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公开(公告)号：US12098069B2
公开(公告)日：2024-09-24
申请号：US17540750
申请日：2021-12-02
Applicant: Sangwoo Lee
Inventor： Sangwoo Lee
CPC classification number: B81C1/00111 , A61B5/293 , B81B1/008 , A61B2562/125 , A61N1/0529 , B81B2201/055 , B81B2203/0361 , B81B2203/04 , B81C2201/0133
Abstract: A method of manufacturing a plurality of neural probes from a silicon wafer in which after neural probes are formed on one side of a silicon wafer, the other side of the silicon wafter is subject to a dicing process that separates and adjusts the thickness of the neural probes.
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公开(公告)号：US20240108817A1
公开(公告)日：2024-04-04
申请号：US18529219
申请日：2023-12-05
Applicant: SNVIA CO., LTD.
Inventor： Seung Yun YANG , Sang-Gu YIM , Young Jun HWANG
CPC classification number: A61M5/3286 , B81B1/008 , B81C1/00111 , A61M2207/00 , B81B2201/055 , B81B2203/0361 , B81C2201/0197
Abstract: An implantable microneedle and a manufacturing method therefor is disclosed. The implantable microneedle includes a coating layer for covering at least one part of the surface of a tip part of the microneedle. When exposed to moisture, the coating layer can be separated from the tip part of the microneedle and thus be implanted.
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公开(公告)号：US11938308B2
公开(公告)日：2024-03-26
申请号：US16959620
申请日：2019-01-17
Applicant: SNVIA CO., LTD.
Inventor： Seung Yun Yang , Sang-Gu Yim , Young Jun Hwang
CPC classification number: A61M5/3286 , B81B1/008 , B81C1/00111 , A61M2207/00 , B81B2201/055 , B81B2203/0361 , B81C2201/0197
Abstract: The present invention provides an implantable microneedle and a manufacturing method therefor. An implantable microneedle according to the present invention comprises a coating layer for covering at least one part of the surface of a tip part of the microneedle. When exposed to moisture, the coating layer can be separated from the tip part of the microneedle and thus be implanted.
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公开(公告)号：US20230248953A1
公开(公告)日：2023-08-10
申请号：US18135775
申请日：2023-04-18
Applicant: Kinneret Rand
Inventor： Kinneret Rand
IPC: A61M37/00
CPC classification number: A61M37/0015 , A61M2037/0053 , B81B2201/055 , B81B2201/057 , B33Y80/00
Abstract: An object of the present invention is to provide an anti-adhesive/anti-clogging and/or color marked/tinted micro-capillary tube (microtube), microneedle, or micropipette. Typically, the color/tint will be selected such that the tip of the microneedle or micropipette is in contrast (e.g., visually) to the biological material. The tint/color may be selected to contrast the stained biological material. In some aspects, the color mark comprises nanoparticles that are modified by adding a non-adhesive coating/material that minimizes protein adhesion/adsorption. The microtubes and/or micropipettes may be treated with an anti-clogging reagent and an anti-adhesive reagent to prevent or reduce clogging and adhesion of the micropipette or microneedle to biological materials. The microtubes and/or micropipettes may be formed using additive printing processes and additive manufacturing techniques or from micropipette and microneedle pullers.
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公开(公告)号：US20180355297A1
公开(公告)日：2018-12-13
申请号：US16066724
申请日：2017-01-03
Inventor： Jürgen KOSEL , Mincho Nikolaev KAVALDZHIEV , Jose Efrain PEREZ
CPC classification number: C12M1/26 , A61B5/685 , A61B10/0045 , A61B10/0233 , A61B2010/0225 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B81B1/008 , B81B2201/055 , B81C1/00111 , B82Y5/00 , C12M23/20
Abstract: Nanoneedles and nanoneedle arrays and methods of making nanoneedles are provided. The methods can include multilayer fabrication methods using a negative photoresist and/or a positive photoresist. The nanoneedle arrays include one or more nanoneedles attached to a surface of a substrate. The nanoneedle can have both a proximal opening and a distal opening, and an inner passageway connecting the proximal opening and the distal opening. The nanoneedle can have a functional coating. The nanoneedle can include iron, cobalt, nickel, gold, and oxides and alloys thereof. The nanoneedle arrays can be used for the administration and/or the extraction of agents from individual cells. In one or more aspects, the nanoneedles can be magnetic nanoneedles. An oscillating magnetic field applied to a magnetic nanoneedle can induce one or both of heating and vibration of the magnetic nanoneedle. The heating and/or vibration can cause a magnetic nanoneedle to penetrate the wall of a cell.
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Patent Agency Ranking
公开(公告)号：US09597490B2
公开(公告)日：2017-03-21
申请号：US13001349
申请日：2009-06-24
Applicant: Johan Willem Berenschot , Jeroen Mathijn Wissink , Niels Roelof Tas , Meint Jelle DeBoer
IPC: A61M37/00
CPC classification number: A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B81B2201/055
Abstract: The present invention provides a microneedle, comprising a shaft of a monocrystalline material having at least three walls which are formed by a crystal plane of the monocrystalline material; and a tip connected to an end of the shaft comprising at least three walls which are formed by a crystal plane of the material. The material is preferably silicon. Two of the walls of the tip are formed by the same crystal planes as two walls of the shaft. These two walls are formed by a crystal plane. Preferably, three walls of the tip are formed by a crystal plane.
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7.发明申请公开(公告)号：US20160107189A1
公开(公告)日：2016-04-21
申请号：US14894397
申请日：2014-05-29
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Eiji HASHIMOTO , Toshiyuki MATSUDO , Shinpei NISHIMURA , Seiji TOKUMOTO
CPC classification number: B05C15/00 , A61M37/0015 , A61M2037/0053 , B05C3/00 , B05C21/00 , B05D3/0486 , B81B2201/055 , B81C99/0025 , F24F3/14 , F24F3/1603
Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.
Abstract translation: 本发明提供一种用于制造治疗性微针的系统，其构造成通过用含有药物的涂布液涂布微针来调节用于制造治疗性微针的涂布室内的空气环境，该制造用微生物的制造系统包括空气压缩机， 配置为调节从空气压缩机供给的空气的湿度的湿度调节器，以及被配置为从供给到涂布室内部的空气中除去微生物的空气过滤器。
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公开(公告)号：US08883015B2
公开(公告)日：2014-11-11
申请号：US12866717
申请日：2009-02-05
CPC classification number: A61M37/0015 , A61K9/0021 , A61K9/0097 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , B81B2201/055 , B81C1/00111 , H01J37/32009 , H01J37/3244 , H01J2237/334
Abstract: A method of producing projections on a patch including providing a mask on a substrate and etching the substrate using an etchant and a passivant to thereby control the etching process and form the projections, wherein the passivant does not include oxygen.
Abstract translation: 一种在贴片上制造突起的方法，包括在基片上提供掩模，并使用蚀刻剂和钝化剂蚀刻基底，从而控制蚀刻工艺并形成突起，其中钝化剂不包括氧。
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公开(公告)号：US20140046262A1
公开(公告)日：2014-02-13
申请号：US13758872
申请日：2013-02-04
Applicant: Transderm, Inc.
Inventor： Roger L. Kaspar , Tycho Speaker
CPC classification number: B29C41/02 , A61B5/685 , A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , A61M2037/0061 , B29C39/38 , B29C39/42 , B29C41/50 , B29C2059/023 , B29L2031/7544 , B81B2201/055 , B81C1/00111
Abstract: The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.
Abstract translation: 本发明提供具有微针阵列的透皮递送装置及其制造和使用的方法。 在一个实施方案中，提供透皮递送装置。 透皮递送装置包括具有从其表面之一突出的微针的聚合物层。 微针与聚合物基层的组成是均匀的。
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公开(公告)号：US20130140267A1
公开(公告)日：2013-06-06
申请号：US13752959
申请日：2013-01-29
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Kazuhiko SHIOMITSU , Hiroshi SUGIMURA , Toshiaki KUROSU , Gaku SUZUKI , Takao TOMONO
IPC: B44C1/22
CPC classification number: B44C1/227 , A61M37/0015 , A61M2037/003 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053 , B29C33/42 , B81B2201/055 , B81C1/00111 , B81C2201/0198
Abstract: The invention discloses a method of manufacturing a microneedle including the steps of forming an island etching mask having thickness distribution on a substrate, and processing the substrate into a needle by taking advantage of a difference in etching rates between the etching mask and the substrate. The invention enables to readily control a point angle and height of the manufactured needle.
Abstract translation: 本发明公开了一种制造微针的方法，包括以下步骤：在衬底上形成具有厚度分布的岛蚀刻掩模，并通过利用蚀刻掩模和衬底之间的蚀刻速率差来将衬底处理成针。 本发明能够容易地控制所制造的针的点角度和高度。
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