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公开(公告)号：US5254732A
公开(公告)日：1993-10-19
申请号：US843692
申请日：1992-02-28
Applicant: Edmond Differding
Inventor： Edmond Differding
IPC: C07B39/00 , C07C17/093 , C07C17/12 , C07C17/20 , C07C41/22 , C07C45/51 , C07C45/63 , C07C67/287 , C07C67/307 , C07C231/12 , C07C311/48 , C07C311/15 , C07C17/14
CPC classification number: C07C311/48 , C07B39/00 , C07C17/093 , C07C17/12 , C07C17/202 , C07C231/12 , C07C41/22 , C07C45/511 , C07C45/63 , C07C67/287 , C07C67/307 , C07C2103/24
Abstract: The invention describes N-fluorosulfonimides which are useful as fluorinating agents. The N-fluorosulfonimides are stable, easily synthesized, and allow the introduction of fluorine into organic compounds under mild conditions.
Abstract translation: 本发明描述了可用作氟化剂的N-氟磺酰亚胺。 N-氟磺酰亚胺稳定，容易合成，并允许在温和条件下将氟引入有机化合物。
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公开(公告)号：US20050171188A1
公开(公告)日：2005-08-04
申请号：US11043176
申请日：2005-01-27
Applicant: Edmond Differding , Benoit Kenda , Benedicte Lallemand , Alain Matagne , Philippe Michel , Patrick Pasau , Patrice Talaga
Inventor： Edmond Differding , Benoit Kenda , Benedicte Lallemand , Alain Matagne , Philippe Michel , Patrick Pasau , Patrice Talaga
IPC: C07D401/04 , A61K31/4015 , A61K31/4025 , A61K31/41 , A61K31/4178 , A61K31/4188 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/541 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/16 , A61P37/08 , C07B61/00 , C07C237/06 , C07C237/12 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04 , C07D207/12
CPC classification number: C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.
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13.发明授权2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses 有权2-氧代-1-吡咯烷衍生物，其制备方法及其用途公开(公告)号：US06806287B2
公开(公告)日：2004-10-19
申请号：US10694090
申请日：2003-10-28
Applicant: Edmond Differding , Benoît Kenda , Bénédicte Lallemand , Alain Matagne , Philippe Michel , Patrick Pasau , Patrice Talaga
Inventor： Edmond Differding , Benoît Kenda , Bénédicte Lallemand , Alain Matagne , Philippe Michel , Patrick Pasau , Patrice Talaga
IPC: A61K314015
CPC classification number: C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.
Abstract translation: 本发明涉及式I的2-氧代-1-吡咯烷衍生物，其中取代基如说明书中所定义，以及它们作为药物的用途。本发明的化合物特别适用于治疗诸如癫痫的神经障碍。
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14.发明授权2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses 有权2-氧代-1-吡咯烷衍生物，其制备方法及其用途公开(公告)号：US06784197B2
公开(公告)日：2004-08-31
申请号：US10204266
申请日：2002-08-20
Applicant: Edmond Differding , Benoît Kenda , Bénédicte Lallemand , Alain Matagne , Philippe Michel , Patrick Pasau , Patrice Talaga
Inventor： Edmond Differding , Benoît Kenda , Bénédicte Lallemand , Alain Matagne , Philippe Michel , Patrick Pasau , Patrice Talaga
IPC: A61K31426
CPC classification number: C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives of formula (I) wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.
Abstract translation: 本发明涉及式（I）的2-氧代-1-吡咯烷衍生物，其中取代基如说明书中所定义，以及它们作为药物的用途。 本发明的化合物特别适用于治疗诸如癫痫的神经障碍。
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15.发明授权Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效用于治疗哮喘，过敏和炎性疾病的化合物和方法公开(公告)号：US06451801B1
公开(公告)日：2002-09-17
申请号：US09534947
申请日：2000-03-24
Applicant: Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
Inventor： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
IPC: A61K31495
CPC classification number: C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/14 , C07D307/52 , C07D401/04
Abstract: The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
Abstract translation: 本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。 本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。 本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。 这些病症包括优选的哮喘，季节性和常年性变态反应性鼻炎，窦炎，结膜炎，食物过敏，偶发性中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性阻塞性肺病，血栓性疾病和中耳炎。 还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。
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Patent Agency Ranking16.发明授权.alpha.-fluoro-.alpha.-1-(1,2,4-triazolyl)-phenylmethyl derivatives useful as aromatase inhibitors 失效用作芳香酶抑制剂的α-氟-α-（1,2,4-三唑基） - 苯基甲基衍生物
公开(公告)号：US5637605A
公开(公告)日：1997-06-10
申请号：US485247
申请日：1995-06-07
Applicant: Marc Lang , Edmond Differding , Jaroslav Stanek
Inventor： Marc Lang , Edmond Differding , Jaroslav Stanek
IPC: A61K31/41 , A61K31/415 , A61K31/4174 , A61K31/4178 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/443 , A61K31/496 , A61K31/505 , A61P5/32 , A61P35/00 , A61P43/00 , C07D209/10 , C07D209/44 , C07D213/26 , C07D213/57 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/56 , C07D233/64 , C07D235/12 , C07D235/16 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/04 , C07D249/08 , C07D257/04 , C07D403/06 , C07D405/06 , C07D521/00
CPC classification number: C07D239/26 , C07D213/26 , C07D231/12 , C07D233/56 , C07D249/04 , C07D249/08 , C07D257/04
Abstract: Compounds of formula I ##STR1## wherein Z, R, R.sub.1, R.sub.2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.
Abstract translation: 其中Z，R，R 1，R 2和X如说明书中所定义的式I化合物（I）具有有价值的药物性质，尤其对肿瘤有效。 它们是以本身已知的方式准备的。
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公开(公告)号：US5478964A
公开(公告)日：1995-12-26
申请号：US988531
申请日：1992-12-10
Applicant: Edmond Differding
Inventor： Edmond Differding
IPC: C07B39/00 , C07C17/093 , C07C17/12 , C07C17/20 , C07C41/22 , C07C45/51 , C07C45/63 , C07C67/287 , C07C67/307 , C07C231/12 , C07C311/48 , C07C311/15 , C07C17/02
CPC classification number: C07C311/48 , C07B39/00 , C07C17/093 , C07C17/12 , C07C17/202 , C07C231/12 , C07C41/22 , C07C45/511 , C07C45/63 , C07C67/287 , C07C67/307 , C07C2103/24
Abstract: The invention describes N-fluorosulfonimides which are useful as fluorinating agents. The N-fluorosulfonimides are stable, easily synthesized, and allow the introduction of fluorine into organic compounds under mild conditions.
Abstract translation: 本发明描述了可用作氟化剂的N-氟磺酰亚胺。 N-氟磺酰亚胺稳定，容易合成，并允许在温和条件下将氟引入有机化合物。
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18.发明授权2-Oxo-1-pyrrolidine derivatives, processes for preparing them and their uses 有权2-氧代-1-吡咯烷衍生物，其制备方法及其用途公开(公告)号：US07358276B2
公开(公告)日：2008-04-15
申请号：US11043176
申请日：2005-01-27
Applicant: Edmond Differding , Benoît Kenda , Bénédicte Lallemand , Alain Matagne , Philippe Michel , Patrick Pasau , Patrice Talaga
Inventor： Edmond Differding , Benoît Kenda , Bénédicte Lallemand , Alain Matagne , Philippe Michel , Patrick Pasau , Patrice Talaga
IPC: C07C205/00 , A61K31/21
CPC classification number: C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.
Abstract translation: 本发明涉及式I的2-氧代-1-吡咯烷衍生物，其中取代基如说明书中所定义，以及它们作为药物的用途。 本发明的化合物特别适用于治疗诸如癫痫的神经障碍。
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19.发明授权2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses 有权2-氧代-1-吡咯烷衍生物，其制备方法及其用途公开(公告)号：US06911461B2
公开(公告)日：2005-06-28
申请号：US10693917
申请日：2003-10-28
Applicant: Edmond Differding , Benoît Kenda , Bénédicte Lallemand , Alain Matagne , Philippe Michel , Patrick Pasau , Patrice Talaga
Inventor： Edmond Differding , Benoît Kenda , Bénédicte Lallemand , Alain Matagne , Philippe Michel , Patrick Pasau , Patrice Talaga
IPC: C07D401/04 , A61K31/4015 , A61K31/4025 , A61K31/41 , A61K31/4178 , A61K31/4188 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/541 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/16 , A61P37/08 , C07B61/00 , C07C237/06 , C07C237/12 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04 , A61K31/426 , C07D277/20
CPC classification number: C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.
Abstract translation: 本发明涉及式I的2-氧代-1-吡咯烷衍生物，其中取代基如说明书中所定义，以及它们作为药物的用途。 本发明的化合物特别适用于治疗诸如癫痫的神经障碍。
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公开(公告)号：US06858740B2
公开(公告)日：2005-02-22
申请号：US10609544
申请日：2003-07-01
Applicant: John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
Inventor： John Surtees , Violeta Marmon , Edmond Differding , Vincent Zimmermann
IPC: C07D401/04 , A61K31/4015 , A61K31/4025 , A61K31/41 , A61K31/4178 , A61K31/4188 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/541 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/16 , A61P37/08 , C07B61/00 , C07C237/06 , C07C237/12 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04 , C07D207/04
CPC classification number: C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives and a process for preparing them and their uses. The invention also concerns a process for preparing α-ethyl-2-oxo-1-pyrrolidine acetamide derivatives from unsaturated 2-oxo-1-pyrrolidine derivatives. Particularly the invention concerns novel intermediates and their use in methods for the preparation of S-α-ethyl-2-oxo-1-pyrrolidine acetamide.
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