公开(公告)号：US20240335478A1

公开(公告)日：2024-10-10

申请号：US18288241

申请日：2022-04-22

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： SHAFIQUE KESHAVJEE ,  MARCELO CYPEL ,  MINGYAO LIU ,  STEPHEN JUVET ,  KUMI MESAKI

IPC: A61K35/42 ,  A61K31/52 ,  A61K31/573 ,  A61K38/13 ,  A61P37/06 ,  C07K14/47 ,  C07K14/54 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

CPC classification number: A61K35/42 ,  A61K31/52 ,  A61K31/573 ,  A61K38/13 ,  A61P37/06 ,  C07K14/4703 ,  C07K14/5428 ,  C12N9/22 ,  C12N15/11 ,  C12N15/907 ,  C12N2310/20

Abstract: The present disclosure relates generally to epigenetically and genetically modified organs and tissues and methods of producing same. In particular, the present disclosure is directed to organs and tissues that have been epigenetically and/or genetically modified at one or multiple loci to control inflammation-regulating or immune-regulating gene expression and thereby improve the condition of the organs and tissues.