公开(公告)号：US07978893B2

公开(公告)日：2011-07-12

申请号：US11974406

申请日：2007-10-12

Applicant: Robert A. Modavis ,  Elvis A. Zambrano

Inventor： Robert A. Modavis ,  Elvis A. Zambrano

IPC: G06K9/00

CPC classification number: G01N21/253 ,  G01N21/7743

Abstract: A system and a method as defined herein for scan interrogation of, for example, a label-independent-detection (LID) biosensor, such as for monitoring a surface change or an event on a biosensor for use, for example, in microplate image analysis.

Abstract translation: 如本文所定义的系统和方法，用于扫描询问例如标签无关检测（LID）生物传感器，例如用于监测生物传感器上的表面变化或事件以用于例如微孔板图像分析 。

公开(公告)号：US20090097013A1

公开(公告)日：2009-04-16

申请号：US11974406

申请日：2007-10-12

Applicant: Robert A. Modavis ,  Elvis A. Zambrano

Inventor： Robert A. Modavis ,  Elvis A. Zambrano

IPC: G01N21/00

CPC classification number: G01N21/253 ,  G01N21/7743

Abstract: A system and a method as defined herein for scan interrogation of, for example, a label-independent-detection (LID) biosensor, such as for monitoring a surface change or an event on a biosensor for use, for example, in microplate image analysis.

Abstract translation: 如本文所定义的系统和方法，用于扫描询问例如标签无关检测（LID）生物传感器，例如用于监测生物传感器上的表面变化或事件以用于例如微孔板图像分析 。

公开(公告)号：US06694075B1

公开(公告)日：2004-02-17

申请号：US09340481

申请日：1999-06-30

Applicant: Vikram Bhatia ,  Thomas A. Cook ,  Robert A. Modavis ,  Christopher D. Robson

Inventor： Vikram Bhatia ,  Thomas A. Cook ,  Robert A. Modavis ,  Christopher D. Robson

IPC: G02B634

CPC classification number: G02B6/02133 ,  G02B6/02085 ,  G02B6/02123

Abstract: Filter gratings are formed in optical waveguides having photosensitive cores by exposing the cores to actinic radiation in the form of interfering beams having peak intensities that are relatively displaced along an optical axis of the waveguides. Each of the interfering beams has a single-lobed intensity profile and a degree of spatial coherence required to achieve a desired fringe contrast between the two relatively displaced beams. Index modulations in the photosensitive core match the illumination (interference) pattern of the radiation. The relative displacement of the interfering beams reduces side lobes of the gratings' spectral responses by leveling the average refractive index of the index modulations. A second exposure with the two beams but without the beams' interference effects further levels the average refractive index.

Abstract translation: 滤光器光栅形成在具有感光芯的光波导中，其通过使核心以具有峰值强度的波束形式的光化辐射的形式，沿着波导的光轴相对移位。 每个干涉光束具有单裂纹强度分布和在两个相对位移的光束之间实现期望条纹对比度所需的空间相干度。 感光芯中的折射率调制与辐射的照明（干涉）图案相匹配。 干涉光束的相对位移通过调整折射率调制的平均折射率来减小光栅的光谱响应的旁瓣。 使用两个光束但没有光束干涉效应的第二次曝光进一步降低了平均折射率。

公开(公告)号：US06301410B1

公开(公告)日：2001-10-09

申请号：US09876208

申请日：2001-06-06

Applicant: Joel P. Carberry ,  Gang Chen ,  Peter Knowles ,  Glenn E. Kohnke ,  William J. Miller ,  Robert A. Modavis ,  Laura A. Weller-Brophy

Inventor： Joel P. Carberry ,  Gang Chen ,  Peter Knowles ,  Glenn E. Kohnke ,  William J. Miller ,  Robert A. Modavis ,  Laura A. Weller-Brophy

IPC: G02B634

CPC classification number: G02B6/02209 ,  G02B6/02095 ,  G02B6/02123 ,  G02B6/2558

Abstract: Packages for long period fiber gratings and other optical components (and methods for forming the packages) are described. According to an aspect of the invention, a hollow tube surrounding an optical fiber containing a long-period grating is collapsed in two areas, forming a seal at each end of the tube. According to another aspect of the invention, a hollow tube with a shelf section at each end surrounds an optical fiber containing a long-period grating. The hollow tube is sealed at each end with a fused frit. According to another aspect of the invention, a hollow tube surrounding an optical fiber containing a long-period grating is sealed at each end with a glass plug.

Abstract translation: 描述了长周期光纤光栅和其他光学部件的封装（以及用于形成封装的方法）。 根据本发明的一个方面，围绕包含长周期光栅的光纤的中空管在两个区域中折叠，在管的每一端形成密封。 根据本发明的另一方面，在每个端部具有搁板部分的中空管围绕包含长周期光栅的光纤。 中空管在每一端用熔融玻璃料密封。 根据本发明的另一方面，围绕包含长周期光栅的光纤的中空管在每端用玻璃塞密封。

公开(公告)号：US6044191A

公开(公告)日：2000-03-28

申请号：US185472

申请日：1998-11-03

Applicant: George E. Berkey ,  Venkata A. Bhagavatula ,  Peter C. Jones ,  Donald B. Keck ,  Yanming Liu ,  Robert A. Modavis ,  Alan J. Morrow ,  Mark A. Newhouse ,  Daniel A. Nolan

Inventor： George E. Berkey ,  Venkata A. Bhagavatula ,  Peter C. Jones ,  Donald B. Keck ,  Yanming Liu ,  Robert A. Modavis ,  Alan J. Morrow ,  Mark A. Newhouse ,  Daniel A. Nolan

IPC: G02B6/00 ,  C03B37/012 ,  C03B37/014 ,  C03B37/018 ,  C03B37/02 ,  C03B37/027 ,  G02B6/02 ,  G02B6/028 ,  G02B6/036

CPC classification number: G02B6/0281 ,  C03B37/01211 ,  C03B37/01228 ,  C03B37/0124 ,  C03B37/01254 ,  C03B37/01257 ,  C03B37/01413 ,  C03B37/01466 ,  C03B37/0148 ,  C03B37/01493 ,  C03B37/027 ,  C03C25/6226 ,  G02B6/02247 ,  C03B2203/18 ,  C03B2203/20 ,  C03B2203/24 ,  C03B2203/36 ,  C03C2218/31

Abstract: A single-mode optical waveguide fiber designed to limit power penalty due to four wave mixing and a method of making the waveguide is disclosed. Variations in properties, e.g., radius or refractive index, of the waveguide fiber core provide a total dispersion which varies along the length of the waveguide. The algebraic sum of products of length times total dispersion is controlled to a pre-selected value for each waveguide fiber which makes up a system link Proper choice of total dispersion variation magnitude and sub-length results in a system link wherein a signal travels only short distances in waveguide portions having total dispersion near zero. However, the variation of the total dispersion provides a system link which has a pre-selected dispersive effect on the signal over a selected wavelength range. The dispersive effect on the signal can be chosen to be essentially zero. A number of techniques for fabricating DM fiber are also disclosed.

Abstract translation: 公开了一种设计用于限制由于四波混频引起的功率损失的单模光纤光纤和制造波导的方法。 波导纤维芯的性质，例如半径或折射率的变化提供沿波导长度变化的总色散。 将长度乘以总色散的乘积的代数和控制为构成系统链路的每个波导光纤的预选值。总体色散变化幅度和子长度的正确选择导致系统链路，其中信号仅传播短 具有接近零的总色散的波导部分的距离。 然而，总色散的变化提供了对所选波长范围上的信号具有预先选择的色散效应的系统链路。 对信号的色散效应可以选择为基本为零。 还公开了用于制造DM纤维的许多技术。

公开(公告)号：US5629998A

公开(公告)日：1997-05-13

申请号：US593637

申请日：1996-01-29

Applicant: Thomas A. Cook ,  Robert A. Modavis

Inventor： Thomas A. Cook ,  Robert A. Modavis

IPC: G02B6/13 ,  C03B37/023 ,  G02B5/18 ,  G02B6/02 ,  G02B6/10 ,  G02B6/34 ,  G02F1/225

CPC classification number: G02B6/02133

Abstract: Apparatus for forming a refractive index grating in a waveguide in accordance with the invention includes a waveguide formed from a material that changes its index of refraction when exposed to a beam of optical radiation, a source of coherent optical radiation for forming a beam of radiation, a mirror arranged to intercept a first part of a beam and to reflect the first part of the beam through an angle, and a phase delay plate arranged to intercept a second part of the beam for delaying the second part of the beam propagating through the plate, in which the mirror and the phase delay plate are arranged so that the first part of the beam and the second delayed part of the beam form an interference pattern on the waveguide for changing the index of refraction of the waveguide, in a pattern corresponding to the interference pattern for forming an index grating in the waveguide.

Abstract translation: 根据本发明的用于在波导中形成折射率光栅的装置包括由暴露于光辐射束时改变其折射率的材料形成的波导，用于形成辐射束的相干光辐射源， 镜子，被布置成拦截光束的第一部分并且将光束的第一部分反射一角度;相位延迟板，被布置成拦截光束的第二部分，用于延迟传播通过光盘的光束的第二部分 其中反射镜和相位延迟板被布置成使得光束的第一部分和光束的第二延迟部分在波导上形成干涉图案以改变波导的折射率，其对应于 用于在波导中形成折射率光栅的干涉图案。

公开(公告)号：US07999944B2

公开(公告)日：2011-08-16

申请号：US12256852

申请日：2008-10-23

Applicant: Stephen J. Caracci ,  Michael J. Dailey, Jr. ,  William J. Miller ,  Robert A. Modavis ,  Deepti J. Mudaliar ,  David A. Pastel ,  Michael B. Webb ,  Qi Wu

Inventor： Stephen J. Caracci ,  Michael J. Dailey, Jr. ,  William J. Miller ,  Robert A. Modavis ,  Deepti J. Mudaliar ,  David A. Pastel ,  Michael B. Webb ,  Qi Wu

IPC: G01N21/55

CPC classification number: G01N21/253 ,  G01N21/39 ,  G01N21/45

Abstract: A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.

Abstract translation: 本文描述了多通道扫频波长光询问系统和方法，其能够询问一个或多个生物传感器，例如其可位于微板的孔内。 在一个实施例中，光学询问系统包括：（a）可调激光器，其在预定时间段内发射具有预定的不同波长序列的光束; （b）分配单元，其将光束分成多个询问光束; （c）光学询问单元的阵列，其接收并将询问光束定向到生物传感器的阵列; （d）光学询问单元的阵列从生物传感器阵列接收多个反射询问光束; （e）数据处理装置，其接收和处理与所反映的询问光束相关联的信息，以确定例如生物传感器中任何一个生化交互是否存在。

公开(公告)号：US07741598B2

公开(公告)日：2010-06-22

申请号：US12402901

申请日：2009-03-12

Applicant: Robert A. Modavis ,  Qi Wu ,  Stephen J. Caracci ,  David A. Pastel

Inventor： Robert A. Modavis ,  Qi Wu ,  Stephen J. Caracci ,  David A. Pastel

IPC: G01J1/04 ,  G01J1/58

CPC classification number: G01N21/253 ,  G01N21/39 ,  G01N21/7743 ,  G01N2021/4742 ,  G01N2201/08

Abstract: An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

Abstract translation: 本文描述了光学询问系统和方法，其能够询问可以位于微板的孔内的一个或多个生物传感器。 在一个实施例中，光学询问系统具有可调谐激光器，N-纤维发射，N型透镜和N个检测器，其被设置成询问N-生物传感器。 在另一个实施例中，光学询问系统具有可调激光器，N-光纤发射，N + 1透镜和N个检测器，其被设置成询问N-生物传感器。

公开(公告)号：US20090097027A1

公开(公告)日：2009-04-16

申请号：US11974231

申请日：2007-10-12

Applicant: Robert A. Modavis ,  Garrett A. Piech

Inventor： Robert A. Modavis ,  Garrett A. Piech

IPC: G01B11/00

CPC classification number: G01N21/253 ,  G01N21/7743

Abstract: The disclosure relates to a system and a method for light beam interrogation of an optical biosensor and for monitoring a biological event on the biosensor for use, for example, in microplate image analysis. The system and method correct pointing-errors that can be encountered, for example, in scanning label-independent-detection biosensor applications.

Abstract translation: 本公开涉及一种用于光学生物传感器的光束询问的系统和方法，并且用于监测生物传感器上的生物学事件以用于例如微孔板图像分析。 系统和方法可能会遇到正确的指向错误，例如扫描标签无关检测生物传感器应用程序。

公开(公告)号：US6088494A

公开(公告)日：2000-07-11

申请号：US290143

申请日：1999-04-13

Applicant: Donald B. Keck ,  William J. Miller ,  Robert A. Modavis ,  Daniel A. Nolan

Inventor： Donald B. Keck ,  William J. Miller ,  Robert A. Modavis ,  Daniel A. Nolan

IPC: G02B6/287 ,  G02B6/28 ,  G02B6/34 ,  G02B6/26 ,  G02B6/42

CPC classification number: G02B6/29352

Abstract: A Mach-Zehnder filter is provided with a strongly aperiodic transfer function including a broad, sharply defined pass band. The filter can be used in conjunction with optical amplifiers.

Abstract translation: Mach-Zehnder滤波器具有强非周期性的传递函数，包括一个宽而清晰的通带。 滤波器可以与光放大器配合使用。