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    Microfluidic Separation Device
    11.
    发明申请
    Microfluidic Separation Device 有权
    微流控分离装置

    公开(公告)号：US20130266479A1

    公开(公告)日：2013-10-10

    申请号：US13796939

    申请日：2013-03-12

    Applicant: ONDAVIA, INC.

    Inventor： Mark C. Peterman ,  Merwan Benhabib ,  Benjamin A. Obrock

    IPC: G01N21/65

    CPC classification number: G01N21/658 ,  B01D57/02 ,  B01D61/427 ,  B01L3/502761

    Abstract: A microfluidic separation device is provided that includes a first sample channel region and a second sample channel region, where the first sample channel region has an array of channels that are smaller than the second channel region, a first detection region and a second detection region located at the interface of the first sample channel region, a detection channel, an illuminating electric field, Raman-scattering nanoparticles having surface plasmon resonances for detection when illuminated by the electric field, where the resonances create an enhanced local electric field along specific directions resulting in an enhanced Raman response, and a nanoparticle input channel disposed to input the nanoparticles into the second sample channel region, where the nanoparticles are larger than the cross-section of the first sample channel region and the cross-section of the second detection region, where the nanoparticles collect in the first detection region to form region of densely packed nanoparticles.

    Abstract translation: 提供了一种微流体分离装置，其包括第一样品通道区域和第二样品通道区域，其中第一样品通道区域具有小于第二通道区域的通道阵列，第一检测区域和第二检测区域 在第一样品通道区域的界面处，检测通道，照明电场，具有用于通过电场照射的检测的表面等离子体共振的拉曼散射纳米颗粒，其中共振沿着特定方向产生增强的局部电场，导致 增强的拉曼响应和纳米颗粒输入通道，其设置成将纳米颗粒输入到第二样品通道区域中，其中纳米颗粒大于第一样品通道区域的横截面和第二检测区域的横截面，其中 纳米颗粒在第一检测区域中收集以形成密集的区域 ed纳米颗粒。

    Measuring concentration of analytes in liquid samples using surface-enhanced Raman spectroscopy
    13.
    发明授权
    Measuring concentration of analytes in liquid samples using surface-enhanced Raman spectroscopy 有权

    公开(公告)号：US11415565B2

    公开(公告)日：2022-08-16

    申请号：US17118482

    申请日：2020-12-10

    Applicant: OndaVia, Inc.

    Inventor： Mark Charles Peterman ,  Merwan Benhabib ,  Carlos Atico Ariza ,  Samuel Louis Kleinman

    IPC: G01N33/18 ,  G01N21/65

    Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port and a cartridge for input to the cartridge receiving port. An optical detection system in the housing is capable of providing an illuminated electric field useful for Raman spectroscopy. The cartridge may have a sample well. The sample well is loaded with a mixture of water containing the analyte, Raman-scattering nanoparticles and a calibration solution. The calibration solution contains an analogue of the analyte differing in its Raman response, for example an isotope of the analyte. Optionally, a chemical compound capable of increasing interaction between the analyte and the nanoparticles may be added.

    Measuring concertation of analytes in liquid samples using surface-enhanced Raman spectroscopy
    14.
    发明授权
    Measuring concertation of analytes in liquid samples using surface-enhanced Raman spectroscopy 有权

    公开(公告)号：US10684267B2

    公开(公告)日：2020-06-16

    申请号：US16560579

    申请日：2019-09-04

    Applicant: OndaVia, Inc.

    Inventor： Mark Charles Peterman ,  Merwan Benhabib ,  Carlos Atico Ariza ,  Samuel Louis Kleinman

    IPC: G01N33/18 ,  G01N21/65

    Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port and a cartridge for input to the cartridge receiving port. An optical detection system in the housing is capable of providing an illuminated electric field useful for Raman spectroscopy. The cartridge may have a sample well. The sample well is loaded with a mixture of water containing the analyte, Raman-scattering nanoparticles and a calibration solution. The calibration solution contains an analogue of the analyte differing in its Raman response, for example an isotope of the analyte. Optionally, a chemical compound capable of increasing interaction between the analyte and the nanoparticles may be added.

    Microfluidic separation device
    16.
    发明授权
    Microfluidic separation device 有权
    微流控分离装置

    公开(公告)号：US08999263B2

    公开(公告)日：2015-04-07

    申请号：US13796939

    申请日：2013-03-12

    Applicant: OndaVia, Inc.

    Inventor： Mark C. Peterman ,  Merwan Benhabib ,  Benjamin A. Obrock

    IPC: G01N21/65 ,  B01L3/00 ,  B01D57/02 ,  B01D61/42

    CPC classification number: G01N21/658 ,  B01D57/02 ,  B01D61/427 ,  B01L3/502761

    Abstract: A microfluidic separation device is provided that includes a first sample channel region and a second sample channel region, where the first sample channel region has an array of channels that are smaller than the second channel region, a first detection region and a second detection region located at the interface of the first sample channel region, a detection channel, an illuminating electric field, Raman-scattering nanoparticles having surface plasmon resonances for detection when illuminated by the electric field, where the resonances create an enhanced local electric field along specific directions resulting in an enhanced Raman response, and a nanoparticle input channel disposed to input the nanoparticles into the second sample channel region, where the nanoparticles are larger than the cross-section of the first sample channel region and the cross-section of the second detection region, where the nanoparticles collect in the first detection region to form region of densely packed nanoparticles.

    Abstract translation: 提供了一种微流体分离装置，其包括第一样品通道区域和第二样品通道区域，其中第一样品通道区域具有小于第二通道区域的通道阵列，第一检测区域和第二检测区域 在第一样品通道区域的界面处，检测通道，照明电场，具有用于通过电场照射的检测的表面等离子体共振的拉曼散射纳米颗粒，其中共振沿着特定方向产生增强的局部电场，导致 增强的拉曼响应和纳米颗粒输入通道，其设置成将纳米颗粒输入到第二样品通道区域中，其中纳米颗粒大于第一样品通道区域的横截面和第二检测区域的横截面，其中 纳米颗粒在第一检测区域中收集以形成密集的区域 ed纳米颗粒。

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