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公开(公告)号：US20220071867A1
公开(公告)日：2022-03-10
申请号：US17309858
申请日：2019-12-17
Applicant: Colgate-Palmolive Company
Inventor： Camille ZENOBIA , Carlo DAEP , Dandan CHEN , Harsh Mahendra TRIVEDI , James MASTERS
Abstract: Methods of increasing proteins that reduce signals associated with neutrophil recruitment and reducing proteins that induce neutrophil recruitment within an individuals gingival crevice are disclosed. The methods comprise applying to the individuals oral cavity in an amount effective to increase proteins that reduce signals associated with neutrophil recruitment and reduce proteins that induce neutrophil recruitment within an individuals gingival crevice, an oral care composition comprising: zinc phosphate, stannous fluoride and optionally, an organic acid buffer system.
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公开(公告)号：US20240024233A1
公开(公告)日：2024-01-25
申请号：US18251428
申请日：2021-11-03
Applicant: Colgate-Palmolive Company
Inventor： Lisa MANUS , Joseph STEELE , Guillaume PICQUET , Christine PADULA , Dandan CHEN , Betty WON , Andrei POTANIN
Abstract: The present invention relates to oral hydrogel compositions, more particularly to thermosensitive gel compositions, which undergo a sol-gel transition in the oral cavity, and which optionally comprise therapeutic actives for sustained release.
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3.发明公开公开(公告)号：US20230250490A1
公开(公告)日：2023-08-10
申请号：US18167664
申请日：2023-02-10
Applicant: Colgate-Palmolive Company
Inventor： Dandan CHEN , Harsj Mahendra TRIVEDI , James MASTERS , Richard P. DARVEAU , Jeffrey S. MCLEAN
IPC: C12Q1/689
CPC classification number: C12Q1/689 , C12Q2600/106
Abstract: Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. The methods are based on the temporal difference in the shift of the ratio of Bacteroidetes to Firmicutes in subgingival plaque samples taken from healthy tissue that is distant from the site of plaque induced inflammation. Methods of treating gingivitis and methods of preventing, reducing the severity of or delaying onset of gingivitis in an individual who is a slow gingivitis responder or a high gingivitis responder are disclosed.
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公开(公告)号：US20230076737A1
公开(公告)日：2023-03-09
申请号：US17668456
申请日：2022-02-10
Applicant: Colgate-Palmolive Company
Inventor： Dandan CHEN , Harsh Mahendra TRIVEDI , James MASTERS , Richard P. DARVEAU , Jeffrey S. MCLEAN
IPC: G01N33/68
Abstract: Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. Some methods are based on IL-1β levels in the individual's GCF at the site of inflammation. Some methods are based on MIF and/or CCL-1 levels in the individual's GCF in healthy tissue distant from the site of inflammation. Some disclosed methods are based on temporal differences in IL-8, IL-6 and/or TNFα levels in the individual's GCF in healthy tissue distant from the site of inflammation during the development of plaque induced inflammation. Methods of treating an individual who has gingivitis and methods of preventing gingivitis are also provided. The treatment and prevention methods comprise determining if individual is a slow gingivitis responder or a high gingivitis responder and applying oral care compositions to the individual's oral cavity.
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公开(公告)号：US20220071868A1
公开(公告)日：2022-03-10
申请号：US17309895
申请日：2019-12-17
Applicant: Colgate-Palmolive Company
Inventor： Camille ZENOBIA , Carlo DAEP , Dandan CHEN , Harsh Mahendra TRIVEDI , James MASTERS
Abstract: Methods of increasing proteins that reduce signals associated with neutrophil recruitment and reducing proteins that induce neutrophil recruitment within an individuals gingival crevice are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase proteins that reduce signals associated with neutrophil recruitment and reduce proteins that induce neutrophil recruitment within an individuals gingival crevice, an oral care composition comprising: zinc oxide, zinc citrate, stannous fluoride, and optionally arginine and/or zingerone.
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Patent Agency Ranking
公开(公告)号：US20170368376A1
公开(公告)日：2017-12-28
申请号：US15629190
申请日：2017-06-21
Applicant: Colgate-Palmolive Company
Inventor： Ying Yang , Dandan CHEN , Robert D'AMBROGIO , Paul THOMSON , Harsh Mahendra TRIVEDI , Michael PRENCIPE , James MASTERS , Stanislav JARACZ
CPC classification number: A61Q11/00 , A61K8/21 , A61K8/22 , A61K8/27 , A61K8/34 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/97 , A61K36/9068 , A61K45/06 , A61Q17/005
Abstract: This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.
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公开(公告)号：US20220219020A1
公开(公告)日：2022-07-14
申请号：US17707822
申请日：2022-03-29
Applicant: Colgate-Palmolive Company
Inventor： Dandan CHEN , Harsh Mahendra TRIVEDI , Peter R. HILLIARD , James MASTERS
Abstract: Provided herein is an oral care composition comprising a basic amino acid or a salt thereof in an amount of from 0.001 weight % to 0.08 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.
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公开(公告)号：US20170368375A1
公开(公告)日：2017-12-28
申请号：US15533697
申请日：2015-12-17
Applicant: Colgate-Palmolive Company
Inventor： Dandan CHEN , Harsh Mahendra TRIVEDI , Peter R. HILLIARD , James MASTERS
Abstract: Provided herein is an oral care composition comprising a basic amino acid or a salt thereof in an amount of from 0.001 weight % to 0.08 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.
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公开(公告)号：US20170348213A1
公开(公告)日：2017-12-07
申请号：US15537975
申请日：2014-12-24
Applicant: Colgate-Palmolive Company
Inventor： Yun Xu , Guangxin LIN , Yuyan ZENG , Wei SONG , Hailiang LU , Dandan CHEN , Shao Peng XU
CPC classification number: A61K8/466 , A61K8/25 , A61K8/602 , A61K8/678 , A61K8/90 , A61K2800/28 , A61K2800/48 , A61K2800/522 , A61K2800/75 , A61Q11/00
Abstract: Provided herein is an oral care composition comprising an antioxidant and a surfactant system, wherein the surfactant system comprises sodium methyl cocoyl taurate in an amount of from 0.7 weight % to 1.2 weight % by total weight of the composition and optionally, a poloxamer in an amount of from 0.4 to 1.2 weight % by total weight of the composition. The composition is useful for preventing or treating periodontal disease.
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公开(公告)号：US20250041196A1
公开(公告)日：2025-02-06
申请号：US18717936
申请日：2022-12-07
Applicant: Colgate-Palmolive Company
Inventor： Yuzhi DENG , Dandan CHEN , Diana Liceth HENAO ADLEVANKIN , Joseph Allan McKinnon STEELE , Julia Maighdlin DUGDALE , Paul THOMSON , Payal ARORA , Manisha JHA , Lisa Marie MANUS , Ying YANG
Abstract: Oral care compositions and methods for treating, preventing, or inhibiting dry mouth and/or inflammation of the oral cavity or a surface thereof are disclosed. Oral care compositions for improving oral care by treating, preventing, or otherwise inhibiting discomfort, irritation, or gum pain of the oral cavity are also disclosed. The oral care composition may include an orally acceptable vehicle, hyaluronic acid, and one or more benefit agents. The method for treating, preventing, or inhibiting dry mouth and/or inflammation of the oral cavity or a surface thereof may include contacting the oral cavity or the surface thereof with the oral care compositions.
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