公开(公告)号：US20220395442A1

公开(公告)日：2022-12-15

申请号：US17774971

申请日：2020-10-29

Applicant: Colgate-Palmolive Company ,  Regents of the University of Michigan

Inventor： Carlo DAEP ,  Deon HINES ,  Harsh Mahendra TRIVEDI ,  James MASTERS ,  LaTonya KILPATRICK-LIVERMAN ,  Luciana RINAUDI MARRON ,  Lynette ZAIDEL ,  Alexander H. RICKARD ,  Derek S. SAMARIAN ,  Rachel GICQUELAIS ,  Gregory KRUSE

IPC: A61K8/44 ,  A61K8/49 ,  A61K8/27 ,  A61K8/19 ,  A61Q17/00 ,  A61Q11/00

Abstract: Described herein are methods of treating biofilm (e.g. modifying surface topography, reducing thickness or reducing biovolume) and compositions and apparatus for use in carrying out such methods.

公开(公告)号：US20220219020A1

公开(公告)日：2022-07-14

申请号：US17707822

申请日：2022-03-29

Applicant: Colgate-Palmolive Company

Inventor： Dandan CHEN ,  Harsh Mahendra TRIVEDI ,  Peter R. HILLIARD ,  James MASTERS

IPC: A61Q11/00 ,  A61K8/44 ,  A61K8/21 ,  A61K8/24

Abstract: Provided herein is an oral care composition comprising a basic amino acid or a salt thereof in an amount of from 0.001 weight % to 0.08 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.

公开(公告)号：US20220091101A1

公开(公告)日：2022-03-24

申请号：US17309896

申请日：2019-12-17

Applicant: Colgate-Palmolive Company

Inventor： Camille ZENOBIA ,  Harsh TRIVEDI ,  Ying YANG ,  Carlo DAEP ,  James MASTERS

IPC: G01N33/50 ,  C12N1/20 ,  G09B23/30

Abstract: An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.

公开(公告)号：US20190262254A1

公开(公告)日：2019-08-29

申请号：US16406069

申请日：2019-05-08

Applicant: Colgate-Palmolive Company

Inventor： Shamim ANSARI ,  Harsh Mahendra TRIVEDI ,  James MASTERS

IPC: A61K8/73 ,  A61K8/9794 ,  A61Q11/00 ,  A61K8/92 ,  A61K8/34

Abstract: Disclosed herein are oral care compositions comprising hemp seed oil and caprylyl glycol. In certain embodiments, the oral care composition optionally further comprises one or more ingredients selected from hyaluronic acid and aloe vera. Methods of making and using the compositions are also provided.

公开(公告)号：US20190117536A1

公开(公告)日：2019-04-25

申请号：US16225588

申请日：2018-12-19

Applicant: Colgate-Palmolive Company

Inventor： Long PAN ,  Jairajh MATTAI ,  Shaotang YUAN ,  James MASTERS

IPC: A61K8/27 ,  A61Q17/00 ,  A61Q5/02 ,  A61Q15/00 ,  A61K8/44 ,  C07F3/06 ,  A61Q11/00 ,  A61Q19/10 ,  A61Q5/12

Abstract: The invention provides a zinc-lysine complex having the formula [Zn(C6H14N2O2)2Cl]+Cl− having antibacterial and antiperspirant properties, together with personal care compositions comprising the complex, and methods of making and using these complexes and compositions.

公开(公告)号：US20180110228A1

公开(公告)日：2018-04-26

申请号：US15788852

申请日：2017-10-20

Applicant: Colgate-Palmolive Company ,  The Trustees of the University of Pennsylvania

Inventor： Carl MYERS ,  Carlo DAEP ,  Lynette ZAIDEL ,  James MASTERS ,  Russell COMPOSTO ,  Hyun-Su LEE

IPC: A01N47/44 ,  C08F126/02 ,  C08F8/30 ,  A61K8/81 ,  C09D139/00 ,  A01N25/08 ,  C09D5/14 ,  A61Q11/00

CPC classification number: A01N47/44 ,  A01N25/08 ,  A61K8/817 ,  A61K8/91 ,  A61K31/785 ,  A61K2800/30 ,  A61K2800/5426 ,  A61Q11/00 ,  A61Q17/005 ,  C08F8/30 ,  C08F126/02 ,  C09D5/14 ,  C09D139/00 ,  C11D3/3769 ,  C11D3/48 ,  A01N25/12

Abstract: Antimicrobial compositions and methods for depositing or coating the antimicrobial or antibacterial compositions on a substrate to prevent microbial adhesion are provided. The antimicrobial composition may include a cationic polymer having a poly-allylamine backbone. A portion of the poly-allylamine backbone may be functionalized with at least one of a guanidine functional group and a biguanide functional group.

公开(公告)号：US20170368375A1

公开(公告)日：2017-12-28

申请号：US15533697

申请日：2015-12-17

Applicant: Colgate-Palmolive Company

Inventor： Dandan CHEN ,  Harsh Mahendra TRIVEDI ,  Peter R. HILLIARD ,  James MASTERS

IPC: A61Q11/00 ,  A61K8/21 ,  A61K8/24 ,  A61K8/44

CPC classification number: A61Q11/00 ,  A61K8/21 ,  A61K8/24 ,  A61K8/44

Abstract: Provided herein is an oral care composition comprising a basic amino acid or a salt thereof in an amount of from 0.001 weight % to 0.08 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.

公开(公告)号：US20170333311A1

公开(公告)日：2017-11-23

申请号：US15668857

申请日：2017-08-04

Applicant: Colgate-Palmolive Company

Inventor： Long Pan ,  Jairajh MATTAI ,  Shaotang YUAN ,  James MASTERS

IPC: A61K8/27 ,  A61Q11/00 ,  A61Q5/02 ,  A61K8/44 ,  A61Q19/10 ,  A61Q17/00 ,  A61Q15/00 ,  C07F3/06 ,  A61Q5/12

CPC classification number: A61K8/27 ,  A61K8/44 ,  A61K2800/58 ,  A61K2800/591 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q17/005 ,  A61Q19/10 ,  C07B2200/13 ,  C07F3/06

Abstract: The invention provides a zinc-lysine complex having the formula [Zn(C6H14N2O2)2Cl]+Cl− having antibacterial and antiperspirant properties, together with personal care compositions comprising the complex, and methods of making and using these complexes and compositions.

公开(公告)号：US20230346670A1

公开(公告)日：2023-11-02

申请号：US18029518

申请日：2021-09-30

Applicant: Colgate-Palmolive Company ,  Katholieke Universiteit Leuven ,  Universiteit Gent

Inventor： Wim TEUGHELS ,  Tim VERSPECHT ,  Kristel BERNAERTS ,  Marc QUIRYNEN ,  Nico BOON ,  Carlo DAEP ,  James MASTERS

IPC: A61Q11/00 ,  A61K8/60

CPC classification number: A61K8/60 ,  A61Q11/00 ,  A61K2800/70

Abstract: The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from hemolysin, N-acetyl-D-glucosamine, α-D-lactose, D-(+)-trehalose or D-(+)-raffinose and mixtures thereof; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.

公开(公告)号：US20220313587A1

公开(公告)日：2022-10-06

申请号：US17250583

申请日：2020-11-12

Applicant: Colgate-Palmolive Company ,  University of Florida Research Foundation, Incorporated

Inventor： Payal ARORA ,  Harsh Mahendra TRIVEDI ,  James MASTERS ,  Rabab AHMED ,  Sarita Vera MELLO ,  Sergio LEITE ,  Venda Porter MALONEY ,  Gill DIAMOND ,  Vyoma PATEL

IPC: A61K8/67 ,  A61K8/34 ,  A61K8/25 ,  A61K8/19 ,  A61Q11/00

Abstract: Described herein are oral care compositions comprising vitamin D, or a derivative thereof. Methods of making and using these compositions are also described.