公开(公告)号：US20220022741A1

公开(公告)日：2022-01-27

申请号：US17498102

申请日：2021-10-11

Applicant: TearScience, Inc.

Inventor： Stephen M. Grenon ,  Donald R. Korb ,  Joshua Grenon ,  Scott Liddle ,  Steve Bacich ,  John M. Jans

IPC: A61B3/00 ,  A61B3/10

Abstract: Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured, showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray-like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

公开(公告)号：US20200060539A1

公开(公告)日：2020-02-27

申请号：US16557276

申请日：2019-08-30

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  Stephen M. Grenon ,  Caroline Blackie ,  Timothy R. Willis ,  Steve Bacich

IPC: A61B3/10 ,  A61B3/14 ,  A61B3/00 ,  G06T7/00 ,  G06T7/11

Abstract: Embodiments disclosed herein include devices, systems, and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms. The apparatus and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms may employ ocular surface interferometry (OSI) devices or other imaging and display devices capable of imaging and displaying a picture of a patient's eye during tear film break-up time and blink rate related procedures.

公开(公告)号：US10413174B2

公开(公告)日：2019-09-17

申请号：US15365267

申请日：2016-11-30

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  Stephen M. Grenon ,  Caroline Blackie ,  Timothy R. Willis ,  Steve Bacich

IPC: A61B3/14 ,  A61B3/02 ,  A61B3/10 ,  A61B3/00 ,  G06T7/00 ,  G06T7/11 ,  G06T7/90 ,  G06K9/00 ,  G06K9/62 ,  G06K9/78

Abstract: Embodiments disclosed herein include devices, systems, and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms. The apparatus and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms may employ ocular surface interferometry (OSI) devices or other imaging and display devices capable of imaging and displaying a picture of a patient's eye during tear film break-up time and blink rate related procedures.

公开(公告)号：US20190209014A1

公开(公告)日：2019-07-11

申请号：US16355039

申请日：2019-03-15

Applicant: TearScience, Inc.

Inventor： Stephen M. Grenon ,  Donald R. Korb ,  Joshua Grenon ,  Scott Liddle ,  Steve Bacich ,  John M. Jans

IPC: A61B5/00

CPC classification number: A61B5/0082 ,  A61B5/0077 ,  A61B5/6821

Abstract: Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

公开(公告)号：US09888839B2

公开(公告)日：2018-02-13

申请号：US14268647

申请日：2014-05-02

Applicant: TEARSCIENCE, Inc.

Inventor： Donald R. Korb ,  Stephen M. Grenon ,  Steve Bacich

IPC: A61B3/14 ,  A61B3/00 ,  A61B3/10 ,  G06T7/00

CPC classification number: A61B3/0025 ,  A61B3/101 ,  G06T7/0012 ,  G06T2207/30041

Abstract: Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on tear film characteristics analysis and dry eye symptoms are disclosed. In embodiments herein, imaging of the ocular tear film is performed during contact lens wear. An analysis of the image of the ocular tear film is performed to determine one or more tear film characteristics of the ocular tear film. The tear film characteristics can be used to determine the effect or possible effect of contact lens wear on the ocular tear film, and thus be used to determine contact lens intolerance of the patient. The tear film characteristics used to analyze contact lens intolerance based on images of the ocular tear film involving contact lens wear may include dry eye symptoms, including but not limited to tear film (e.g., lipid and/or aqueous) thickness, tear film viscosity, and tear film movement rate in the eye.

公开(公告)号：US20170079525A1

公开(公告)日：2017-03-23

申请号：US15365267

申请日：2016-11-30

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  Stephen M. Grenon ,  Caroline Blackie ,  Timothy R. Willis ,  Steve Bacich

IPC: A61B3/10 ,  G06T7/11 ,  G06T7/00 ,  A61B3/00 ,  A61B3/14

Abstract: Embodiments disclosed herein include devices, systems, and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms. The apparatus and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms may employ ocular surface interferometry (OSI) devices or other imaging and display devices capable of imaging and displaying a picture of a patient's eye during tear film break-up time and blink rate related procedures.

公开(公告)号：US09545197B2

公开(公告)日：2017-01-17

申请号：US13887429

申请日：2013-05-06

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  Stephen M. Grenon ,  Caroline Blackie ,  Timothy R. Willis ,  Steve Bacich

IPC: A61B3/14 ,  A61B3/00 ,  A61B3/10 ,  G06T7/00

CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/0058 ,  A61B3/1005 ,  A61B3/14 ,  G06K9/00335 ,  G06K9/00604 ,  G06K9/0061 ,  G06K9/6212 ,  G06K9/78 ,  G06T7/0016 ,  G06T7/11 ,  G06T7/90 ,  G06T7/97 ,  G06T2207/10024 ,  G06T2207/10152 ,  G06T2207/30041

Abstract: Embodiments disclosed herein include devices, systems, and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms. The apparatus and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms may employ ocular surface interferometry (OSI) devices or other imaging and display devices capable of imaging and displaying a picture of a patient's eye during tear film break-up time and blink rate related procedures.

Abstract translation: 本文公开的实施方案包括用于确定泪膜破裂时间和用于检测眼睑边缘接触和眨眼速率的装置，系统和方法，特别是用于诊断，测量和/或分析干眼症状和症状。 用于确定泪膜破裂时间和用于检测眼睑边缘接触和眨眼频率，特别是用于诊断，测量和/或分析干眼症状和症状的装置和方法可以采用眼表干涉测量（OSI）装置或其他成像和 显示装置能够在撕裂膜分解时间和眨眼速率相关程序期间成像和显示患者眼睛的图像。

公开(公告)号：US20150216725A1

公开(公告)日：2015-08-06

申请号：US14422948

申请日：2013-08-22

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  Steve Bacich ,  Caroline Blackie ,  Stephen M. Grenon

IPC: A61F9/007

CPC classification number: A61F9/00718 ,  A61B17/32002 ,  A61B2017/320008 ,  A61B2017/320012 ,  A61B2090/0817

Abstract: Methods and apparatuses are disclosed for the diagnosis and removal of the devitalized and/or dead cell material formed in the lid margin to attempt to restore a normal lid margin. In this manner, the devitalized and/or dead cell material are removed or the amount present is reduced or no longer present to prevent, reduce, or affect the transport of lipid secreted by the meibomian glands to the tear film to reduce evaporative dry eye and improve dry eye conditions in patients. The diagnosis and removal of devitalized and/or dead cell material may be performed at desired intervals. Patients that suffer from conditions that block meibomian gland orifices, partial, infrequent, or inhibited blinking resulting in reduced lipid secretions from meibomian glands, and/or blockages in meibomian gland channels reducing secretion of lipids through the meibomian gland orifices may require more frequent diagnosis and treatment to remove devitalized and/or dead cell material.

Abstract translation: 公开了用于诊断和去除在盖边缘中形成的失活的和/或死细胞材料以尝试恢复正常盖边缘的方法和装置。 以这种方式，去除失活的和/或死细胞材料，或者减少或不再存在量以防止，减少或影响由睑板腺分泌的脂质转移到泪膜以减少蒸发干眼， 改善患者的干眼症状。 可以以期望的间隔进行失活和/或死细胞材料的诊断和去除。 患有阻塞睑板腺腺泡，部分，不频繁或抑制性眨眼，导致睑板腺脂肪分泌减少和/或睑板腺通道阻塞的病症的患者减少通过睑板腺腺泡分泌脂质可能需要更频繁的诊断和 处理以除去失活的和/或死细胞材料。