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    Obtaining an Improved Therapeutic Ligand
    161.
    发明申请
    Obtaining an Improved Therapeutic Ligand 审中-公开
    获得改进的治疗配体

    公开(公告)号：US20160125124A1

    公开(公告)日：2016-05-05

    申请号：US14897459

    申请日：2014-06-13

    Applicant: UCB BIOPHARMA SPRL

    Inventor： Jiye Shi ,  Terence Seward Baker ,  Alastair David Griffiths Lawson ,  Xiaofeng Liu

    IPC: G06F19/12 ,  C07K16/24

    CPC classification number: G16B5/00 ,  C07K16/244 ,  C07K2317/55 ,  C07K2317/76 ,  G16B15/00 ,  G16C20/50 ,  G16C20/90

    Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.

    Abstract translation: 涉及设计一种将结合大分子靶标的结合位点的配位体或者鉴定对配体的修饰以改善配体对大分子靶标的结合位点的亲和力的方法和相关设备，包括使用关于 从生物大分子数据库中提取的非键合，分子内或分子间或分子间原子与原子接触，以鉴定与特定原子类型的结合位点相邻的有利区域，并修饰候选配体以增加候选配体的原子之间的相交 和优惠地区。 方法的一个或多个步骤可以由计算机执行。

    AUTO-INJECTOR
    163.
    发明申请
    AUTO-INJECTOR 有权
    自动注射器

    公开(公告)号：US20150182691A1

    公开(公告)日：2015-07-02

    申请号：US14418441

    申请日：2013-07-29

    Applicant: UCB Biopharma SPRL

    Inventor： Martin John McLoughlin ,  Michael James David Heald ,  Ilario Melzi ,  Stefan Verlaak ,  Tatiana Palombi

    IPC: A61M5/145 ,  A61M5/158

    CPC classification number: A61M5/1456 ,  A61M5/002 ,  A61M5/158 ,  A61M5/20 ,  A61M5/3134 ,  A61M5/31505 ,  A61M5/31515 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/326 ,  A61M2005/2013 ,  A61M2005/206 ,  A61M2005/2477 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/583 ,  A61M2205/586 ,  A61M2205/8206

    Abstract: Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity and a needle projection aperture. The housing cavity may receive a syringe. Axially movable within the barrel of the syringe for forward movement into contact with the syringe plunger, there is a plunger slaving part defining a circumferential wall arranged for frictional sliding relationship with the inner wall of the barrel, a rear drive-receiving face and a front plunger-contacting face. The plunger slaving part is arranged such that when a drive load is applied to its rear drive-receiving face to bring the front plunger-contacting face into contact with the plunger the drive load is evenly transmitted. The circumferential wall is provided with slide restrictors that restrict frictional sliding movement thereof in relation to the inner wall of the barrel.

    Abstract translation: 提供了适用于具有电动驱动单元的自动注射器的盒单元。 盒单元包括限定盒单元容纳腔和针突起孔的盒单元壳体。 容纳腔可以接收注射器。 在注射器的筒体内可轴向移动以向前运动以与注射器柱塞接触，存在一个柱塞从动部件，其限定周向壁布置成与筒体的内壁摩擦滑动关系，后驱动接收面和前部 柱塞接触面。 柱塞从动部件布置成使得当驱动负载施加到其后驱动接收面以使前柱塞接触面与柱塞接触时，驱动负载被均匀地传递。 圆周壁上设有滑动限制器，其限制了相对于筒体的内壁的摩擦滑动运动。

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