公开(公告)号：US20150141267A1

公开(公告)日：2015-05-21

申请号：US14543865

申请日：2014-11-17

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Benjamin Cipriany ,  Jack Jewell ,  Lawrence West ,  Michael Ferrigno ,  Paul E. Glenn ,  Anthony Bellofiore

IPC: C12Q1/68 ,  G01N21/64

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/0893 ,  B01L2300/168 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2521/101 ,  C12Q2537/157 ,  C12Q2563/107 ,  C12Q2565/607 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/7743 ,  G01N21/7746 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/125 ,  Y10T29/49016 ,  C12Q2525/101

Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.

Abstract translation: 用于分析单分子和进行核酸测序的装置和方法。 集成器件包括多个像素，其中样品阱被配置为接收样品，当被激发时，样品阱发射辐射; 用于在特定方向上引导发射辐射的至少一个元件; 以及发射辐射从样品阱向传感器行进的光路。 该装置还包括与集成装置接口的仪器。 每个传感器可以检测来自相应样品阱中的样品的发射辐射。 该仪器包括用于激发每个样品孔中的样品的激发光源。

公开(公告)号：US20150086997A1

公开(公告)日：2015-03-26

申请号：US14554205

申请日：2014-11-26

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller ,  Jason Taylor

IPC: G01N21/59 ,  G01N33/543 ,  G01N33/574

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

Abstract translation: 描述了用于分析样品的系统和方法，并且在某些实施方案中，被配置为接收包含样品的盒以执行样品分析的微流体样品分析器。 微流体样品分析仪可用于控制各种微流体系统（如微流体点护理诊断平台）中的流体流动，混合和样品分析。 有利地，在一些实施例中，与常规台式系统相比，微流体样品分析仪可能是便宜的，尺寸减小并且使用简单。 还描述了可以与样品分析仪一起操作的盒。

公开(公告)号：US20140268125A1

公开(公告)日：2014-09-18

申请号：US13830201

申请日：2013-03-14

Applicant: LAXCO INC.

Inventor： Congliang Chen

IPC: G01N21/03

CPC classification number: G01N21/0303 ,  B01L3/5085 ,  B01L2300/0829 ,  B01L2300/0858 ,  G01N21/03 ,  G01N2021/0307 ,  G01N2201/02

Abstract: An apparatus for taking an accurate photometric measurement of a liquid by way of forming a specimen volume of a controlled optical path length for use with photometric measurement equipment is disclosed herein. In some embodiments, the apparatus comprises a transparent body configured for displacing a volume of a fluid and at least one support element wherein the support element is configured to maintain the transparent body at a location such that specimen fluid may enter a void volume to form a specimen volume of a controlled optical path length. In some embodiments, the apparatus comprises a plurality of transparent bodies interconnected by a web such that the transparent bodies are maintained at a spacing arrangement which allows for them to be inserted into the wells of a microplate in order to create a plurality of specimen volumes of a controlled optical path length.

Abstract translation: 本文公开了一种用于通过形成用于光度测量设备的受控光程长度的检体体积而对液体进行准确的光度测量的装置。 在一些实施例中，该装置包括被配置为移动一定体积的流体和至少一个支撑元件的透明体，其中该支撑元件构造成将该透明体保持在使得该样品流体可进入空隙体积以形成 受检光路长度的试样体积。 在一些实施例中，该装置包括多个通过网互连的透明体，使得透明体保持间隔布置，允许将它们插入微板的孔中，以便产生多个样品体积 受控的光程长度。

公开(公告)号：US08765062B2

公开(公告)日：2014-07-01

申请号：US13849084

申请日：2013-03-22

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller ,  Jason Taylor

IPC: B01L3/00 ,  G01N21/05 ,  G01N21/77 ,  G01N1/10

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

Abstract translation: 描述了用于分析样品的系统和方法，并且在某些实施方案中，被配置为接收包含样品的盒以执行样品分析的微流体样品分析器。 微流体样品分析仪可用于控制各种微流体系统（如微流体点护理诊断平台）中的流体流动，混合和样品分析。 有利地，在一些实施例中，与常规台式系统相比，微流体样品分析仪可能是便宜的，尺寸减小并且使用简单。 还描述了可以与样品分析仪一起操作的盒。

公开(公告)号：US08580569B2

公开(公告)日：2013-11-12

申请号：US13088112

申请日：2011-04-15

Applicant: Vincent Linder ,  David Steinmiller

Inventor： Vincent Linder ,  David Steinmiller

IPC: G01N35/08

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.

公开(公告)号：US20130288347A1

公开(公告)日：2013-10-31

申请号：US13791971

申请日：2013-03-09

Applicant: SINGULEX, INC.

Inventor： Richard Livingston

IPC: G01N33/53

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/53 ,  G01N2015/0038 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0697

Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.

公开(公告)号：US08462339B2

公开(公告)日：2013-06-11

申请号：US13608519

申请日：2012-09-10

Applicant: Richard Livingston

Inventor： Richard Livingston

IPC: G01N21/00

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/53 ,  G01N2015/0038 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0697

Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.

Abstract translation: 本发明包括分析仪和分析仪系统，其包括单分子分析仪，使用分析仪和分析仪系统分析样品的单分子或分子复合物的方法。 单分子使用通过样品翻译的电磁辐射来检测单个分子的存在或不存在。 本文提供的单分子分析仪可用于诊断，因为分析仪检测样品之间具有零携带的单分子。

公开(公告)号：US20130059400A1

公开(公告)日：2013-03-07

申请号：US13608519

申请日：2012-09-10

Applicant: Richard A. Livingston

Inventor： Richard A. Livingston

IPC: G01N21/75 ,  G01N21/64

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/53 ,  G01N2015/0038 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0697

Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.

公开(公告)号：US20130010280A1

公开(公告)日：2013-01-10

申请号：US13542100

申请日：2012-07-05

Applicant: Angelo W. Palmieri ,  Donald A. Palmieri

Inventor： Angelo W. Palmieri ,  Donald A. Palmieri

IPC: G01N21/87

CPC classification number: G01N21/87 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/0633

Abstract: A device for producing a reproducible identification pattern of a polished gemstone includes light directing means for directing a focused beam of light onto a gemstone orientated in a particular known manner to produce an output of the internal refraction and reflection characteristics of the gemstone including reflected light beams having particular locations, sizes and intensities. The device also includes automated means for changing a position of the gemstone relative to the focused beam of light; and also a means for recording the output in a manner to record the relative size and location of the reflected light beams.

Abstract translation: 用于产生抛光宝石的可再现识别图案的装置包括用于将聚焦光束引导到以特定已知方式定向的宝石的光引导装置，以产生包括反射光束的宝石的内部折射和反射特性的输出 具有特定的位置，大小和强度。 该装置还包括用于改变宝石相对于聚焦光束的位置的自动装置; 以及用于以记录反射光束的相对大小和位置的方式记录输出的装置。

公开(公告)号：US20110297590A1

公开(公告)日：2011-12-08

申请号：US13149140

申请日：2011-05-31

Applicant: E. Michael ACKLEY ,  Mark Ford

Inventor： E. Michael ACKLEY ,  Mark Ford

IPC: B07C5/342 ,  B07C5/00 ,  B07C5/34

CPC classification number: B07C5/3422 ,  B07C5/34 ,  B07C5/3412 ,  B07C5/362 ,  B07C5/363 ,  G01N21/85 ,  G01N21/8806 ,  G01N21/8851 ,  G01N2021/845 ,  G01N2021/8592 ,  G01N2201/02 ,  G01N2201/062 ,  G01N2201/0621 ,  Y10T29/49826

Abstract: An inspection system is configured for use with a conveyer apparatus including carrier bars. Each carrier bar conveys pellet-shaped articles along a predetermined path. The inspection system includes at least one camera unit for sensing a predetermined characteristic of the pellet-shaped articles, a removal unit, and a controller. The removal unit, downstream from the at least one camera unit, removes selected pellet-shaped article(s) from the carrier bar(s) depending on whether the characteristic is sensed by the at least one camera unit. The controller is in communication with the at least one camera unit and the removal unit. The controller provides a signal to the removal unit in accordance with the sensed characteristic. The removal unit includes a rotatable ejection drum having extended vacuum nozzles along its length, equal to the number of articles conveyed in each carrier bar. Each vacuum nozzle selectively removes article(s) from the carrier bar(s) by suction.

Abstract translation: 检查系统构造成与包括承载杆的输送装置一起使用。 每个承载杆沿预定路径传送颗粒状物品。 检查系统包括用于感测颗粒状物品的预定特征的至少一个照相机单元，去除单元和控制器。 去除单元，从至少一个照相机单元的下游，取决于该特性是否被至少一个照相机单元感测到，从载体棒移除所选的颗粒状物品。 控制器与至少一个相机单元和拆卸单元通信。 控制器根据感测到的特性向去除单元提供信号。 移除单元包括可旋转的排出滚筒，其具有沿其长度延伸的真空喷嘴，其等于在每个承载杆中输送的物品的数量。 每个真空喷嘴通过抽吸选择性地从承载杆去除物品。