公开(公告)号：US20230112993A1

公开(公告)日：2023-04-13

申请号：US17913313

申请日：2021-03-15

Applicant: Agilent Technologies, Inc.

Inventor： Dwight Robert Stoll ,  Stephan Buckenmaier ,  Sascha Lege ,  Thomas Ortmann ,  Konstantin Shoykhet

IPC: G01N30/34 ,  B01D15/14 ,  B01D15/16 ,  G01N30/20 ,  G01N30/46

Abstract: A sample separation device for separating a fluidic sample includes a fluid drive for driving a mobile phase and the fluidic sample when injected in the mobile phase, a sample separation unit for separating the fluidic sample in the mobile phase, and a control unit configured for bracketing the fluidic sample between two mobile phase portions of the mobile phase. At least one of the mobile phase portions is arranged directly next to the fluidic sample and has a higher solvent strength compared to a solvent of the fluidic sample.

公开(公告)号：US11519885B2

公开(公告)日：2022-12-06

申请号：US17239238

申请日：2021-04-23

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Michael Lang ,  Blasius Nocon

IPC: G01N30/22 ,  G01N30/02

Abstract: A sample injector for a chromatography system is configured for injecting a sample fluid into a mobile phase, and includes a needle and a conduit. The needle is configured for aspirating the sample fluid and includes a needle tip, a needle channel through the needle for guiding the aspirated sample fluid, and a needle opening at the needle tip into which the needle channel opens. The conduit is configured for fluidically coupling with the needle and includes a conduit tip, and a conduit channel through the conduit for guiding fluid and having a conduit opening at the conduit tip. The conduit tip and the needle tip are configured to be pressed against each other for fluidically coupling the conduit channel with the needle channel, with at least a portion of the conduit tip penetrating into the needle opening for providing the fluidic coupling between the conduit and needle channels.

公开(公告)号：US20220283127A1

公开(公告)日：2022-09-08

申请号：US17826018

申请日：2022-05-26

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Daniel Thielsch

IPC: G01N30/20 ,  B01D15/14 ,  G01N30/04 ,  G01N30/10 ,  G01N30/36

Abstract: A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

公开(公告)号：US20220236235A1

公开(公告)日：2022-07-28

申请号：US17584250

申请日：2022-01-25

Applicant: Agilent Technologies, Inc.

Inventor： Daniela Loraing ,  Lena Höninger ,  Uwe Effelsberg ,  Andreas Otto ,  Ansgar Waldbaur ,  Armin Steinke ,  Thomas Ortmann ,  Michael Lang

IPC: G01N30/60

Abstract: A mounting device for mounting a sample separation unit configured for separating, preferably chromatographically separating, compounds in a fluidic sample includes a first fluid connector configured for being mechanically and fluidically coupled with a first fluid interface of the sample separation unit, a second fluid connector configured for being mechanically and fluidically coupled with a second fluid interface of the sample separation unit, and a swivel mechanism configured for swivelling the first fluid connector between a mounting orientation for mounting the first fluid interface of the sample separation unit at the first fluid connector and an alignment orientation for aligning the second fluid interface of the mounted sample separation unit with the second fluid connector for subsequently coupling the second fluid interface with the second fluid connector.

公开(公告)号：US20210333247A1

公开(公告)日：2021-10-28

申请号：US17239238

申请日：2021-04-23

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Michael Lang ,  Blasius Nocon

IPC: G01N30/22

Abstract: A sample injector for a chromatography system is configured for injecting a sample fluid into a mobile phase, and includes a needle and a conduit. The needle is configured for aspirating the sample fluid and includes a needle tip, a needle channel through the needle for guiding the aspirated sample fluid, and a needle opening at the needle tip into which the needle channel opens. The conduit is configured for fluidically coupling with the needle and includes a conduit tip, and a conduit channel through the conduit for guiding fluid and having a conduit opening at the conduit tip. The conduit tip and the needle tip are configured to be pressed against each other for fluidically coupling the conduit channel with the needle channel, with at least a portion of the conduit tip penetrating into the needle opening for providing the fluidic coupling between the conduit and needle channels.

公开(公告)号：US12235248B2

公开(公告)日：2025-02-25

申请号：US18369739

申请日：2023-09-18

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann ,  Sam Wouters

IPC: G01N30/20 ,  G01N30/02 ,  G01N30/32

Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls an outlet flow rate value according to which a combination of the mobile phase and the fluidic sample is driven through the separation unit.

公开(公告)号：US20240011957A1

公开(公告)日：2024-01-11

申请号：US18037714

申请日：2021-11-19

Applicant: Agilent Technologies, Inc.

Inventor： Dominik Ruf ,  Thomas Ortmann

IPC: G01N30/86 ,  G01N30/24 ,  G01N30/32

CPC classification number: G01N30/8658 ,  G01N30/24 ,  G01N30/32 ,  G01N2030/027

Abstract: A sampling unit is fluidically coupled to a source. The sampling unit is configured for receiving a fluidic sample from the source and chromatographically separating the received fluidic sample. The sampling unit is operated to introduce a test sample into the source. At least a portion of the introduced test sample from the source is received into the sampling unit, and the received portion of the test sample is chromatographically separated in the sampling unit.

公开(公告)号：US11630090B2

公开(公告)日：2023-04-18

申请号：US16943868

申请日：2020-07-30

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Thomas Glauner

IPC: G01N30/20 ,  G01N30/38

Abstract: A sample dispatcher for a fluid separation apparatus includes a sampling path including a sampling volume, a sampling unit, and a retaining unit. The sampling unit receives a fluidic sample, and the sampling volume temporarily stores an amount of the received sample. The retaining unit receives and retains from the sampling volume at least a portion of the stored sample, and has different retention characteristics for different components of the sample. A switching unit is coupled to the sampling path, a sampling fluid drive, a mobile phase drive, and a separating device. In a feed injection configuration of the switching unit, the mobile phase drive, the separating device, and the sampling path are coupled together in a coupling point for combining a flow from the sampling fluid drive containing the fluidic sample retained by the retaining unit with a flow of the mobile phase from the mobile phase drive.

公开(公告)号：US20230039500A1

公开(公告)日：2023-02-09

申请号：US17787107

申请日：2020-12-01

Applicant: Agilent Technologies, Inc.

Inventor： Stephan Buckenmaier ,  Sascha Lege ,  Thomas Ortmann ,  Konstantin Shoykhet

IPC: B01D15/18 ,  G01N30/46

Abstract: A fluid processing apparatus includes a first fluid separation apparatus including a first fluid pump, configured for driving a first mobile phase, and a first separation unit configured for separating a fluidic sample when within the first mobile phase. A sampling unit includes a modulation buffering unit and a modulation drive, wherein the modulation drive is configured for introducing fluid into the modulation buffering unit. A switching unit is configured, in a first switching state, for introducing fluid into the modulation buffering unit from downstream of the first separation unit, and, in a second switching state, for introducing fluid buffered in the modulation buffering unit in a first flow path between the first fluid pump and the first separation unit.

公开(公告)号：US11371968B2

公开(公告)日：2022-06-28

申请号：US16917908

申请日：2020-07-01

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Daniel Thielsch ,  Dominik Ruf

IPC: G01N30/20 ,  B01D15/14 ,  G01N30/04 ,  G01N30/10 ,  G01N30/36 ,  G01N30/32

Abstract: A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.