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    CELL-BASED BIOSENSOR ARRAY AND ASSOCIATED METHODS FOR MANUFACTURING THE SAME
    13.
    发明申请
    CELL-BASED BIOSENSOR ARRAY AND ASSOCIATED METHODS FOR MANUFACTURING THE SAME 审中-公开
    基于细胞的生物传感器阵列及其相关方法制造方法

    公开(公告)号：US20160047770A1

    公开(公告)日：2016-02-18

    申请号：US14825140

    申请日：2015-08-12

    Applicant: Axion BioSystems, Inc.

    Inventor： Phillip Edward Tyler ,  Swaminathan Rajaraman ,  Amanda Jervis Preyer

    IPC: G01N27/27

    CPC classification number: G01N33/4836 ,  B01L3/5085

    Abstract: A cell-based biosensor array includes a base plate having a plurality of substantially transparent areas. The cell-based biosensor array also includes a flexible substrate coupled to the base plate and having disposed thereon a plurality of electrode sets, a plurality of terminal contacts, and a plurality of conductive traces. Each electrode set is disposed proximate a respective one of the substantially transparent areas, and each electrode set includes at least one electrode configured to detect an electric signal. Each terminal contact is associated with a respective one of the at least one electrode and disposed proximate a perimeter of the flexible substrate. Each conductive trace is electrically coupling a respective at least one electrode to the corresponding terminal contact. A first portion of flexible substrate including the electrode sets is disposed on a first surface of the base plate. A second portion of the flexible substrate including the terminal contacts is disposed on a second surface of the base plate.

    Abstract translation: 基于细胞的生物传感器阵列包括具有多个基本透明区域的基板。 基于细胞的生物传感器阵列还包括耦合到基板并且在其上设置有多个电极组，多个端子触点和多个导电迹线的柔性基板。 每个电极组被设置在基本上透明区域中的相应一个附近，并且每个电极组包括配置成检测电信号的至少一个电极。 每个端子触点与所述至少一个电极中的相应的一个相关联并且设置在柔性基板的周边附近。 每个导电迹线将相应的至少一个电极电耦合到相应的端子触点。 包括电极组的柔性基板的第一部分设置在基板的第一表面上。 包括端子触头的柔性基板的第二部分设置在基板的第二表面上。

    Devices, systems and methods for high-throughput electrophysiology
    17.
    发明授权
    Devices, systems and methods for high-throughput electrophysiology 有权
    用于高通量电生理学的装置，系统和方法

    公开(公告)号：US09329168B2

    公开(公告)日：2016-05-03

    申请号：US14744513

    申请日：2015-06-19

    Applicant: AXION BIOSYSTEMS, INC.

    Inventor： Swaminathan Rajaraman ,  James D Ross ,  Amanda Preyer

    IPC: G01N27/327 ,  G01N33/50 ,  G01N33/483

    CPC classification number: G01N33/5014 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2300/0645 ,  B01L2300/0829 ,  C12M23/12 ,  G01N33/4836

    Abstract: Electrophysiology culture plates are provided and are formed from a transparent microelectrode array (MEA) plate. The MEA plate comprises a substrate, a first layer and a first insulating layer. The substrate has a plurality of vias extending from an upper to a lower surface, each via being in electrical contact with each of a plurality of contact pads disposed on the lower surface. The first layer is disposed on the upper surface of the substrate and has a plurality of MEA arrays in electrical communication with at least a first routing layer. Each MEA array comprises a plurality of reference electrodes and a plurality of microelectrodes and the first routing layer is in electrical communication with a select number of the plurality of vias. A first insulating layer is disposed on the first layer. The MEA plate is joined to a biologic culture plate having a plurality of culture wells such that each culture well defines an interior cavity having a bottom surface that is at least partially transparent and in positioned in registration with a select optical port. The MEA plate is coupled to the biologic culture well plate such that each MEA array is operatively coupled to one culture well wherein each microelectrode and each reference electrode are in electrical communication with the interior cavity through the bottom surface of the culture well.

    Abstract translation: 提供电生理培养板并由透明微电极阵列（MEA）板形成。 MEA板包括基底，第一层和第一绝缘层。 衬底具有从上表面延伸到下表面的多个通孔，每个通孔与设置在下表面上的多个接触焊盘中的每一个电接触。 第一层设置在衬底的上表面上并且具有与至少第一路由层电连通的多个MEA阵列。 每个MEA阵列包括多个参考电极和多个微电极，并且第一路由层与选择数量的多个通孔电连通。 第一绝缘层设置在第一层上。 将MEA板连接到具有多个培养孔的生物培养板，使得每个培养井定义具有至少部分透明的底表面并定位成与选择光学端口对准的内部空腔。 将MEA板耦合到生物培养孔板，使得每个MEA阵列可操作地偶联到一个培养孔，其中每个微电极和每个参比电极通过培养孔的底表面与内腔电连通。

    Devices, systems and methods for high-throughput electrophysiology
    18.
    发明授权
    Devices, systems and methods for high-throughput electrophysiology 有权
    用于高通量电生理学的装置，系统和方法

    公开(公告)号：US09279801B2

    公开(公告)日：2016-03-08

    申请号：US14279961

    申请日：2014-05-16

    Applicant: AXION BIOSYSTEMS, INC.

    Inventor： Swaminathan Rajaraman ,  James D. Ross ,  Amanda Preyer

    IPC: G01N27/327 ,  G01N33/50 ,  G01N33/483

    CPC classification number: G01N33/5014 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2300/0645 ,  B01L2300/0829 ,  C12M23/12 ,  G01N33/4836

    Abstract: Electrophysiology culture plates are provided and are formed from a transparent microelectrode array (MEA) plate. The MEA plate comprises a substrate, a first layer and a first insulating layer. The substrate has a plurality of vias extending from an upper to a lower surface, each via being in electrical contact with each of a plurality of contact pads disposed on the lower surface. The first layer is disposed on the upper surface of the substrate and has a plurality of MEA arrays in in electrical communication with at least a first routing layer. Each MEA array comprises a plurality of reference electrodes and a plurality of microelectrodes and the first routing layer is in electrical communication with a select number of the plurality of vias. A first insulating layer is disposed on the first layer. The MEA plate is joined to a biologic culture plate having a plurality of culture wells such that each culture well defines an interior cavity having a bottom surface that is at least partially transparent and in positioned in registration with a select optical port. The MEA plate is coupled to the biologic culture well plate such that each MEA array is operatively coupled to one culture well wherein each microelectrode and each reference electrode are in electrical communication with the interior cavity through the bottom surface of the culture well.

    Abstract translation: 提供电生理培养板并由透明微电极阵列（MEA）板形成。 MEA板包括基底，第一层和第一绝缘层。 衬底具有从上表面延伸到下表面的多个通孔，每个通孔与设置在下表面上的多个接触焊盘中的每一个电接触。 第一层设置在衬底的上表面上并且具有与至少第一路由层电通信的多个MEA阵列。 每个MEA阵列包括多个参考电极和多个微电极，并且第一路由层与选择数量的多个通孔电连通。 第一绝缘层设置在第一层上。 将MEA板连接到具有多个培养孔的生物培养板，使得每个培养井定义具有至少部分透明的底表面并定位成与选择光学端口对准的内部空腔。 将MEA板耦合到生物培养孔板，使得每个MEA阵列可操作地偶联到一个培养孔，其中每个微电极和每个参比电极通过培养孔的底表面与内腔电连通。

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