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11.发明授权公开(公告)号：US11965100B2
公开(公告)日：2024-04-23
申请号：US17301941
申请日：2021-04-20
Inventor： Benzhong Tang , Ruoyao Zhang
CPC classification number: C09B23/06 , G01N21/6402 , G01N21/6428 , G01N21/6458 , G01N2021/6439 , G01N2201/06113
Abstract: Provided herein are aggregation-induced emission luminogens useful for imaging and/or detecting cancer cells and dynamically monitoring the viability of cancer cells and methods of use and preparation thereof.
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公开(公告)号：US11815457B2
公开(公告)日：2023-11-14
申请号：US17249369
申请日：2021-03-01
Inventor： Benzhong Tang , Liang Luo , Chenchen Liu
IPC: G01N21/64 , G01N21/359 , C07D417/04 , A61K49/00 , B82Y30/00 , B82Y5/00 , B82Y40/00 , B82Y15/00
CPC classification number: G01N21/6456 , A61K49/0093 , C07D417/04 , G01N21/359 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N2223/406 , G01N2223/6126
Abstract: Compounds including triphenylamine and luminol moieties exhibiting near-infrared chemiluminescence useful as reactive oxygen sensors, pharmaceutical compositions including the same, and methods of preparation and use thereof.
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13.发明授权公开(公告)号：US11770972B2
公开(公告)日：2023-09-26
申请号：US16940597
申请日：2020-07-28
Inventor： Benzhong Tang , Haoran Wang , Hao Xing
IPC: C07D263/57 , H10K85/60 , C09K11/06 , B81B3/00
CPC classification number: H10K85/657 , B81B3/0029 , C07D263/57 , C09K11/06 , B81B2201/032 , C09K2211/1007 , C09K2211/1018
Abstract: Provided herein are multifunctional photoresponsive compositions that can undergo conversion from an aggregation-caused quenching (ACQ) state to an aggregation-induced emission (AIE) state and macroscopic actuation and systems comprising the same and methods of use thereof.
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公开(公告)号：US11332449B2
公开(公告)日：2022-05-17
申请号：US16613370
申请日：2018-05-16
Inventor： Benzhong Tang , Parvej Alam , Nelson Lik Ching Leung
IPC: G01N33/12 , G01N21/78 , C07D241/42 , G01N21/77
Abstract: AIE-active chemosensors, according to the present teachings, exhibit UV-vis absorption change and become non-luminescent upon protonation. Upon deprotonation, the chemosensors revert to their original absorption and emission. This deprotonation process can be triggered in the presence of amines, and specifically, biogenic amines. The chemosensors can detect amine species, e.g., biogenic amines produced during food fermentation, quickly and with high sensitivity. Further, due to the AIE nature of the compounds, the chemosensors can be loaded onto a physical support and sealed inside a food package to monitor food spoilage.
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公开(公告)号：US11220629B2
公开(公告)日：2022-01-11
申请号：US16961569
申请日：2019-01-11
Inventor： Benzhong Tang , Guangle Niu
IPC: C09K11/06 , C07C255/43 , C07D213/57 , G01N21/64 , G02B21/00
Abstract: Fluorescent compounds that have aggregation-induced emission (AIE) characteristics. The compounds can be utilized as lipid droplet (LD)-specific bio-probes in cell imaging, with high photostability and brightness. For example, the compounds can be used for specific two-photon LDs staining in live cells and deep-tissues at ultralow concentrations. The compounds exhibit a large Stokes shift (>110 nm), high solid fluorescence quantum yields (up to 0.30), a good two-photon absorption cross-section (45-100 GM at 860 nm), high biocompatibility, and good photostability.
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Patent Agency Ranking
公开(公告)号：US11186586B2
公开(公告)日：2021-11-30
申请号：US16469037
申请日：2017-12-12
Inventor： Benzhong Tang , Ji Qi , Ming Chen , Wei Qin , Pengfei Zhang
IPC: C07D495/04 , A61K49/00 , C07D241/24 , C07D285/14 , C07D417/14 , C07D487/02 , C07D513/02 , C07D517/02
Abstract: A compound comprises a donor and an acceptor, wherein at least one donor (“D”) and at least one acceptor (“A”) may be arranged in an order of D-A; D-A-D; A-D-A; D-D-A-D-D; A-A-D-A-A; D-A-D-A-D; and A-D-A-D-A. The compound may be selected from the group consisting of: MTPE-TP, MTPE-TT, TPE-TPA-TT, PTZ-BT-TPA, NPB-TQ, TPE-TQ-A, MTPE-BTSe, DCDPP-2TPA, DCDPP-2TPA4M, DCDP-2TPA, DCDP-2TPA4M, TTS, ROpen-DTE-TPECM, and RClosed-DTE-TPECM. The compound may be used as a probe and may be functionalized with special targeted groups to image biological species. As non-limiting examples, the compound may be used in cellular cytoplasms or tissue imaging, blood vessel imaging, in vivo fluorescence imaging, brain vascular imaging, sentinel lymph node mapping, and tumor imaging, and the compound may be used as a photoacoustic agent.
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公开(公告)号：US11118111B2
公开(公告)日：2021-09-14
申请号：US16680861
申请日：2019-11-12
Inventor： Benzhong Tang , Wing Yip Lam , Fengyan Song
IPC: C09K19/04 , G02F1/01 , G02F1/13357 , G02F1/1335
Abstract: The present subject matter relates to a fluorescent compound having aggregation-induced emission (AIE) characteristics. The compound can be a rod-like chiral luminogen bearing a chiral moiety at one end and long aliphatic chains at an opposing end. The compound emits circularly polarized light or luminescence (CPL) in the aggregate state. For example, the compound does not exhibit a chiroptical signal when dispersed in solution, but demonstrates tunable CPL signals in the aggregate state.
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18.发明授权Photostable AIE luminogens for specific mitochondrial imaging and its method of manufacturing thereof 有权用于特定线粒体成像的光稳定型AIE发光体及其制造方法公开(公告)号：US09315465B2
公开(公告)日：2016-04-19
申请号：US14164591
申请日：2014-01-27
Inventor： Benzhong Tang , Yuning Hong , Sijie Chen , Wai Tung Leung , Engui Zhao , Haiqin Deng
IPC: G01N33/52 , C07D217/04 , C07F9/54 , C07D209/08 , A61K49/00
CPC classification number: C07D217/04 , A61K49/0023 , C07D209/08 , C07F9/5449 , G01N33/52
Abstract: AIE (aggregation-induced emission)-active TPE derivatives, TPE-TPP, TPE-MitoR and TPE-IQ are contemplated. These specific TPE derivatives are useful as fluorescent agents for mitochondrial imaging and as apoptosis inducers. Possessing high specificity to mitochondria, superior photostability and appreciable tolerance to microenvironment change, TPE derivatives are well-suited imaging agents for mitochondrial targeting and morphological change tracking. Because of their synthetic flexibility, TPE derivatives can be further modified as dual-functional probes for an array of applications such as sensing of ROS, metal ions, or pH change in mitochondria.
Abstract translation: 考虑了AIE（聚集诱发发射）活性TPE衍生物，TPE-TPP，TPE-MitoR和TPE-IQ。 这些特异性TPE衍生物可用作线粒体成像和凋亡诱导剂的荧光剂。 对线粒体具有高度的特异性，优异的光稳定性和对微环境变化的显着耐受性，TPE衍生物是用于线粒体靶向和形态学变化追踪的非常适合的成像剂。 由于其合成灵活性，TPE衍生物可进一步修改为用于应用阵列的双功能探针，例如感测ROS，金属离子或线粒体中的pH变化。
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公开(公告)号：US11871662B2
公开(公告)日：2024-01-09
申请号：US15733399
申请日：2019-02-14
Inventor： Benzhong Tang , Fengyan Song
IPC: H10K85/60 , C07D209/86 , C07D219/16 , C09K11/02 , C09K11/06 , H10K50/11 , H10K50/15 , H10K50/16 , H10K50/17 , H10K101/20
CPC classification number: H10K85/6572 , C07D209/86 , C07D219/16 , C09K11/02 , C09K11/06 , H10K85/626 , C09K2211/1018 , H10K50/11 , H10K50/15 , H10K50/16 , H10K50/17 , H10K50/171 , H10K2101/20
Abstract: Provided herein are chiral compounds that exhibit circularly polarized photoluminescence and electroluminescence and electroluminescent devices and circularly polarized fluorescent probes comprising the same.
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20.发明授权公开(公告)号：US11754498B2
公开(公告)日：2023-09-12
申请号：US17066655
申请日：2020-10-09
Inventor： Benzhong Tang , Ruoyao Zhang
IPC: G01N33/58 , G01N21/64 , C07D215/12 , C12Q1/44
CPC classification number: G01N21/6428 , C07D215/12 , C12Q1/44 , G01N33/582 , G01N2021/6439
Abstract: A fluorescent probe can include a compound exhibiting aggregation-induced emission (AIE). The probe can be used for selectively staining mitochondria and lipid droplets and detecting esterase activity. The probe includes an acetoxyl group which can be recognized by esterase in an esterase activity assay. As enzyme activity can reflect cell viability, the probe can be useful in cell viability detection. In addition, the probe includes a cationic moiety to target mitochondria and a lipophilic moiety that can target lipid droplets. A calculated log P value of the lipophilic moiety can be larger than 5.
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