公开(公告)号：US12203994B2

公开(公告)日：2025-01-21

申请号：US18080189

申请日：2022-12-13

Applicant: California Institute of Technology

Inventor： Farshid Roumi ,  Mahshid Roumi

IPC: G01R31/389 ,  G01R31/367 ,  G01R31/385 ,  G01R31/392 ,  G01R31/396 ,  G01R31/52

Abstract: A system and method for monitoring characteristics of an electric energy device includes generating an external short from the electric energy device. The external short occurs at a known distance from a sensor and has at least one known external resistance. The received signal representing change in electromagnetic field due to the applied external short may be analyzed to determine a signal parameter that is then analyzed in comparison to a lookup table, based on the known conditions including distance, temperature and the external resistance. The output of this analyses in comparison with expected values may be utilized to identify a characteristic of the energy device.

公开(公告)号：US20250015900A1

公开(公告)日：2025-01-09

申请号：US18211057

申请日：2023-06-16

Applicant: California Institute of Technology

Inventor： Mohammad Mirhosseini ,  Alkim Bozkurt ,  Han Zhao ,  Chaitali Joshi

IPC: H04B10/70 ,  G06N10/40 ,  H04B10/516

Abstract: Systems and methods for transducing and storing qubit signals are provided. The system includes a voltage source, a substrate, and a membrane suspended over the substrate. A phononic crystal oscillator is disposed in a first region of the membrane. The phononic crystal oscillator includes a capacitor having a moving electrode including an array of multiple phononic crystal unit cells. The moving electrode is connected to the voltage source. A superconducting circuit disposed in a second region of the membrane. A plurality of phonon shields and an optical resonator may also be disposed on the membrane.

公开(公告)号：US20250013080A1

公开(公告)日：2025-01-09

申请号：US18665480

申请日：2024-05-15

Applicant: California Institute of Technology

Inventor： Baris Volkan Gurses ,  Seyed Ali Hajimiri

IPC: G02F1/01

Abstract: A method of correcting for crosstalk in thermo-optics phase shifters (TOPS) integrated on a substrate, includes, in part, determining a first value representative of an amount of electrical power applied to a heater associated with a first TOPS causing a known phase shift in an optical signal passing through the first TOPS' associated waveguide; determining a second value representative of a time constant of the first TOPS; determining a third value representative of an amount of electrical power applied to a heater associated with a second TOPS causing a known phase shift in an optical signal passing through the waveguide associated with the first TOPS; determining a multitude of thermal couplings between a multitude of heaters, waveguides and positions in the substrate using one or more of the first, second and third values; and making a correction associated with the crosstalk in accordance with the thermal couplings.

公开(公告)号：US12191552B2

公开(公告)日：2025-01-07

申请号：US17846971

申请日：2022-06-22

Applicant: California Institute of Technology

Inventor： Goutam Chattopadhyay ,  Jacob W. Kooi ,  Choonsup Lee ,  Sofia Rahiminejad ,  Subash Khanal

IPC: H04B1/04 ,  H01P1/22 ,  H01P11/00 ,  H04B1/16

Abstract: A waveguide based variable attenuator device including one or more attenuators each including a porous dielectric material; and a metal coating on the top of the dielectric material; and an actuator coupled to the attenuator. The actuator is configured to position, with nanometer resolution, the one or more attenuators in a waveguide configured and dimensioned to guide an electromagnetic wave having a frequency in a range of 100 gigahertz (GHz) to 1 terahertz (THz). The actuator controls at least one of a position or a volume of the one attenuator inserted in the waveguide to achieve a variable or pre-determined attenuation of the electromagnetic wave transmitted through waveguide.

公开(公告)号：US20250001007A1

公开(公告)日：2025-01-02

申请号：US18709720

申请日：2022-11-16

Applicant: California Institute of Technology

Inventor： Viviana Gradinaru ,  Xinhong Chen

IPC: A61K48/00 ,  C07K14/005 ,  C12N15/86

Abstract: Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with increased transduction enrichment in the heart and/or skeletal muscle and, in some cases, reduced transduction in the liver. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. Gene therapy using the rAAVs is described. Also described are methods of treating diseases and conditions of the heart and/or skeletal muscle.

公开(公告)号：US20240427045A1

公开(公告)日：2024-12-26

申请号：US18752231

申请日：2024-06-24

Applicant: California Institute of Technology

Inventor： Ettore Biondi ,  Zhongwen Zhan ,  Jiaxuan Li ,  Weiqiang Zhu

IPC: G01V1/34 ,  G01V1/22 ,  G01V1/28 ,  G01V1/30

Abstract: A computer-implemented method useful for performing seismic tomography, including obtaining seismic data comprising distributed acoustic sensing (DAS) data, comprising at least one of P-wave or S-wave travel times from a plurality of seismic events to a plurality of recording stations coupled to a network of optical fibers in a geological structure; and generating tomography data from the DAS data, wherein tomography data is useful for characterizing the geological structure. We employ distributed acoustic sensing data recorded along a 100-km fiber-optic cable traversing the caldera to image its subsurface structure. Our images highlight a definite separation between the shallow hydrothermal system and the large magma chamber located at ˜12 km depth. The combination of the geological evidence with our results shows how fluids exsolved through second boiling provide the source of the observed uplift and seismicity. Thus Fiber-seismic tomography reveals that the unrest in the Long Valley Caldera is likely driven by fluid from second boiling, not new magma intrusion.

公开(公告)号：US12173052B2

公开(公告)日：2024-12-24

申请号：US17500171

申请日：2021-10-13

Applicant: The Rockefeller University ,  California Institute of Technology

Inventor： Ron Diskin ,  Anthony P. West ,  Michel Nussenzweig ,  Pamela J. Bjorkman

IPC: C07K16/10 ,  A61K39/00

Abstract: Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for neutralizing a range of HIV strains. Combinations of broadly neutralizing antibodies can also improve potency over a single antibody composition.

公开(公告)号：US20240410442A1

公开(公告)日：2024-12-12

申请号：US18737918

申请日：2024-06-07

Applicant: California Institute of Technology

Inventor： Sergio Pellegrino ,  Alexander Wen

IPC: F16F15/121 ,  F16F1/10

Abstract: Systems and devices for dynamic damping of vibrations are described. Traditional methods of vibration damping often involve trade-offs between stiffness and damping, potentially compromising structural integrity for increased damping. The performance of these damping techniques can also be influenced by the specific profile of the vibrational excitation, presenting challenges in ensuring consistent and reliable damping across different operating conditions. A tunable friction-damping device formed from concentric layers can overcome many of these limitations and presents methods for dynamic damping of vibrations as an alternative solution.

公开(公告)号：US20240402568A1

公开(公告)日：2024-12-05

申请号：US18317533

申请日：2023-05-15

Applicant: California Institute of Technology

Inventor： Robert M. Gray ,  Selina Zhou ,  Mingchen Liu ,  Arkadev Roy ,  Alireza Marandi

IPC: G02F1/35 ,  G02F1/39

Abstract: A sensor including a resonator comprising a nonlinear material comprising a nonlinear susceptibility configured to convert a pump electromagnetic wave (EM) wave to a signal EM wave and an idler EM wave, wherein at least one of the pump EM wave, the signal EM wave and/or the idler EM wave is fed back through the nonlinear material to form one or more resonant EM waves. An actuator coupled to the resonator or a pump path to the resonator, controls at least one of a pump power of the pump EM wave, a detuning of the frequency modes of the resonator relative to one or more frequencies of the resonant EM waves, or a phase matching of the nonlinear material. An output of the resonator outputs one or more output EM waves comprising information about a sample coupled to the resonator.

公开(公告)号：US20240398374A1

公开(公告)日：2024-12-05

申请号：US18780407

申请日：2024-07-22

Applicant: California Institute of Technology

Inventor： Lihong Wang ,  Shuai Na

IPC: A61B8/15 ,  A61B8/00 ,  A61B8/06 ,  A61B8/08

Abstract: Cross-ray ultrasound tomography systems and methods that employ an ultrasonic emitter and an ultrasonic detector array where the ultrasonic emitter is outside a plane at elements of the ultrasonic detector array, and ultrasonic wave(s) are emitted by the ultrasonic emitter at an angle to the plane at the elements of the ultrasonic detector array.