-
11.发明公开公开(公告)号：US20240346658A1
公开(公告)日：2024-10-17
申请号：US18629603
申请日：2024-04-08
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ralph DACOSTA
CPC classification number: G06T7/0016 , A61B5/0071 , A61B5/0077 , A61B5/445 , G01N21/6486 , G06T2207/10016 , G06T2207/10024 , G06T2207/10048 , G06T2207/10064 , G06T2207/30088 , G06T2207/30096
Abstract: A system for determining a bacterial load of a target is provided. The system includes an adaptor for configuring a mobile communication device for tissue imaging and a mobile communication device. The adaptor includes a housing configured to be removably coupled to a mobile communication device and, an excitation light source for fluorescent imaging. The excitation light source is configured to emit light in one of ultraviolet, visible, near-infrared, and infrared ranges.
-
公开(公告)号：US20240335478A1
公开(公告)日：2024-10-10
申请号：US18288241
申请日：2022-04-22
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： SHAFIQUE KESHAVJEE , MARCELO CYPEL , MINGYAO LIU , STEPHEN JUVET , KUMI MESAKI
IPC: A61K35/42 , A61K31/52 , A61K31/573 , A61K38/13 , A61P37/06 , C07K14/47 , C07K14/54 , C12N9/22 , C12N15/11 , C12N15/90
CPC classification number: A61K35/42 , A61K31/52 , A61K31/573 , A61K38/13 , A61P37/06 , C07K14/4703 , C07K14/5428 , C12N9/22 , C12N15/11 , C12N15/907 , C12N2310/20
Abstract: The present disclosure relates generally to epigenetically and genetically modified organs and tissues and methods of producing same. In particular, the present disclosure is directed to organs and tissues that have been epigenetically and/or genetically modified at one or multiple loci to control inflammation-regulating or immune-regulating gene expression and thereby improve the condition of the organs and tissues.
-
13.发明公开公开(公告)号：US20240294895A1
公开(公告)日：2024-09-05
申请号：US18441770
申请日：2024-02-14
Inventor： Marcelo CYPEL , Aizhou WANG , Shafique KESHAVJEE , Stephen G. WITHERS , Peter RAHFELD , Jayachandran KIZHAKKEDATHU
CPC classification number: C12N9/80 , A01N1/0226 , C12N9/2402 , C12N11/00 , C12Y302/01049 , C12Y305/01025 , C07K2319/00
Abstract: Provided herein are perfusion fluids for enzymatically cleaving A-antigens from a donor organ, and methods. uses. associated therewith. In particular, the perfusion fluids comprise two enzymes. GalNAcDeacetylase and Galactosaminidase and the fluids may further comprise a buffered extracellular solution and/or a crowing agent. Furthermore. the compositions described herein were found to have activity at temperatures and ph levels suitable for cell viability.
-
14.发明公开公开(公告)号：US20240293029A1
公开(公告)日：2024-09-05
申请号：US18662583
申请日：2024-05-13
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ralph S. DaCosta , Brian C. Wilson , Kai Zhang
CPC classification number: A61B5/0071 , A61B5/0059 , A61B5/01 , A61B5/445 , A61B5/72 , A61B5/742 , G01N21/6456 , G01N21/6486 , A61B5/0042 , A61B5/4519 , A61B10/00 , G01N21/6408 , G01N2021/6421 , G01N2021/6471 , G01N2201/0221 , Y02A90/10
Abstract: A method of visualizing bacteria in real time includes positioning a portable frame of a portable imaging system relative to a target, wherein the portable imaging system includes a camera and an excitation light source mounted on the portable frame, operating the portable imaging system in a hands-free manner to illuminate the target with excitation light having at least one wavelength to cause at least one biomarker associated with the target to fluoresce and to detect fluorescence of the at least one biomarker with the camera.
-
15.发明公开公开(公告)号：US20240182966A1
公开(公告)日：2024-06-06
申请号：US18210490
申请日：2023-06-15
Applicant: University Health Network
Inventor： Sowmya Viswanathan , Kevin Robb
IPC: C12Q1/6876 , C12N5/0775
CPC classification number: C12Q1/6876 , C12N5/0663 , C12Q2600/158
Abstract: The present disclosure provides critical quality attributes for assessing immunomodulatory fitness or angiogenic fitness of mesenchymal stromal cells. Also provided is use of these critical quality attributes to determine quantitative values for assessing the fitness of a sample from a particular donor and/or grown using particular critical processing parameters.
-
Patent Agency Ranking
公开(公告)号：US20240150462A1
公开(公告)日：2024-05-09
申请号：US18549897
申请日：2022-03-11
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Richard BROKX , Jacqueline M. MASON , Mark Robert BRAY , Gordon S. DUNCAN
CPC classification number: C07K16/2803 , A61K45/06 , A61K2039/505 , C07K2317/52 , C07K2317/565
Abstract: The invention provides novel anti-LILR antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer, autoimmune disease, or allergic inflammation.
-
公开(公告)号：US20240141025A1
公开(公告)日：2024-05-02
申请号：US18414178
申请日：2024-01-16
Applicant: NOVO NORDISK A/S , University Health Network
Inventor： YUE LIU , TARLOCHAN S. NIJJAR , AVIJIT CHAKRABARTTY , JEFFREY N. HIGAKI
CPC classification number: C07K16/18 , A61K51/1018 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/92
Abstract: The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
-
18.发明公开公开(公告)号：US20240138698A1
公开(公告)日：2024-05-02
申请号：US17974867
申请日：2022-10-27
Applicant: GE Precision Healthcare LLC , University Health Network
Inventor： Afis Ajala , Jianwei Qiu , John Karigiannis , Radhika Madhavan , Desmond Teck Beng Yeo , Thomas Kwok-Fah Foo , Andres M. Lozano , Alexandre Boutet , Jurgen Germann
CPC classification number: A61B5/055 , G06T7/0012 , G06T2207/10088
Abstract: A system for optimizing DBS parameters for a subject includes automatically performing actions via a processor. The actions include obtaining functional MRI data of a brain of the subject acquired utilizing an MRI system during DBS of the brain utilizing a first set of DBS parameters. The actions include generating functional MRI response maps from the functional MRI data. The actions include extracting, utilizing an unsupervised autoencoder-based neural network, features from the functional MRI response maps. The actions include determining, utilizing a deep learning-based DBS parameter classification model, whether the first set of DBS parameters are optimal DBS parameters for the subject based on the features. The actions include, when the first set of DBS parameters are not the optimal DBS parameters, predicting, utilizing a deep learning-based DBS parameter prediction model, a second set of DBS parameters that are the optimal DBS parameters for the subject based on the features.
-
公开(公告)号：US11925649B2
公开(公告)日：2024-03-12
申请号：US16160403
申请日：2018-10-15
Applicant: University of Manitoba , University Health Network , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Paul Fernyhough , Nigel A. Calcutt , Lakshmi Kotra
IPC: A61K31/5513 , A61K31/46 , A61K31/496 , A61K31/5517 , C07D417/12
CPC classification number: A61K31/5513 , A61K31/46 , A61K31/496 , A61K31/5517 , C07D417/12
Abstract: Treatments for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof. The treatments includes administration of compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.
-
公开(公告)号：US11925467B2
公开(公告)日：2024-03-12
申请号：US17052247
申请日：2019-04-30
Applicant: University Health Network
Inventor： Vijay Singh Chauhan , Adrian Michael Suszko
CPC classification number: A61B5/352 , A61B5/30 , A61B5/35 , A61B5/4836 , A61B5/4848 , A61N1/362 , A61B2562/222
Abstract: Various embodiments are described herein for a system and a method for assessing a risk of ventricular arrhythmias for a patient. For example, the method may comprise receiving ECG data obtained from the patient; analyzing the ECG data to detect abnormal QRS peaks; determining the risk of ventricular arrhythmias for the patient based on the detected abnormal QRS peaks; and providing an indication of the risk of ventricular arrhythmias for the patient. The system may be configured to perform this method.
-
-
-
-
-
-
-
-
-
Search Results
585
records
(took 0.031 seconds)
