Device and method for compensating short-term pressure or volume fluctuations of a medium in a continuous biopharmaceutical process

    公开(公告)号:US12179184B2

    公开(公告)日:2024-12-31

    申请号:US17419572

    申请日:2019-12-19

    Abstract: A device for compensating short-term pressure or volume fluctuations of a medium in a continuously managed biopharmaceutical process including a receiving space in fluid communication with a process line through which a medium flows, an equalizing space, which is separated from the receiving space by a deflectable element, and a counter-pressure mechanism in the equalizing space for applying a counter-pressure to the deflectable element towards the receiving space. A method of compensating short-term pressure or volume fluctuations of a medium in a continuously managed biopharmaceutical process including providing a receiving space in fluid communication with a process line through which a medium flows, receiving an excess amount of the medium flowing into the receiving space, charging an energy storage device by the medium flowing into the receiving space, and expelling at least part of the excess amount if the pressure or flow rate falls below a set amount.

    AUTOCLAVE VACUUM SYSTEM AND FILTER
    159.
    发明申请

    公开(公告)号:US20240367128A1

    公开(公告)日:2024-11-07

    申请号:US18654347

    申请日:2024-05-03

    Abstract: An autoclave vacuum system uses two vacuum sources to selectively impart a vacuum. In an exemplary embodiment, the vacuum sources are different types, wherein the first vacuum source is a vacuum pump, and the second source is a Venturi vacuum. The autoclave vacuum system uses a valve system for controlling whether the first and/or second vacuum sources are fluidly coupled to the vacuum enclosure. The valve system allows the autoclave vacuum system to assume a plurality of different configurations chosen such that a constant desired pressure is attained in the autoclave. The valve system may be triggered by a control system configured to recognize and act upon autoclave requirements such as temperature, pressure, duration of use, and number of cycles.

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