公开(公告)号：US20110267614A1

公开(公告)日：2011-11-03

申请号：US13142939

申请日：2010-01-11

Applicant: Bjoern Markus Reinhard ,  Luca Dal Negro

Inventor： Bjoern Markus Reinhard ,  Luca Dal Negro

IPC: G01J3/44 ,  B05D5/06 ,  B05D5/02

CPC classification number: G02B5/008 ,  B82Y30/00 ,  C03C17/40 ,  C03C2217/255 ,  C03C2217/425 ,  G01N21/01 ,  G01N21/658 ,  G01N2201/02 ,  Y10T428/12104 ,  Y10T428/24909

Abstract: Defined nanoparticle cluster arrays (NCAs) with total lateral dimensions of up to 25.4 μm by 25.4 μm have been fabricated on top of a 10 nm thin gold film using template guided self-assembly. This approach provides precise control of the structural parameters in the arrays allowing a systematic variation of the average number of nanoparticles in the clusters (n) and the edge to edge separation (Λ) between 1

Abstract translation: 使用模板引导自组装，在10nm薄金膜的顶部上制造了总侧向尺寸高达25.4μm×25.4μm的定义的纳米颗粒簇阵列（NCAs）。 该方法提供对阵列中的结构参数的精确控制，允许在1

公开(公告)号：US20110263043A1

公开(公告)日：2011-10-27

申请号：US13031784

申请日：2011-02-22

Applicant: Richard A. Livingston

Inventor： Richard A. Livingston

IPC: G01N27/00 ,  G01N21/64 ,  G01N21/75

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/53 ,  G01N2015/0038 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0697

Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.

Abstract translation: 本发明包括分析仪和分析仪系统，其包括单分子分析仪，使用分析仪和分析仪系统分析样品的单分子或分子复合物的方法。 单分子使用通过样品翻译的电磁辐射来检测单个分子的存在或不存在。 本文提供的单分子分析仪可用于诊断，因为分析仪检测样品之间具有零携带的单分子。

公开(公告)号：US07999927B2

公开(公告)日：2011-08-16

申请号：US13007502

申请日：2011-01-14

Applicant: James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: G01N33/48

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US20110040164A1

公开(公告)日：2011-02-17

申请号：US12859055

申请日：2010-08-18

Applicant: John R. Galasso

Inventor： John R. Galasso

IPC: A61B5/1468

CPC classification number: G01N33/487 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1468 ,  A61B2562/0295 ,  A61B2562/18 ,  A61B2562/225 ,  G01N21/17 ,  G01N27/26 ,  G01N2201/02 ,  H01R13/5224

Abstract: The present disclosure provides a contamination resistant sensor port which includes one or more sealing members positioned so as to limit and/or prevent internal contamination of the sensor port with fluids and/or particles present in the environment outside the sensor port.

Abstract translation: 本公开提供了一种抗污染传感器端口，其包括一个或多个密封构件，所述密封构件被定位成限制和/或防止传感器端口的内部污染，所述流体和/或颗粒存在于传感器端口外部的环境中。

公开(公告)号：US07480032B2

公开(公告)日：2009-01-20

申请号：US11337943

申请日：2006-01-23

Applicant: James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: G01N33/48

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US20090000188A1

公开(公告)日：2009-01-01

申请号：US11823140

申请日：2007-06-27

Applicant: Adda Sayers ,  Dean M. Tranel ,  Travis A. Hanselman ,  Stephen D. Strachan

Inventor： Adda Sayers ,  Dean M. Tranel ,  Travis A. Hanselman ,  Stephen D. Strachan

IPC: G01N15/10 ,  G01N21/01 ,  G01N33/483 ,  G01N1/40 ,  A01G7/00

CPC classification number: G01N21/17 ,  A01G7/00 ,  G01N1/4077 ,  G01N15/06 ,  G01N15/10 ,  G01N15/1463 ,  G01N33/0098 ,  G01N2021/1765 ,  G01N2201/02 ,  G01N2201/125 ,  G06K9/00134 ,  G06Q99/00

Abstract: An apparatus and method of quantitatively obtaining a measurement of pollen of a plant. One method of counting comprises imaging the sample with the pollen well-distributed in the focal plane of the imager. Image evaluation software can identify and count objects in the image that are consistent with pollen. Total pollen count for the plant can be derived from the count of pollen of the sample, proportionality of the sample volume to the starting volume, and proportionality of area of sample imaged to total area of sample. Pollen quantification can be used for research or commercial production decisions relative to the plant or its seed.

Abstract translation: 一种定量获得植物花粉测量的装置和方法。 一种计数方法包括用分布在成像器的焦平面中的花粉成像样品。 图像评估软件可以识别和计数与花粉一致的图像中的对象。 植物的总花粉计数可以从样品的花粉计数，样品体积与起始体积的比例以及样品的面积与样品总面积的比例来得出。 花粉量化可用于相对于植物或其种子的研究或商业生产决策。

公开(公告)号：US20060268258A1

公开(公告)日：2006-11-30

申请号：US11337943

申请日：2006-01-23

Applicant: James Braig

Inventor： James Braig

IPC: G01N33/48

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

公开(公告)号：US20060195058A1

公开(公告)日：2006-08-31

申请号：US11316685

申请日：2005-12-21

Applicant: Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61M31/00 ,  A61B5/00

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A fluid handling and analysis system comprises a fluid transport network comprising at least a first fluid passageway. The fluid transport network includes a patient end that is configured to maintain fluid communication with a bodily fluid in a patient. A sample analysis chamber and waste container are each accessible via the fluid transport network. A pump unit is in operative engagement with the fluid transport network. The pump unit has an infusion mode in which the pump unit is operable to deliver an infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a volume of the bodily fluid from the patient through the patient end, towards the sample analysis chamber. A spectroscopic fluid analyzer is configured to analyze a sample of the bodily fluid while the sample is in the sample analysis chamber, and determine a concentration of at least one analyte. The fluid transport network and the pump unit are configured to draw a volume of the bodily fluid from the patient, isolate a fraction of the bodily fluid from the volume, and pass the fraction to the sample analysis chamber and then to the waste container.

Abstract translation: 流体处理和分析系统包括至少包括第一流体通道的流体输送网络。 流体输送网络包括被配置为保持患者体内与体液的流体连通的患者端。 样品分析室和废物容器均可通过流体输送网络接近。 泵单元与流体输送网络操作地接合。 泵单元具有输注模式，在该模式中，泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中，泵单元可操作以从患者抽取体积的体液 通过患者端，朝向样品分析室。 光谱流体分析器被配置为当样品在样品分析室中时分析体液样品，并确定至少一种分析物的浓度。 流体输送网络和泵单元被配置成从患者抽取体积的体液，将体液的一部分与体积隔离，并将分数通过样品分析室，然后传递到废物容器。

公开(公告)号：US20060194325A1

公开(公告)日：2006-08-31

申请号：US11316701

申请日：2005-12-21

Applicant: Jennifer Gable ,  James Braig ,  Kenneth Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer Gable ,  James Braig ,  Kenneth Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: G01N31/22

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A fluid handling and analysis system is provided. The system includes a main analysis and control instrument and a fluid handling module that are removably engageable with the main instrument. The main instrument comprises a spectroscopic bodily fluid analyzer and at least one control element. The fluid handling module includes a spectroscopic sample cell and at least one fluid handling element, and the sample cell is accessible via the fluid handling element. The fluid handling element has a control interface configured to engage the control element when the main instrument and the fluid handling module are engaged.

Abstract translation: 提供流体处理和分析系统。 该系统包括可拆卸地与主仪器接合的主分析和控制仪器和流体处理模块。 主要仪器包括光谱体液分析仪和至少一个控制元件。 流体处理模块包括光谱样品池和至少一个流体处理元件，并且样品池可通过流体处理元件接近。 流体处理元件具有控制接口，该控制接口构造成当主仪器和流体处理模块接合时接合控制元件。

公开(公告)号：US20060189925A1

公开(公告)日：2006-08-24

申请号：US11314748

申请日：2005-12-21

Applicant: Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61M31/00 ,  A61B5/00

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: In some embodiments, a system for bodily fluid sampling and analysis comprises a first fluid passageway having a patient end which is configured to provide fluid communication with a bodily fluid within a patient. A sample analysis chamber is accessible via the first fluid passageway. At least one pump is in operative engagement with the first fluid passageway such that the system is operable to periodically draw a sample of the bodily fluid from the patient through the first fluid passageway and toward the sample analysis chamber. A separator is accessible via the first fluid passageway and configured to remove at least one component from the sample of bodily fluid. A spectroscopic analyte detection system is configured to analyze the component of bodily fluid while the component of bodily fluid is in the sample analysis chamber, and determine a concentration of at least one analyte.

Abstract translation: 在一些实施例中，用于体液取样和分析的系统包括具有患者端的第一流体通道，其被配置为提供与患者体内的体液的流体连通。 样品分析室可通过第一流体通道进入。 至少一个泵与第一流体通道操作接合，使得系统可操作以通过第一流体通道并朝向样品分析室周期性地从患者体内抽取体液样品。 分离器可经由第一流体通道接近并且构造成从体液样品中移除至少一种组分。 光谱分析物检测系统被配置为分析身体液体的组分，同时体液的组分在样品分析室中，并且确定至少一种分析物的浓度。