公开(公告)号：US20230381960A1

公开(公告)日：2023-11-30

申请号：US18032425

申请日：2021-12-13

Applicant: Daegu Gyeongbuk Institute of Science and Technology

Inventor： Jae Hong LEE ,  Hwa Joong KIM

IPC: B25J9/16 ,  B25J19/02

CPC classification number: B25J9/1635 ,  B25J19/02

Abstract: Disclosed is an integral self-monitoring soft actuator including a body portion configured to be driven by deformation due to stimulation; a first limiter integrally formed with respect to the longitudinal direction of the body portion to limit deformation of the body portion in the longitudinal direction; a second limiter that limits deformation of the body portion in the radial direction by including at least a pair of electrodes in a spiral shape integrally provided on the outer surface of the body portion; and a controller for controlling motion of the body portion, wherein the controller self-monitors deformation of the body portion by self-sensing changes in the intervals between the electrodes according to deformation of the body portion. According to the above configuration, deformation of the body portion may be self-detected in real time using the second limiter integrally provided with the body portion, thereby improving control efficiency.

公开(公告)号：US11826368B2

公开(公告)日：2023-11-28

申请号：US17050800

申请日：2019-04-26

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyang Sook Hoe ,  Jeoung Yeon Kim ,  Hye Yeon Nam ,  Ju Young Lee ,  Young Pyo Nam ,  Ri Jin Kang ,  Hyun Ju Lee

IPC: A61K31/519 ,  A61P25/28

CPC classification number: A61K31/519 ,  A61P25/28

Abstract: The present disclosure relates to a pharmaceutical composition comprising ibrutinib as an effective ingredient for preventing or treating neurodegenerative brain disease. Ibrutinib according to the present disclosure inhibits LPS-induced proinflammatory cytokine levels and BV2 microglial cell migration. In addition, ibrutinib treatment significantly reduced LPS-mediated microglial and astroglial activation. Ibrutinib treatment significantly diminished AP plaque numbers, tau hyperphosphorylation, and tau kinase CDK5 phosphorylation. Moreover, ibrutinib treatment enhances memory and thus can be used as a therapeutic agent for prevention or treatment of neurodegenerative brain disease.

公开(公告)号：US11774439B2

公开(公告)日：2023-10-03

申请号：US17212248

申请日：2021-03-25

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyung In Jang ,  Jun Woo Yea ,  Han Hee Jung

IPC: G01N33/487 ,  G01N27/327 ,  G01N27/416 ,  G01N27/403

CPC classification number: G01N33/48728 ,  G01N27/327 ,  G01N27/403 ,  G01N27/4163

Abstract: Disclosed is an integrated biochemical sensor including a reference electrode, a plurality of working electrodes each having different artificial lipid membranes, and partition layers for electrically insulating the reference electrode and each of the working electrodes.

公开(公告)号：US20230279325A1

公开(公告)日：2023-09-07

申请号：US18019854

申请日：2021-04-27

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Min Seok KIM ,  Hyun Gyu KANG ,  Woon Hae KIM

IPC: C12M3/06 ,  C12M1/42

CPC classification number: C12M23/16 ,  C12M1/42 ,  C12M35/02

Abstract: The present invention relates to an electroceutical screening device and a screening method using same, respectively, wherein an electrical stimulation is applied, through the electrodes, to the cell clusters received in the channels, and the potentials of the cell clusters are measured so as to measure neural activity, and thus electrical stimulation tests are conducted in various ways, and by measuring conduction velocity according to the various electrical stimulation tests, conditions for electrical stimulation therapy are assessed.

公开(公告)号：US11717267B2

公开(公告)日：2023-08-08

申请号：US17458737

申请日：2021-08-27

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Youn Hwang ,  Chun Yeol You ,  Moon Hwan Lee

IPC: A61B8/00 ,  A61B8/08 ,  A61B8/12

CPC classification number: A61B8/483 ,  A61B8/12 ,  A61B8/5207 ,  A61B8/54 ,  A61B2562/0247

Abstract: Disclosed are an ultrasound imaging system for analysis of a body composition and an operation method of an ultrasound imaging system which is designed for analysis of a body composition. An ultrasound imaging system may include: a scan device into which an object is insertable; an ultrasonic probe connected to a part of the scan device; a controller configured to control the ultrasonic probe to emit a transmission ultrasonic signal to the object at multiple positions at the scan device, and receive a reflection ultrasonic signal reflected from the object; and an image processor configured to generate multiple 2D ultrasound images based on reflection ultrasonic signals received at the multiple positions at the scan device, respectively, and generate a 3D ultrasound image based on the multiple 2D ultrasound images.

公开(公告)号：US20230176076A1

公开(公告)日：2023-06-08

申请号：US17296306

申请日：2019-11-27

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION ,  DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Il Doo HWANG ,  Hyun Woo CHO ,  Sung Bae LEE ,  Hyun Seob CHO

IPC: G01N33/68 ,  G01N33/574 ,  A61P25/28 ,  A61K38/16 ,  A61P35/00

CPC classification number: G01N33/6896 ,  A61K38/168 ,  A61P25/28 ,  A61P35/00 ,  G01N33/574

Abstract: The present disclosure relates to a use of JULGI in diagnosing and treating guanine quadruplex-related disease and, more particularly, to a guanine-quadruplex (G-quadruplex) detecting composition comprising JULGI protein or a protein having a homology of 80% or higher to the JULGI protein, a diagnostic composition comprising the detecting composition, a diagnostic kit comprising the diagnostic composition, a method for providing information for diagnosis of a neurodegenerative disease, cancer, or a viral infection disease which are in pathological correlation with G-quadruplex, and a pharmaceutical composition for prevention or treatment of a neurodegenerative disease, cancer, or a viral infection disease, the pharmaceutical composition comprising JULGI protein, a protein having a homology of 80% or more with the JULGI protein, or a mutant protein thereof. Thanks to the activity of binding to the G-quadruplex structure, JULGI according to the present disclosure is expected to be advantageously used in diagnosing or treating various diseases that are in pathological correlation with the abnormal formation and dissociation of the G-quadruplex structure.

公开(公告)号：US20230174931A1

公开(公告)日：2023-06-08

申请号：US17437411

申请日：2020-03-11

Applicant: Daegu Gyeongbuk Institute of Science and Technology

Inventor： Cheil MOON ,  Won Bae JEON ,  Sam Hwan KIM ,  Seong Kyoon CHOI

IPC: C12N5/0793

CPC classification number: C12N5/062 ,  C12N2533/50

Abstract: The present invention relates to a method for culturing neural stem cells into spheroids, the method including: culturing neural stem cells in a culture vessel coated with a protein containing a VGVPG pentapeptide and an RGD integrin receptor ligand; and isolating the neural stem cells that are aggregated and formed into spheroids during the culturing.

公开(公告)号：US20230130827A1

公开(公告)日：2023-04-27

申请号：US17893826

申请日：2022-08-23

Applicant: Hyundai Motor Company ,  Kia Corporation ,  Daegu Gyeongbuk Institute of Science and Technology

Inventor： Jun Ki Rhee ,  Sung Ho Ban ,  Yoon Sung Lee ,  Ko Eun Kim ,  Hyun Tae Lee ,  Hong Kyung Lee

IPC: H01M4/62 ,  H01M10/052 ,  H01M4/525 ,  H01M4/505

Abstract: Disclosed are, inter alia, a positive electrode slurry containing reduced content of a binder, a method of preparing the positive electrode slurry, a positive electrode made from the slurry and a lithium secondary battery including the positive electrode.

公开(公告)号：US11637846B2

公开(公告)日：2023-04-25

申请号：US16836369

申请日：2020-03-31

Applicant: Daegu Gyeongbuk Institute of Science and Technology

Inventor： Ji Woong Choi ,  Eun Min Choi ,  Sung Min Han

IPC: H04L9/40

Abstract: A method, performed by an observer node, of securing a network, includes: receiving a signal over the network; determining, based on a frequency characteristic of the received signal, which is determined according to a physical characteristic of a node, which transmits the received signal, a node, which has transmitted the received signal among a plurality of nodes included in the network; comparing a pre-learned signal pattern of the determined transmission node with a pattern of the received signal to determine whether the determined transmission node is a malicious node; and blocking the signal transmitted from the malicious node by determining that the transmission node is a malicious node.

公开(公告)号：US11596369B2

公开(公告)日：2023-03-07

申请号：US15499116

申请日：2017-04-27

Applicant: Daegu Gyeongbuk Institute of Science and Technology

Inventor： Jae-Sung Hong ,  Sang-Seo Jeon ,  Seong-Pung Lee

IPC: A61B6/12 ,  A61B6/00 ,  A61B34/20 ,  A61B90/00

Abstract: Provided is a method of generating a virtual x-ray image, the method including: obtaining a 3-dimensional (3D) image of a patient; determining a projection direction of the 3D image in consideration of a position relationship between an x-ray source of an x-ray device and the patient; and generating a virtual x-ray image by projecting the 3D image on a 2D plane in the determined projection direction.