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公开(公告)号：US20190129158A1
公开(公告)日：2019-05-02
申请号：US16146518
申请日：2018-09-28
Applicant: SamanTree Medical SA
Inventor： Etienne Shaffer , Jonathan Abel Pirolet , Frédéric Schmitt , Bastien Rachet , Diego Joss
Abstract: Disclosed herein are sample dishes for use with microscopes that are simple to mount on a microscope and facilitate easy manipulation of tissue samples disposed thereon during imaging as well as methods of their use. A sample dish comprises an optical interface and, optionally, a support member that holds the optical interface. The optical interface of a sample dish is suitably transparent and planar such that a focal plane of a microscope can reside uniformly at or within a surface of a sample during imaging. In certain embodiments, a support member comprises a dish for holding excess fluid. In certain embodiments, a sample dish comprises separation ribs. In certain embodiments, a sample dish comprises one or more manipulation members (e.g., tabs). In certain embodiments, a sample dish is used with an imaging artifact reducing fluid.
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12.发明申请公开(公告)号：US20160305926A1
公开(公告)日：2016-10-20
申请号：US15087601
申请日：2016-03-31
Applicant: SamanTree Medical SA
Inventor： Bastien Rachet , Davor Kosanic , Etienne Shaffer
IPC: G01N33/483 , G01N21/64 , G02B21/16
CPC classification number: G01N21/77 , G01N21/6428 , G01N21/6458 , G01N33/4833 , G01N2021/6439 , G01N2021/6463 , G01N2021/7786 , G01N2201/0633 , G01N2201/068 , G02B21/0012 , G02B21/0032 , G02B21/004 , G02B21/0044 , G02B21/0076 , G02B21/0088 , G02B21/16 , G02B21/24 , G02B21/26 , G02B21/34 , G02B21/361
Abstract: The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.
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公开(公告)号：US11966037B2
公开(公告)日：2024-04-23
申请号：US17739612
申请日：2022-05-09
Applicant: SamanTree Medical SA
Inventor： Etienne Shaffer , Jonathan Abel Pirolet , Frédéric Schmitt , Bastien Rachet , Diego Joss , Aurèle Timothée Horisberger
CPC classification number: G02B21/34 , G01N21/01 , G01N21/6428 , G02B21/367
Abstract: Disclosed herein are sample dishes for use with microscopes that are simple to mount on a microscope and facilitate easy manipulation of tissue samples disposed thereon during imaging as well as methods of their use. A sample dish comprises an optical interface and, optionally, a support member that holds the optical interface. The optical interface of a sample dish is suitably transparent and planar such that a focal plane of a microscope can reside uniformly at or within a surface of a sample during imaging. In certain embodiments, a support member comprises a dish for holding excess fluid. In certain embodiments, a sample dish comprises separation ribs. In certain embodiments, a sample dish comprises one or more manipulation members (e.g., tabs). In certain embodiments, a sample dish is used with an imaging artifact reducing fluid.
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公开(公告)号：US20230359007A1
公开(公告)日：2023-11-09
申请号：US18216980
申请日：2023-06-30
Applicant: SamanTree Medical SA
Inventor： Etienne Shaffer , Bastien Rachet , Aurèle Timothée Horisberger , Jonathan Abel Pirolet , Diego Joss , Andrey Naumenko , Frédéric Schmitt
CPC classification number: G02B21/0012 , G02B21/0076 , G02B21/008 , G02B21/368 , G02B21/0032 , G01N21/6428 , G01N21/6458 , G02B21/26 , G01N2021/6439 , A61B10/0266
Abstract: Disclosed herein are systems for imaging of samples, for example, using an array of micro optical elements and methods of their use. In some embodiments, an optical chip comprising an array of micro optical elements moves relative to an imaging window and a detector in order to scan over a sample to produce an image. A focal plane can reside within a sample or on its surface during imaging. In some embodiments, detecting optics a reused to detect back-emitted light collected by an array of micro optical elements that is generated by an illumination beam impinging on a sample. In some embodiments, an imaging system has a large field of view and a large optical chip such that an entire surface of a sample can be imaged quickly. In some embodiments, a sample is accessible by a user during imaging due to the sample being exposed.
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15.发明公开公开(公告)号：US20230175969A1
公开(公告)日：2023-06-08
申请号：US18103069
申请日：2023-01-30
Applicant: SamanTree Medical SA
Inventor： Bastien Rachet , Davor Kosanic , Etienne Shaffer
CPC classification number: G01N21/77 , G02B21/0032 , G02B21/004 , G02B21/0076 , G02B21/0088 , G02B21/26 , G02B21/34 , G02B21/361 , G01N21/6458 , G01N21/6428 , G01N33/4833 , G02B21/16 , G02B21/0044 , G02B21/24
Abstract: The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.
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Patent Agency Ranking
公开(公告)号：US11609416B2
公开(公告)日：2023-03-21
申请号：US17502431
申请日：2021-10-15
Applicant: SamanTree Medical SA
Inventor： Etienne Shaffer , Bastien Rachet , Aurèle Timothée Horisberger , Jonathan Abel Pirolet , Diego Joss , Andrey Naumenko , Frédéric Schmitt
IPC: G01N21/00 , G02B21/36 , G02B21/00 , A61B90/20 , G01N21/64 , G02B21/08 , G02B21/16 , H04N5/225 , H04N7/18
Abstract: Disclosed herein are systems for imaging of samples using an array of micro optical elements and methods of their use. In some embodiments, an optical chip comprising an array of micro optical elements moves relative to an imaging window and a detector in order to scan over a sample to produce an image. A focal plane can reside within a sample or on its surface during imaging. Detecting optics are used to detect back-emitted light collected by an array of micro optical elements that is generated by an illumination beam impinging on a sample. In some embodiments, an imaging system has a large field of view and a large optical chip such that an entire surface of a sample can be imaged quickly. In some embodiments, a sample is accessible by a user during imaging due to the sample being exposed while disposed on or over an imaging window.
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公开(公告)号：US20220035147A1
公开(公告)日：2022-02-03
申请号：US17502431
申请日：2021-10-15
Applicant: SamanTree Medical SA
Inventor： Etienne Shaffer , Bastien Rachet , Aurèle Timothée Horisberger , Jonathan Abel Pirolet , Diego Joss , Andrey Naumenko , Frédéric Schmitt
Abstract: Disclosed herein are systems for imaging of samples using an array of micro optical elements and methods of their use. In some embodiments, an optical chip comprising an array of micro optical elements moves relative to an imaging window and a detector in order to scan over a sample to produce an image. A focal plane can reside within a sample or on its surface during imaging. Detecting optics are used to detect back-emitted light collected by an array of micro optical elements that is generated by an illumination beam impinging on a sample. In some embodiments, an imaging system has a large field of view and a large optical chip such that an entire surface of a sample can be imaged quickly. In some embodiments, a sample is accessible by a user during imaging due to the sample being exposed while disposed on or over an imaging window.
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公开(公告)号：US10539776B2
公开(公告)日：2020-01-21
申请号：US16146695
申请日：2018-09-28
Applicant: SamanTree Medical SA
Inventor： Etienne Shaffer , Bastien Rachet , Aurèle Timothée Horisberger , Jonathan Abel Pirolet , Diego Joss
IPC: G01J3/46 , G02B21/36 , A61B90/20 , G01N21/64 , G02B21/00 , G02B21/08 , G02B21/16 , H04N5/225 , H04N7/18
Abstract: Disclosed herein are systems for imaging of samples using an array of micro optical elements and methods of their use. In some embodiments, an optical chip comprising an array of micro optical elements moves relative to an imaging window and a detector in order to scan over a sample to produce an image. A focal plane can reside within a sample or on its surface during imaging. Detecting optics are used to detect back-emitted light collected by an array of micro optical elements that is generated by an illumination beam impinging on a sample. In some embodiments, an imaging system has a large field of view and a large optical chip such that an entire surface of a sample can be imaged quickly. In some embodiments, a sample is accessible by a user during imaging due to the sample being exposed while disposed on or over an imaging window.
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19.发明公开公开(公告)号：US20240044805A1
公开(公告)日：2024-02-08
申请号：US18381379
申请日：2023-10-18
Applicant: SamanTree Medical SA
Inventor： Bastien Rachet , Davor Kosanic , Etienne Shaffer
CPC classification number: G01N21/77 , G02B21/0032 , G02B21/004 , G02B21/0076 , G02B21/0088 , G02B21/26 , G02B21/34 , G02B21/361 , G01N21/6458 , G01N21/6428 , G01N33/4833 , G02B21/16 , G02B21/0044 , G02B21/24
Abstract: The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.
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公开(公告)号：US11747603B2
公开(公告)日：2023-09-05
申请号：US16862497
申请日：2020-04-29
Applicant: SamanTree Medical SA
Inventor： Etienne Shaffer , Bastien Rachet , Aurèle Timothée Horisberger , Jonathan Abel Pirolet , Diego Joss , Andrey Naumenko , Frédéric Schmitt
CPC classification number: G02B21/0012 , G01N21/6428 , G01N21/6458 , G02B21/008 , G02B21/0032 , G02B21/0076 , G02B21/26 , G02B21/368 , A61B10/0266 , G01N2021/6439
Abstract: Exemplary systems are for imaging of samples, for example using an array of micro optical elements. In some embodiments, an optical chip including an array of micro optical elements moves relative to an imaging window and a detector in order to scan over a sample to produce an image. A focal plane can reside within a sample or on its surface during imaging. In some embodiments, detecting optics are used to detect back-emitted light collected by an array of micro optical elements that is generated by an illumination beam impinging on a sample. In some embodiments, an imaging system has a large field of view and a large optical chip such that an entire surface of a sample can be imaged quickly. In some embodiments, a sample is accessible by a user during imaging due to the sample being exposed.
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