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    Compact spectrum analyzer module
    13.
    发明授权
    Compact spectrum analyzer module 失效
    紧凑型频谱分析仪模块

    公开(公告)号：US5589717A

    公开(公告)日：1996-12-31

    申请号：US527290

    申请日：1995-09-12

    Applicant: Chiu Chau

    Inventor： Chiu Chau

    IPC: G01J3/02 ,  G01J3/18 ,  G01J3/28

    CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0291 ,  G01J3/18

    Abstract: A compact spectrum analyzer module suitable as a subsystem in optoelectronic instrumentation is disclosed which analyzer module employs two mirror surfaces to provide a folded optical path to and from a stock concave focusing diffraction grating. The module has mutually perpendicular input and output optical paths whereby input and output slits, or apertures, can be positioned on adjacent, mutually perpendicular faces of a box-like rectangular housing providing more convenience in the location of external system components such as light samplers and detector arrays, in many situations. Mirror orientation is effective to turn the output optical path through ninety degrees from the input path and to generate from polychromatic light a focused output spectrum in a plane parallel with the input path. Both the input path and the focused output spectrum lie, in preferred embodiments, in planes, not necessarily coincident, that are perpendicular to the optical axis of the grating.

    Abstract translation: 公开了一种适用于光电仪器中的子系统的紧凑型频谱分析仪模块，其分析器模块采用两个镜面，以提供与库存凹面聚焦衍射光栅的折叠光路。 模块具有相互垂直的输入和输出光路，由此输入和输出狭缝或孔可以定位在盒状矩形壳体的相邻的相互垂直的面上，从而在外部系统部件（例如光采样器）和 检测器阵列，在许多情况下。 镜面方向有效地将输出光路从输入路径转过九十度，并从多色光产生与输入路径平行的平面中的聚焦输出光谱。 在优选实施例中，输入路径和聚焦输出频谱都位于与光栅的光轴垂直的平面中，不一定重合。

    Probe density self-considerations and elongation of complementary looped probes where probes are attached to a solid phase
    14.
    发明授权
    Probe density self-considerations and elongation of complementary looped probes where probes are attached to a solid phase 有权
    探针密度自我考虑和互补环状探针的伸长，其中探针连接到固相

    公开(公告)号：US08795966B2

    公开(公告)日：2014-08-05

    申请号：US12708362

    申请日：2010-02-18

    Applicant: Michael Seul ,  Yi Zhang ,  Sukanta Banerjee ,  Jiacheng Yang ,  Chiu Chau

    Inventor： Michael Seul ,  Yi Zhang ,  Sukanta Banerjee ,  Jiacheng Yang ,  Chiu Chau

    IPC: C12Q1/68 ,  C07H21/04

    CPC classification number: C12Q1/6837 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q2565/1015 ,  C12Q2537/143 ,  C12Q2533/101 ,  C12Q2535/125 ,  C12Q2525/301

    Abstract: In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps:adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.

    Abstract translation: 在溶液中进行的多重测定方法中，其中溶液含有核酸靶，并且其中使用几个不同类型的寡核苷酸探针，每个类型在被称为靶结合结构域的区域中具有不同序列，以检测核酸 目标，所述测定方法包括通过一个或多个以下步骤增加寡核苷酸探针结合珠粒表面上的核酸靶的有效浓度的方法：调节测定条件以增加有效 通过一种或多种以下方法可用于结合探针的靶的浓度：（i）在珠的表面上选择特定的探针密度; （ii）选择具有大于阈值的离子强度的溶液; （ii）选择小于阈值的大小的目标域; 或（iii）在目标的终端的指定接近范围内选择目标域。

    Analysis, secure access to, and transmission of array images
    15.
    发明授权
    Analysis, secure access to, and transmission of array images 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US08712123B2

    公开(公告)日：2014-04-29

    申请号：US13084869

    申请日：2011-04-12

    Applicant: Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    Inventor： Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    IPC: G06K9/00

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

    NUMBER CODING FOR IDENTIFICATION OF SUBTYPES OF CODED TYPES OF SOLID PHASE CARRIERS
    16.
    发明申请
    NUMBER CODING FOR IDENTIFICATION OF SUBTYPES OF CODED TYPES OF SOLID PHASE CARRIERS 失效
    编号固定相载波编码类型的编号编号

    公开(公告)号：US20110184655A1

    公开(公告)日：2011-07-28

    申请号：US13071055

    申请日：2011-03-24

    Applicant: Michael Seul ,  Enqing Tan ,  Chiu Chau

    Inventor： Michael Seul ,  Enqing Tan ,  Chiu Chau

    IPC: G06F19/00

    CPC classification number: G01N33/6845 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/564

    Abstract: Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the bases of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele.

    Abstract translation: 公开了固态载波的对（“双”）或小集（“多重”）的数字编码，其提供给定类型的这种载波的可区分的子类型，其中每个载波类型基于不同的码可区分。 这种数字编码对于增加诸如颜色代码的编码系统是有用的，从而有效地乘以“颜色”的数量（可区分的子类型）。 例如，它可以应用于确定样品在两个不同等位基因之一的多个不同位点是纯合的还是杂合的，其中针对两个等位基因中的每一个应用相同的颜色代码，并且具有相同的等位基因 通过知道多少载体与检测每​​个不同等位基因的分子相关联来区分颜色代码。

    Low aberration diffraction grating system
    20.
    发明授权
    Low aberration diffraction grating system 失效
    低像差衍射光栅系统

    公开(公告)号：US5371586A

    公开(公告)日：1994-12-06

    申请号：US960091

    申请日：1992-10-09

    Applicant: Chiu Chau

    Inventor： Chiu Chau

    IPC: G01J3/18 ,  G01N21/65 ,  G01N21/64

    CPC classification number: G01J3/02 ,  G01J3/0227 ,  G01J3/18 ,  G01N2021/6471 ,  G01N2021/6473 ,  G01N21/65

    Abstract: A light analysis system is disclosed and comprises a source of substantially collimated light to be analyzed. The source comprises a sample excited by a collimated laser light source, and further comprises a holographic notch filter having the characteristic of reflecting light at the excitation wavelenghth at which the source is excited. An aberration corrected concave focusing diffraction grating receives the collimated light and focuses it at a point corresponding to its wavelength. A detector detects light at a desired wavelength focused by the diffraction grating. The holographic notch filter is positioned to filter the source of substantially collimated light to be filtered and the holographic notch filter is oriented substantially at an angle with respect to the collimated laser light source to result in a path length for the collimated laser light source which constrains a path length through the notch filter which causes the collimated laser light to be reflected by the filter away from the grating. The grating is an aberration corrected concave focusing diffraction grating. The collimated light is in the form of a bundle having a width on the order of ten millimeters.

    Abstract translation: 公开了一种光分析系统，其包括将被分析的基本准直的光源。 源包括由准直激光源激发的样品，并且还包括具有在源被激发的激发波长处反射光的特征的全息陷波滤波器。 像差校正凹面聚焦衍射光栅接收准直光并将其聚焦在与其波长对应的点处。 检测器检测由衍射光栅聚焦的期望波长的光。 全息陷波滤波器被定位成对要被滤波的基本上准直的光源进行滤波，并且全息陷波滤波器基本上相对于准直激光光源成一定角度取向，从而导致准直激光光源的路径长度 通过陷波滤波器的路径长度，其使得准直激光被滤光器反射离开光栅。 光栅是像差校正凹面聚焦衍射光栅。 准直光是具有大约十毫米的宽度的束的形式。

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