中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

21 records (took 0.02 seconds)

    DUAL RESPONSIVE BRAIN TARGETED NANOPARTICLES AND THEIR APPLICATIONS
    14.
    发明申请
    DUAL RESPONSIVE BRAIN TARGETED NANOPARTICLES AND THEIR APPLICATIONS 审中-公开
    双重应对脑靶向纳米颗粒及其应用

    公开(公告)号：US20160346208A1

    公开(公告)日：2016-12-01

    申请号：US15164994

    申请日：2016-05-26

    Applicant: UNIVERSITY OF SOUTH CAROLINA

    Inventor： Peisheng Xu ,  Eleni Markoutsa

    IPC: A61K9/14 ,  A61K31/197

    CPC classification number: A61K31/198 ,  A61K47/54 ,  A61K47/55 ,  A61K47/6933 ,  A61K47/6935

    Abstract: The preparation of dual functionalized nanoparticles is generally provided along with their application. The dual functionalized nanoparticles provide dual targeting and can effectively pass the blood brain barrier and target brain tissue. The dual targeted and dual responsive nanoparticles are functionalized to include at least two different ligands that are capable of transport across the blood brain barrier. The nanoparticles can be prepared from polymeric materials that can be biocompatible, provide long circulation life in a body, and be successfully ligated to both functionalities by use of acid-sensitive and/or redox potential-sensitive bonds for delivery across the blood brain barrier and delivery of a payload to brain tissue.

    Abstract translation: 双功能纳米颗粒的制备通常与其应用一起提供。 双功能纳米颗粒提供双重靶向，并可有效地通过血脑屏障和靶脑组织。 双靶向和双重应答纳米颗粒被功能化以包括能够跨越血脑屏障传输的至少两种不同的配体。 纳米颗粒可以由可生物相容的聚合物材料制备，在体内提供长的循环寿命，并且通过使用酸敏感和/或氧化还原电位敏感性粘合物通过血脑屏障传递并成功地连接到两个功能上， 将有效载荷递送到脑组织。

    Tetrary gene delivery system for gene therapy and methods of its use
    16.
    发明授权
    Tetrary gene delivery system for gene therapy and methods of its use 有权

    公开(公告)号：US10045945B2

    公开(公告)日：2018-08-14

    申请号：US14859661

    申请日：2015-09-21

    Applicant: UNIVERSITY OF SOUTH CAROLINA

    Inventor： Peisheng Xu ,  Remant Bahadur K C

    IPC: A61K9/50 ,  A61K31/713 ,  A61K47/34 ,  A61K9/51 ,  C12N15/87 ,  C12N15/113 ,  A61K48/00

    Abstract: Delivery systems and their methods of formation are generally provided. The delivery system can protect a delivery molecule (e.g., DNA/RNA) and deliver it into a cell via serum. In one embodiment, the method can include binding a delivery molecule with polyethylenimine such that an end of the delivery molecule is exposed; capping the end of the delivery molecule with a first biocompatible polymer to form a core; and encapsulating the core with a second biocompatible polymer. The resulting delivery system can include a delivery molecule bonded with polyethylenimine such that an end of the delivery molecule is exposed; a first biocompatible polymer electrostatically bonded to the end of the delivery molecule to form a core; and a second biocompatible polymer encapsulating the core.

    Polymeric prodrug of disulfiram and application thereof
    18.
    发明授权
    Polymeric prodrug of disulfiram and application thereof 有权

    公开(公告)号：US09861704B2

    公开(公告)日：2018-01-09

    申请号：US14962426

    申请日：2015-12-08

    Applicant: University of South Carolina

    Inventor： Peisheng Xu ,  Huacheng He

    IPC: A61K47/48

    CPC classification number: A61K47/59 ,  A61K47/58 ,  A61K47/60

    Abstract: Polymer/drug conjugates that can selectively target and kill cancer cells are described. Conjugates can include a copolymer formed by the reaction of a biocompatible hydrophilic component and a disulfiram derivative. The copolymer reaction product can include additional functional groups pendant to the backbone via a disulfide linkage, for instance copper chelators. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.

    Polymeric Prodrug of Disulfiram and Application Thereof
    19.
    发明申请
    Polymeric Prodrug of Disulfiram and Application Thereof 有权
    双硫仑的聚合前药及其应用

    公开(公告)号：US20160166706A1

    公开(公告)日：2016-06-16

    申请号：US14962426

    申请日：2015-12-08

    Applicant: University of South Carolina

    Inventor： Peisheng Xu ,  Huacheng He

    IPC: A61K47/48 ,  A61K31/145

    CPC classification number: A61K47/59 ,  A61K47/58 ,  A61K47/60

    Abstract: Polymer/drug conjugates that can selectively target and kill cancer cells are described. Conjugates can include a copolymer formed by the reaction of a biocompatible hydrophilic component and a disulfiram derivative. The copolymer reaction product can include additional functional groups pendant to the backbone via a disulfide linkage, for instance copper chelators. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.

    Abstract translation: 描述了可以选择性靶向和杀死癌细胞的聚合物/药物共轭物。 缀合物可以包括通过生物相容的亲水组分与二硫吡喃衍生物的反应形成的共聚物。 共聚物反应产物可以包括通过二硫键垂饰于主链的另外的官能团，例如铜螯合剂。 亲水性组分可以形成聚合物主链和/或可形成脱离主链的亲水侧基。 铜离子可与共聚物缔合。

    Polymer/Copper Combination for Targeted Cancer Therapy
    20.
    发明申请
    Polymer/Copper Combination for Targeted Cancer Therapy 有权
    聚合物/铜组合靶向癌症治疗

    公开(公告)号：US20160108160A1

    公开(公告)日：2016-04-21

    申请号：US14887373

    申请日：2015-10-20

    Applicant: University of South Carolina

    Inventor： Peisheng Xu ,  Huacheng He

    IPC: C08F220/28 ,  A61K31/795

    CPC classification number: C08F220/28 ,  A61K31/00 ,  A61K31/795 ,  A61K33/34 ,  C08F2220/282 ,  A61K2300/00

    Abstract: Polymer/copper combination that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.

    Abstract translation: 描述了可选择性靶向和杀死癌细胞的聚合物/铜组合。 材料可以包括生物相容的亲水性聚合物和含吡啶-2-硫醇的单体的反应产物。 共聚物反应产物可以包括通过二硫键悬挂于主链的吡啶-2-硫醇侧基。 亲水性组分可以形成聚合物主链和/或可形成脱离主链的亲水侧基。 铜离子可与共聚物缔合。

Patent Agency Ranking