装置

    公开(公告)号:US4054390A

    公开(公告)日:1977-10-18

    申请号:US686029

    申请日:1976-05-13

    Inventor: Carl-Roland Rabl

    Abstract: An apparatus for investigating the course of fast chemical reactions, which are initiated in a liquid chemical system under investigation by an external perturbation, e.g. a steep temperature rise (temperature jump). The apparatus comprises first and second light paths conveying a probing light beam and a sense light beam, respectively, and an optical system of extremely high aperture which allows a wide variety of types of measurements, including absorption, fluorescence, fluorescence polarization, and the like with a high signal-to-noise ratio even if small sample concentrations are used.

    Abstract translation: 一种用于调查快速化学反应过程的装置,其在通过外部扰动研究的液体化学系统中开始,例如, 温度升高(温度上升)。 该装置包括分别传送探测光束和感测光束的第一和第二光路以及极高孔径的光学系统,其允许多种类型的测量,包括吸收,荧光,荧光偏振等 即使使用小的样品浓度,也具有高的信噪比。

    Methods and assemblies for determining and using standardized spectral responses for calibration of spectroscopic analyzers

    公开(公告)号:US11860069B2

    公开(公告)日:2024-01-02

    申请号:US17988210

    申请日:2022-11-16

    CPC classification number: G01N21/31 G01J3/28 G01J2003/2866 G01N2201/127

    Abstract: Methods and assemblies may be used for determining and using standardized spectral responses for calibration of spectroscopic analyzers. The methods and assemblies may be used to calibrate or recalibrate a spectroscopic analyzer when the spectroscopic analyzer changes from a first state to a second state, the second state being defined as a period of time after a change to the spectroscopic analyzer causing a need to calibrate or recalibrate the spectroscopic analyzer. The calibration or recalibration may result in the spectroscopic analyzer outputting a standardized spectrum, such that the spectroscopic analyzer outputs a corrected material spectrum for an analyzed material, and defining the standardized spectrum. The corrected material spectrum may include signals indicative of material properties of an analyzed material, the material properties of the material being substantially consistent with material properties of the material output by the spectroscopic analyzer in the first state.

    GAS ANALYSIS DEVICE AND GAS ANALYSIS METHOD
    157.
    发明公开

    公开(公告)号:US20230417660A1

    公开(公告)日:2023-12-28

    申请号:US18039316

    申请日:2021-11-22

    CPC classification number: G01N21/3504 G01N21/0332 G01N21/39 G01N2201/127

    Abstract: The present invention is a gas analysis device that measures a concentration or partial pressure of a halide contained in a material gas used in semiconductor manufacturing process or a by-product gas generated in semiconductor manufacturing process with good accuracy, the device being for analyzing a concentration or partial pressure of a halide contained in a material gas used in a semiconductor manufacturing process or a by-product gas generated in a semiconductor manufacturing process, the device including a gas cell into which the material gas or the by-product gas is introduced, a laser light source that irradiates the gas cell with laser light whose wavelength is modulated, a light detector that detects the laser light transmitted through the gas cell, and a signal processing unit that calculates the concentration or partial pressure of the halide by using a light absorption signal obtained from an output signal of the light detector.

    RAMAN ANALYSIS OF PHARMACEUTICAL DOSAGE FORMS
    158.
    发明公开

    公开(公告)号:US20230304935A1

    公开(公告)日:2023-09-28

    申请号:US18015007

    申请日:2021-06-24

    CPC classification number: G01N21/65 G01N21/9508 G01N33/15 G01N2201/127

    Abstract: Methods and apparatus (10) for Raman spectral analysis of a sample (12), such as a pharmaceutical dosage form, are disclosed. Delivery optics (16) are used to deliver probe light to a delivery region (13) on the sample, and collection optics (20) are used to collect, from a collection region (17) on the sample spaced from the delivery region, the probe light following scattering through the sample. Each of a plurality of target Raman spectral features are measured in the collected light, and a spectral distortion of the collected light arising during scattering through the sample is determined. A property of the sample is then quantified using the target Raman spectral features in combination with the determined spectral distortion, such that the quantified property is compensated for the spectral distortion.

    FIELD CALIBRATION FOR NEAR REAL-TIME FABRY PEROT SPECTRAL MEASUREMENTS

    公开(公告)号:US20230304925A1

    公开(公告)日:2023-09-28

    申请号:US17705095

    申请日:2022-03-25

    CPC classification number: G01N21/35 G01N2201/127

    Abstract: A system includes a tunable Fabry-Perot etalon, a detector, and a processor. The tunable Fabry-Perot etalon has a settable gap. The detector measures light intensity transmitted through the tunable Fabry-Perot etalon. The processor is configured to determine the calibrated spectral measurement, wherein the calibrated spectral measurement is based at least in part on a measurement set of detected light intensities for a selected set of settable gaps and a reconstruction matrix. The reconstruction matrix is based at least in part on calibration measurements using one or more field material targets, prior stored full calibrations for each of the one or more field material targets, and the selected set of settable gaps.

    REAL-TIME RAMAN CALIBRATION
    160.
    发明公开

    公开(公告)号:US20230288340A1

    公开(公告)日:2023-09-14

    申请号:US17386723

    申请日:2021-07-28

    Applicant: Harry Owen

    Inventor: Harry Owen

    CPC classification number: G01N21/65 G01N2201/127 G01N2201/06113

    Abstract: A Raman calibration standard incorporated within an optical Raman sampling accessory facilitates wavelength calibration in real time. The accessory may be a microscope objective, immersion probe, non-contact probe optic or flow cell utilizing laser light from the UV to the NIR, and the calibration standard material may comprise calcium fluoride, sapphire, diamond, magnesium fluoride or silicon. The calibration standard material may be disposed in a collimated light space within the accessory, and/or may function as a lens, sealed window, reflector or a combination thereof. A plurality of calibration standard materials may be incorporated into the accessory and used for independent calibration verification. The accessory may include a single lens or an achromatic focusing lens. The system may further include features to improve curve fitting and generate a more precise wavenumber value for the position of a reference Raman band generated by the calibration standard material.

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