公开(公告)号：US08603384B2

公开(公告)日：2013-12-10

申请号：US12922450

申请日：2009-03-11

Applicant: Regina Lüttge ,  Svetlana Nikolajevna Bystrova ,  Joost Gerardus van Bennekom ,  Maciej Domanski ,  Patrick Wilhelmus Hendrikus Loeters ,  Rob Gerhardus Hendrikus Lammertink ,  Aloysius Johannes Antonius Winnubst

Inventor： Regina Lüttge ,  Svetlana Nikolajevna Bystrova ,  Joost Gerardus van Bennekom ,  Maciej Domanski ,  Patrick Wilhelmus Hendrikus Loeters ,  Rob Gerhardus Hendrikus Lammertink ,  Aloysius Johannes Antonius Winnubst

IPC: B29C59/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C99/0085 ,  B81C2201/034

Abstract: The invention relates to a method of manufacturing of a microneedle array comprising the steps of selecting a soft production mold comprising a set of microscopic incisions defining geometry of the microneedles, said soft production mold being capable of providing the microneedle array integrated into a base plate; using a filler material for abundantly filling the microscopic incisions of the soft production mold thereby producing the microneedle array with pre-defined geometry integrated into the base plate; wherein for the filler material a water or alcohol based ceramic or polymer-ceramic slurry is selected. The invention further relates to a microneedle array, a composition comprising a microneedle array, a system for enabling transport of a substance through a barrier and a system for measuring an electric signal using an electrode.

Abstract translation: 本发明涉及一种制造微针阵列的方法，包括以下步骤：选择包括限定微针几何形状的一组微观切口的软生产模具，所述软生产模具能够提供集成到基板中的微针阵列; 使用填充材料充分填充柔软生产模具的微观切口，从而产生具有预定义几何形状的微针阵列集成到基板中; 其中对于填充材料，选择水或醇基陶瓷或聚合物 - 陶瓷浆料。 本发明还涉及一种微针阵列，包括微针阵列的组合物，用于使物质通过屏障传送的系统和用于使用电极测量电信号的系统。

公开(公告)号：US20130323840A1

公开(公告)日：2013-12-05

申请号：US13996961

申请日：2011-12-19

Applicant: Sang Hoon Lee ,  Edward Kang

Inventor： Sang Hoon Lee ,  Edward Kang

IPC: B81B1/00 ,  C12N5/079 ,  B81C1/00

CPC classification number: B81B1/002 ,  B01L3/502707 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0887 ,  B01L2400/086 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C1/00103 ,  B81C1/00634 ,  B81C99/0085 ,  B81C2201/019 ,  B81C2201/034 ,  C12N5/0618 ,  C12N2535/00 ,  Y10T428/13

Abstract: The present disclosure relates to a cylinder channel having a sawtooth-shaped cross section, a method for manufacturing same, a coaxial channel including same and a method for manufacturing a microfiber or a microparticle having a sawtooth-shaped cross section using same.

Abstract translation: 本发明涉及具有锯齿形横截面的气缸通道，其制造方法，包括其的同轴通道，以及使用其具有锯齿状截面的微细纤维或微粒的制造方法。

公开(公告)号：US20130270225A1

公开(公告)日：2013-10-17

申请号：US13862023

申请日：2013-04-12

Applicant: Technische Universitaet Ilmenau

Inventor： Joerg Hampl ,  Frank Weise ,  Gregor Schlingloff ,  Andreas Schober ,  Uta Fernekorn

IPC: B44C1/22

CPC classification number: B44C1/227 ,  B81B2201/06 ,  B81B2203/0346 ,  B81B2207/056 ,  B81C99/0085 ,  B81C2201/034 ,  Y10T428/24281

Abstract: A method is provided for producing a microstructured molded object that is intended for culturing of biological cells. According to this method, a plastically deformable first porous film is prepared, as well as a deformable second film and a deformable sacrificial film. The first, second and sacrificial film are placed in a stack. Next, the sacrificial film is subjected to pressure to press the stack into a mold. The mold has recesses, such that deformed regions in the form of cavities are produced in the sacrificial film, the first film and the second film, and undeformed regions remain. During the pressing of the film stack into the mold, the first film and the second film are joined to each other, so that they form a composite film. At least portions of the deformed regions of the second film are etched so that sections of the second film are chemically dissolved. In these sections of the second film, sections in the deformed regions of the first film are opened up, so that the pores in these sections are again free.

Abstract translation: 提供了用于生产用于培养生物细胞的微结构模制物体的方法。 根据该方法，制备可塑性变形的第一多孔膜，以及可变形的第二膜和可变形的牺牲膜。 第一，第二和牺牲膜被放置在堆叠中。 接下来，牺牲膜经受压力以将叠层压入模具中。 模具具有凹部，使得在牺牲膜，第一膜和第二膜中产生空腔形式的变形区域，并且保留未变形的区域。 在将膜堆叠压入模具期间，第一膜和第二膜彼此接合，从而形成复合膜。 蚀刻第二膜的变形区域的至少部分，使得第二膜的部分化学溶解。 在第二膜的这些部分中，第一膜的变形区域中的部分被打开，使得这些部分中的孔再次游离。

公开(公告)号：US20130216641A1

公开(公告)日：2013-08-22

申请号：US13646746

申请日：2012-10-08

Applicant: CHIA-LING HSU

Inventor： CHIA-LING HSU

IPC: B29C59/04 ,  B32B37/00 ,  B32B38/10

CPC classification number: B29C33/3857 ,  B29C33/424 ,  B29K2827/18 ,  B44B5/026 ,  B81C99/009 ,  B81C2201/034 ,  Y10T156/1064

Abstract: A mold roller and a method of manufacturing the mold roller comprising heating a metal substrate which has a microstructure pattern and attaching an ethylene tetrafluoroethylene (ETFE) film on the heated metal substrate. The ETFE film is pressed on the heated metal substrate and the microstructure pattern is thereby transferred and formed on a first side of the ETFE film The FIFE film with the microstructure pattern is than transferred to a circumferential surface of a core roller by a roller-to-roller process as its second side opposite to the first side attached to the circumferential surface.

Abstract translation: 一种成型辊及其制造方法，其特征在于：在加热后的金属基板上加热金属基板，该金属基板具有显微组织图案，并附着有乙烯四氟乙烯（ETFE）膜。 ETFE膜被压在加热的金属基底上，并且微结构图案由此转移并形成在ETFE膜的第一侧上。具有微结构图案的FIFE膜不是通过辊到辊转移到芯辊的圆周表面 作为其第二侧的第二侧，该第二侧与连接到圆周表面的第一侧相对。

公开(公告)号：US08404193B2

公开(公告)日：2013-03-26

申请号：US13057466

申请日：2009-07-13

Applicant: Kanji Sekihara ,  Takehiko Goshima

Inventor： Kanji Sekihara ,  Takehiko Goshima

IPC: G01N33/48 ,  B29C45/14

CPC classification number: B81C99/009 ,  B01J2219/00891 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/141 ,  B01L2300/0816 ,  B29C45/2628 ,  B29C45/40 ,  B29C65/02 ,  B29C66/54 ,  B29L2031/756 ,  B81B2201/051 ,  B81B2203/0338 ,  B81B2203/0384 ,  B81C2201/034

Abstract: A microchip which comprises: a resinous base having a plurality of fine channels formed on one side thereof, one or more cylindrical parts disposed so as to protrude from the other side, and a through-hole which pierces each cylindrical part along the axis thereof and communicates with the fine channel so that the diameter of the inner wall of the through-hole gradually decreases from the tip end of the cylindrical part toward the fine channel at a first inclination angle; and a resinous covering member bonded to that side of the resinous base on which the fine channels have been formed. The microchip has been configured so that a liquid sample can be introduced from the tip end of each cylindrical part through the through-hole. The wall thickness of the cylindrical part on the end side where a liquid sample is to be introduced has been made smaller than the wall thickness thereof on the base side where the cylindrical part has been formed, by forming a step therebetween.

Abstract translation: 一种微芯片，包括：具有形成在其一侧上的多个细通道的树脂基底，一个或多个从另一侧突出设置的圆柱形部分，以及沿着其轴线刺穿每个圆柱形部分的通孔， 与细通道连通，使得通孔的内壁的直径从圆筒部的前端朝向第一倾斜角的细通道逐渐减小; 以及与形成有微细通道的树脂基底的该侧接合的树脂覆盖部件。 微芯片已经被构造成使得液体样品可以通过通孔从每个圆柱形部分的末端引入。 通过在它们之间形成一个台阶，使得待引入液体样品的端侧的圆筒部分的壁厚比通过形成圆柱形部分的基底侧的壁厚小。

公开(公告)号：US08104515B2

公开(公告)日：2012-01-31

申请号：US12540994

申请日：2009-08-13

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: F15C1/06

CPC classification number: B29C51/00 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  B81B5/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  C12Q1/6874 ,  F04B43/043 ,  F15C1/06 ,  F15C5/00 ,  F16K11/20 ,  F16K13/00 ,  F16K31/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/0497 ,  Y10T137/2224 ,  Y10T137/87249 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24744 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US08012382B2

公开(公告)日：2011-09-06

申请号：US12398132

申请日：2009-03-04

Applicant: Enoch Kim ,  Younan Xia ,  Milan Mrksich ,  Rebecca J. Jackman ,  Xiao-Mei Zhao ,  Stephen P. Smith ,  Christian Marzolin ,  Mara G. Prentiss ,  George M. Whitesides

Inventor： Enoch Kim ,  Younan Xia ,  Milan Mrksich ,  Rebecca J. Jackman ,  Xiao-Mei Zhao ,  Stephen P. Smith ,  Christian Marzolin ,  Mara G. Prentiss ,  George M. Whitesides

IPC: B29D11/00 ,  G02B6/00 ,  G02B6/10 ,  G02B1/12 ,  D04H1/20 ,  B29C45/14 ,  B29C43/00 ,  B29C35/08 ,  B29C39/00 ,  B29C41/00 ,  B28B1/14 ,  B44C1/22 ,  C03C15/00 ,  C03C25/68 ,  C23F1/00

CPC classification number: B81C1/00206 ,  A61K47/6957 ,  B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00416 ,  B01J2219/0043 ,  B01J2219/00466 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00713 ,  B29C31/04 ,  B29C33/42 ,  B29C37/0053 ,  B29C39/24 ,  B29C43/021 ,  B29C67/246 ,  B29D11/00346 ,  B29D11/00663 ,  B29K2105/0002 ,  B29L2011/0016 ,  B81B2201/0214 ,  B81C1/00031 ,  B81C99/0085 ,  B81C2201/034 ,  B82Y30/00 ,  C40B60/14 ,  G01N21/7703 ,  G01N2021/7776 ,  G02B6/138 ,  H05K3/0079 ,  H05K3/061

Abstract: Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of indentical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.

Abstract translation: 化学或生物化学活性剂或其它物质通过提供具有轮廓表面的微胶体并在基底表面上形成结构的化学或生物化学活性剂或流体前体而在基底表面上图案化。 化学或生物化学活性剂或流体前体也可以从敷料器中的凹陷转移到基底表面。 衬底表面可以是平面的或非平面的。 聚合物结构，无机陶瓷和盐等的流体前体可用于在表面形成图案化聚合物制品，无机盐和陶瓷，反应离子蚀刻掩模等。 制品可以形成为包括横向尺寸小于约1毫米或更小的部分的图案。 涂抹器的压痕图案可以用于将单独的，不同的化学或生物化学活性剂或流体前体转移到基底表面的分离的，分离的区域。 可以制作波导阵列，组合化学或生化图谱等。 波导和包层的折射率差异可以通过将由凹凸预聚物材料制成的波导和包层进行不同的聚合或交联条件来产生。 干涉仪通过耦合波导阵列来定义，其中可以通过改变阵列的任何所需位置处的包层和波导之间的折射率差来控制耦合。 改变和折射率可以通过光化学，化学等方式产生。 还公开了传感器，包括生化传感器。

公开(公告)号：US20110174040A1

公开(公告)日：2011-07-21

申请号：US13006951

申请日：2011-01-14

Applicant: Wen Jin Meng ,  Fanghua Mei

Inventor： Wen Jin Meng ,  Fanghua Mei

IPC: B21D39/03 ,  B21D53/04

CPC classification number: B81C1/00071 ,  B81C2201/034

Abstract: A process is disclosed for producing metal-based, high-aspect-ratio microscale structures (HARMs), for example microchannels in a heat exchanger. The preferred manufacturing method operates in a continuous mode, and employs low-temperature rolling of metals. A process is disclosed for bonding metal microchannel sheets or plates to flat metal sheets or plates to form single-, double-, and multiple-layered microchannel structures. The process can operate at much lower temperatures than prior methods of compression microscale molding of metals, at room temperature or even lower.

Abstract translation: 公开了用于生产金属基高纵横比微结构（HARM）的方法，例如热交换器中的微通道。 优选的制造方法以连续模式操作，并且采用金属的低温轧制。 公开了一种用于将金属微通道片或板接合到平板金属片或板以形成单层，双层和多层微通道结构的方法。 该方法可以在比现有的金属压缩微细成型方法低得多的温度下操作，在室温甚至更低的温度下。

公开(公告)号：US20110039100A1

公开(公告)日：2011-02-17

申请号：US12811674

申请日：2008-12-22

Applicant: Johan Willem Berenschot ,  Niels Roelof Tas

Inventor： Johan Willem Berenschot ,  Niels Roelof Tas

IPC: B81C1/00 ,  D02G3/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: B81C1/00111 ,  B33Y10/00 ,  B33Y80/00 ,  B81C2201/034 ,  B82Y35/00 ,  G01Q70/10 ,  G01Q70/16 ,  Y10T428/2913 ,  Y10T428/2982

Abstract: Abstract: The invention relates to a method for making a 3D nanostructure having a nanosubstructure, comprising the steps of: i) providing a mold comprising at least one sharp concave corner; ii) conformational depositing at least one structural material in the sharp concave corner; iii) isotropically removing structural material; iv) depositing at least one other structural material; v) removing earlier deposited structural material; vi) forming a nanosubstructure; and vii) removing the mold thereby providing the 3D nanostructure having the nanosubstructure.

Abstract translation: 摘要：本发明涉及一种制备具有纳米级结构的3D纳米结构的方法，包括以下步骤：i）提供包含至少一个锐角凹入角的模具; ii）在锋利的凹角中构造沉积至少一种结构材料; iii）各向同性地除去结构材料; iv）沉积至少一种其他结构材料; v）清除较早沉积的结构材料; vi）形成纳米结构; 和vii）去除模具，从而提供具有纳米结构的3D纳米结构。

公开(公告)号：US07744947B2

公开(公告)日：2010-06-29

申请号：US11461086

申请日：2006-07-31

Applicant: Byung Chul Lee ,  Jeong Oen Lee ,  Yang Kyu Choi ,  Jun-Bo Yoon

Inventor： Byung Chul Lee ,  Jeong Oen Lee ,  Yang Kyu Choi ,  Jun-Bo Yoon

IPC: B05D5/12

CPC classification number: H01L21/76877 ,  B81B2203/04 ,  B81B2207/07 ,  B81C99/0085 ,  B81C2201/034 ,  B82Y10/00 ,  H01F41/041 ,  H01L21/76885 ,  H01L23/5223 ,  H01L23/5227 ,  H01L23/53276 ,  H01L51/0048 ,  H01L2221/1094 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A method of fabricating a semiconductor device by filling carbon nanotubes in a recess is disclosed. The method of fabricating the semiconductor device comprises patterning a mold on a substrate, coating carbon nanotubes on an entire surface of the recess and the mold formed by the patterning, filling the carbon nanotubes coated on the an entire surface of the mold in the recess, and removing the mold.

Abstract translation: 公开了一种通过在凹槽中填充碳纳米管来制造半导体器件的方法。 制造半导体器件的方法包括在基底上图案化模具，在凹部的整个表面上涂覆碳纳米管和通过图案化形成的模具，填充涂覆在凹部中的模具的整个表面上的碳纳米管， 并移除模具。