公开(公告)号：US07354772B2

公开(公告)日：2008-04-08

申请号：US11120030

申请日：2005-05-02

Applicant: Naresh Menon ,  John D. Minelly

Inventor： Naresh Menon ,  John D. Minelly

IPC: C12Q1/68 ,  G01N21/00 ,  H01L31/00 ,  G01B9/02 ,  H01S3/00 ,  H01S3/08

CPC classification number: G01N21/39 ,  G01N21/253 ,  G01N21/552 ,  G01N21/774 ,  G01N2021/391 ,  G01N2021/7753 ,  G01N2021/7773 ,  G01N2021/7776 ,  G01N2201/06113 ,  G01N2201/08

Abstract: A system and method for determining information about an assay. In one embodiment the method includes positioning a filter assembly, having an assay disposed on its surface, relative to a light source such that light from the light source is incident on the filter assembly and at least a portion of the light incident on the filter assembly is reflected from the filter assembly, illuminating the filter assembly with light from the light source, receiving light reflected from the filter assembly in an optical element, analyzing one or more characteristics of the light received in the optical element to determine information about a reaction in the assay, wherein a reaction in the assay results in a change of one or more characteristics of the light received from the filter assembly. In another embodiment, a system for analyzing an assay, comprises a structure in a resonating cavity configured to receive a filter assembly having an assay disposed on a first surface thereof such that the assay is positioned outside the resonating cavity, a light source positioned in the resonating cavity to communicate light to a second surface area of the filter assembly disposed in the resonating cavity, and an analysis system configured to receive light emitted from the filter assembly and detect information about a reaction in the assay based on one or more characteristics of the light.

Abstract translation: 用于确定测定信息的系统和方法。 在一个实施例中，该方法包括相对于光源定位具有设置在其表面上的测定的过滤器组件，使得来自光源的光入射到过滤器组件上，并且入射到过滤器组件上的光的至少一部分 从所述过滤器组件反射，用来自所述光源的光照射所述过滤器组件，接收在所述光学元件中从所述过滤器组件反射的光，分析在所述光学元件中接收的光的一个或多个特性，以确定关于 其中所述测定中的反应导致从所述过滤器组件接收的光的一个或多个特性的变化。 在另一个实施例中，用于分析测定的系统包括谐振腔中的结构，其被配置为接收具有设置在其第一表面上的测定的过滤器组件，使得所述测定位于所述谐振腔外部，光源位于所述 谐振腔以将光传送到设置在谐振腔中的过滤器组件的第二表面区域，以及分析系统，被配置为接收从过滤器组件发射的光，并且基于检测中的一个或多个特性检测关于测定中的反应的信息 光。

公开(公告)号：US20070290145A1

公开(公告)日：2007-12-20

申请号：US11665768

申请日：2005-10-21

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Alexandre Loiseau ,  Frederic Louradour ,  Mikael Lelek ,  Alain Barthelemy ,  Domoinique Pagnoux

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Alexandre Loiseau ,  Frederic Louradour ,  Mikael Lelek ,  Alain Barthelemy ,  Domoinique Pagnoux

IPC: G21K5/04 ,  F21K2/00 ,  F21V9/16

CPC classification number: G02B23/2484 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0086 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/1053 ,  G02B6/04 ,  G02B21/002 ,  G02B21/16 ,  G02B23/2469

Abstract: A system for carrying out fibered multiphoton microscopic imagery of a sample (10) for use in endoscopy or fluorescence microscopy includes: a femtosecond pulsed laser (1, 2) for generating a multiphoton excitation laser radiation; an image guide (8) having a number of optical fibers and permitting the sample to be illuminated by a point-by-point scanning in a subsurface plane; pre-compensating elements (4) for pre-compensating for dispersion effects of the excitation pulses in the image guide (8), these elements being situated between the pulsed laser and the image guide (8); scanning elements for directing, in succession, the excitation laser beam in a fiber of the image guide, and; in particular, an optical head (9) for focussing the excitation laser beam exiting the image guide in the sample (10).

Abstract translation: 用于进行用于内窥镜检查或荧光显微镜检查的样品（10）的纤维多光子显微镜图像的系统包括：用于产生多光子激发激光辐射的飞秒脉冲激光器（1,2） 具有多个光纤的图像引导件（8），并允许通过在地下平面中的逐点扫描照亮样品; 预补偿元件（4），用于对图像引导件（8）中的激励脉冲的色散效应进行预补偿，这些元件位于脉冲激光器和图像引导件（8）之间; 用于连续地引导图像引导件的光纤中的激发激光束的扫描元件，以及 特别地，用于聚焦离开图像引导件的激发激光束在样品（10）中的光学头（9）。

公开(公告)号：US07294837B2

公开(公告)日：2007-11-13

申请号：US11133830

申请日：2005-05-20

Applicant: Richard Mertens ,  Heino Prinz

Inventor： Richard Mertens ,  Heino Prinz

IPC: G01N21/35 ,  B30B11/00

CPC classification number: B30B11/08 ,  B30B11/005 ,  G01N21/15 ,  G01N21/3563 ,  G01N21/9508 ,  G01N2021/151 ,  G01N2201/08 ,  G01N2201/084

Abstract: The tablets press according to the invention comprises an integral measuring device for the determination of the quantitative content of at least one substance in a tablet, comprising: at least one radiation source, which emits radiation in the near infrared range, for the irradiation of the tablet, a radiation receiving device contained in a measuring head, which receives the radiation reflected by the tablet, a spectrometer for receiving the radiation from the radiation receiving device and for supplying an output signal according to the intensity of the received radiation at a number of different wavelengths and a device for the quantitative determination of the content of at least one substance contained in the tablet and/or for the determination of the ratios of all or some of the contained components based on the output signal, wherein the measuring device is suitable for measuring each individual pressed tablet, and the trigger times of the measurements are correlated with the conveying speed of the tablets press.

Abstract translation: 根据本发明的压片机包括用于确定片剂中至少一种物质的定量含量的整体测量装置，包括：至少一个辐射源，其在近红外范围内发射辐射，用于照射 片剂，包含在测量头中的辐射接收装置，其接收由平板电脑反射的辐射，用于接收来自辐射接收装置的辐射的光谱仪，并且用于根据所接收的辐射的强度以多个 不同的波长和用于定量确定片剂中所含的至少一种物质的含量的装置和/或用于基于输出信号确定所含或部分所含成分的比例，其中测量装置是合适的 用于测量每个单独的压制片，并且测量的触发时间与c相关 片剂的输送速度。

公开(公告)号：US07277175B2

公开(公告)日：2007-10-02

申请号：US10946209

申请日：2004-09-21

Applicant: Judith A. Thompson ,  John C. Kralik

Inventor： Judith A. Thompson ,  John C. Kralik

IPC: G01J3/51

CPC classification number: G01N21/31 ,  G01J3/0202 ,  G01J3/027 ,  G01J3/12 ,  G01J2003/1217 ,  G01N2021/3133 ,  G01N2021/3174 ,  G01N2201/08

Abstract: A system for measuring properties of small volume liquid samples, where the system includes wavelength selective filters.

Abstract translation: 用于测量小体积液体样品的性质的系统，其中系统包括波长选择性滤光器。

公开(公告)号：US20070201020A1

公开(公告)日：2007-08-30

申请号：US11740569

申请日：2007-04-26

Applicant: Falai Li

Inventor： Falai Li

IPC: G01N21/88

CPC classification number: H01L21/67288 ,  G01N21/8806 ,  G01N21/9501 ,  G01N2021/8822 ,  G01N2201/08 ,  G01N2201/0826

Abstract: A fiber optic darkfield ring light with many angled fiber optic light lines with direct illumination in a very small package. The fiber optic darkfield ring light includes a base with multiple light heads and multiple light covers attached thereto, a main cover, an optional cord grip, and an optional hood. It incorporates multiple fiber optic line arrays positioned at low angle and used in conjunction with a strobe light source.

Abstract translation: 一种光纤暗场环形灯，具有许多成角度的光纤光线，具有非常小的封装中的直接照明。 光纤暗场环形灯包括具有多个光头的基座和附接到其上的多个灯罩，主盖，可选的绳把和可选的罩。 它集成了多个光栅线阵列，它们以低角度定位并与闪光灯光源一起使用。

公开(公告)号：US07253904B2

公开(公告)日：2007-08-07

申请号：US10522374

申请日：2003-07-29

Applicant: Pierre-Jean Krauth ,  Marco Bini

Inventor： Pierre-Jean Krauth ,  Marco Bini

IPC: G01N21/55 ,  G01N21/86 ,  G02B26/00

CPC classification number: G01N21/474 ,  G01N21/359 ,  G01N21/55 ,  G01N21/8901 ,  G01N33/20 ,  G01N2021/4709 ,  G01N2021/4735 ,  G01N2021/4742 ,  G01N2201/0612 ,  G01N2201/08

Abstract: To measure the characteristics of the surface coating of a moving metal strip, such as the alliation level of a coating including zinc and iron, the product is exposed to the radiation of a radiative source with a predetermined wavelength directed orthogonally to the surface of the product and the energy reflected by the surface is measured also in a direction orthogonal to the surface so as to overcome reflectivity variations due to the morphological characteristics of the surface and these operations are performed with the help of off-the-shelf optical fibres previously stripped at their free ends of their normal optical focusing accessories so that they can be brought as near to each other as possible and placed parallel to each other.

Abstract translation: 为了测量移动的金属带的表面涂层的特性，例如包括锌和铁的涂层的分级水平，将产品暴露于具有与产品表面正交的预定波长的辐射源的辐射 并且在与表面正交的方向上也测量由表面反射的能量，以克服由于表面的形态特征引起的反射率变化，并且这些操作借助于先前剥离的现有光纤 它们的正常光学聚焦配件的自由端，使得它们可以尽可能彼此靠近并且彼此平行放置。

公开(公告)号：US07248909B2

公开(公告)日：2007-07-24

申请号：US11103963

申请日：2005-04-12

Applicant: Jangwoen Lee ,  Bruce J. Tromberg ,  Albert E. Cerussi ,  Matthew Brenner

Inventor： Jangwoen Lee ,  Bruce J. Tromberg ,  Albert E. Cerussi ,  Matthew Brenner

IPC: A61B5/00

CPC classification number: A61B5/14551 ,  A61B5/14552 ,  A61B5/412 ,  G01N21/31 ,  G01N21/359 ,  G01N21/49 ,  G01N2201/08

Abstract: A device and method utilizes a broadband diffuse optical spectroscopy (DOS) system to dynamically calculate the concentrations of multiple chromophores in vivo using a non-invasive probe. The device and method permit dynamic monitoring of multiple in vivo tissue chromophores non-invasively with sensitivities necessary for effective therapeutic monitoring. The device includes a probe containing first and second source optical fibers as well as first and second detector optical fibers. The probe is placed adjacent to a sample of interest and detects reflected light which is passed to a proximally located detector and spectrometer. The concentrations of multiple chromophores are determined in real time. In a preferred embodiment, the multiple tissue chromophores include at least two of methemoglobin (MetHb), deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), water (H2O), and methylene blue (MB). The device and method can be used quantify and monitor methemoglobin formation in subjects suffering from methemoglobinemia.

Abstract translation: 一种使用宽带漫射光谱（DOS）系统的装置和方法使用非侵入性探针来动态地计算体内多个发色团的浓度。 该装置和方法允许非侵入性地动态监测多个体内组织发色团，具有有效治疗监测所需的灵敏度。 该装置包括包含第一和第二源光纤以及第一和第二检测器光纤的探针。 将探针放置在感兴趣的样本附近，并检测反射光，其被传递到位于近端的检测器和光谱仪。 多个发色团的浓度实时测定。 在优选实施方案中，多组织发色团包括高铁血红蛋白（MetHb），脱氧血红蛋白（Hb-R），氧合血红蛋白（Hb-O 2 H），水（H 2 O 2） SUB）和亚甲基蓝（MB）。 该装置和方法可用于定量和监测患有高铁血红蛋白血症的受试者中的高铁血红蛋白形成。

公开(公告)号：US20070133002A1

公开(公告)日：2007-06-14

申请号：US11548468

申请日：2006-10-11

Applicant: Adam Wax ,  John Pyhtila

Inventor： Adam Wax ,  John Pyhtila

IPC: G01B9/02 ,  G01B11/02 ,  G01J3/45

CPC classification number: G01J3/4412 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/7257 ,  G01B9/02044 ,  G01B9/02084 ,  G01B9/02087 ,  G01B9/0209 ,  G01J3/4531 ,  G01N21/31 ,  G01N21/4795 ,  G01N2021/4704 ,  G01N2021/4709 ,  G01N2021/4735 ,  G01N2201/08

Abstract: Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth-resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

Abstract translation: 傅里叶域a / LCI（faLCI）系统和方法，使用单次扫描能够以快速的速率进行体内数据采集。 通过一次扫描获得角度分辨和深度分辨的光谱信息。 由于仅需要一次扫描，参考臂可以相对于样品保持固定。 参考信号和反射的采样信号以相对于样本的多个反射角度相互相关并分散，从而同时并行地表示来自样品上的多个点的反射。 可以通过大约40毫秒量级的一次扫描获得关于样本上多个不同点的每个样本的所有深度的信息。 从空间相互关联的参考信号，也可以使用允许从角度分辨数据获得散射体的尺寸信息的技术来获得结构（尺寸）信息。

公开(公告)号：US20070132990A1

公开(公告)日：2007-06-14

申请号：US11561950

申请日：2006-11-21

Applicant: Yukiko Fukami ,  Toru Ishikura ,  Hideo Mori

Inventor： Yukiko Fukami ,  Toru Ishikura ,  Hideo Mori

IPC: G01N21/88

CPC classification number: G01N21/954 ,  G01N2021/4747 ,  G01N2021/9546 ,  G01N2201/08

Abstract: In a surface inspection apparatus that receives, through receiving optical fibers, reflected light from light from a light source projected onto the surface of an article being inspected through a projection optical fiber and generates a two-dimensional image corresponding to the surface of that article being inspected based on the amount of that light received, a plurality of receiving optical fibers are disposed around the projection optical fiber and the diameter of those receiving optical fibers is greater than the diameter of the projection optical fiber.

Abstract translation: 在表面检查装置中，通过接收光纤，从通过投影光纤投射到被检查物品的表面上的来自光源的光的反射光，并且产生与该物品的表面对应的二维图像 基于所接收的光量进行检查，在投影光纤周围设置多个接收光纤，并且接收光纤的直径大于投影光纤的直径。

公开(公告)号：US20070120057A1

公开(公告)日：2007-05-31

申请号：US11324481

申请日：2006-01-04

Applicant: Ming-Lang Tsai ,  Jin-Sheng Chang ,  Yii-Tay Chiou ,  Chun-Hsun Chu

Inventor： Ming-Lang Tsai ,  Jin-Sheng Chang ,  Yii-Tay Chiou ,  Chun-Hsun Chu

IPC: G01J5/00

CPC classification number: G01N21/3504 ,  G01N21/274 ,  G01N2021/317 ,  G01N2201/08 ,  G01N2201/082 ,  G01N2201/0873

Abstract: The apparatus for sensing plural gases is substantially a gas sensor adopting planar lightwave circuit for constructing reference optical path and sensing optical path, which is a flat structure with abilities of high accuracy, long-term stability, and short response time. The gas sensor can be widely applied for monitoring the safety of a working environment, securing the safety of workers, alerting potential hazard in a factory, inspecting harmful materials in a specific area, testing leakage of a pipeline, inspecting waste gas exhausted from automobile/motorcycle, and monitoring the living quality of household environment.

Abstract translation: 用于感测多种气体的装置基本上是采用平面光波电路的气体传感器，用于构建参考光路和感测光路，该光路是具有高精度，长期稳定性和响应时间短的能力的平坦结构。 气体传感器可广泛用于监测工作环境的安全性，确保工人的安全，警惕工厂的潜在危险，检查特定区域的有害物质，检测管道的泄漏，检查汽车/ 摩托车，并监测住户环境的生活质量。