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    Bio-sensing nanodevice
    21.
    发明授权
    Bio-sensing nanodevice 有权

    公开(公告)号：US09714941B2

    公开(公告)日：2017-07-25

    申请号：US12183916

    申请日：2008-07-31

    Applicant: Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

    Inventor： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

    IPC: G01N33/543

    CPC classification number: G01N33/54366 ,  G01N2333/726

    Abstract: The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

    Multiplexed olfactory receptor-based microsurface plasmon polariton detector
    24.
    发明授权
    Multiplexed olfactory receptor-based microsurface plasmon polariton detector 有权
    基于多重嗅觉受体的微表面等离子体激元检测器

    公开(公告)号：US08748111B2

    公开(公告)日：2014-06-10

    申请号：US13015851

    申请日：2011-01-28

    Applicant: Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

    Inventor： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

    IPC: G01N33/53 ,  C07K2/00 ,  B82Y30/00 ,  G01N33/00 ,  G01N21/55

    CPC classification number: G01N21/553 ,  B82Y30/00 ,  C07K2/00 ,  G01N21/554 ,  G01N33/0031 ,  G01N2201/06113 ,  G01N2201/08

    Abstract: The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

    Abstract translation: 本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。 纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

    Method for improving print performance of flexographic printing elements
    25.
    发明授权
    Method for improving print performance of flexographic printing elements 有权
    提高柔版印刷元件印刷性能的方法

    公开(公告)号：US08669041B2

    公开(公告)日：2014-03-11

    申请号：US13183558

    申请日：2011-07-15

    Applicant: Brian Cook ,  David A. Recchia ,  Timothy Gotsick

    Inventor： Brian Cook ,  David A. Recchia ,  Timothy Gotsick

    IPC: G03F7/00 ,  G03F7/26 ,  B41N1/00

    CPC classification number: G03F7/092 ,  G03F7/202

    Abstract: A method of making a relief image printing element having a relief pattern comprising a plurality of relief dots, wherein the photocurable printing blank comprises a backing layer having at least one photocurable layer disposed thereon and a masking layer on the at least one photocurable layer is provided. The method comprising the steps of: a) selectively ablating the masking layer to create an overall image in the masking layer, such that the overall image comprises a sub-image, comprising a pattern of cells, in it; b) applying an oxygen barrier layer on top of the masking layer; c) exposing the printing element to actinic radiation through the oxygen barrier layer and the masking layer; and d) developing the printing blank by removing the barrier layer and the uncured portions of the photocurable layer to reveal the relief image.

    Abstract translation: 一种形成具有包括多个浮雕点的浮雕图案的浮雕图像打印元件的方法，其中所述光固化印刷坯料包括其上设置有至少一个光固化层的背衬层，并且在所述至少一个光固化层上设置掩模层 。 该方法包括以下步骤：a）选择性地烧蚀掩模层以在掩模层中产生整体图像，使得整个图像包括其中包含单元格图案的子图像; b）在掩蔽层的顶部上施加氧阻挡层; c）将印刷元件暴露于通过氧阻隔层和掩蔽层的光化辐射; 以及d）通过去除光固化层的阻挡层和未固化部分来显影印刷毛坯以露出浮雕图像。

    Methods and apparatuses for measuring print area using hand-held printer
    26.
    发明申请
    Methods and apparatuses for measuring print area using hand-held printer 审中-公开
    使用手持打印机测量打印区域的方法和设备

    公开(公告)号：US20070076082A1

    公开(公告)日：2007-04-05

    申请号：US11241094

    申请日：2005-09-30

    Applicant: Brian Cook

    Inventor： Brian Cook

    IPC: B41J3/36

    CPC classification number: B41J3/36 ,  B41J11/003

    Abstract: The size of a print area may be determined using a hand-held printer including an internal tracking device, such as an optical mouse device. Based on the size of the print area, and one or more user settings, an image to be printed on the print surface by the hand-held printer may be scaled and/or repositioned. The hand-held printer may print the image to a desired size while centering the image or otherwise repositioning it, scaling it to fit within user-defined margins or areas, and the like.

    Abstract translation: 可以使用包括诸如光学鼠标装置的内部跟踪装置的手持式打印机来确定打印区域的尺寸。 基于打印区域的大小和一个或多个用户设置，可以缩放和/或重新定位由手持打印机在打印表面上打印的图像。 手持打印机可以将图像打印到期望的尺寸，同时使图像居中或以其它方式重新定位，将其缩放以适合用户定义的边缘或区域等。

    Bio-sensitized solar cells (BSSC)
    27.
    发明授权
    Bio-sensitized solar cells (BSSC) 有权
    生物敏化太阳能电池（BSSC）

    公开(公告)号：US08796544B2

    公开(公告)日：2014-08-05

    申请号：US11639372

    申请日：2006-12-14

    Applicant: Andreas Mershin ,  Brian Cook ,  Shuguang Zhang

    Inventor： Andreas Mershin ,  Brian Cook ,  Shuguang Zhang

    IPC: H01G9/20 ,  H01L51/42

    CPC classification number: H01G9/2027 ,  B82Y10/00 ,  B82Y30/00 ,  H01G9/204 ,  H01G9/2059 ,  H01L51/0093 ,  Y02E10/542 ,  Y02E10/549

    Abstract: The present invention provides a wet or dry bio-sensitized photoelectric conversion device (photodetector or photovoltaic) comprising: a stabilized biologically-derived sensitizer, such as a stablilized photosystem I (PS-I), deposited on nanowires, semiconductor material, electrodes and a support. The nanowires provide a greater surface area of the light absorption layer for better energy conversion efficiency and are chosen such as to complement the absorption spectrum of the sensitizer and protect the sensitizer from photobleaching.

    Abstract translation: 本发明提供一种湿或干生物敏化光电转换装置（光电检测器或光伏），其包括：稳定的生物衍生的敏化剂，例如沉积在纳米线，半导体材料，电极上的稳定的光系统I（PS-1） 支持。 纳米线提供更大的光吸收层的表面积以获得更好的能量转换效率，并且被选择为补充敏化剂的吸收光谱并保护敏化剂免受漂白。

    Method and apparatus for thermal processing of photosensitive printing elements
    28.
    发明授权
    Method and apparatus for thermal processing of photosensitive printing elements 有权
    光敏印刷元件的热处理方法和装置

    公开(公告)号：US08739701B2

    公开(公告)日：2014-06-03

    申请号：US12183461

    申请日：2008-07-31

    Applicant: Ryan Vest ,  Brian Cook ,  Jim Hennessy ,  David Elwell

    Inventor： Ryan Vest ,  Brian Cook ,  Jim Hennessy ,  David Elwell

    IPC: B41N6/00 ,  G03F7/00

    CPC classification number: G03F7/40 ,  B41C1/1075 ,  B41C1/1083 ,  G03F7/36

    Abstract: The present invention pertains to a process and an apparatus for treating a photosensitive element to form a relief structure suitable for flexographic printing plate. The apparatus comprises an enclosure, a conveyor, a heatable roller with absorbent material conducted over it, and a roller that can significantly smooth or uniformly roughen the relief structure of the flexographic printing plate. Previously selectively cured photosensitive elements are developed by means of the heatable roller by blotting with the absorbent material, and the resulting relief structure is made uniform by way of a smoothing or roughening roller. The flexographic plates produced by the method and apparatus are especially suited to processes that require substantially smoothed or uniformly roughened printing plate surfaces, which are capable of producing better quality printing.

    Abstract translation: 本发明涉及一种用于处理感光元件以形成适于柔性版印刷版的浮雕结构的方法和设备。 该装置包括外壳，输送机，带有吸收材料的可加热辊，并且能够显着平滑或均匀地粗糙柔性版印刷版的浮雕结构。 先前选择性地固化的感光元件通过用吸收材料吸墨通过可加热辊显影，并且通过平滑或粗糙的辊使得到的浮雕结构均匀。 通过该方法和设备生产的柔版印刷板特别适用于需要基本上平滑或均匀粗糙的印版表面的工艺，其能够生产更好质量的印刷。

    Multiplexed Olfactory Receptor-Based Microsurface Plasmon Polariton Detector
    30.
    发明申请
    Multiplexed Olfactory Receptor-Based Microsurface Plasmon Polariton Detector 有权
    多重嗅觉受体基微表面等离子体极谱探测器

    公开(公告)号：US20120021932A1

    公开(公告)日：2012-01-26

    申请号：US13015851

    申请日：2011-01-28

    Applicant: Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

    Inventor： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

    IPC: C40B30/04 ,  C40B40/10 ,  G01N21/75 ,  G01N21/55 ,  G01N24/08

    CPC classification number: G01N21/553 ,  B82Y30/00 ,  C07K2/00 ,  G01N21/554 ,  G01N33/0031 ,  G01N2201/06113 ,  G01N2201/08

    Abstract: The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

    Abstract translation: 本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。 纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

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