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    Identification of mycoplasm contamination in biotechnology production using Raman spectroscopy
    11.
    发明授权
    Identification of mycoplasm contamination in biotechnology production using Raman spectroscopy 有权
    使用拉曼光谱鉴定生物技术生产中的支原体污染

    公开(公告)号：US09334520B2

    公开(公告)日：2016-05-10

    申请号：US14191887

    申请日：2014-02-27

    Applicant: Battelle Memorial Institute

    Inventor： Andrew P. Bartko

    IPC: G01J3/44 ,  C12Q1/04 ,  C12M3/00 ,  A61B5/00 ,  G01N33/48 ,  G01N21/65 ,  G01N33/569 ,  G01N21/85

    CPC classification number: C12Q1/04 ,  G01N21/65 ,  G01N21/85 ,  G01N33/56933 ,  G01N2333/30

    Abstract: Mycoplasma contamination of a known cell line is detected by collecting a Raman spectrum of a targeted volume within a sample, the targeted volume containing a known cell line of interest, obtaining a reference spectrum uniquely associated with the known cell line where the obtained reference spectrum is known to be free of mycoplasma and comparing, using a processing device, the reference spectrum to the collected spectrum. Mycoplasma is further detected by identifying whether there are unnatural molecular compositions within the collected spectrum based upon the comparison of the reference spectrum to the collected spectrum and providing an indication as to whether mycoplasma is detected in the collected Raman spectrum based upon whether unnatural molecular compositions are identified within the collected spectrum.

    Abstract translation: 通过收集样品内目标体积的拉曼光谱来检测已知细胞系的支原体污染物，目标体积包含已知的感兴趣细胞系，获得与已知细胞系唯一相关的参考光谱，其中获得的参考光谱为 已知无支原体，并使用处理装置比较采集光谱的参考光谱。 基于参考光谱与收集的光谱的比较，通过鉴定收集的光谱中是否存在非天然分子组成进一步检测支原体，并提供关于在所收集的拉曼光谱中是否检测到支原体的指示，这是基于非天然分子组成是否为 在收集的频谱内确定。

    ACTIVE HYPERSPECTRAL IMAGING WITH A LASER ILLUMINATOR AND WITHOUT DISPERSION
    13.
    发明申请
    ACTIVE HYPERSPECTRAL IMAGING WITH A LASER ILLUMINATOR AND WITHOUT DISPERSION 审中-公开

    公开(公告)号：US20200065582A1

    公开(公告)日：2020-02-27

    申请号：US16545846

    申请日：2019-08-20

    Applicant: BATTELLE MEMORIAL INSTITUTE

    Inventor： Andrew P. Bartko ,  Theodore J. Ronningen ,  Jared Schuetter

    IPC: G06K9/00 ,  G01J3/28 ,  G01J3/40 ,  G01J3/10 ,  G01N21/31 ,  G06K9/20 ,  G06K9/62 ,  H04N5/232

    Abstract: Hyperspectral imaging is carried out by utilizing a set of lasers to illuminate a scene containing a sample in a series of successive laser illuminations by turning on at least one laser in the set of lasers for each successive illumination in the series. Here, each laser generates a known wavelength of light. Imaging is further carried out by utilizing a camera to capture an image of the scene during each successive laser illumination, thus generating a series of successive images. However, no dispersive element is utilized between the scene and the camera. Imaging is still further carried out by processing the captured images to produce scene data. The scene data is compared with target profiles to determine whether the scene includes at least one target of interest and taking a predetermined action in response to detecting at least one target of interest.

    EXPLOSIVES DETECTION USING OPTICAL SPECTROSCOPY
    14.
    发明申请
    EXPLOSIVES DETECTION USING OPTICAL SPECTROSCOPY 审中-公开

    公开(公告)号：US20180306722A1

    公开(公告)日：2018-10-25

    申请号：US15991885

    申请日：2018-05-29

    Applicant: BATTELLE MEMORIAL INSTITUTE

    Inventor： Andrew P. Bartko ,  Theodore J. Ronningen

    IPC: G01N21/65 ,  G01N21/64 ,  G01N33/22 ,  G01N21/35 ,  G01N33/00

    CPC classification number: G01N21/65 ,  G01N21/35 ,  G01N21/64 ,  G01N33/0057 ,  G01N33/227 ,  G01N2021/3595

    Abstract: Detecting threat materials used in explosives is performed by receiving a sample, and selecting an area of interest on the sample suspected of containing a threat material indicative of an explosive. Detection also includes interrogating the area of interest with a Raman laser producing a Raman spectrum, and comparing an amplitude of a first spectral region in the Raman spectrum to a first predetermined threshold. Detection further includes performing a verification, if the determination indicates that the area of interest includes the threat material, by checking the interrogated area of interest for a secondary indicator of the presence of the threat material, by comparing an amplitude of a second spectral region in the Raman spectrum, which is different from the first spectral region in the Raman spectrum, to a second predetermined threshold, and activating an indicator if the verification indicates that the area of interest contains the threat material.

    Identification of mycoplasm contamination using Raman spectroscopy
    16.
    发明授权
    Identification of mycoplasm contamination using Raman spectroscopy 有权

    公开(公告)号：US09856505B2

    公开(公告)日：2018-01-02

    申请号：US15082330

    申请日：2016-03-28

    Applicant: Battelle Memorial Institute

    Inventor： Andrew P. Bartko

    IPC: G01J3/44 ,  C12Q1/04 ,  G01N33/48 ,  A61B5/00 ,  G01N21/65 ,  G01N33/569 ,  G01N21/85

    CPC classification number: C12Q1/04 ,  G01N21/65 ,  G01N21/85 ,  G01N33/56933 ,  G01N2333/30

    Abstract: A manufacturing method comprises collecting a sample from a cell culture used by a manufacturing application, and controlling a Raman spectrometer to collect a Raman spectrum of a targeted volume within the sample. The method further comprises obtaining reference spectra uniquely associated with a known cell line, which comprise at least two of: spectral measurements of mycoplasma by itself, a contaminated cell line, and a pure cell line. Moreover, the method comprises comparing the reference spectra to the collected spectrum, and identifying whether there is at least one unnatural molecular composition within the collected spectrum based upon the comparison of the reference spectra to the collected spectrum. An indication is provided as to whether mycoplasma is detected in the collected Raman spectrum where at least one unnatural molecular composition is identified within the collected spectrum, and the manufacturing application is stopped where mycoplasma is detected in the collected Raman spectrum.

    Line light source for Raman or other spectroscopic system
    20.
    发明授权
    Line light source for Raman or other spectroscopic system 有权

    公开(公告)号：US10126169B2

    公开(公告)日：2018-11-13

    申请号：US15207112

    申请日：2016-07-11

    Applicant: Battelle Memorial Institute

    Inventor： Bradley B. Ross ,  Andrew P. Bartko

    IPC: G01J3/02 ,  G01J3/12 ,  G01J3/10 ,  G02B21/00 ,  G01J3/28 ,  G01J3/44 ,  G01N21/59 ,  G01N21/65 ,  G01N21/55 ,  G01N21/64 ,  G01J3/18

    Abstract: An apparatus comprises: a microscope objective focused on a microscope field of view; a light source including a laser generating an astigmatic beam and optics configured to couple the astigmatic beam into the microscope objective to produce high aspect ratio illumination at the microscope field of view; and a data acquisition system configured to generate data pertaining to light emanating from the microscope field of view responsive to the high aspect ratio illumination. The apparatus may be a Raman spectroscopy system. The laser may be an edge emitting laser. The optics of the light source may include an aspherical lens arranged to compensate the astigmatism of the astigmatic beam. The optics of the light source may include a diffraction grating arranged respective to the laser to provide feedback reducing a spectral full width at half maximum (FWHM) of the astigmatic beam.

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