公开(公告)号：US20240050942A1

公开(公告)日：2024-02-15

申请号：US18257819

申请日：2021-12-14

Applicant: Colgate-Palmolive Company

Inventor： Carlo DAEP ,  Ayoub HBAICH

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/5025 ,  B01L2300/0609 ,  B01L2300/0829 ,  B01L2300/123 ,  B01L2300/0877 ,  B01L2200/0689

Abstract: A device for testing aqueous laboratory samples in one embodiment includes a base member extending along a longitudinal axis and defining a plurality of sample chambers recessed in a first outer surface. A resiliently deformable first gasket is disposed on the first outer surface and comprises openings each corresponding to a respective one of the chambers. At least a first cover glass is disposed on the first gasket to enclose the openings. A peripheral clamping frame disposed on the first cover glass comprises resiliently flexible cantilevered locking protrusions configured to form a snap interlock with the base member and compress the first cover glass between the clamping frame and first gasket to seal the chambers. Some embodiments include a second resiliently deformable gasket compressed between the clamping frame and first cover glass. Fluid couplings associated with each chamber allow fluid to enter and exit the chambers.

公开(公告)号：US20220071868A1

公开(公告)日：2022-03-10

申请号：US17309895

申请日：2019-12-17

Applicant: Colgate-Palmolive Company

Inventor： Camille ZENOBIA ,  Carlo DAEP ,  Dandan CHEN ,  Harsh Mahendra TRIVEDI ,  James MASTERS

IPC: A61K8/27 ,  A61K8/21

Abstract: Methods of increasing proteins that reduce signals associated with neutrophil recruitment and reducing proteins that induce neutrophil recruitment within an individuals gingival crevice are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase proteins that reduce signals associated with neutrophil recruitment and reduce proteins that induce neutrophil recruitment within an individuals gingival crevice, an oral care composition comprising: zinc oxide, zinc citrate, stannous fluoride, and optionally arginine and/or zingerone.

公开(公告)号：US20190015313A1

公开(公告)日：2019-01-17

申请号：US16067014

申请日：2016-12-30

Applicant: Colgate-Palmolive Company

Inventor： Carlo DAEP ,  Michael FITZGERALD ,  Ekta MAKWANA ,  Peter R. HILLIARD, JR. ,  Shamim ANSARI ,  Robert D'AMBROGIO

IPC: A61K8/64 ,  A61K47/60 ,  A61K38/17 ,  A61K8/21 ,  A61K8/27 ,  A61K8/02

Abstract: Disclosed herein is mucin-coated silica, compositions comprising the same, and methods of promoting the aggregation and/or clearance of oral bacteria using such compositions.

公开(公告)号：US20240150809A1

公开(公告)日：2024-05-09

申请号：US18548719

申请日：2022-03-03

Applicant: Colgate-Palmolive Company ,  The Ohio State University

Inventor： Carlo DAEP ,  Paul STOODLEY ,  Erin GLOAG

IPC: C12Q1/18 ,  C12Q1/02

CPC classification number: C12Q1/18 ,  C12Q1/02

Abstract: Disclosed are methods of monitoring the detachment of a biofilm from the surface of an object or rearrangement of the structure of the biofilm in response to shear stress and also methods of identifying compositions having biofilm detachment activity or evaluating the biofilm detachment efficacy of compositions.

公开(公告)号：US20220071877A1

公开(公告)日：2022-03-10

申请号：US17309859

申请日：2019-12-17

Applicant: Colgate-Palmolive Company

Inventor： Camille Zenobia ,  Carlo DAEP ,  Dandan CHEN ,  Harsh Mahendra TRIVEDI ,  James MASTERS

IPC: A61K8/44 ,  A61K8/27 ,  A61K8/21 ,  A61Q11/00

Abstract: Methods of shifting biofilm composition in an individuals oral cavity are disclosed. The methods comprise applying to the individuals oral cavity an oral care composition in an amount effective to shift biofilm composition to increase the amount from healthy bacteria in biofilm relative to pathogenic bacteria in biofilm. The oral care composition comprising: zinc oxide, zinc citrate, and arginine. The shift in biofilm composition provides a balance having a greater amount of healthy bacteria in biofilm compared to pathogenic bacteria.

公开(公告)号：US20210299018A1

公开(公告)日：2021-09-30

申请号：US17214731

申请日：2021-03-26

Applicant: Colgate-Palmolive Company

Inventor： Carlo DAEP ,  Harsh Mahendra TRIVEDI ,  Paul THOMSON

IPC: A61K8/43 ,  A61K8/27 ,  A61K8/21 ,  A61Q11/00 ,  A61Q11/02

Abstract: This invention relates to oral care compositions comprising guanidine, zinc citrate and zinc oxide, and a fluoride source, as well as to methods of using and of making these compositions.

公开(公告)号：US20190142365A1

公开(公告)日：2019-05-16

申请号：US16186639

申请日：2018-11-12

Applicant: Colgate-Palmolive Company

Inventor： Xiaonan ZHANG ,  Alan SORRENTINO ,  Carlo DAEP ,  Zi WU

IPC: A61B8/08 ,  A61C17/22 ,  A61B8/12 ,  A61B8/00

Abstract: An ultrasonic system may include: an oral care device including: a head; a plurality of teeth cleaning elements extending from a first side of the head; and an ultrasound module including an ultrasound transceiver positioned in the head, the ultrasound transceiver configured to produce an ultrasound signal on the first side of the head and to generate a detection signal from a reflected ultrasound signal; and a processing module operably coupled to the ultrasound module to receive the detection signal; wherein the processing module includes a programmable processor configured to process the detection signal non-linearly with respect to time by first identifying a first reflection representing a surface of a tooth and then determining whether a second reflection peak is present in the detection signal at a time prior to the first reflection peak, the second reflection peak representing a biofilm on the surface of the tooth.

公开(公告)号：US20230346670A1

公开(公告)日：2023-11-02

申请号：US18029518

申请日：2021-09-30

Applicant: Colgate-Palmolive Company ,  Katholieke Universiteit Leuven ,  Universiteit Gent

Inventor： Wim TEUGHELS ,  Tim VERSPECHT ,  Kristel BERNAERTS ,  Marc QUIRYNEN ,  Nico BOON ,  Carlo DAEP ,  James MASTERS

IPC: A61Q11/00 ,  A61K8/60

CPC classification number: A61K8/60 ,  A61Q11/00 ,  A61K2800/70

Abstract: The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from hemolysin, N-acetyl-D-glucosamine, α-D-lactose, D-(+)-trehalose or D-(+)-raffinose and mixtures thereof; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.

公开(公告)号：US20230092135A1

公开(公告)日：2023-03-23

申请号：US17951734

申请日：2022-09-23

Applicant: Colgate-Palmolive Company

Inventor： Carlo DAEP ,  Rabab AHMED

IPC: A61K8/43 ,  A61K8/41 ,  A61K8/21 ,  A61K8/27 ,  A61Q11/00

Abstract: The disclosure relates to oral care compositions comprising guanidine in free or orally acceptable salt form, a cationic quaternary ammonium compound (e.g., a pyridinium compound) (e.g., cetyl pyridinium chloride (CPC)), a fluoride source, and optionally a zinc source (e.g., zinc lactate or zinc citrate and zinc oxide) as well as to methods of using and of making these compositions.

公开(公告)号：US20220257491A1

公开(公告)日：2022-08-18

申请号：US17673480

申请日：2022-02-16

Applicant: Colgate-Palmolive Company ,  Katholieke Universiteit Leuven ,  Universiteit Gent

Inventor： Wim TEUGHELS ,  Tim VERSPECHT ,  Kristel BERNAERTS ,  Marc QUIRYNEN ,  Nico BOON ,  Carlo DAEP ,  James MASTERS

IPC: A61K8/60 ,  A61K8/25 ,  A61K8/29 ,  A61K8/34 ,  A61K8/21 ,  A61Q11/00

Abstract: The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-mannose, N-acetyl-D-mannosamine and mixtures thereof; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.