公开(公告)号：US09069255B2

公开(公告)日：2015-06-30

申请号：US12620715

申请日：2009-11-18

Applicant: Jim Hennessy ,  David X. Elwell ,  Nicholas R. Pina ,  Brian Cook ,  Ryan Vest

Inventor： Jim Hennessy ,  David X. Elwell ,  Nicholas R. Pina ,  Brian Cook ,  Ryan Vest

IPC: B41N6/00 ,  B41N10/02 ,  G03F7/34 ,  B41F27/00

CPC classification number: G03F7/34 ,  B41F27/00 ,  B41N6/00 ,  B41N10/02

Abstract: An improved apparatus for thermally developing a flexographic printing element to reveal a relief image on the surface and a method of using the apparatus to develop a flexographic printing element. The apparatus typically comprises means for softening or melting a crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element; at least one roll that is contactable with the imaged surface of the flexographic printing element and capable of moving over at least a portion of the imaged surface of the flexographic printing element to remove the softened or melted non-crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element; and means for maintaining contact between the at least one roll and the imaged and exposed surface of the flexographic printing element. A layer of resilient compressible material is positioned between the flexographic printing element and a supporting conveying means. The means for softening or melting non-crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element comprise a heater positioned adjacent to the imaged surface of the flexographic printing element and/or heating the at least one roll that contactable with the imaged surface of the flexographic printing element. The apparatus may also contain an exposure device to crosslink and cure the imaged surface of the flexographic printing element prior to thermal development.

Abstract translation: 用于热显影柔性版印刷元件以在表面上露出浮雕图像的改进的装置以及使用该装置来开发柔性版印刷元件的方法。 该装置通常包括用于软化或熔化柔性版印刷元件的成像和暴露表面上的交联光聚合物的装置; 至少一个辊，其能够与柔性版印刷元件的成像表面接触并且能够移动柔性版印刷元件的成像表面的至少一部分以去除成像和曝光表面上的软化或熔融的非交联光聚合物 的柔性版印刷元件; 以及用于保持柔性版印刷元件的至少一个辊与成像和暴露的表面之间的接触的装置。 弹性可压缩材料层位于柔性版印刷元件和支撑输送装置之间。 用于软化或熔化柔性版印刷元件的成像和暴露表面上的非交联光聚合物的装置包括邻近柔性版印刷元件的成像表面定位的加热器和/或加热可与成像表面接触的至少一个辊 的柔性版印刷元件。 该装置还可以包含用于在热显影之前交联和固化柔性版印刷元件的成像表面的曝光装置。

公开(公告)号：US20100211153A1

公开(公告)日：2010-08-19

申请号：US12389070

申请日：2009-02-19

Applicant: Brian Cook ,  James Mitchell ,  Natividad Vasquez ,  Gianfranco Pellegrini

Inventor： Brian Cook ,  James Mitchell ,  Natividad Vasquez ,  Gianfranco Pellegrini

IPC: A61F2/84

CPC classification number: A61M25/0082 ,  A61F2/91 ,  A61F2/95 ,  A61F2/966 ,  A61F2002/9665 ,  A61F2250/0068 ,  A61M25/0068 ,  A61M2025/0057 ,  A61M2025/0681

Abstract: A system for treating a vascular condition includes a catheter having an inner member and an outer member, the outer member concentrically arranged about the inner member and a retractable drug delivery device disposed at a distal end of the inner member. A coating disposed on at least a portion of an outer surface of the retractable drug delivery device includes at least one therapeutic agent.

Abstract translation: 用于治疗血管病症的系统包括具有内部构件和外部构件的导管，所述外部构件围绕内部构件同心地布置，以及设置在内部构件的远端处的可伸缩药物输送装置。 设置在可伸缩药物输送装置的外表面的至少一部分上的涂层包括至少一种治疗剂。

公开(公告)号：US20090156427A1

公开(公告)日：2009-06-18

申请号：US12183916

申请日：2008-07-31

Applicant: Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

Inventor： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

IPC: C40B30/10 ,  B01J19/00 ,  C40B40/10 ,  C40B60/12 ,  C40B30/00 ,  C12P21/00

CPC classification number: G01N33/54366 ,  G01N2333/726

Abstract: The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

Abstract translation: 本发明提供一种生物感测纳米装置，其包括：稳定的生物衍生的G蛋白偶联受体 - 支持物上的嗅觉受体，实时受体 - 配体结合检测方法，加味剂递送系统和气味识别程序。 生物衍生的G蛋白偶联受体可以使用表面活性剂肽在纳米技术上稳定。 所述纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其包含稳定的生物衍生的G蛋白偶联受体 - 嗅觉受体 - 固定在载体上，并且布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

公开(公告)号：US20060071391A1

公开(公告)日：2006-04-06

申请号：US10930446

申请日：2004-08-31

Applicant: Mahesan Chelvayohan ,  Brian Cook ,  Timothy Howard ,  Kevin Johnson ,  William Klein ,  Michael Lawrence

Inventor： Mahesan Chelvayohan ,  Brian Cook ,  Timothy Howard ,  Kevin Johnson ,  William Klein ,  Michael Lawrence

IPC: B65H5/00 ,  B65H7/02

CPC classification number: B65H7/02 ,  B65H2402/54 ,  B65H2403/72 ,  B65H2511/51 ,  B65H2553/81

Abstract: An imaging apparatus includes a printing mechanism having a media path. A print media source is provided for supplying a sheet of print media to the printing mechanism. A drive unit is provided, with a drive shaft coupled to the drive unit. A media sensor device is mounted to the drive shaft, wherein as the drive shaft is rotated in a first direction the media sensor device is moved from a first position that is out of the media path to a second position that is in the media path for sensing the sheet of print media. As the drive shaft is rotated in a second direction opposite to the first direction the media sensor device is moved from the second position that is in the media path for sensing the sheet of print media to the first position that is out of the media path.

Abstract translation: 成像装置包括具有媒体路径的打印机构。 提供了一种打印介质源，用于将一张打印介质供给到打印机构。 提供了一个驱动单元，其中驱动轴联接到驱动单元。 介质传感器装置安装到驱动轴上，其中当驱动轴沿第一方向旋转时，介质传感器装置从介质路径外的第一位置移动到位于介质路径中的第二位置 感测印张介质。 当驱动轴沿与第一方向相反的第二方向旋转时，介质传感器装置从用于感测印张介质的介质路径的第二位置移动到介质路径外的第一位置。

公开(公告)号：US20050203158A1

公开(公告)日：2005-09-15

申请号：US10632888

申请日：2003-08-01

Applicant: Joerg Bentzien ,  Brian Cook ,  Charles Cywin ,  Roman Fleck ,  Ho Lo ,  Peter Nemoto ,  Steven Pullen ,  Gregory Roth ,  Roger Snow ,  Hidenori Takahashi ,  Ji Wang ,  Kevin Moriarty ,  Lei Qiao ,  Michael Winters

Inventor： Joerg Bentzien ,  Brian Cook ,  Charles Cywin ,  Roman Fleck ,  Ho Lo ,  Peter Nemoto ,  Steven Pullen ,  Gregory Roth ,  Roger Snow ,  Hidenori Takahashi ,  Ji Wang ,  Kevin Moriarty ,  Lei Qiao ,  Michael Winters

IPC: A61K31/4184 ,  A61K39/00 ,  A61P1/04 ,  A61P3/10 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P17/00 ,  A61P17/06 ,  A61P25/00 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07D235/28 ,  C07D235/30 ,  C07D409/12 ,  C07D43/02

CPC classification number: C07D409/12 ,  C07D235/30

Abstract: Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

Abstract translation: 公开了式（I）的取代的苯并咪唑化合物：其中R 1，R 2，R 3，R 4， >和X > 。 本发明的化合物抑制Itk激酶，因此可用于治疗涉及炎症，免疫学障碍和过敏性疾病的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。

公开(公告)号：US20130017493A1

公开(公告)日：2013-01-17

申请号：US13183558

申请日：2011-07-15

Applicant: Brian Cook ,  David A. Recchia ,  Timothy Gotsick

Inventor： Brian Cook ,  David A. Recchia ,  Timothy Gotsick

IPC: G03F1/02

CPC classification number: G03F7/092 ,  G03F7/202

Abstract: A method of making a relief image printing element having a relief pattern comprising a plurality of relief dots, wherein the photocurable printing blank comprises a backing layer having at least one photocurable layer disposed thereon and a masking layer on the at least one photocurable layer is provided. The method comprising the steps of: a) selectively ablating the masking layer to create an overall image in the masking layer, such that the overall image comprises a sub-image, comprising a pattern of cells, in it; b) applying an oxygen barrier layer on top of the masking layer; c) exposing the printing element to actinic radiation through the oxygen barrier layer and the masking layer to selectively crosslink and cure the at least one photocurable layer, thereby creating the relief image therein and a textured surface on the printing element; and d) developing the printing blank by removing the barrier layer and the uncured portions of the photocurable layer to reveal the relief image. The method results in printing plate having improved print performance for optimal printing and a higher achievable solid ink density.

Abstract translation: 一种形成具有包括多个浮雕点的浮雕图案的浮雕图像打印元件的方法，其中所述光固化印刷坯料包括其上设置有至少一个光固化层的背衬层，并且在所述至少一个光固化层上设置掩模层 。 该方法包括以下步骤：a）选择性地烧蚀掩模层以在掩模层中产生整体图像，使得整个图像包括其中包含单元格图案的子图像; b）在掩蔽层的顶部上施加氧阻挡层; c）将印刷元件暴露于通过氧阻隔层和掩模层的光化辐射，以选择性地交联和固化至少一个光固化层，从而在印刷元件上形成浮雕图案和纹理表面; 以及d）通过去除光固化层的阻挡层和未固化部分来显影印刷毛坯以露出浮雕图像。 该方法产生具有改善的印刷性能以获得最佳印刷的印刷版和更高可实现的固体油墨密度。

公开(公告)号：US08147898B2

公开(公告)日：2012-04-03

申请号：US12179783

申请日：2008-07-25

Applicant: Paul Coates ,  Brian Cook

Inventor： Paul Coates ,  Brian Cook

IPC: A61L33/00 ,  B05D3/00 ,  A61K9/14 ,  A61F2/06

CPC classification number: C23C14/12 ,  A61F2/82 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/02 ,  C23C14/024

Abstract: A drug coating is formed by vaporizing a drug in a deposition chamber having an implantable medical device such as a stent loaded therein. A vacuum is utilized to lower the pressure within the deposition chamber, thereby reducing the temperature necessary to vaporize the drug. The drug is then deposited onto the implantable medical device while in a vapor phase to form the drug coating.

Abstract translation: 通过在具有植入式医疗装置（诸如其中装载的支架）的沉积室中蒸发药物来形成药物涂层。 利用真空来降低沉积室内的压力，从而降低蒸发药物所需的温度。 然后将药物在气相中沉积到可植入医疗装置上以形成药物涂层。

公开(公告)号：US08016880B2

公开(公告)日：2011-09-13

申请号：US11941591

申请日：2007-11-16

Applicant: Brian Cook ,  Mark Dolan

Inventor： Brian Cook ,  Mark Dolan

IPC: A61F2/06

CPC classification number: A61F2/88 ,  A61F2/86 ,  A61F2250/0035 ,  A61F2250/0068

Abstract: A drug delivery stent is formed by a metallic or polymeric tubular strut which is shaped into a generally cylindrical configuration, the tubular strut having a central lumen for containing a therapeutic substance or drug therein. The tubular strut has a continuous channel extending from the inside surface of the strut to the outside surface of the strut positioned spirally about or in a corkscrew fashion around a circumference of the tubular strut for delivering the therapeutic substance or drug to a stenotic lesion. The spiral or corkscrew channel width may be varied along the length of the strut to control elution rate and/or flexibility of the stent. The pitch of the spiral or corkscrew channel may also be varied along the length of the strut to control flexibility of the stent. The stent may be carried on a balloon of a balloon catheter to a site of a stenotic lesion where the stent is implanted.

Abstract translation: 药物递送支架由金属或聚合物管状支柱形成，其形状为大致圆柱形的构造，管状支柱具有用于在其中容纳治疗物质或药物的中心腔。 管状支柱具有从支柱的内表面延伸到支柱的外表面的连续通道，所述支柱的外表面围绕螺旋状围绕或以开瓶器方式围绕管状支柱的圆周定位，用于将治疗物质或药物输送至狭窄病变。 螺旋或螺旋状通道宽度可以沿着支柱的长度变化以控制支架的洗脱速率和/或柔性。 螺旋或螺旋状通道的螺距也可以沿着支柱的长度变化以控制支架的柔性。 支架可以携带在球囊导管的球囊上，以移植支架的狭窄病变部位。

公开(公告)号：US20070220422A1

公开(公告)日：2007-09-20

申请号：US11378216

申请日：2006-03-17

Applicant: Brian Cook

Inventor： Brian Cook

IPC: G06F15/00 ,  G06F17/00

CPC classification number: H04N1/00681 ,  H04N1/00702 ,  H04N1/00734 ,  H04N1/00745 ,  H04N1/0075 ,  H04N1/00779 ,  H04N1/047 ,  H04N1/12 ,  H04N1/128 ,  H04N2201/0082 ,  H04N2201/04737 ,  H04N2201/04758

Abstract: A method for achieving accurate page margins on a media and a duplex imaging apparatus thereof. The method comprises: detecting a leading edge position by an edge sensor and a first left-to-right position of the media by an alignment sensor in a first imaging path; imaging a first side of the media in a print zone of the duplex imaging apparatus; removing the media from the print zone and disposing the media in a second imaging path; detecting a leading edge position by the edge sensor and a second left-to-right position of the media by the alignment sensor; determining a carrier reset distance by calculating a difference between first and second left-to-right positions, and shifting a print image by a distance substantially equal to the carrier reset distance thereby achieving accurate page margins for imaging a second side of the media with the print image. In another embodiment, the first left-to-right position can be determined by feeding the media into a preset first left-to-right position.

Abstract translation: 一种用于在介质及其双面成像装置上实现精确的页边距的方法。 该方法包括：通过第一成像路径中的对准传感器，通过边缘传感器和介质的第一左至右位置检测前缘位置; 在所述双面成像设备的打印区域中成像所述介质的第一侧; 从打印区域移除介质并将介质布置在第二成像路径中; 通过边缘传感器检测前缘位置和由对准传感器检测介质的第二左至右位置; 通过计算第一和第二左至右位置之间的差异来确定载体复位距离，并且将打印图像移位基本上等于载波复位距离的距离，从而实现用于对介质的第二面进行成像的精确的页边距， 打印图像。 在另一个实施例中，可以通过将介质馈送到预设的第一左至右位置来确定第一左至右位置。

公开(公告)号：US20060280534A1

公开(公告)日：2006-12-14

申请号：US11152487

申请日：2005-06-14

Applicant: Brian Cook ,  Gregory Washnock ,  Gregory Webb

Inventor： Brian Cook ,  Gregory Washnock ,  Gregory Webb

IPC: G03G15/00

CPC classification number: G03G15/60 ,  G03G2215/00202

Abstract: A duplexing auto-document feeder for an all-in-one device having an input tray for stacking a plurality of sheets in feeding communication with a unidirectional feedpath including a simplex path and a duplex path. An image sensor is aligned with first and second platens along the unidirectional feedpath and a selectively actuatable gate is disposed downstream of the input tray directing each of the plurality of sheets through one of a simplex or duplex scanning path. An image sensor is in optical communication with the first and second platens and the simplex and duplex paths.

Abstract translation: 一种用于一体式设备的双面自动文档馈送器，具有用于堆叠多个片材的输入托盘，用于与包括单向路径和双工路径的单向馈送路径进行通信。 图像传感器沿着单向进给路径与第一和第二压板对准，并且可选择性地启动的门设置在输入托盘的下游，其指导多个纸张中的每一个通过单面或双面扫描路径中的一个。 图像传感器与第一和第二压板以及单工和双工路径光学通信。