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公开(公告)号：US12139415B2
公开(公告)日：2024-11-12
申请号：US17290292
申请日：2018-11-15
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Pakize Neslihan Tasli , Oguz Kaan Kirbas , Taha Bartu Hayal , Batuhan Turhan Bozkurt , Berna Bulbul , Seda Beyaz
Abstract: Use of nano-sized lanthanide borate (erbium borate and dysprosium borate) compounds for wound treatment due to their significant level of wound healing effect on the cells is disclosed. In the scope of the invention, the synthesis of nanometer-sized erbium borate and dysprosium borate compound by buffered-precipitation method at room conditions and the use of these compounds in biological applications are discussed.
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公开(公告)号：US12129384B2
公开(公告)日：2024-10-29
申请号：US18076432
申请日：2022-12-07
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Zeynep Iyigundogdu , Okan Demir , Merve Gulerim , Sanem Argin
IPC: C09D105/06 , B65D81/28 , C08K3/38 , C09D5/02 , C09D7/61
CPC classification number: C09D105/06 , B65D81/28 , C08K3/38 , C09D5/025 , C09D7/61 , C08K2003/387
Abstract: The present invention relates to a pectin based antimicrobial surface coating material. In the present invention, boron compounds are cross-linked with pectin and a surface coating material in the form of a film is obtained. The said coating material can be used in all packaging industry requiring hygiene particularly in food industry. The invention enables packages to be antifungal, anticandidal and antibacterial.
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公开(公告)号：US11911713B2
公开(公告)日：2024-02-27
申请号：US16969997
申请日：2019-02-15
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Pakize Neslihan Tasli , Oguz Kaan Kirbas , Batuhan Turhan Bozkurt
CPC classification number: B01D15/34 , A61K35/16 , A61K35/20 , A61K35/22 , A61K35/38 , A61K35/50 , A61K35/52
Abstract: The present invention is an exosome isolation method for obtaining high purity exosomes inexpensively from samples of large and small amounts and types of samples from which exosomes could not be obtained before such as plant lysates. The exosome isolation method incorporates a two phase fluid extraction system, and includes the steps of isolation using dextran and PEG for removing proteins and undesired substances therein, and the steps of washing and dextran removal to collect exosomes in a pure form.
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公开(公告)号：US11154056B2
公开(公告)日：2021-10-26
申请号：US15771391
申请日：2016-10-21
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Zeynep Iyigundogdu , Okan Demir
Abstract: The present invention relates to surfaces which are featured with antimicrobial property. Combinations made with zinc pyrithione, chlorhexidine gluconate and/or triclosan are used in the invention. The invention enables to prevent biodegradation or biocontamination occurring on surfaces. In sectors where surface coating materials are widely used, the pathogen factors (bacteria, yeasts and fungi), which are the causes of surface-borne hygiene, allergy and infectious diseases, are controlled.
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Patent Agency Ranking
公开(公告)号：US09827269B2
公开(公告)日：2017-11-28
申请号：US14433677
申请日：2013-10-04
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Mehmet Emir Yalvac , Abdullah Ekizer , Tancan Uysal , Mehmet Fatih Sonmez
Abstract: This invention relates to the contributions of the bone marrow—and adipose tissue—derived mesenchymal stem cells applied following the maxillary expansion—a frequently used method for the orthodontic treatment—to the healing of the expanded bone tissues. In the invention, adipose tissue and bone marrow-derived stem cell applications increased the healing and quality of the bones following the maxillary expansion and the applied stem cells were involved in the bone structure. Thus, the relapse following the maxillary expansion treatment was avoided. This application will shorten the treatment period for patients undergoing the maxillary expansion treatment and the patients will not have to use apparatus for a long period of time.
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公开(公告)号：US12208117B2
公开(公告)日：2025-01-28
申请号：US17614386
申请日：2020-05-29
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Mustafa Erhan Aysan , Okan Demir
Abstract: A glycerol and sodium pentaborate based formulation developed for preventing postoperative adhesions occurring between manipulated tissues and organs is provided. An objective of the glycerol and sodium pentaborate based formulation is to provide a formulation comprising a mixture of glycerol, wherein the glycerol is one of the most abundant biomolecules in a human body, and sodium pentaborate, wherein the sodium pentaborate is known to have positive effects on a wound healing, with a purpose of preventing the postoperative adhesions.
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公开(公告)号：US12138235B2
公开(公告)日：2024-11-12
申请号：US17840700
申请日：2022-06-15
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Pakize Neslihan Tasli , Oguz Kaan Kirbas , Ezgi Avsar Apdik , Huseyin Apdik
IPC: A61K31/216 , A61K9/127
Abstract: A method of producing a caffeic acid phenethyl ester loaded microvesicular cancer drug targeting SH-SY5Y neuroblastoma cancer. The method includes seeding a plurality of skin stem cells in a medium; enabling the plurality of skin stem cells in the medium to reach a confluency of 70-80% to be seeded in a plurality of culture plates; preparing a caffeic acid phenethyl ester stock solution by dissolving the caffeic acid phenethyl ester in dimethyl sulfoxide DMSO; performing a microvesicle isolation from specialized skin cells; adding the caffeic acid phenethyl ester into a plurality of microvesicles; and separating the caffeic acid phenethyl ester loaded microvesicles from the caffeic acid phenethyl ester which is free in the solution and not loaded to a microvesicle.
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公开(公告)号：US20180244895A1
公开(公告)日：2018-08-30
申请号：US15755561
申请日：2016-08-16
Applicant: YEDITEPE UNIVERSITESI
Inventor： Zeynep IYIGUNDOGDU , Okan DEMIR , Fikrettin Sahin
IPC: C08K5/136 , A01N31/16 , A01N47/44 , C08K5/31 , C08K5/00 , A01N55/02 , A01N59/14 , C08K3/38 , A01N25/10
CPC classification number: C08K5/136 , A01N25/10 , A01N31/16 , A01N47/44 , A01N55/02 , A01N59/14 , C08K3/38 , C08K5/0091 , C08K5/31 , C08K5/378 , C08K2003/387 , C08K2201/018
Abstract: The present invention relates to composite polymer surfaces which are endowed with antimicrobial and antiviral properties. In the present invention, polymer composites containing additives are obtained, wherein combinations (comprising at least two or more substances) of boron compounds and/or zinc pyrithione made with chlorhexidine gluconate and/or triclosan are used. The invention enables to prevent biodegradation or biocontamination occurring on surfaces. The invention is for controlling the pathogen factors (bacteria, yeasts, fungi and viruses), which are the causes for surface-borne hygiene, allergy and infectious diseases, in sectors (particularly agriculture, health, food and defense) where polymer composites are widely used.
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公开(公告)号：US20150231179A1
公开(公告)日：2015-08-20
申请号：US14433677
申请日：2013-10-04
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Mehmet Emir Yalvac , Abdullah Ekizer , Tancan Uysal , Mehmet Fatih Sonmez
Abstract: This invention relates to the contributions of the bone marrow—and adipose tissue—derived mesenchymal stem cells applied following the maxillary expansion—a frequently used method for the orthodontic treatment—to the healing of the expanded bone tissues. In the invention, adipose tissue and bone marrow-derived stem cell applications increased the healing and quality of the bones following the maxillary expansion and the applied stem cells were involved in the bone structure. Thus, the relapse following the maxillary expansion treatment was avoided. This application will shorten the treatment period for patients undergoing the maxillary expansion treatment and the patients will not have to use apparatus for a long period of time.
Abstract translation: 本发明涉及在上颌扩张后施用的骨髓和脂肪组织的间充质干细胞（经常使用的正畸治疗方法）对扩张的骨组织的愈合的贡献。 在本发明中，脂肪组织和骨髓来源的干细胞应用增加了上颌扩张后骨骼的愈合和质量，并且所应用的干细胞参与骨结构。 因此，避免了上颌扩张治疗后的复发。 该应用将缩短上颌扩张治疗患者的治疗期，患者长时间不用使用器械。
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