公开(公告)号：US20200270674A1

公开(公告)日：2020-08-27

申请号：US16872855

申请日：2020-05-12

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Takumi HIRASE ,  Yoichi MAKINO ,  Yosuke HORIUCHI

IPC: C12Q1/6806 ,  C12Q1/686 ,  G01N33/536 ,  B01L3/00

Abstract: A method for detecting a target molecule, including supplying a liquid dispersion of a structural substance including a target molecule into a well array such that the structural substance is introduced into wells of the well array, supplying a sealing solution into the well array such that a layer of the sealing solution is formed on the liquid dispersion in the wells, and that the liquid dispersion is sealed in the wells, extracting the target molecule from the structural substance, and detecting the target molecule.

公开(公告)号：US20180196059A1

公开(公告)日：2018-07-12

申请号：US15914756

申请日：2018-03-07

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Yoichi MAKINO

IPC: G01N33/58 ,  C12Q1/68 ,  G01N33/68

Abstract: A method of detecting a biological substance, including introducing a first substance dispersed in a solvent into a flow channel formed between a first substrate and a second substrate such that the first substance is placed in a first well formed in the first substrate, and detecting the first substance. The first well is formed such that the first well has an open side which faces downwards and is communicated with the flow channel, and the solvent has a specific gravity larger than a specific gravity of the first sub stance.

公开(公告)号：US20160238497A1

公开(公告)日：2016-08-18

申请号：US15135919

申请日：2016-04-22

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Yoichi MAKINO ,  Shinji IRIE

IPC: G01N1/40 ,  C12Q1/68 ,  G01N33/68 ,  B01L3/00

CPC classification number: G01N1/4055 ,  B01L3/5085 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/0848 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2300/165 ,  C12M47/06 ,  C12Q1/68 ,  G01N1/4005 ,  G01N33/6842

Abstract: A membrane vesicle recovery device includes: a liquid filler; and at least a fused membrane having a lipid bilayer membrane which covers at least a part of the outer periphery of the liquid filler, in which a content of a membrane vesicle is mixed into the liquid filler through fusing of the membrane vesicle and the fused membrane.

Abstract translation: 膜囊泡回收装置包括：液体填充剂; 并且至少具有脂质双层膜的熔融膜，其覆盖所述液体填充剂的外周的至少一部分，其中膜囊泡的含量通过所述膜囊泡和所述熔融膜的融合而混入所述液体填充剂中 。

公开(公告)号：US20150132752A1

公开(公告)日：2015-05-14

申请号：US14315806

申请日：2014-06-26

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Yoichi MAKINO ,  Akio Yamane ,  Tomohiko Azuma ,  Masato Nakayama

IPC: C12Q1/68

CPC classification number: C12Q1/6881 ,  C12Q2600/156

Abstract: The method of the present invention is a method for determining an HLA-A*24 group, which includes determining the HLA-A*24 group on the basis of the results of the typing of (a) a 211st base and (b) a 395th base, in which A (adenine) in the initiation codon for an HLA gene is defined as the 1st base in the genomic DNA of a test subject.

Abstract translation: 本发明的方法是一种确定HLA-A * 24组的方法，其包括基于（a）211st碱基的分型结果确定HLA-A * 24组，（b）a 第395位碱基，其中HLA基因起始密码子中的A（腺嘌呤）被定义为测试对象的基因组DNA中的第一碱基。