公开(公告)号：US20220104876A1

公开(公告)日：2022-04-07

申请号：US17426553

申请日：2020-01-29

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Matthew Kidd ,  Shailesh Joshi

IPC: A61B18/18

Abstract: A microwave antenna apparatus comprises a radiating element configured to perform a treatment, the treatment comprising heating a volume of tissue using microwave radiation emitted from the radiating element; a cooling structure arranged for flowing a coolant through at least one lumen of the cooling structure during the treatment; and a controller configured to control the flow of coolant such as to provide a first flow rate of coolant through the at least one lumen during a first period of the treatment and to provide a second, different flow rate of coolant through the at least one lumen during a second, later period of the treatment.

公开(公告)号：US20220160427A1

公开(公告)日：2022-05-26

申请号：US17601013

申请日：2020-03-31

Applicant: Emblation Limited

Inventor： Eamon McErlean ,  Matthew Kidd ,  Gary Beale ,  Shailesh Joshi

IPC: A61B18/18

Abstract: A microwave system, comprises: a microwave generator; a microwave applicator for delivering microwave radiation generated by the microwave generator to a surface, wherein the microwave applicator is moveable relative to the surface; one or more sensors for sensing at least one of a position, an orientation, an acceleration, a speed and/or a velocity of the microwave applicator, and a controller configured to monitor sensor output from the one or more sensors and further configured to control one or more operational parameters of the microwave system based at least on the monitored sensor output.

公开(公告)号：US20220266048A1

公开(公告)日：2022-08-25

申请号：US17629030

申请日：2020-07-23

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Matthew Kidd ,  Shailesh Joshi

IPC: A61N5/02 ,  A61B18/18

Abstract: A microwave system comprises: a microwave generator; a controller configured to control the microwave generator to generate microwave energy having a selected operational frequency or range of frequencies; a microwave cable configured to deliver the microwave energy to a microwave antenna extending from or coupled to a distal end of the microwave cable; and the microwave antenna, the microwave antenna comprising a plurality of slots distributed along a portion of the microwave antenna, wherein a width of the slots varies with distance along the portion of the microwave antenna.

公开(公告)号：US20210161595A1

公开(公告)日：2021-06-03

申请号：US17047982

申请日：2019-04-16

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Matthew Donald Kidd ,  Shailesh Joshi

IPC: A61B18/18

Abstract: A microwave antenna apparatus comprises an electrically conductive ground element defining an aperture, an electrically conductive elongated element extending through the aperture and terminating at a distal end, and one or more dielectric elements. The one or more of the dielectric elements electrically insulate the elongated element and the ground element from one another. The microwave antenna apparatus may be configured for use in radiating microwave energy into surface tissue of a uterine cervix so as to provide a therapeutic effect in one or more regions of the uterine cervix, such as one or more regions of the cervix infected with human papillomavirus (HPV) and/or diagnosed with cervical intraepithelial neoplasia (CIN) or so as to create the correct biological response in one or more such regions. The microwave antenna apparatus may be configured for localized non-ablative hyperthermia of the surface tissue of the uterine cervix, localized ablation of the surface tissue of the uterine cervix, and/or cauterisation of the surface tissue of the uterine cervix.

公开(公告)号：US20240173561A1

公开(公告)日：2024-05-30

申请号：US18562654

申请日：2022-05-20

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Shailesh Joshi ,  Matthew Kidd

IPC: A61N5/02 ,  C12N13/00

CPC classification number: A61N5/025 ,  C12N13/00

Abstract: The disclosure is based on the finding that microwave energy may be used to modulate, for example up- or down-regulate the expression of certain genes. For example, where a disease or condition is associated with the aberrant expression of a particular gene or genes, microwave energy may be used to modulate the expression of those genes, thereby resolving and/or improving one or more of the symptoms of the disease or condition. Disclosed is a microwave system or microwave-generating apparatus, for use in a method of modulating the expression of one or more genes. Also disclosed are uses of microwave energy for modulating the expression of one or more genes in tissues, tissue samples and biopsies.

公开(公告)号：US20220219007A1

公开(公告)日：2022-07-14

申请号：US17557602

申请日：2021-12-21

Applicant: Emblation Limited

Inventor： Gary Beale ,  Eamon McErlean ,  Matthew Kidd ,  Shailesh Joshi

IPC: A61N5/02 ,  A61P31/10

Abstract: The present disclosure provides compositions, medicaments and methods for treating or preventing disorders, conditions and/or diseases affecting keratinised structures or tissues such as, for example, nails.

公开(公告)号：US20220175448A1

公开(公告)日：2022-06-09

申请号：US17598712

申请日：2020-03-27

Applicant: Emblation Limited

Inventor： Eamon Mcerlean ,  Gary Beale ,  Shailesh Joshi

IPC: A61B18/18 ,  H05B6/70 ,  H05B6/64

Abstract: A microwave apparatus comprises: a microwave feed line configured to deliver microwave energy having a selected operational frequency or range of frequencies to a radiating element extending from or coupled to a distal end of the microwave feed line; the radiating element; and a reactive element formed in or on the microwave feed line; wherein the operational frequency or range of frequencies is selected such that the reactive element both provides a desired degree of match between an impedance of the radiating element and an impedance of the microwave feed line, and reduces or eliminates surface currents flowing on a ground of the feed line.

公开(公告)号：US20210244469A1

公开(公告)日：2021-08-12

申请号：US17273554

申请日：2019-08-30

Applicant: Emblation Limited

Inventor： Eamon McErlean ,  Gary Beale ,  Matthew Kidd ,  Shailesh Joshi

IPC: A61B18/18

Abstract: A microwave system comprises: a microwave generator; and a microwave cable apparatus comprising a coaxial cable, wherein an exposed distal portion of an inner conductor of the coaxial cable is longer than an outer conductor of the coaxial cable, and wherein at least part of the exposed distal portion of the inner conductor is bent with respect to a longitudinal axis of the coaxial cable, thereby to provide a directional radiating element; wherein the microwave generator is configured to provide microwave energy to the cable apparatus at a frequency that provides directional radiation of microwave energy having a desired directionality from the radiating element.