公开(公告)号：US20220190453A1

公开(公告)日：2022-06-16

申请号：US17442530

申请日：2020-03-25

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean

IPC: H01P1/202 ,  A61B18/18 ,  H01P1/20

Abstract: A filtering device for use in a medical microwave delivery system is disclosed. The filtering device comprises a DC block and a microwave absorbing element. The microwave absorbing element is disposed around the DC block and/or around one or more elements within the DC block. Also disclosed is a medical microwave delivery system comprising a microwave generator system and the filtering device, wherein the filtering device is coupled to an output of the microwave generator system.

公开(公告)号：US20210161595A1

公开(公告)日：2021-06-03

申请号：US17047982

申请日：2019-04-16

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Matthew Donald Kidd ,  Shailesh Joshi

IPC: A61B18/18

Abstract: A microwave antenna apparatus comprises an electrically conductive ground element defining an aperture, an electrically conductive elongated element extending through the aperture and terminating at a distal end, and one or more dielectric elements. The one or more of the dielectric elements electrically insulate the elongated element and the ground element from one another. The microwave antenna apparatus may be configured for use in radiating microwave energy into surface tissue of a uterine cervix so as to provide a therapeutic effect in one or more regions of the uterine cervix, such as one or more regions of the cervix infected with human papillomavirus (HPV) and/or diagnosed with cervical intraepithelial neoplasia (CIN) or so as to create the correct biological response in one or more such regions. The microwave antenna apparatus may be configured for localized non-ablative hyperthermia of the surface tissue of the uterine cervix, localized ablation of the surface tissue of the uterine cervix, and/or cauterisation of the surface tissue of the uterine cervix.

公开(公告)号：US20210128932A1

公开(公告)日：2021-05-06

申请号：US16974000

申请日：2019-06-17

Applicant: Emblation Limited

Inventor： Eamon McErlean ,  Gary Beale

IPC: A61N5/02 ,  A61B5/318 ,  A61B5/0205 ,  A61B5/369 ,  A61N1/36 ,  A61N5/10 ,  G01N33/50

Abstract: An electromagnetic energy delivery system is configured to deliver energy in specific timing arrangements to improve an immune response. The electromagnetic energy delivery system may comprise a controlled electromagnetic energy source and an electromagnetic energy applicator, wherein the controlled electromagnetic energy source is configured to emit electromagnetic energy according to the specific timing arrangements as defined by a treatment profile which is configured so that the emitted electromagnetic energy stimulates and/or inhibits an immune response in a host when the emitted electromagnetic energy is delivered to the host via the electromagnetic energy applicator. A method of electromagnetic energy delivery,comprises delivering energy in specific timing arrangements to improve an immune response.

公开(公告)号：US20190298447A1

公开(公告)日：2019-10-03

申请号：US16447663

申请日：2019-06-20

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean

IPC: A61B18/18 ,  H05B6/70 ,  H05B6/72 ,  B05D5/00 ,  B29C45/00

Abstract: A method of forming a microwave applicator comprising forming a body comprising dielectric material so that there is a void in the dielectric material, and depositing conductive material in the void to form a feed for coupling energy into the dielectric material.

公开(公告)号：US20190274758A1

公开(公告)日：2019-09-12

申请号：US16277146

申请日：2019-02-15

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Matthew Kidd

IPC: A61B18/18 ,  A61K9/00

Abstract: Described herein are methods and apparatus for treating or preventing epidermal dysplasias, including, for example, dysplastic epidermal lesions and dermatological pre-cancerous disease.

公开(公告)号：US20240173561A1

公开(公告)日：2024-05-30

申请号：US18562654

申请日：2022-05-20

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Shailesh Joshi ,  Matthew Kidd

IPC: A61N5/02 ,  C12N13/00

CPC classification number: A61N5/025 ,  C12N13/00

Abstract: The disclosure is based on the finding that microwave energy may be used to modulate, for example up- or down-regulate the expression of certain genes. For example, where a disease or condition is associated with the aberrant expression of a particular gene or genes, microwave energy may be used to modulate the expression of those genes, thereby resolving and/or improving one or more of the symptoms of the disease or condition. Disclosed is a microwave system or microwave-generating apparatus, for use in a method of modulating the expression of one or more genes. Also disclosed are uses of microwave energy for modulating the expression of one or more genes in tissues, tissue samples and biopsies.

公开(公告)号：US11980769B2

公开(公告)日：2024-05-14

申请号：US15938238

申请日：2018-03-28

Applicant: Emblation Limited

Inventor： Eamon McErlean ,  Gary Beale ,  Matthew Donald Kidd

IPC: A61N5/02 ,  A61F2/82 ,  A61K41/00 ,  A61N5/04 ,  A61P9/10 ,  A61B18/18 ,  A61M25/10

CPC classification number: A61N5/025 ,  A61F2/82 ,  A61K41/0052 ,  A61N5/045 ,  A61P9/10 ,  A61B2018/1861 ,  A61M25/10

Abstract: Heat and heat based treatments that may be used to modulate, inhibit and/or prevent one or more of the processes that contribute to certain vascular and/or arterial complications.

公开(公告)号：US20230255686A1

公开(公告)日：2023-08-17

申请号：US18017157

申请日：2021-07-19

Applicant: Emblation Limited

Inventor： Eamon McErlean ,  Gary Beale

IPC: A61B18/18 ,  H03F3/19 ,  H03G3/00

CPC classification number: A61B18/1815 ,  H03F3/19 ,  H03G3/004 ,  A61B2018/00702 ,  H03G2201/103

Abstract: An electromagnetic energy delivery apparatus comprises: an amplifier; an amplifier input configured to provide to the amplifier a signal to be amplified; bias circuitry configured to provide a bias signal to the amplifier, wherein amplifying of the input signal by the amplifier is dependent on the bias signal provided by the bias circuitry; an amplifier output configured to provide an output signal comprising an amplified version of the input signal, for providing energy delivery to a radiating element to produce electromagnetic radiation; and a controller configured to control operation of the bias circuitry to provide a time- varying bias signal thereby to provide a desired time variation of the output signal.

公开(公告)号：US20230129737A1

公开(公告)日：2023-04-27

申请号：US17912465

申请日：2021-03-18

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean

IPC: A61L9/18

Abstract: Apparatus for electromagnetic treatment of at least one pathogen in air or other gas, comprises a waveguide structure including a treatment region within the waveguide structure, wherein the treatment region is configured to receive the air or other gas that contains the at least one pathogen, means for providing electromagnetic radiation to the treatment region, and at least one structure permeable to the air or other gas and that is configured to at least partially confine the electromagnetic radiation, wherein the at least one permeable structure forms at least one boundary of the treatment region.

公开(公告)号：US10335231B2

公开(公告)日：2019-07-02

申请号：US14364404

申请日：2012-12-14

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean

IPC: A61B18/18 ,  H05B6/70 ,  H05B6/72 ,  B05D5/00 ,  B29C45/00 ,  B29L31/34

Abstract: A method of forming a microwave applicator comprising forming a body comprising dielectric material so that there is a void in the dielectric material, and depositing conductive material in the void to form a feed for coupling energy into the dielectric material.