公开(公告)号：US10092192B2

公开(公告)日：2018-10-09

申请号：US14979797

申请日：2015-12-28

Applicant: Bahman Lashkari ,  Andreas Mandelis ,  Kaicheng Zhang

Inventor： Bahman Lashkari ,  Andreas Mandelis ,  Kaicheng Zhang

IPC: A61B5/00 ,  G01S15/89 ,  A61B5/05 ,  A61B5/055 ,  A61B8/00 ,  A61B8/12 ,  A61B8/08

Abstract: The present disclosure provides systems and methods for imaging based on the generation and use of mismatched coded excitation signals. Cross-correlation properties of the received signal reveal the location and/or timing and/or properties of the source. The use of mismatched signals enables spatial and/or temporal and/or functional encoding of the transmitted signals. In some embodiments, high-speed imaging may be performed by employing mismatched codes for spatial and/or temporal encoding, and by employing a subset of transducer elements as transmitters, and another subset of elements as receivers. Various example embodiments of different types of mismatched codes are provided, including codes that employ multiple frequency chirps, codes that employ concatenated multi-frequency binary phase-coded waveforms, and chirped binary phase-coded waveforms.

公开(公告)号：US20160109393A1

公开(公告)日：2016-04-21

申请号：US14518984

申请日：2014-10-20

Applicant: Andreas MANDELIS ,  Sreekumar KAIPLAVIL

Inventor： Andreas MANDELIS ,  Sreekumar KAIPLAVIL

IPC: G01N25/72 ,  G01N29/06 ,  G01J5/10

CPC classification number: G01N25/72 ,  G01J5/10 ,  G01J2005/0077 ,  G01J2005/106 ,  G01N29/0672 ,  G01N29/2418 ,  G01N29/343

Abstract: Photothermal imaging systems and methods are disclosed that employ truncated-correlation photothermal coherence tomography (TC-PCT). According to the example methods disclosed herein, photothermal radiation is detected with an infrared camera while exciting a sample with the chirped delivery of incident laser pulses (where the pulses have a fixed width), and time-dependent photothermal signal data is obtained from the infrared camera and processed using a time-evolving filtering method employing cross-correlation truncation. The cross-correlation truncation method results in pulse-compression-linewidth-limited depth-resolved images with axial and lateral resolution well beyond the well-known thermal-diffusion-length-limited, depth-integrated nature of conventional thermographic and thermophotonic modalities. As a consequence, an axially resolved layer-by-layer photothermal image sequence can be obtained, capable of reconstructing three-dimensional visualizations (tomograms) of photothermal features in wide classes of materials. Additional embodiments are disclosed in which the aforementioned systems and methods are adapted to photo-acoustic and acousto-thermal imaging.

Abstract translation: 公开了采用截断相关光热相干断层扫描（TC-PCT）的光热成像系统和方法。 根据本文公开的示例方法，用红外照相机检测光热辐射，同时用激光脉冲（其中脉冲具有固定宽度）的啁啾传递激发样品，并且从红外线获得时间依赖的光热信号数据 摄像机，并使用采用互相关截断的时变演进滤波方法进行处理。 互相关截断法导致脉冲压缩 - 线宽限制的深度分辨图像，其轴向和横向分辨率远远超出了常规热成像和热光学模式的公知的热扩散长度限制的深度集成性质。 因此，可以获得轴向分辨的逐层光热图像序列，能够重建宽范围材料中光热特征的三维可视化（断层图）。 公开了另外的实施例，其中上述系统和方法适用于光声和声 - 热成像。

公开(公告)号：US20140085449A1

公开(公告)日：2014-03-27

申请号：US13522936

申请日：2012-01-20

Applicant: Andreas Mandelis ,  Nima Tabatabaei ,  Stephen Abrams

Inventor： Andreas Mandelis ,  Nima Tabatabaei ,  Stephen Abrams

IPC: H04N7/18

CPC classification number: H04N7/183 ,  A61B5/0073 ,  A61B5/0088 ,  G01N21/71

Abstract: Systems and methods for improved thermophotonic imaging are provided in which both amplitude and phase image information is obtained with a high signal to noise ratio and depth-resolved capabilities. Image data obtained from an imaging camera is dynamically averaged and subsequently processed to extract amplitude and/or phase image data. The system may be configured for a wide range of imaging modalities, including single frequency modulation (thermophotonic lock-in imaging), Thermal-Wave Radar imaging or Thermophotonic Radar imaging involving chirp modulation, and Binary Phase Coded Modulation. Such imaging modalities may find application in many diverse areas, including non-destructive testing and biomedical diagnostic imaging including the imaging of teeth and monitoring changes in the tooth over time which are due to pathology such as dental caries or erosion.

Abstract translation: 提供了用于改进的热光子成像的系统和方法，其中以高信噪比和深度分辨能力获得幅度和相位图像信息。 从成像摄像机获得的图像数据被动态地平均并随后被处理以提取幅度和/或相位图像数据。 该系统可以被配置用于广泛的成像模式，包括单频调制（热荧光锁定成像），热波雷达成像或涉及啁啾调制的热磷光雷达成像和二进制相位编码调制。 这种成像方式可以应用于许多不同的领域，包括非破坏性测试和生物医学诊断成像，包括牙齿的成像以及由于诸如龋齿或侵蚀的病理学造成的牙齿随时间的变化。

公开(公告)号：US20130278749A1

公开(公告)日：2013-10-24

申请号：US13827110

申请日：2013-03-14

Applicant: Andreas MANDELIS ,  Alexander Melnikov

Inventor： Andreas MANDELIS ,  Alexander Melnikov

IPC: H04N5/33

CPC classification number: H04N5/33 ,  G01N21/6489 ,  G01N21/9501

Abstract: Methods are provided for producing optical carrierographic images of a semiconductor sample. Focused and spatially overlapped optical beams excite carriers across within the semiconductor sample, where the optical beams are modulated such that a beat frequency is substantially less than either modulation frequency. An infrared detector detects infrared radiation emitted from the semiconductor sample in response to absorption of the optical beams, thereby obtaining a plurality of carrierographic signals at different points in time during at least one beat period, which are processed with a lock-in amplifier, with a reference signal at the beat frequency, to obtain an amplitude signal and a phase signal. Carrierographic lock-in images of the sample are obtained in a scanning configuration, or in an imaging format using an imaging detector. The images carry quantitative information about recombination lifetimes in substrate Si wafers and electrical parameters in solar cells, namely photogeneration current density, diode saturation current density, ideality factor, and maximum power photovoltage.

Abstract translation: 提供了用于制造半导体样品的光学摄影图像的方法。 聚焦和空间重叠的光束在半导体样品内激发载流子，其中调制光束使得拍频大大小于任一调制频率。 红外检测器响应于光束的吸收而检测从半导体样品发射的红外辐射，从而在至少一个拍摄周期期间的不同时间点获得多个载波信号，该拍频周期由锁定放大器处理， 以拍频为参考信号，得到振幅信号和相位信号。 以扫描配置或使用成像检测器的成像格式获得样品的Carrierographic锁定图像。 这些图像携带有关基板Si晶片的复合寿命和太阳能电池中的电参数的定量信息，即光生电流密度，二极管饱和电流密度，理想因子和最大功率光电压。

公开(公告)号：US20210389234A1

公开(公告)日：2021-12-16

申请号：US16900471

申请日：2020-06-12

Applicant: Andreas Mandelis ,  Koneswaran S. Sivagurunathan ,  Pantea Tavakolian

Inventor： Andreas Mandelis ,  Koneswaran S. Sivagurunathan ,  Pantea Tavakolian

IPC: G01N21/17 ,  A61B5/00 ,  A61B5/01 ,  G06T11/00

Abstract: Systems and methods are provided for performing thermophotonic imaging using cross-correlation and subsequent time-gated truncation. Photothermal radiation is detected with an infrared camera while exciting a sample with a chirped set of incident optical pulses and time-dependent photothermal signal data is processed using a method that involves performing cross-correlation and subsequent time-gated truncation. The post-cross-correlation truncation method results in depth-resolved images with axial and lateral resolution beyond the well-known thermal-diffusion-length-limited, depth-integrated nature of conventional imaging modalities. An axially resolved photothermal image sequence can be obtained, capable of reconstructing three-dimensional visualizations of photothermal features in wide classes of materials.

公开(公告)号：US09810650B2

公开(公告)日：2017-11-07

申请号：US14518984

申请日：2014-10-20

Applicant: Andreas Mandelis ,  Sreekumar Kaiplavil

Inventor： Andreas Mandelis ,  Sreekumar Kaiplavil

IPC: G01J5/02 ,  G01N25/72 ,  G01J5/10 ,  G01N29/06 ,  G01N29/24 ,  G01N29/34 ,  G01J5/00

CPC classification number: G01N25/72 ,  G01J5/10 ,  G01J2005/0077 ,  G01J2005/106 ,  G01N29/0672 ,  G01N29/2418 ,  G01N29/343

Abstract: Photothermal imaging systems and methods are disclosed that employ truncated-correlation photothermal coherence tomography (TC-PCT). According to the example methods disclosed herein, photothermal radiation is detected with an infrared camera while exciting a sample with the chirped delivery of incident laser pulses (where the pulses have a fixed width), and time-dependent photothermal signal data is obtained from the infrared camera and processed using a time-evolving filtering method employing cross-correlation truncation. The cross-correlation truncation method results in pulse-compression-linewidth-limited depth-resolved images with axial and lateral resolution well beyond the well-known thermal-diffusion-length-limited, depth-integrated nature of conventional thermographic and thermophotonic modalities. As a consequence, an axially resolved layer-by-layer photothermal image sequence can be obtained, capable of reconstructing three-dimensional visualizations (tomograms) of photothermal features in wide classes of materials. Additional embodiments are disclosed in which the aforementioned systems and methods are adapted to photo-acoustic and acousto-thermal imaging.

公开(公告)号：US08452360B2

公开(公告)日：2013-05-28

申请号：US12782277

申请日：2010-05-18

Applicant: Andreas Mandelis ,  Sergey Telenkov

Inventor： Andreas Mandelis ,  Sergey Telenkov

IPC: A61B5/1455

CPC classification number: A61B5/01 ,  A61B5/0091 ,  A61B5/14532 ,  A61B5/7228

Abstract: There is provided a glucose monitoring method and apparatus based on the principle of Wavelength-Modulated Differential Laser Photothermal Radiometry (WM-DPTR). Two intensity modulated laser beams operating in tandem at specific mid-infrared (IR) wavelengths and current-modulated synchronously by two electrical waveforms 180 degrees out-of-phase, are used to interrogate the tissue surface. The laser wavelengths are selected to absorb in the mid infrared range (8.5-10.5 μm) where the glucose spectrum exhibits a discrete absorption band. The differential thermal-wave signal generated by the tissue sample through modulated absorption between two specific wavelengths within the band (for example, the peak at 9.6 and the nearest baseline at 10.5 μm) lead to minute changes in sample temperature and to non-equilibrium blackbody radiation emission. This modulated emission is measured with a broadband infrared detector. The detector is coupled to a lock-in amplifier for signal demodulation. Any glucose concentration increases will be registered as differential photothermal signals above the fully suppressed signal baseline due to increased absorption at the probed peak or near-peak of the band at 9.6 μm at the selected wavelength modulation frequency. The emphasis is on the ability to monitor blood glucose levels in diabetic patients in a non-invasive, non-contacting manner with differential signal generation methods for real-time baseline corrections, a crucial feature toward precise and universal calibration (independent of person-to-person contact, skin, temperature or IR-emission variations) in order to offer accurate absolute glucose concentration readings.

Abstract translation: 提供了基于波长调制差分激光光热辐射计（WM-DPTR）原理的葡萄糖监测方法和装置。 两个强度调制的激光束在特定的中红外（IR）波长下串联工作，并通过180度异相的两个电波同步电流调制，用于询问组织表面。 选择激光波长在中红外范围（8.5-10.5μm）中吸收，其中葡萄糖光谱呈现离散的吸收带。 由组织样品通过带内两个特定波长之间的调节吸收产生的差分热波信号（例如，9.6处的峰值和10.5mum处的最接近的基线）导致样品温度和非平衡黑体的微小变化 辐射发射。 这种调制的发射是用宽带红外探测器测量的。 检测器耦合到锁定放大器进行信号解调。 任何葡萄糖浓度增加将被记录为高于完全抑制的信号基线上的差示光热信号，这是由于在所选波长调制频率处的9.6mum波段的探测峰值或近峰值处的吸收增加。 重点在于以非侵入式非接触方式监测糖尿病患者血糖水平的能力，使用差分信号生成方法进行实时基线校正，这是精确和通用校准的关键特征（独立于人 - 人员接触，皮肤，温度或红外发射变化），以提供准确的绝对葡萄糖浓度读数。

公开(公告)号：US20110118571A1

公开(公告)日：2011-05-19

申请号：US12948525

申请日：2010-11-17

Applicant: Andreas MANDELIS ,  Xinxin GUO

Inventor： Andreas MANDELIS ,  Xinxin GUO

IPC: A61B5/1455 ,  G01D18/00 ,  G01T1/04

CPC classification number: A61B5/14532 ,  A61B5/0093 ,  A61B5/1455 ,  A61B5/7228 ,  G01D3/022 ,  G01D5/32 ,  G01D18/008 ,  G01T1/1603

Abstract: Methods are provided for the detection of an analyte in a sample using wavelength modulated differential photothermal radiometry with enhanced sensitivity. A wavelength modulated differential photothermal radiometry system, comprising two optical modulated beams, where each beam experiences different absorption by the analyte, is calibrated by controlling the relative phase difference between the modulated beams so that individual photothermal signals corresponding to each modulated beam are 180° out of phase, corresponding to peak sensitivity to analyte concentration. The system may be further calibrated by varying the relative intensities of the two modulated beams and measuring standards containing known analyte concentration in order to determine an optimal relative intensity for a given concentration range of interest.

Abstract translation: 提供了使用具有增强的灵敏度的波长调制差分光热辐射测量来检测样品中分析物的方法。 波长调制的差分光热辐射测量系统包括两个光调制光束，其中每个光束经受分析物的不同吸收，通过控制调制光束之间的相对相位来校准，使得对应于每个调制光束的各个光热信号为180° 的相位，对应于对分析物浓度的峰值敏感性。 可以通过改变两个调制束的相对强度和包含已知分析物浓度的测量标准来进一步校准系统，以便确定给定的感兴趣浓度范围的最佳相对强度。

公开(公告)号：US20100227296A1

公开(公告)日：2010-09-09

申请号：US12718746

申请日：2010-03-05

Applicant: Andreas Mandelis ,  Stephen Abrams

Inventor： Andreas Mandelis ,  Stephen Abrams

IPC: A61C19/00

CPC classification number: A61C19/04

Abstract: A method of oral health risk assessment is provided in which diagnostic data from an oral health detection device and patient risk factor data is processed to provide a integrated risk measure relating to a patient's dental health. The patient risk factor data preferably includes risk factor data such as pathological risk factors, protective risk factors, historical factors, self care factors, behavioral factors, and extrinsic factors. The integrated risk assessment and patient data is preferably provided to a remote server for access by various authorized stakeholders.

Abstract translation: 提供了一种口腔健康风险评估方法，其中处理来自口腔健康检测装置和患者危险因素数据的诊断数据，以提供与患者牙齿健康有关的综合风险度量。 患者危险因素数据优选包括风险因素数据，如病理危险因素，保护性危险因素，历史因素，自我护理因素，行为因素和外在因素。 综合风险评估和患者数据优选地被提供给远程服务器以供各种授权利益相关者访问。

公开(公告)号：US20070213607A1

公开(公告)日：2007-09-13

申请号：US11368698

申请日：2006-03-07

Applicant: Andreas Mandelis ,  Sergey Telenkov

Inventor： Andreas Mandelis ,  Sergey Telenkov

IPC: A61B5/00

CPC classification number: A61B5/01 ,  A61B5/0091 ,  A61B5/14532 ,  A61B5/7228

Abstract: There is provided a glucose monitoring method and apparatus based on the principle of Wavelength-Modulated Differential Laser Photothermal Radiometry (WM-DPTR). Two intensity modulated laser beams operating in tandem at specific mid-infrared (IR) wavelengths and current-modulated synchronously by two electrical waveforms 180 degrees out-of-phase, are used to interrogate the tissue surface. The laser wavelengths are selected to absorb in the mid infrared range (8.5-10.5 μm) where the glucose spectrum exhibits a discrete absorption band. The differential thermal-wave signal generated by the tissue sample through modulated absorption between two specific wavelengths within the band (for example, the peak at 9.6 and the nearest baseline at 10.5 μm) lead to minute changes in sample temperature and to non-equilibrium blackbody radiation emission. This modulated emission is measured with a broadband infrared detector. The detector is coupled to a lock-in amplifier for signal demodulation. Any glucose concentration increases will be registered as differential photothermal signals above the fully suppressed signal baseline due to increased absorption at the probed peak or near-peak of the band at 9.6 μm at the selected wavelength modulation frequency. The emphasis is on the ability to monitor blood glucose levels in diabetic patients in a non-invasive, non-contacting manner with differential signal generation methods for real-time baseline corrections, a crucial feature toward precise and universal calibration (independent of person-to-person contact, skin, temperature or IR-emission variations) in order to offer accurate absolute glucose concentration readings.

Abstract translation: 提供了基于波长调制差分激光光热辐射计（WM-DPTR）原理的葡萄糖监测方法和装置。 两个强度调制的激光束在特定的中红外（IR）波长下串联工作，并通过180度异相的两个电波同步电流调制，用于询问组织表面。 选择激光波长在中红外范围（8.5-10.5μm）中吸收，其中葡萄糖光谱呈现离散的吸收带。 由组织样品通过带内两个特定波长之间的调节吸收产生的差分热波信号（例如，9.6处的峰值和10.5mum处的最接近的基线）导致样品温度和非平衡黑体的微小变化 辐射发射。 用宽带红外探测器测量该调制的发射。 检测器耦合到锁定放大器进行信号解调。 任何葡萄糖浓度增加将被记录为高于完全抑制的信号基线上的差示光热信号，这是由于在所选波长调制频率处的9.6mum波段的探测峰值或近峰值处的吸收增加。 重点在于以非侵入式非接触方式监测糖尿病患者血糖水平的能力，使用差分信号生成方法进行实时基线校正，这是精确和通用校准的关键特征（独立于人 - 人员接触，皮肤，温度或红外发射变化），以提供准确的绝对葡萄糖浓度读数。