公开(公告)号：US20240033240A1

公开(公告)日：2024-02-01

申请号：US18479393

申请日：2023-10-02

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Peisheng Xu ,  Eleni Markoutsa

IPC: A61K31/198 ,  A61K47/69 ,  A61K47/54 ,  A61K47/55

CPC classification number: A61K31/198 ,  A61K47/6933 ,  A61K47/6935 ,  A61K47/54 ,  A61K47/55

Abstract: The preparation of dual functionalized nanoparticles is generally provided along with their application. The dual functionalized nanoparticles provide dual targeting and can effectively pass the blood brain barrier and target brain tissue. The dual targeted and dual responsive nanoparticles are functionalized to include at least two different ligands that are capable of transport across the blood brain barrier. The nanoparticles can be prepared from polymeric materials that can be biocompatible, provide long circulation life in a body, and be successfully ligated to both functionalities by use of acid-sensitive and/or redox potential-sensitive bonds for delivery across the blood brain barrier and delivery of a payload to brain tissue.

公开(公告)号：US20160346208A1

公开(公告)日：2016-12-01

申请号：US15164994

申请日：2016-05-26

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Peisheng Xu ,  Eleni Markoutsa

IPC: A61K9/14 ,  A61K31/197

CPC classification number: A61K31/198 ,  A61K47/54 ,  A61K47/55 ,  A61K47/6933 ,  A61K47/6935

Abstract: The preparation of dual functionalized nanoparticles is generally provided along with their application. The dual functionalized nanoparticles provide dual targeting and can effectively pass the blood brain barrier and target brain tissue. The dual targeted and dual responsive nanoparticles are functionalized to include at least two different ligands that are capable of transport across the blood brain barrier. The nanoparticles can be prepared from polymeric materials that can be biocompatible, provide long circulation life in a body, and be successfully ligated to both functionalities by use of acid-sensitive and/or redox potential-sensitive bonds for delivery across the blood brain barrier and delivery of a payload to brain tissue.

Abstract translation: 双功能纳米颗粒的制备通常与其应用一起提供。 双功能纳米颗粒提供双重靶向，并可有效地通过血脑屏障和靶脑组织。 双靶向和双重应答纳米颗粒被功能化以包括能够跨越血脑屏障传输的至少两种不同的配体。 纳米颗粒可以由可生物相容的聚合物材料制备，在体内提供长的循环寿命，并且通过使用酸敏感和/或氧化还原电位敏感性粘合物通过血脑屏障传递并成功地连接到两个功能上， 将有效载荷递送到脑组织。