公开(公告)号：US20050158875A1

公开(公告)日：2005-07-21

申请号：US11036616

申请日：2005-01-18

Applicant: Patrick Kaltenbach ,  Konstantin Choikhet ,  Gerhard Ple ,  Clemens Linowski

Inventor： Patrick Kaltenbach ,  Konstantin Choikhet ,  Gerhard Ple ,  Clemens Linowski

IPC: G01N35/10 ,  B01L3/00

CPC classification number: G01N35/1011 ,  Y10T436/2575

Abstract: A liquid transfer appliance and a well plate are moved towards each other and a current is detected that flows upon contact between the liquid transfer appliance and a first electrically conductive element of the well plate. The position of the well plate relative to the liquid transfer appliance is determined at the time of contact. The determined position is used as a reference position for further positioning at least one of the well plate and the liquid transfer appliance.

Abstract translation: 液体输送器具和孔板彼此相对移动，并且检测在液体转移器具和孔板的第一导电元件之间接触时流动的电流。 在接触时确定孔板相对于液体转移器具的位置。 确定的位置用作用于进一步定位井板和液体输送装置中的至少一个的参考位置。

公开(公告)号：US08297936B2

公开(公告)日：2012-10-30

申请号：US11900578

申请日：2007-09-12

Applicant: Klaus Witt ,  Konstantin Choikhet ,  Alexander Bierbaum

Inventor： Klaus Witt ,  Konstantin Choikhet ,  Alexander Bierbaum

IPC: F04B49/10

CPC classification number: G01N30/32 ,  G01N30/34 ,  G01N2030/324 ,  G01N2030/326

Abstract: A method for controlling movement of a piston in a metering device is described. The method comprises supplying a fluid by actuating the metering device's piston, wherein compression or expansion of the fluid causes corresponding temperature variations. The method further comprises superposing a corrective movement onto the piston movement, with the corrective movement at least partly compensating for at least one of thermal expansion and contraction of the fluid induced by the temperature variations. In one embodiment, the corrective movement imposed onto the piston movement comprises two components: a reduction (74) of the compression jump (73), and a subsequent increase (75) of the piston's forward displacement rate (71) during a period (76) of time (72).

Abstract translation: 描述了一种用于控制计量装置中活塞运动的方法。 该方法包括通过致动计量装置的活塞来供应流体，其中流体的压缩或膨胀引起相应的温度变化。 该方法还包括将校正运动叠加到活塞运动上，校正运动至少部分地补偿由温度变化引起的流体的热膨胀和收缩中的至少一种。 在一个实施例中，施加到活塞运动上的校正运动包括两个部件：压缩跳跃（73）的减小（74）和在一段时间内的活塞向前移位速率（71）的随后增加（75） ）的时间（72）。

公开(公告)号：US20120216886A1

公开(公告)日：2012-08-30

申请号：US13464309

申请日：2012-05-04

Applicant: Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

Inventor： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

IPC: F04B49/06 ,  E03B7/07

CPC classification number: F04B49/08 ,  B01D15/14 ,  F04B11/0058 ,  F04B2201/0201 ,  F04B2205/05 ,  G01N30/32 ,  G01N2030/326 ,  Y10T137/794

Abstract: A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

Abstract translation: 一种用于控制泵单元的操作的方法，其中所述泵单元包括具有主活塞的主活塞泵和具有次活塞的次级活塞泵。 主活塞泵与次级活塞泵流体连接。 主活塞泵包括入口阀和出口阀，并且泵单元根据泵循环周期性地运行。 该方法包括确定由泵单元分配的流体的流体压力，以及根据在泵的第一时间间隔期间由泵单元分配的流体的流体压力执行主活塞的位置的闭环控制 周期。

公开(公告)号：US20100275678A1

公开(公告)日：2010-11-04

申请号：US12431972

申请日：2009-04-29

Applicant: Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

Inventor： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

IPC: G01N30/64 ,  F04B49/00 ,  B01D15/08

CPC classification number: F04B49/08 ,  B01D15/14 ,  F04B11/0058 ,  F04B2201/0201 ,  F04B2205/05 ,  G01N30/32 ,  G01N2030/326 ,  Y10T137/794

Abstract: A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

Abstract translation: 一种用于控制泵单元的操作的方法，其中所述泵单元包括具有主活塞的主活塞泵和具有次活塞的次级活塞泵。 主活塞泵与次级活塞泵流体连接。 主活塞泵包括入口阀和出口阀，并且泵单元根据泵循环周期性地运行。 该方法包括确定由泵单元分配的流体的流体压力，以及根据在泵的第一时间间隔期间由泵单元分配的流体的流体压力执行主活塞的位置的闭环控制 周期。

公开(公告)号：US20090014373A1

公开(公告)日：2009-01-15

申请号：US12212669

申请日：2008-09-18

Applicant: Konstantin CHOIKHET

Inventor： Konstantin CHOIKHET

IPC: G01N30/00 ,  G01N30/60

CPC classification number: G01N30/6047 ,  G01N30/466 ,  G01N30/6043 ,  G01N30/6091

Abstract: A separation unit comprising a magazine unit with a magazine is described. The magazine comprises a plurality of pockets, each pocket being adapted for accommodating a separation column for separating compounds of a fluid sample. The magazine unit is adapted for moving any of the pockets to a structural component, wherein a pocket and the structural component are adapted for complementing one another to form a column compartment.

Abstract translation: 描述了包括具有盒的盒单元的分离单元。 杂志包括多个口袋，每个口袋适于容纳用于分离流体样品化合物的分离柱。 杂志单元适于将任何口袋移动到结构部件，其中口袋和结构部件适于彼此补充以形成柱室。

公开(公告)号：US20070240773A1

公开(公告)日：2007-10-18

申请号：US11807242

申请日：2007-05-25

Applicant: Hans-Peter Zimmermann ,  Konstantin Choikhet ,  Tobias Preckel

Inventor： Hans-Peter Zimmermann ,  Konstantin Choikhet ,  Tobias Preckel

IPC: F16K37/00 ,  E03B7/07

CPC classification number: G01N21/05 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2400/0644 ,  F16K99/0001 ,  F16K99/0013 ,  F16K2099/0084 ,  G01N2021/0346 ,  Y10T137/8242 ,  Y10T137/8326

Abstract: Methods and devices for delivering fluids into microfluidic device body structures (112, 202, 316, 508) are described. The methods and devices include the use of fluid manifolds (200, 300, 400, 500) which are integrated or interchangeable with device body structures. Methods of fabricating manifolds are also provided.

Abstract translation: 描述了将流体输送到微流体装置主体结构（112,202,316,508）中的方法和装置。 所述方法和装置包括使用与装置主体结构集成或可互换的流体歧管（200,300,400,500）。 还提供了制造歧管的方法。

公开(公告)号：US06629775B2

公开(公告)日：2003-10-07

申请号：US09903963

申请日：2001-07-12

Applicant: Konstantin Choikhet ,  Gerard Rozing

Inventor： Konstantin Choikhet ,  Gerard Rozing

IPC: B01F506

CPC classification number: B01F5/0602 ,  B01F5/064

Abstract: Disclosed is a mixing apparatus where a fluid is progressing from an Inlet tubing to an Outlet tubing. Every segment of the liquid is part by part transferred to the Outlet channel via numerous restrictor channels. The distances between the restrictor channels determine a dispersion pattern for any segment of the flow, progressing from the inlet chamber in the form of a reservoir channel to the Outlet. The nearer the outlet channels are placed one to another, the higher is the permeability to the outlet collector at the respective location. Delaying partial flows of the fluid with different flow delays and providing different flow volumes for the partial flows results in a predetermined flow distribution function thus determining a dispersion pattern. This allows for a continuous dispersion of a fluid property which is intended to be mixed, in accordance with a predefined fluid distribution function.

Abstract translation: 公开了一种混合装置，其中流体从入口管道进入出口管道。 液体的每个部分通过许多限流器通道部分地部分转移到出口通道。 限流器通道之间的距离确定了流体的任何段的分散模式，从储存器通道形式的入口室进入出口。 出口通道越靠近放置，相应位置的出口收集器的渗透性越高。 延迟具有不同流动延迟的流体的部分流动并且为部分流提供不同的流量导致预定的流量分布函数，从而确定分散模式。 这允许根据预定的流体分配功能连续分散旨在混合的流体性质。

公开(公告)号：US06601439B2

公开(公告)日：2003-08-05

申请号：US09907365

申请日：2001-07-17

Applicant: Konstantin Choikhet

Inventor： Konstantin Choikhet

IPC: G01N3054

CPC classification number: G01N30/30 ,  G01N30/54 ,  G01N2030/027

Abstract: A method of reducing baseline instabilities in liquid chromatographic measurements is disclosed. A mobile phase comprising sample substances passes through a chromatographic column comprising a stationary phase, and subsequently through a detector. An additional solid body or liquid bath having a high heat capacity and heat conductance is coupled to the column and to an inlet capillary of the column such that the inlet capillary and the column are enclosed by said solid body or liquid bath. In that way temperature stabilization of the column and inlet capillaries is achieved and baseline variations due to temperature dependent adsorption of water at the stationary phase, in particular stationary phases with amino functional groups, are reduced.

Abstract translation: 公开了一种降低液相色谱测量中基线不稳定性的方法。 包含样品物质的流动相通过包含固定相的色谱柱，随后通过检测器。 具有高热容量和热导率的另外的固体或液体浴连接到塔和塔的入口毛细管，使得入口毛细管和塔被所述固体或液体浴包围。 以这种方式实现柱和入口毛细管的温度稳定性，并且由于在固定相，特别是具有氨基官能团的固定相的温度依赖性吸附而导致的基线变化减小。

公开(公告)号：US09671375B2

公开(公告)日：2017-06-06

申请号：US14344113

申请日：2011-09-15

Applicant: Martin Baeuerle ,  Konstantin Choikhet

Inventor： Martin Baeuerle ,  Konstantin Choikhet

IPC: G01N30/32 ,  B01L3/00 ,  B01D15/10 ,  B01D53/02 ,  B01D57/02 ,  G01L13/02 ,  G01L13/06 ,  G01L27/00 ,  G01N30/36 ,  G01N30/60

CPC classification number: G01N30/32 ,  B01D15/10 ,  B01D53/025 ,  B01D57/02 ,  B01L3/5027 ,  B01L2200/146 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/14 ,  B01L2400/0487 ,  G01L13/023 ,  G01L13/06 ,  G01L27/002 ,  G01N30/36 ,  G01N30/6095 ,  G01N2030/326

Abstract: A fluidic chip device configured for processing a fluid, wherein the fluidic chip device comprises a plurality of layers laminated to one another, wherein at least a part of the layers comprises a patterned section of an alternating sequence of bars and fluidic channels for conducting the fluid under pressure, the patterned section being configured for being displaceable in response to the pressure, and a pressure detector responding to the displacement of the patterned section by generating a detector signal being indicative of a value of the pressure.

公开(公告)号：US09417219B2

公开(公告)日：2016-08-16

申请号：US12619283

申请日：2009-11-16

Applicant: Konstantin Choikhet

Inventor： Konstantin Choikhet

IPC: G01N30/02 ,  G01N30/38 ,  G01N30/34 ,  G01N30/20

CPC classification number: G01N30/38 ,  G01N30/20 ,  G01N30/34 ,  G01N2030/347

Abstract: A sample separation device for separating a sample comprises a first fluid supply path for supplying a first fluid, a second fluid supply path for supplying a second fluid, a sample separation unit adapted for separating the sample, a sensor configured for determining a value of a parameter related to the fluid, and a valve configured for selectively coupling both of the first and second fluid supply paths to the sensor and to the sample separation unit, or coupling one of the first and second fluid supply paths to the sensor.

Abstract translation: 用于分离样品的样品分离装置包括用于供应第一流体的第一流体供应路径，用于供应第二流体的第二流体供应路径，适于分离样品的样品分离单元，被配置为确定 与流体相关的参数以及被配置为选择性地将第一和第二流体供应路径耦合到传感器和样品分离单元，或者将第一和第二流体供应路径之一耦合到传感器的阀。