公开(公告)号：US20060275911A1

公开(公告)日：2006-12-07

申请号：US11145038

申请日：2005-06-03

Applicant: Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li

IPC: G01N33/00

CPC classification number: G01N21/658 ,  B01L3/5027 ,  B01L2200/0663 ,  B82Y15/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N33/48707 ,  Y10T436/17 ,  C12Q2565/632 ,  C12Q2565/631

Abstract: Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device includes a molecule sensor and a molecule guide. The molecule sensor comprises a nanostructure, which is configured for producing a nanostructure-enhanced Raman scattered radiation when an excitation radiation irradiates at least a portion of a molecule disposed near the NERS structure.

Abstract translation: 公开了用于检测生物聚合物的组成部分的装置和方法。 分子分析装置包括分子传感器和分子指导。 分子传感器包括纳米结构，其被配置为当激发辐射照射设置在NERS结构附近的分子的至少一部分时产生纳米结构增强的拉曼散射辐射。

公开(公告)号：US20060233481A1

公开(公告)日：2006-10-19

申请号：US11107098

申请日：2005-04-15

Applicant: Zhiyong Li

Inventor： Zhiyong Li

IPC: G02B6/00

CPC classification number: G02B6/1225 ,  B82Y20/00 ,  G02B2006/1215

Abstract: An apparatus for sensing at least one property of a fluid is described. A first photonic crystal structure and a second photonic crystal structure are defined in a dielectric slab. The first and second photonic crystal structures comprise differently patterned arrays of channels extending through the dielectric slab. The apparatus further comprises a fluid introduction device configured to introduce a common volume of the fluid into the channels of the first and second photonic crystal structures. The at least one property of the fluid can be sensed by measuring the propagation of radiation through the first and second photonic crystal structures.

Abstract translation: 描述了用于感测流体的至少一个性质的装置。 在介质板中限定第一光子晶体结构和第二光子晶体结构。 第一和第二光子晶体结构包括延伸穿过电介质板的不同图案的通道阵列。 该装置还包括流体引入装置，其构造成将共同体积的流体引入第一和第二光子晶体结构的通道中。 可以通过测量通过第一和第二光子晶体结构的辐射的传播来感测流体的至少一个性质。

公开(公告)号：US20060108322A1

公开(公告)日：2006-05-25

申请号：US10993451

申请日：2004-11-19

Applicant: Wei Wu ,  Zhiyong Li

Inventor： Wei Wu ,  Zhiyong Li

IPC: B44C1/22 ,  B32B27/00 ,  C08L33/00 ,  B32B3/00

CPC classification number: B81C1/0046 ,  B81B2207/07 ,  B81C2201/0153 ,  B82Y10/00 ,  B82Y30/00

Abstract: A lift-off material for use in fabricating a nanostructure. The lift-off material includes a first material adapted to, and present in an amount sufficient to provide a predetermined amount of mechanical strength to the nanostructure during fabrication; and a second material adapted to, and present in an amount sufficient to provide a predetermined solubility to the lift-off material.

Abstract translation: 用于制造纳米结构的剥离材料。 剥离材料包括第一材料，其适于并且以足以在制造期间向纳米结构提供预定量的机械强度的量存在; 以及第二材料，其适于并且以足以向剥离材料提供预定溶解度的量存在。

公开(公告)号：US20060056463A1

公开(公告)日：2006-03-16

申请号：US10942004

申请日：2004-09-14

Applicant: Shih-Yuan Wang ,  M. Islam ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  M. Islam ,  Zhiyong Li

IPC: H01S3/30

CPC classification number: G01N21/658 ,  G01J3/10 ,  G01N21/774 ,  H01S3/1086 ,  H01S3/169 ,  H01S5/026 ,  H01S5/1021 ,  H01S5/183 ,  H01S5/423

Abstract: Integrated radiation source/amplifying structures for use in surface enhanced Raman spectroscopy (SERS) and hyper-SERS are disclosed. The structures include a radiation source integrated with a SERS-active structure that is provided within a resonant cavity. SERS and hyper-SERS systems employing the integrated radiation source/amplifying structures are disclosed. Methods of performing SERS and hyper-SERS are also disclosed.

Abstract translation: 公开了用于表面增强拉曼光谱（SERS）和超SERS的集成放射源/放大结构。 该结构包括与设置在谐振腔内的SERS-活性结构集成的辐射源。 公开了采用集成放射源/放大结构的SERS和超SERS系统。 还公开了执行SERS和超SERS的方法。

公开(公告)号：US20060054881A1

公开(公告)日：2006-03-16

申请号：US10942693

申请日：2004-09-16

Applicant: Zhiyong Li ,  Shih-Yuan Wang

Inventor： Zhiyong Li ,  Shih-Yuan Wang

IPC: H01L29/06 ,  H01L31/0328

CPC classification number: G01N21/658 ,  B82Y30/00

Abstract: A SERS-active structure is disclosed that includes a substrate and at least one nanowire disposed on the substrate. The at least one nanowire includes a core including a first material and a coating including a SERS-active material. A SERS system is also disclosed that includes a SERS-active structure. Also disclosed are methods for forming a SERS-active structure and methods for performing SERS with SERS-active structures.

Abstract translation: 公开了一种SERS-活性结构，其包括衬底和设置在衬底上的至少一个纳米线。 所述至少一个纳米线包括包含第一材料和包含SERS-活性材料的涂层的芯。 还公开了包括SERS活性结构的SERS系统。 还公开了形成SERS活性结构的方法和用SERS活性结构进行SERS的方法。

公开(公告)号：US20050040417A1

公开(公告)日：2005-02-24

申请号：US10917751

申请日：2004-08-12

Applicant: Zhiyong Li ,  Yong Chen ,  Sean Zhang

Inventor： Zhiyong Li ,  Yong Chen ,  Sean Zhang

IPC: B82B1/00 ,  H01L29/22 ,  H01L31/0352 ,  H01L51/00 ,  H01L51/30

CPC classification number: H01L51/42 ,  H01L51/005 ,  H01L51/0071 ,  H01L51/0077 ,  H01L51/428 ,  Y02E10/549 ,  Y10S977/954

Abstract: An optical sensor is provided, comprising (a) a silicon nanowire of finite length having an electrical contact pad at each end thereof; and (b) a plurality of self-assembled molecules on a surface of the silicon nanowire, the molecules serving to modulate electrical conductivity of the silicon nanowire by either a reversible change in dipole moment of the molecules or by a reversible molecule-assisted electron/energy transfer from the molecules onto the silicon nanowire. Further, a method of making the optical sensor is provided. The concept of molecular self-assembly is applied in attaching functional molecules onto silicon nanowire surfaces, and the requirement of molecule modification (hydroxy group in molecules) is minimal from the point view of synthetic difficulty and compatibility. Self-assembly will produce well-ordered ultra-thin films with strong chemical bonding on a surface that cannot be easily achieved by other conventional methods.

Abstract translation: 提供了一种光学传感器，其包括（a）有限长度的硅纳米线，其每端具有电接触焊盘; 和（b）在硅纳米线的表面上的多个自组装分子，所述分子用于通过分子的偶极矩的可逆变化或通过可逆分子辅助电子/分子调制硅纳米线的导电性， 能量从分子转移到硅纳米线上。 此外，提供了制造光学传感器的方法。 分子自组装的概念应用于将功能分子附着在硅纳米线表面上，从合成难度和相容性的观点来看，分子修饰（分子中的羟基）的要求是最小的。 自组装将产生在表面上具有强化学键合的良好有序的超薄膜，其不能通过其它常规方法实现。

公开(公告)号：US10342852B2

公开(公告)日：2019-07-09

申请号：US15729420

申请日：2017-10-10

Applicant: Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

Inventor： Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

IPC: A61K38/19 ,  C07K14/52 ,  A61K38/22 ,  A23L33/17 ,  A61K39/00 ,  C07K14/475

Abstract: The present invention provides an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement. The present invention further provides a method for preparing a mouse with fat-specific overexpression of Metrnl.

公开(公告)号：US20180030102A1

公开(公告)日：2018-02-01

申请号：US15729420

申请日：2017-10-10

Applicant: Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

Inventor： Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

IPC: C07K14/475 ,  A61K38/22 ,  A61K39/00

CPC classification number: A61K38/19 ,  A23L33/17 ,  A23V2002/00 ,  A61K39/00 ,  C07K14/475 ,  C07K14/52

Abstract: The present invention provides an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement. The present invention further provides a method for preparing a mouse with fat-specific overexpression of Metrnl.

公开(公告)号：US09638625B2

公开(公告)日：2017-05-02

申请号：US14345277

申请日：2011-10-27

Applicant: Ansoon Kim ,  Zhiyong Li ,  Wei Wu

Inventor： Ansoon Kim ,  Zhiyong Li ,  Wei Wu

IPC: G01J3/44 ,  G01N21/05 ,  G01N21/65 ,  G01N21/552 ,  G01N33/49 ,  G01N1/40 ,  B82Y20/00

CPC classification number: G01N21/05 ,  B82Y20/00 ,  G01N21/554 ,  G01N21/658 ,  G01N33/491 ,  G01N2001/4088 ,  G01N2021/651

Abstract: An apparatus for filtering species in a fluid includes a body having a first side and a second side, a first set of nano-fingers positioned on the body near the first side, a second set of nano-fingers positioned on the body closer to the second side than the first set of nano-fingers, wherein the nano-fingers in the second set of nano-fingers are arranged on the body at a relatively more densely than the nano-fingers in the first set of nano-fingers, and a cover positioned over the first set of nano-fingers and the second set of nano-fingers to form a channel with the body within which the first and second sets of nano-fingers are positioned.

公开(公告)号：US09588048B2

公开(公告)日：2017-03-07

申请号：US14118801

申请日：2011-05-20

Applicant: Ansoon Kim ,  Zhiyong Li

Inventor： Ansoon Kim ,  Zhiyong Li

IPC: G01N21/65 ,  G01J3/44 ,  B82Y15/00

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/44

Abstract: A surface enhanced Raman spectroscopy (SERS) sensor, system and method employ nanorods and independent nanoparticles that interact. The sensor includes at least two spaced apart nanorods attached at first ends to a substrate and an independent nanoparticle. Second ends of the nanorods are movable into close proximity to one another and include a Raman active surface. The nanoparticle has a functionalized surface that includes a Raman signal generator. An interaction between the nanoparticle and the nanorod second ends in close proximity is detectable. The system includes the SERS sensor, an illumination source and a Raman signal detector. The method includes illuminating the interaction of the nanoparticle and the nanorods with an analyte, and detecting an effect on a Raman signal caused by the analyte.

Abstract translation: 表面增强拉曼光谱（SERS）传感器，系统和方法采用纳米棒和独立纳米粒子相互作用。 传感器包括至少两个间隔开的纳米棒，其在第一端附着到基底和独立的纳米颗粒。 纳米棒的第二端可以彼此靠近移动并且包括拉曼活性表面。 纳米颗粒具有包括拉曼信号发生器的官能化表面。 纳米颗粒和纳米棒第二末端之间的相互作用是可以接近的。 该系统包括SERS传感器，照明源和拉曼信号检测器。 该方法包括用分析物照射纳米颗粒和纳米棒的相互作用，并检测由分析物引起的对拉曼信号的影响。