公开(公告)号：US20160129045A1

公开(公告)日：2016-05-12

申请号：US14925991

申请日：2015-10-29

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Won Bae JEON ,  Seong Kyoon CHOI ,  Jin Kyu PARK

IPC: A61K35/35 ,  A61K38/39 ,  A61K47/48 ,  A61K9/00

CPC classification number: A61K38/39 ,  A61K35/28 ,  A61K35/30 ,  A61L26/0047 ,  A61L26/0057 ,  A61K2300/00

Abstract: Provided is a composition for wound-healing containing adult stem cells and elastin-like polypeptides, and more specifically, to a composition for wound-healing capable of effectively treating skin wounds by simultaneously administering elastin-like polypeptides along with adult stem cells thereby increasing the viability of the adult stem cells transplanted on the wounds and promoting angiogenesis.

Abstract translation: 提供了一种用于伤口愈合的组合物，其包含成体干细胞和弹性蛋白样多肽，更具体地，涉及一种用于伤口愈合的组合物，其能够通过同时施用弹性蛋白样多肽以及成体干细胞来有效治疗皮肤伤口，由此增加 成体干细胞移植在伤口上并促进血管发生的活力。

公开(公告)号：US20160131644A1

公开(公告)日：2016-05-12

申请号：US14930718

申请日：2015-11-03

Applicant: Daegu Gyeongbuk Institute of Science and Technology

Inventor： Eun Joo KIM ,  Won Bae JEON ,  Sung Jun LEE ,  Se Geun LEE ,  Eun Sook CHOI

IPC: G01N33/558 ,  G01N21/78 ,  G01N33/543

CPC classification number: G01N33/558 ,  C07K16/44 ,  G01N21/78 ,  G01N33/54346 ,  G01N33/54366 ,  G01N2021/7759

Abstract: The present invention relates to a method for the detection of a protein including a histidine-tag using immunochromatography. The detection method of the present invention uses immunochromatography using the polymer particle fixed with the histidine-tag, wherein a histidine-tag specific antibody alone is used to detect a histidine-tag conjugated protein (recombinant protein) quickly without using a target protein specific antibody. This method is also efficient in detecting and quantifying the histidine-tagged protein included in the sample without using an additional apparatus but quickly and accurately.

Abstract translation: 本发明涉及使用免疫色谱法检测包含组氨酸标签的蛋白质的方法。 本发明的检测方法使用使用固定有组氨酸标签的聚合物颗粒的免疫色谱法，其中单独使用组氨酸标签特异性抗体快速检测组氨酸标签结合蛋白（重组蛋白），而不使用靶蛋白特异性抗体 。 该方法在检测和定量样品中包含的组氨酸标记的蛋白质中也是有效的，而不使用另外的装置，但是快速且准确。

公开(公告)号：US20230174931A1

公开(公告)日：2023-06-08

申请号：US17437411

申请日：2020-03-11

Applicant: Daegu Gyeongbuk Institute of Science and Technology

Inventor： Cheil MOON ,  Won Bae JEON ,  Sam Hwan KIM ,  Seong Kyoon CHOI

IPC: C12N5/0793

CPC classification number: C12N5/062 ,  C12N2533/50

Abstract: The present invention relates to a method for culturing neural stem cells into spheroids, the method including: culturing neural stem cells in a culture vessel coated with a protein containing a VGVPG pentapeptide and an RGD integrin receptor ligand; and isolating the neural stem cells that are aggregated and formed into spheroids during the culturing.

公开(公告)号：US20150030655A1

公开(公告)日：2015-01-29

申请号：US14273557

申请日：2014-05-09

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Won Bae JEON ,  Seong Kyoon CHOI

IPC: A61L27/18 ,  A61L27/34 ,  A61L27/54

CPC classification number: A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/21 ,  A61L2300/428 ,  C08L89/00 ,  C08L67/04

Abstract: Disclosed is a PLGA (poly(D,L-lactide-co-glycolide)) cell scaffold. The cell scaffold is based on a PLGA scaffold, which is an FDA-approved material with no cytotoxicity, and overcomes the problem with conventional PLGA scaffolds of poor cell adhesion.

Abstract translation: 公开了一种PLGA（聚（D，L-丙交酯 - 共 - 乙交酯））细胞支架。 细胞支架基于PLGA支架，其是经FDA认可的材料，没有细胞毒性，并且克服了传统的PLGA支架不良细胞粘附的问题。

公开(公告)号：US20180318357A1

公开(公告)日：2018-11-08

申请号：US15773496

申请日：2016-11-03

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyeong Min LEE ,  Won Bae JEON ,  Jung Hee KIM

IPC: A61K35/39 ,  A61K38/39 ,  A61P3/10

CPC classification number: A61K35/39 ,  A61K38/39 ,  A61P3/10 ,  C07K7/00 ,  C07K14/78 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition for treating diabetes, which includes a pancreatic islet cell and an elastin-like artificial extracellular matrix (REP), and more particularly, to a pharmaceutical composition for treating diabetes, in which pancreatic islet cells are reacted with an elastin-like artificial extracellular matrix and then the resulting cells are administered along with the elastin-like artificial extracellular matrix, thus increasing a survival rate of the transplanted pancreatic islet cells, rapidly restoring a blood glucose level to normal, and maintaining the restored blood glucose level for a long period of time, and, accordingly, diabetes may be more effectively treated.

公开(公告)号：US20160228470A1

公开(公告)日：2016-08-11

申请号：US14929435

申请日：2015-11-02

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Won Bae JEON ,  Jung-Hee KIM ,  Kyeong-Min LEE ,  Seong-Kyoon CHOI

IPC: A61K35/30 ,  C07K5/09 ,  A61K47/42 ,  C07K7/06

CPC classification number: A61K35/30 ,  A61K9/0019 ,  A61K38/39 ,  A61L27/34 ,  A61L27/3675 ,  A61L31/10 ,  A61L31/16 ,  C07K14/78

Abstract: The present invention relates to a composition including neural cells and an elastin-like polypeptide for treating Parkinson's diseases. More particularly, the present invention relates to a composition for treating Parkinson's diseases, which can more effectively increase a survival rate and settling rate of neural cells transplanted to an acutely or chronically damaged nerve region for treatment of Parkinson's disease, by simultaneously administering an elastin-like polypeptide with neural cells.

Abstract translation: 本发明涉及包含用于治疗帕金森病的神经细胞和弹性蛋白样多肽的组合物。 更具体地说，本发明涉及一种用于治疗帕金森病的组合物，其可以通过同时施用弹性蛋白酶，更有效地增加移植到急性或慢性损伤的神经区域的神经细胞的存活率和沉降率，以治疗帕金森病， 像具有神经细胞的多肽。