公开(公告)号：US09778185B2

公开(公告)日：2017-10-03

申请号：US14923998

申请日：2015-10-27

Applicant: Laxco Inc.

Inventor： Congliang Chen ,  Kevin Cassady

IPC: G01N21/59 ,  G01N21/27 ,  G01N21/03

CPC classification number: G01N21/59 ,  G01N21/0303 ,  G01N21/27 ,  G01N2021/035 ,  G01N2021/036 ,  G01N2201/0826

Abstract: This disclosure relates generally to analytical instruments for measuring one or more properties of specimens or samples to be analyzed and, more particularly, to an analytical instrument with an adjustable optical path length. An analytical instrument may include a specimen support upon which a specimen may rest and a compression plate for controllably adjusting an optical path length of the specimen between the specimen support and the compression plate. In particular, a specimen may contact both the specimen support and the compression plate such that controlling a distance of the compression plate with respect to the specimen support effectively controls the optical path length of the specimen. An analytical instrument may include collimating lenses to collimate electromagnetic energy for transmission through a specimen and converging lenses for directing electromagnetic energy transmitted through the specimen into one or more sensors.

公开(公告)号：US20170241872A1

公开(公告)日：2017-08-24

申请号：US15507055

申请日：2014-11-05

Applicant: Aaron CHEUNG ,  Siu Wai Jacky MAK

Inventor： Aaron CHEUNG ,  Siu Wai Jacky MAK

IPC: G01N1/28 ,  A61B5/00 ,  G01N21/65 ,  G01N1/08 ,  G01N33/483 ,  A61B10/02 ,  G01N1/31

CPC classification number: G01N1/286 ,  A61B5/0075 ,  A61B5/4064 ,  A61B5/4836 ,  A61B10/0266 ,  G01N1/08 ,  G01N1/31 ,  G01N21/65 ,  G01N33/4833 ,  G01N2201/06113 ,  G01N2201/0826

Abstract: The present invention provides a system and method for collection, storage and processing of tissues and cells. The system includes a collection container with chambers for storing and processing tissues, which are controllably separated and maintain a physiologic environment for the tissues. The system also includes a fluidic device for isolating target cells of interest. The method includes receiving the tissue into a collection chamber, transferring the tissue to a processing chamber, dissociating the tis sue into single cells, and passing the single cells to a device for isolating one or more target cells.

公开(公告)号：US20170205346A1

公开(公告)日：2017-07-20

申请号：US15326995

申请日：2014-07-17

Applicant: KUANTAG NANOTEKNOLOJILER GELISTIRME VE URETIM A.S. ,  KOÇ ÜNIVERSITESI

Inventor： HAKAN UREY ,  OSMAN VEDAT AKGUN ,  EMRE HEVES ,  FEHMI CIVITCI ,  BASARBATU CAN

IPC: G01N21/64 ,  G01N21/85

CPC classification number: G01N21/643 ,  G01N21/645 ,  G01N21/8507 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0624 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: In the present invention, a fluorescent substance detection system (S) for detecting fluorescent substances in any environment is provided. Said detection system (S) comprises at least one illumination unit (1) which emits light to said environment in order to excite said substances; detection units (2), at least at a number equal to the number of types of fluorescent substances, for detecting emissions coming from said excited fluorescent substances and bandpass filters (3), each connected to detection units (2) one by one, wherein bandpass filters (3) have a center wavelength matched to the center emission wavelength of corresponding fluorescent substance.

公开(公告)号：US09709733B2

公开(公告)日：2017-07-18

申请号：US12442505

申请日：2007-09-28

Applicant: Anuradha Godavarty ,  Steven A. Regalado ,  Bhavani Jayachandran ,  Banghe Zhu

Inventor： Anuradha Godavarty ,  Steven A. Regalado ,  Bhavani Jayachandran ,  Banghe Zhu

IPC: A61B5/05 ,  G02B6/06 ,  A61B5/00 ,  A61B5/06 ,  G01N21/359 ,  G01N21/47 ,  G02B6/08 ,  G01N21/64 ,  G01N21/17

CPC classification number: G02B6/06 ,  A61B5/0091 ,  A61B5/064 ,  A61B5/4312 ,  G01N21/359 ,  G01N21/474 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1787 ,  G01N2021/4742 ,  G01N2201/0221 ,  G01N2201/0826 ,  G01N2201/0833 ,  G02B6/08

Abstract: The claimed method and system uses a hand-held based optical process to image large tissue volumes using a flexible probe head, increased data acquisition using multi-source illumination and multi-detector sensing, and tomographic reconstruction of sub-surface structures of a target object using ultrasonic tracking facilities.

公开(公告)号：US20170143213A1

公开(公告)日：2017-05-25

申请号：US15428012

申请日：2017-02-08

Applicant: The General Hospital Corporation

Inventor： Seemantini K. Nadkarni

IPC: A61B5/00 ,  G02B23/26 ,  G01N21/49 ,  G02B23/24 ,  A61B5/02 ,  G01N21/47

CPC classification number: A61B5/0084 ,  A61B5/0062 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/6853 ,  A61B5/6869 ,  A61B5/6876 ,  A61B5/7203 ,  A61B5/7275 ,  G01N21/474 ,  G01N21/4788 ,  G01N21/49 ,  G01N2021/4742 ,  G01N2021/479 ,  G01N2201/0683 ,  G01N2201/08 ,  G01N2201/0826 ,  G02B6/0005 ,  G02B23/2453 ,  G02B23/26

Abstract: An apparatus for obtaining information regarding a biological structure(s) can include, for example a light guiding arrangement which can include a fiber through which an electromagnetic radiation(s) can be propagated, where the electromagnetic radiation can be provided to or from the structure. An at least partially reflective arrangement can have multiple surfaces, where the reflecting arrangement can be situated with respect to the optical arrangement such that the surfaces thereof each can receive a(s) beam of the electromagnetic radiations instantaneously, and a receiving arrangement(s) which can be configured to receive the reflected radiation from the surfaces which include speckle patterns.

公开(公告)号：US09581491B2

公开(公告)日：2017-02-28

申请号：US14501544

申请日：2014-09-30

Applicant: PerkinElmer Health Sciences, Inc.

Inventor： Joseph L. DiCesare ,  Feng Jin ,  Timothy P. Neal ,  David Aikens

IPC: G01J3/02 ,  G01J3/44 ,  G02B6/26 ,  G01N21/05 ,  G01N21/64 ,  G01N21/03

CPC classification number: G01J3/0202 ,  G01J3/0218 ,  G01J3/4406 ,  G01N21/05 ,  G01N21/645 ,  G01N2021/0389 ,  G01N2021/6417 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0642 ,  G01N2201/0826 ,  G01N2201/0833 ,  G02B6/262

Abstract: A flow cell for a fluorescence spectrometer includes a flow channel to receive a flow of a liquid sample, an excitation light entrance window to receive excitation light from a light source, and an emission light exit window to transmit fluorescent emission light from the liquid sample in the flow channel from the flow cell. The excitation light entrance window and/or emission light exit window includes a waveguide including: a waveguide core formed of a core material; and a cladding medium surrounding a portion of the waveguide core, wherein the cladding medium has a refractive index less than the refractive index of the core material. The waveguide defines a portion of the flow channel.

Abstract translation: 用于荧光光谱仪的流动池包括用于接收液体样品流动的流动通道，用于接收来自光源的激发光的激发光入射窗口和用于从液体样品透射荧光发射光的发射光出射窗口 来自流动池的流动通道。 激发光入射窗口和/或发射光出射窗口包括波导，包括：由芯材形成的波导芯; 以及围绕所述波导芯的一部分的包层介质，其中所述包层介质具有小于所述芯材料的折射率的折射率。 波导限定了流动通道的一部分。

公开(公告)号：US20160231230A1

公开(公告)日：2016-08-11

申请号：US15027179

申请日：2014-11-18

Applicant: VERSALIS S.P.A.

Inventor： Francesco BONACINI ,  Erik MANTOVANI ,  Angelo FERRANDO

IPC: G01N21/27 ,  C08F112/08 ,  G01N21/359

CPC classification number: G01N21/272 ,  C08F112/08 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/8507 ,  G01N2201/061 ,  G01N2201/0826 ,  G01N2201/13

Abstract: The present invention relates to a method for monitoring a control parameter of a polymerization reaction mixture in heterogeneous phase comprising the following steps: (a) acquiring at least one NIR reflectance spectrum of said mixture; (b) calculating a value of said control parameter by means of a calibration curve which correlates the NIR reflectance spectrum with the values of said control parameter measured with a reference measurement method. The present invention also relates to an apparatus for implementing said method.

Abstract translation: 本发明涉及用于监测异相聚合反应混合物的控制参数的方法，包括以下步骤：（a）获得所述混合物的至少一个NIR反射光谱; （b）通过校正曲线计算所述控制参数的值，该校准曲线将NIR反射光谱与用参考测量方法测量的所述控制参数的值相关联。 本发明还涉及一种用于实现所述方法的装置。

公开(公告)号：US20160223509A1

公开(公告)日：2016-08-04

申请号：US15022453

申请日：2014-09-08

Applicant: INSTITUT FRANCAIS DE RECHERCHER POUR L'EXPLOITATION DE LA MER-IFREMER

Inventor： Florian CARADEC ,  Agathe LAËS-HUON ,  Sophie CHATAING-PARIAUD ,  Karenn BUCAS

IPC: G01N33/18 ,  G01N21/75

CPC classification number: G01N33/182 ,  G01N21/75 ,  G01N21/85 ,  G01N2201/062 ,  G01N2201/0826

Abstract: The invention relates to an analysis device (1) comprising: a tight analytical circuit (3) comprising an injection loop (BI), at least one mixing loop (BM), and a turbidimetry analysis means (CD), a liquid being able to continuously circulate through the injection loop, the mixing loop and the analysis means; a means (IL) for injecting said liquid into said injection loop and a means for removing said liquid from a source (S); a means (ISR) for injecting, into said injection loop, a solution for displaying sulfates in said liquid by means of turbidimetry; and a means (ISP) for injecting a rinsing solution, comprising a peristaltic pump (PPB) and a system (VF, VG) of valves placed between the pump (PPB) and said injection loop. The invention is especially applicable in fields of the offshore oil industry.

Abstract translation: 本发明涉及一种分析装置（1），包括：紧密分析电路（3），包括注射回路（BI），至少一个混合回路（BM）和比浊法分析装置（CD），液体能够 连续循环通过注射回路，混合回路和分析装置; 用于将所述液体注入所述注射回路的装置（IL）和用于从源（S）去除所述液体的装置; 一种用于通过比浊法将在所述液体中显示硫酸盐的溶液注入所述注射回路的装置（ISR）; 以及用于注射冲洗溶液的装置（ISP），其包括设置在泵（PPB）和所述注射回路之间的阀的蠕动泵（PPB）和系统（VF，VG）。 本发明特别适用于海上石油工业。

公开(公告)号：US20160139036A1

公开(公告)日：2016-05-19

申请号：US15005375

申请日：2016-01-25

Applicant: INSTITUT NATIONAL D'OPTIQUE

Inventor： François BABIN

IPC: G01N21/25 ,  G01N21/27

CPC classification number: G01N21/255 ,  G01N21/27 ,  G01N21/274 ,  G01N21/65 ,  G01N21/7703 ,  G01N21/78 ,  G01N21/80 ,  G01N2021/7709 ,  G01N2021/772 ,  G01N2021/7793 ,  G01N2201/0612 ,  G01N2201/082 ,  G01N2201/0826 ,  G01N2201/0833 ,  G01N2201/084 ,  G01N2201/088

Abstract: An optical system for sensing an environmental parameter, comprising: an optical pulse generator for generating an excitation pulse; a pulse splitter for splitting the excitation pulse into a sensing pulse and a reference pulse; a sensing arm for receiving the sensing pulse, the sensing arm comprising an emission sensor for sensing the environmental parameter, the optical emission sensor generating a first measurement pulse having a measurement wavelength; a reference arm for receiving the reference pulse, the reference arm comprising an emission artefact adapted to convert the reference pulse into a second measurement pulse having the measurement wavelength; a time delay line for delaying a relative propagation of the measurement pulses; a light detector for measuring an optical energy of the first and second measurement pulses; and an optical link for optically connecting the pulse generator to the pulse splitter, and the sensing and reference arms to the light detector.

Abstract translation: 一种用于感测环境参数的光学系统，包括：用于产生激励脉冲的光脉冲发生器; 用于将激励脉冲分成感测脉冲和参考脉冲的脉冲分离器; 用于接收感测脉冲的感测臂，所述感测臂包括用于感测所述环境参数的发射传感器，所述光发射传感器产生具有测量波长的第一测量脉冲; 用于接收参考脉冲的参考臂，所述参考臂包括适于将所述参考脉冲转换成具有所述测量波长的第二测量脉冲的发射伪影; 用于延迟测量脉冲的相对传播的延时线; 用于测量第一和第二测量脉冲的光能的光检测器; 以及用于将脉冲发生器光学连接到脉冲分离器的光学链路，以及用于光检测器的感测和参考臂。

公开(公告)号：US09279763B2

公开(公告)日：2016-03-08

申请号：US13697120

申请日：2011-04-27

Applicant: Eduard Johannes Meijer ,  Srinivas Rao Kudavelly

Inventor： Eduard Johannes Meijer ,  Srinivas Rao Kudavelly

IPC: G01N21/25 ,  G01N21/49 ,  A61B5/1455 ,  A61B5/00 ,  G01N21/31

CPC classification number: G01N21/49 ,  A61B5/1455 ,  A61B5/443 ,  G01N21/255 ,  G01N2021/3144 ,  G01N2021/3148 ,  G01N2021/3177 ,  G01N2021/3181 ,  G01N2201/0627 ,  G01N2201/0826

Abstract: An analyte measuring device (5) for monitoring, for example, levels of a tissue analyte (e.g., bilirubin), includes a number of narrow band light sources (10), each narrow band light source being structured to emit a spectrum of light covering a number of wavelengths, and a number of detector assemblies (15) configured to receive light reflected from the transcutaneous tissues of a subject. Each of the detector assemblies includes a filter (20) and a photodetector (25), each filter being structured to transmit a main transmission band and one or more transmission sidebands, wherein for each narrow band light source the spectrum thereof includes one or more wavelengths that fall within the transmission band of at least one of the filters, and wherein for each narrow band light source the spectrum thereof does not include any wavelengths that fall within the one or more transmission sidebands of any of the optical filters.

Abstract translation: 用于监测例如组织分析物（例如，胆红素）的水平的分析物测量装置（5）包括多个窄带光源（10），每个窄带光源被构造成发射光谱覆盖 多个波长和多个检测器组件（15），其构造成接收从受试者的经皮组织反射的光。 每个检测器组件包括滤波器（20）和光电检测器（25），每个滤波器被构造为传输主传输频带和一个或多个传输边带，其中对于每个窄带光源，其频谱包括一个或多个波长 其落在至少一个滤波器的传输频带内，并且其中对于每个窄带光源，其频谱不包括落入任何光学滤波器的一个或多个传输边带内的任何波长。