公开(公告)号：US11638719B2

公开(公告)日：2023-05-02

申请号：US16492197

申请日：2018-03-07

Applicant: YEDITEPE UNIVERSITESI

Inventor： Fikrettin Sahin ,  Nezaket Turkel Sesli ,  Aysu Yilmaz

IPC: A61P3/04 ,  A61K47/24 ,  A61K31/765

Abstract: A product containing a boron compound for use in obesity treatment. By means of the present invention, a product can be obtained for obesity treatment which is not toxic to the other tissues and organs of the body. In obtaining the said product, sodium pentaborate pentahydrate, which is a poloxamer derivative, are used.

公开(公告)号：US11123432B2

公开(公告)日：2021-09-21

申请号：US16463407

申请日：2017-11-08

Applicant: YEDITEPE UNIVERSITESi

Inventor： Fikrettin Sahin ,  Zeynep Iyigundogdu ,  Okan Demir ,  Sadik Kalayci ,  Binnur Kiratli

IPC: A61K47/10 ,  A61P31/10 ,  A61P31/04 ,  A61K33/40 ,  A61K33/22 ,  A01N25/22 ,  A01N37/18 ,  A01N59/00 ,  A01N59/14 ,  A61K31/221 ,  A61P31/20

Abstract: An antimicrobial (anticandidal, antibacterial, antifungal) and antiviral composition which repels insects such as flies, mosquitoes and ticks. The composition includes poloxamer, boron compound, ethyl butyl acetylaminopropionate and preferably hydrogen peroxide. The present composition is a composition which can be applied in different forms via oral, nasal, ophthalmic, otic, local, ventricle, vaginal, rectal, dermal, intravenous, intramuscular, subcutaneous and intradermal route.

公开(公告)号：US09655990B2

公开(公告)日：2017-05-23

申请号：US14783081

申请日：2014-04-08

Applicant: YEDITEPE UNIVERSITESI

Inventor： Fikrettin Sahin ,  Selami Demirci ,  Aysegul Dogan

IPC: A61L26/00 ,  A61K9/00 ,  A61K47/32 ,  A61L15/26 ,  A61L15/44 ,  A61L15/46 ,  A61K47/34 ,  A61K8/04 ,  A61K8/19 ,  A61K8/84 ,  A61Q17/00 ,  A61Q19/08 ,  C08K3/38

CPC classification number: A61L26/0019 ,  A61K8/042 ,  A61K8/19 ,  A61K8/84 ,  A61K8/90 ,  A61K9/0014 ,  A61K47/32 ,  A61K47/34 ,  A61L15/26 ,  A61L15/44 ,  A61L15/46 ,  A61L26/0004 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/10 ,  A61L2300/404 ,  A61L2300/412 ,  A61Q17/005 ,  A61Q19/08 ,  C08K3/38 ,  C08K2003/387 ,  C08L71/02

Abstract: The present invention relates to an anti-aging antimicrobial wound healing polymer based hydrogel. In the study of the present invention, a wound healing gel formulation is developed by combining poloxamer polymers and boron component at adequate concentrations in a carbopol based gel. The said gel exhibits fast action on the damaged area and prevents scar formation.

公开(公告)号：US11578229B2

公开(公告)日：2023-02-14

申请号：US16323270

申请日：2017-07-14

Applicant: YEDITEPE UNIVERSITESI

Inventor： Fikrettin Sahin ,  Zeynep Iyigundogdu ,  Okan Demir ,  Merve Gulerim ,  Sanem Argin

IPC: C09D105/06 ,  C09D7/61 ,  C09D5/25 ,  B65D81/28 ,  C08K3/38 ,  C09D5/02

Abstract: The present invention relates to a gelatin or pectin based antimicrobial surface coating material. In the present invention, boron compounds are mixed with gelatin or pectin and a surface coating material in the form of a film is obtained. The said coating material can be used in all packaging industry requiring hygiene particularly in food industry. The invention enables packages to be antifungal, anticandidal and antibacterial.

公开(公告)号：US11510891B2

公开(公告)日：2022-11-29

申请号：US16955087

申请日：2018-12-17

Applicant: YEDITEPE UNIVERSITESI

Inventor： Fikrettin Sahin ,  Pakize Neslihan Tasli ,  Oguz Kaan Kirbas ,  Ezgi Avsar Apdik ,  Huseyin Apdik

IPC: A61K31/216 ,  A61K9/127

Abstract: A production of a drug, wherein the drug is specific for SH-SY5Y neuroblastoma cancer by loading caffeic acid phenethyl ester (CAPE) to a plurality of microvesicles that a specialized skin cell leaves into a nutrient solution. The objective of the present invention is to provide a cell-specific targeted vesicle development by loading the CAPE to the plurality of microvesicles obtained as a result of culturing and subsequent specialization of a plurality of tissue cells; and to use the CAPE at lower concentrations compared to a state of the art applications to minimize a toxicity of the CAPE to both a plurality of cells other than a plurality of targeted cells and a body.

公开(公告)号：US09962405B2

公开(公告)日：2018-05-08

申请号：US14783428

申请日：2014-04-07

Applicant: YEDITEPE UNIVERSITESI

Inventor： Fikrettin Sahin ,  Selami Demirci ,  Aysegul Dogan ,  Ayla Burcin Asutay

IPC: A61K33/22 ,  A61K31/205 ,  A61K9/06 ,  A61K47/32 ,  A61K31/155 ,  A61K47/10

CPC classification number: A61K33/22 ,  A61K9/06 ,  A61K31/155 ,  A61K31/205 ,  A61K47/10 ,  A61K47/32 ,  A61K2300/00

Abstract: The present invention relates to an antiviral gel combination. The said gel is composed of a boron compound, and the poloxamer and chlorhexidine compounds; and the gel obtained with the present invention demonstrates high activity on Herpes Simplex Type 1 Virus (HSV).

公开(公告)号：US11510943B2

公开(公告)日：2022-11-29

申请号：US16980436

申请日：2019-03-11

Applicant: YEDITEPE UNIVERSITESI

Inventor： Fikrettin Sahin ,  Ezgi Kasikci ,  Esra Aydemir Coban

IPC: A61K33/22 ,  A61P35/00 ,  A61K31/155

Abstract: The present invention relates to a chemotherapeutic agent comprising a combination of alexidine dihydrochloride and sodium pentaborate pentahydrate. The chemotherapeutic agent includes 2.9 mg alexidine dihydrochloride compound and 2.5 mg sodium pentaborate pentahydrate compound, and is obtained by adding 0.5 ml dimethylsulfoxide compound into the alexidine dihydrochloride compound. Upon injecting them to the media containing healthy cells and cancer cells, their effects on cell viability were observed. In accordance with the obtained results; it was observed that when alexidine dihydrochloride solution at concentrations not harming healthy cells is combined with sodium pentaborate pentahydrate, pancreatic cancer cell viability decreased 10% more compared to use of alexidine dihydrochloride alone, and it was realized that this combination can be used as a chemotherapeutic agent for treatment of pancreatic cancer.

公开(公告)号：US10881706B2

公开(公告)日：2021-01-05

申请号：US16482719

申请日：2018-01-31

Applicant: YEDITEPE UNIVERSITESI

Inventor： Fikrettin Sahin ,  Merve Yildirim ,  Polen Kocak ,  Burge Ulukan

IPC: A61K36/899 ,  A61K36/9068 ,  A61K36/8962

Abstract: A product containing plant derived exosome that may be used in cancer treatment and wound healing. The product enables to provide a low-cost product, which does not cause toxic effects in human body, does not cause damage in the healthy cells during the course of the cancer treatment, does not pose any infection risk since it does not require any procedure such as radiotherapy or surgery, and the side effects occurring in chemotherapy treatment are not experienced. Wheatgrass, garlic and ginger can be used alone or in combination in the product as the plant source.

公开(公告)号：US10124085B2

公开(公告)日：2018-11-13

申请号：US15531465

申请日：2015-11-23

Applicant: YEDITEPE UNIVERSITESI

Inventor： Fikrettin Sahin ,  Zeynep Ustaoglu ,  Selami Demirci ,  Okan Demir ,  Ayla Burcin Asutay

IPC: A61F13/20 ,  A61F13/51 ,  A61F13/84 ,  A61L15/18 ,  A61L15/20 ,  A61L15/44 ,  A61L15/46 ,  A61L15/60 ,  A61F13/511

Abstract: The present invention relates to hygienic products such as sanitary pads and tampons, patient/adult diapers and baby diapers which are made antimicrobial. In the present invention, a mixture of glucopon, chlorhexidine gluconate and triclosan is obtained from the boron compounds called sodium borate, zinc borate, sodium perborate tetrahydrate, borax pentahydrate and disodium octaborate tetrahydrate; and this mixture provides antifungal, anticandidal, antibacterial and antiviral properties to the woven or non-woven textile products and hygienic products. Additionally, the said hygienic products are made hydrophilic by means of the invention.

公开(公告)号：US20150030532A1

公开(公告)日：2015-01-29

申请号：US14368691

申请日：2012-12-27

Applicant: YEDITEPE UNIVERSITESI

Inventor： Fikrettin Sahin ,  Nurcan Bac ,  Selami Demirci ,  Zeynep Ustaoglu

IPC: A01N59/20 ,  C01B39/22 ,  C01B39/14 ,  C08K3/28 ,  C04B22/12 ,  C04B22/08 ,  C08K3/30 ,  C08K3/16 ,  A01N59/16 ,  C04B22/14

CPC classification number: A01N59/20 ,  A01N25/08 ,  A01N25/34 ,  A01N59/16 ,  C01B39/14 ,  C01B39/22 ,  C04B20/1062 ,  C04B22/085 ,  C04B22/12 ,  C04B22/142 ,  C04B2103/67 ,  C08K3/16 ,  C08K3/28 ,  C08K3/30 ,  C08K2003/168 ,  C08K2003/3045 ,  A01N2300/00 ,  C04B14/047

Abstract: The present invention relates to development of paint, plaster, cement and plastic construction materials containing silver, zinc and copper metal ion-charged zeolite ( 1/10 w/w). The new construction materials are antimicrobial and prevent microorganism growth and reproduction of fungi, yeasts and bacteria. The product, made from construction materials containing metallic ion-exchanged zeolite, provides hygiene by preventing microbial contamination in areas and surfaces for a long time. Furthermore, lifespan of the materials produced with this technology is longer since they will be protected from biological deterioration, corrosion and decays.

Abstract translation: 本发明涉及含有银，锌和铜金属离子充电沸石（1/10w / w）的油漆，石膏，水泥和塑料建筑材料的开发。 新的建筑材料是抗菌的，防止微生物生长和繁殖真菌，酵母菌和细菌。 该产品由含有金属离子交换沸石的建筑材料制成，通过长时间防止区域和表面的微生物污染，提供卫生。 此外，使用该技术生产的材料的使用寿命更长，因为它们将被保护免受生物降解，腐蚀和衰变。