公开(公告)号：US20240027481A1

公开(公告)日：2024-01-25

申请号：US18164918

申请日：2023-02-06

Applicant: NanoCytomics, LLC ,  Northwestern University

Inventor： Jarema Czarnecki ,  Justin Derbas ,  Sergey Rozhok ,  Hariharan Subramanian ,  Parvathi Viswanathan

IPC: G01N35/00 ,  G01N1/31 ,  G01N35/10 ,  G01N1/28

CPC classification number: G01N35/00029 ,  G01N1/312 ,  G01N35/1011 ,  G01N1/2813 ,  G01N35/1065 ,  G01N35/00871 ,  G01N2035/00138 ,  G01N2035/00168 ,  G01N2035/00881 ,  G01N2001/317

Abstract: Systems and methods that enable automated spray deposition of biological specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to automated specimen deposition systems and methods of generating high-quality, reproducible specimen-bearing microscope slides in automated processing systems.

公开(公告)号：US10584389B2

公开(公告)日：2020-03-10

申请号：US15727924

申请日：2017-10-09

Applicant: NORTHWESTERN UNIVERSITY ,  NorthShore University HealthSystem

Inventor： Vadim Backman ,  Hariharan Subramanian ,  Dhwanil Damania ,  Hemant Roy ,  Dhananjay Kunte ,  Mart Angelo De la Cruz

IPC: C12Q1/68 ,  C12Q1/6886 ,  G01N21/41 ,  G01N33/574 ,  C12Q1/6806 ,  G01N21/64 ,  G01N1/28

Abstract: The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject.

公开(公告)号：US10229310B2

公开(公告)日：2019-03-12

申请号：US15794101

申请日：2017-10-26

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Vadim Backman ,  Hariharan Subramanian ,  John E. Chandler ,  Craig White ,  Jeremy D. Rogers ,  Lusik Cherkezyan

IPC: G06K9/00 ,  G02B21/36 ,  G02B21/06 ,  G02B21/16 ,  H04N21/232 ,  H04N21/235 ,  G01J3/44 ,  G01J3/12 ,  G01J3/28 ,  G01N21/47 ,  H04N5/235 ,  H04N5/232

Abstract: The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (PWS) microscopic images. In particular, provided herein are high-throughput, automated partial wave spectroscopy (HT/A-PWS) instruments and systems capable of rapid acquisition of PWS Microscopic images and clinical, diagnostic, and research applications thereof.

公开(公告)号：US20180129863A1

公开(公告)日：2018-05-10

申请号：US15794101

申请日：2017-10-26

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Vadim Backman ,  Hariharan Subramanian ,  John E. Chandler ,  Craig White ,  Jeremy D. Rogers ,  Lusik Cherkezyan

IPC: G06K9/00 ,  H04N5/235 ,  H04N5/232 ,  G02B21/36 ,  G02B21/16 ,  G01J3/12 ,  G02B21/06 ,  G01N21/47 ,  G01J3/44 ,  G01J3/28

CPC classification number: G06K9/00127 ,  G01J3/1256 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/47 ,  G01N2021/4709 ,  G02B21/06 ,  G02B21/16 ,  G02B21/365 ,  H04N5/23212 ,  H04N5/2354

Abstract: The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (PWS) microscopic images. In particular, provided herein are high-throughput, automated partial wave spectroscopy (HT/A-PWS) instruments and systems capable of rapid acquisition of PWS Microscopic images and clinical, diagnostic, and research applications thereof.

公开(公告)号：US09783855B2

公开(公告)日：2017-10-10

申请号：US14747596

申请日：2015-06-23

Applicant: Northwestern University ,  NorthShore University HealthSystem

Inventor： Vadim Backman ,  Hariharan Subramanian ,  Dhwanil Damania ,  Hemant Roy ,  Dhananjay Kunte ,  Mart Angelo De la Cruz

IPC: C12Q1/68 ,  G01N1/28 ,  G01N21/41 ,  G01N33/574 ,  G01N21/64

CPC classification number: C12Q1/6886 ,  C12Q1/6806 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  G01N21/41 ,  G01N21/64 ,  G01N21/6486 ,  G01N33/57407 ,  G01N33/57411 ,  G01N33/57419 ,  G01N33/57484

Abstract: The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject.

公开(公告)号：US12196770B2

公开(公告)日：2025-01-14

申请号：US18333828

申请日：2023-06-13

Applicant: NanoCytomics, LLC ,  Northwestern University

Inventor： Hariharan Subramanian ,  Michael Verleye ,  Micah Litow ,  Justin R. Derbas ,  Sergey Rozhok ,  John Hart ,  Chester Henderson ,  Rebecca Bartel ,  Nathan Ray ,  Anthony White

IPC: G01N1/00 ,  G01N1/28 ,  G01N1/31 ,  G01N35/00 ,  G01N35/10

Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

公开(公告)号：US20240133905A1

公开(公告)日：2024-04-25

申请号：US18333828

申请日：2023-06-12

Applicant: NanoCytomics, LLC ,  Northwestern University

Inventor： Hariharan Subramanian ,  Michael Verleye ,  Micah Litow ,  Justin R. Derbas ,  Sergey Rozhok ,  John Hart ,  Chester Henderson ,  Rebecca Bartel ,  Nathan Ray ,  Anthony White

IPC: G01N35/00 ,  G01N1/28 ,  G01N1/31 ,  G01N35/10

CPC classification number: G01N35/00029 ,  G01N1/2813 ,  G01N1/312 ,  G01N35/1002 ,  G01N2001/317 ,  G01N2035/00039

Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

公开(公告)号：US11719712B2

公开(公告)日：2023-08-08

申请号：US17258873

申请日：2019-07-10

Applicant: NanoCytomics, LLC ,  Northwestern University

Inventor： Hariharan Subramanian ,  Michael Verleye ,  Micah Litow ,  Justin R. Derbas ,  Sergey Rozhok ,  John Hart ,  Chester Henderson ,  Rebecca Bartel ,  Nathan Ray ,  Anthony White

IPC: G01N1/00 ,  G01N35/00 ,  G01N1/28 ,  G01N1/31 ,  G01N35/10

CPC classification number: G01N35/00029 ,  G01N1/2813 ,  G01N1/312 ,  G01N35/1002 ,  G01N2001/317 ,  G01N2035/00039

Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

公开(公告)号：US11573242B2

公开(公告)日：2023-02-07

申请号：US17751127

申请日：2022-05-23

Applicant: NanoCytomics, LLC ,  Northwestern University

Inventor： Jarema Czarnecki ,  Justin Derbas ,  Sergey Rozhok ,  Hariharan Subramanian ,  Parvathi Viswanathan

IPC: G01N1/00 ,  G01N35/00 ,  G01N1/31 ,  G01N35/10 ,  G01N1/28

Abstract: Systems and methods that enable automated spray deposition of biological specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to automated specimen deposition systems and methods of generating high-quality, reproducible specimen-bearing microscope slides in automated processing systems.

公开(公告)号：US11460383B2

公开(公告)日：2022-10-04

申请号：US16310130

申请日：2017-06-16

Applicant: NanoCytomics, LLC ,  NORTHWESTERN UNIVERSITY

Inventor： Sergey Rozhok ,  Justin R. Derbas ,  Jarema Czarnecki ,  Hariharan Subramanian

IPC: G01N1/31 ,  G01N1/30 ,  B05C3/02 ,  B05C3/08 ,  G01N1/28

Abstract: Automated cell staining systems and methods are disclosed herein. In particular, the staining systems disclosed herein provide low-volume, automated bench top staining systems for staining biological samples contained on a cytological slide.