公开(公告)号：US20160061742A1

公开(公告)日：2016-03-03

申请号：US14784764

申请日：2014-04-15

Applicant: DRÄGER SAFETY AG & CO. KGAA

Inventor： Philipp ROSTALSKI ,  Hans-Ullrich HANSMANN ,  Andreas MOHRMANN ,  Arne TRÖLLSCH ,  Karsten HILTAWSKY

IPC: G01N21/78 ,  G01N31/22 ,  G01N21/27 ,  G01N33/00

CPC classification number: G01N21/783 ,  G01N21/272 ,  G01N31/223 ,  G01N33/0013 ,  G01N33/0031 ,  G01N33/0073 ,  G01N2201/1241 ,  G01N2201/1242 ,  G01N2201/1248

Abstract: A measuring device (10) and a measurement method measure a concentration of gaseous/aerosol components of a gas mixture. A reaction carrier (14) has a flow channel (42) defining a reaction chamber (46) having a optically detectable reaction material (48), that reacts with a gas mixture component or with a reaction product. The measuring device (12) includes a gas-conveying assembly (2) with a gas-conveying apparatus (28) conveying the gas mixture and a detection assembly (3), which has a lighting apparatus (37) for lighting the reaction chamber (46), an optical sensor (38) for sensing the optically detectable reaction, and an evaluating unit (4) evaluating sensor data and determining a concentration of the component of the gas mixture. The detection assembly (3) senses a speed of a reaction front (6) propagating in the flow direction in the reaction chamber (46) and determines a preliminary concentration from the speed of the reaction front (6).

Abstract translation: 测量装置（10）和测量方法测量气体混合物的气体/气溶胶组分的浓度。 反应载体（14）具有限定具有光学可检测反应材料（48）的反应室（46）的流动通道（42），其与气体混合物组分或与反应产物反应。 测量装置（12）包括具有输送气体混合物的气体输送装置（28）和检测组件（3）的气体输送组件（2），该检测组件具有用于点亮反应室的照明装置（37） 46），用于感测可光学检测的反应的光学传感器（38），以及评估传感器数据和确定气体混合物的组分浓度的评估单元（4）。 检测组件（3）感测在反应室（46）中沿流动方向传播的反应前沿（6）的速度，并根据反应前沿（6）的速度确定初步浓度。

公开(公告)号：US07301628B2

公开(公告)日：2007-11-27

申请号：US11404430

申请日：2006-04-13

Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

公开(公告)号：US20030032039A1

公开(公告)日：2003-02-13

申请号：US10180647

申请日：2002-06-26

Applicant: SRU Biosystems, LLC

Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Frank DeFilippi

IPC: C12Q001/68 ,  G01N033/53 ,  G01N033/542 ,  C12M001/34 ,  G01J003/42

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

Abstract translation: 用于检测生物分子相互作用的方法和装置。 不需要使用标签，并且可以以高通量的方式执行方法。 用于检测在生物传感器的表面上发生的生物化学相互作用的装置包括光源。 第一光纤耦合到光源并照亮生物传感器。 第二光纤检测从生物传感器反射的波长。 光谱仪确定来自生物传感器的反射信号的光谱。

公开(公告)号：US5530551A

公开(公告)日：1996-06-25

申请号：US199298

申请日：1994-03-02

Applicant: Chistopher J. Cantrall ,  Timothy P. Dabbs ,  Monty Glass ,  William Humphries ,  Leslie J. Wills

Inventor： Chistopher J. Cantrall ,  Timothy P. Dabbs ,  Monty Glass ,  William Humphries ,  Leslie J. Wills

IPC: G01B11/02 ,  G01B11/06 ,  G01B11/08 ,  G01B11/10 ,  G01B11/24 ,  G01B11/245 ,  G01B21/00 ,  G01D21/00 ,  G01N15/00 ,  G01N15/02 ,  G01N15/14 ,  G01N21/27 ,  G01N21/39 ,  G01N21/59 ,  G01N21/84 ,  G01N33/36 ,  G01B11/00

CPC classification number: G01N15/0205 ,  G01B11/105 ,  G01N21/27 ,  G01N33/362 ,  G01N15/0227 ,  G01N2015/0057 ,  G01N2015/0277 ,  G01N2021/1738 ,  G01N2021/391 ,  G01N2021/5957 ,  G01N2021/845 ,  G01N2201/082 ,  G01N2201/1248 ,  G01N2291/048

Abstract: Disclosed is a method/apparatus to determine any one of a plurality of parameters: shape, area, chemical composition, diameter, color, number, thickness, width, length, absorptivity, reflectivity, transmittivity, dielectric constant, raman scattering profile, fluorescence, surface tension, roughness, profile, density, position and orientation. Also use of a plurality of energy beams as source energy: charged and neutral particle beams, gamma-, X-, micro-, optical and acoustic waves. The described apparatus determines the mean and standard deviation of a plurality of diameters of wool fibers, and includes a He-Ne laser (101), and a pinhole (102) which produce an expanding laser beam which passes through cell (105). Beam splitter (103) is operatively disposed to pinhole (102) and laser (101) to direct a portion of the laser beam to reference detector (109) which is electrically connected to processor (110) via line (111). When apparatus (100) is operating wool fibers in an isopropanol-wool slurry pass through cell (105) generally at a non-zero degree angle to the direction of slurry flow through cell (105) to interact with the laser beam in cell (105 ). Beam splitter (104) and microscope objective (106) are operatively disposed with respect to laser (101), pinhole (102) and cell (105) to produce an in focus magnified transmission image of wool fibers in cell (105) in the plane of end (107) of optical fiber bundle (108). Each of the fibers in bundle (108) is connected to a photodiode detector (112). Processor/timer (113) is connected electrically to detector (112) by line (114). Processor/timer (113) is also connected electrically to computer (115) by line (116) and to processor (110) by line (117). Detector (118) is connected electrically to processor (110) by line (119). Processor (110) is connected electrically to computer (115) by line (120). Detector (118) is operatively disposed with respect to laser (101), pinhole (102) and cell (105) to detect outgoing light.

公开(公告)号：US09880103B2

公开(公告)日：2018-01-30

申请号：US14784764

申请日：2014-04-15

Applicant: Dräger Safety AG & Co. KGaA

Inventor： Philipp Rostalski ,  Hans-Ullrich Hansmann ,  Andreas Mohrmann ,  Arne Tröllsch ,  Karsten Hiltawsky

IPC: G01N21/78 ,  G01N21/27 ,  G01N33/00 ,  G01N31/22

CPC classification number: G01N21/783 ,  G01N21/272 ,  G01N31/223 ,  G01N33/0013 ,  G01N33/0031 ,  G01N33/0073 ,  G01N2201/1241 ,  G01N2201/1242 ,  G01N2201/1248

Abstract: A measuring device (10) and a measurement method measure a concentration of gaseous/aerosol components of a gas mixture. A reaction carrier (14) has a flow channel (42) defining a reaction chamber (46) having a optically detectable reaction material (48), that reacts with a gas mixture component or with a reaction product. The measuring device (12) includes a gas-conveying assembly (2) with a gas-conveying apparatus (28) conveying the gas mixture and a detection assembly (3), which has a lighting apparatus (37) for lighting the reaction chamber (46), an optical sensor (38) for sensing the optically detectable reaction, and an evaluating unit (4) evaluating sensor data and determining a concentration of the component of the gas mixture. The detection assembly (3) senses a speed of a reaction front (6) propagating in the flow direction in the reaction chamber (46) and determines a preliminary concentration from the speed of the reaction front (6).

公开(公告)号：US20140195189A1

公开(公告)日：2014-07-10

申请号：US13737179

申请日：2013-01-09

Applicant: PPG INDUSTRIES OHIO, INC.

Inventor： Alison M. Norris

IPC: G01N21/55 ,  G06F17/00

CPC classification number: G01N21/55 ,  G01J3/462 ,  G01J3/504 ,  G01N21/255 ,  G01N21/8422 ,  G01N21/8851 ,  G01N2021/8877 ,  G01N2201/1245 ,  G01N2201/1248

Abstract: A computer implemented method. The method includes obtaining, using a processor, spectral reflectance data from a coated surface having a target coating theron; and determining, using the processor, whether the data includes any outlier data points. The method also includes removing, using the processor, at least one of the outlier data points to produce final spectral reflectance data; and calculating, using the processor, a characteristic of the target coating based at least in part on the final spectral reflectance data.

Abstract translation: 一种计算机实现的方法。 该方法包括：使用处理器获得来自具有目标涂层的涂层表面的光谱反射率数据; 以及使用所述处理器来确定所述数据是否包括任何异常值数据点。 该方法还包括使用处理器去除异常值数据点中的至少一个以产生最终的光谱反射率数据; 以及至少部分地基于最终光谱反射率数据来计算使用所述处理器的所述目标涂层的特性。

公开(公告)号：US20100099194A1

公开(公告)日：2010-04-22

申请号：US12641178

申请日：2009-12-17

Applicant: Osamu Okabayashi

Inventor： Osamu Okabayashi

IPC: G01N21/00 ,  G01N21/75

CPC classification number: G01N21/274 ,  G01N21/253 ,  G01N21/31 ,  G01N21/78 ,  G01N35/025 ,  G01N2201/1248 ,  Y10T436/12

Abstract: An analyzer analyzes a specimen on basis of an absorbance of a reaction liquid of the specimen and a reagent and includes a measuring unit that measures absorbances of two or more identifying samples having different concentrations and having absorbance characteristics such that there is no extremum in a wavelength band including a desired wavelength to be measured and also measures an absorbance of a reaction liquid; a calculating unit that calculates a gradient of a straight line indicating a relationship between the concentrations and the absorbances of the identifying samples; a correcting unit that corrects the absorbance of the reaction liquid by using a reference gradient of a straight line indicating a relationship between concentrations and absorbances of the identifying samples obtained in advance for the desired wavelength, and the calculated gradient; and an analyzing unit that analyzes the specimen on the basis of the corrected absorbance.

Abstract translation: 分析仪基于样品的反应液的吸光度和试剂分析样品，并且包括测量单元，其测量两种或更多种具有不同浓度的识别样品的吸光度，并且具有吸收特性，使得波长没有极值 包括要测量的所需波长，并且还测量反应液体的吸光度; 计算单元，计算表示所述识别样品的浓度与吸光度之间的关系的直线的梯度; 校正单元，其通过使用表示预先获得的所需波长的识别样品的浓度和吸光度之间的关系的直线的参考梯度和所计算的梯度来校正反应液的吸光度; 以及分析单元，其基于校正的吸光度分析样本。

公开(公告)号：US07298477B1

公开(公告)日：2007-11-20

申请号：US11506639

申请日：2006-08-18

Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

公开(公告)号：US20070041012A1

公开(公告)日：2007-02-22

申请号：US11404485

申请日：2006-04-13

Applicant: Brian Cunningham ,  Peter Li ,  Frank DeFilippi

Inventor： Brian Cunningham ,  Peter Li ,  Frank DeFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

公开(公告)号：US07148964B2

公开(公告)日：2006-12-12

申请号：US11404162

申请日：2006-04-13

Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.