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    PROXIMAL DEGAS DRIVEN MICROFLUIDIC ACTUATION
    14.
    发明申请
    PROXIMAL DEGAS DRIVEN MICROFLUIDIC ACTUATION 有权
    接近度驱动微流控制

    公开(公告)号：US20160144362A1

    公开(公告)日：2016-05-26

    申请号：US14947893

    申请日：2015-11-20

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Luke P. Lee ,  Debkishore Mitra ,  John R. Waldeisen ,  Jixiao Liu

    IPC: B01L3/00

    CPC classification number: B01L3/502723 ,  B01D19/0031 ,  B01L3/50273 ,  B01L2200/0684 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0883 ,  B01L2300/10 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/049 ,  B01L2400/0605 ,  B01L2400/0638 ,  B01L2400/0694

    Abstract: An apparatus with a self-contained, tunable, microfluidic pumping system that utilizes the high air permeability of the matrix material to actuate fluid flow in a network of fluidic microchannels and microstructures is provided. The pumping relies upon partial evacuation of degas/vacuum channels that are located next to the fluid channels to degas air from the fluid channels or structures producing a reduction of pressure in the fluidic channel leading to the flow of fluid from an inlet at atmospheric pressure through the device. The solution is isolated from the pumping apparatus since the liquid does not pass through the diffusion barriers. The apparatus and method can also provide bubble-free microfluidic pumping, without any auxiliary equipment or device pre-treatment, and can fill dead-end channels and chambers, providing a powerful liquid handling tool for a broad range of applications.

    Abstract translation: 提供了一种具有独立的，可调谐的微流体泵送系统的装置，其利用基质材料的高透气性来驱动流体微通道和微结构网络中的流体流动。 抽吸依赖于位于流体通道旁边的脱气/真空通道的部分抽空，以使来自流体通道的空气脱气，从而产生流体通道中的压力降低，导致流体从大气压下的入口流动通过 装置。 该溶液与泵送装置隔离，因为液体不通过扩散阻挡层。 该设备和方法还可以提供无气泡微流体泵送，无需任何辅助设备或设备预处理，并且可以填充死端通道和室，为广泛的应用提供强大的液体处理工具。

    OPTICAL CAVITY PCR
    15.
    发明申请
    OPTICAL CAVITY PCR 有权

    公开(公告)号：US20210008562A1

    公开(公告)日：2021-01-14

    申请号：US16938197

    申请日：2020-07-24

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Luke P. Lee ,  Jun Ho Son

    IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/686

    Abstract: An LED-driven optical cavity PCR system and method is disclosed for fast, accurate and reliable PCR based diagnostics. An optical cavity comprising two thin light absorbing metal (AU) films is used for uniform light absorption and subsequent photo thermal light-to-heat conversion is employed for PCR thermal cycling.

    Digital fluid sample separation apparatus and methods for one-step quantitative sample analysis
    20.
    发明授权
    Digital fluid sample separation apparatus and methods for one-step quantitative sample analysis 有权

    公开(公告)号：US10589270B2

    公开(公告)日：2020-03-17

    申请号：US15017851

    申请日：2016-02-08

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Luke P. Lee ,  Erh-Chia Yeh

    IPC: B01L3/00 ,  C12Q1/6806 ,  C12Q1/6851 ,  C12Q1/689 ,  C12Q1/70 ,  B01L7/00 ,  G01N35/00

    Abstract: A Digital Separation (DS) chip for separating, digitizing and analyzing a fluid sample is presented. The DS chip includes a fluidic layer that prepares and compartmentalizes the fluid sample for analysis. Cliff structures that are adjacent to wells skim the fluid sample and prevent particles, which may interfere with fluid sample analysis, from entering the wells. Skimmed fluid sample analysis occurs in the wells and endpoint data can be collected and used to determine an original concentration of a desired component in the fluid sample very quickly. Using the described apparatus and methods, a fluid sample can be prepared, digitized, compartmentalized, assayed and the endpoint data collected in ˜30 minutes. The apparatus and methods can easily be adapted to provide parallel processing of a sample.

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